Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: Evidence for the formation of a novel quinone methide intermediate

Chemical Research in Toxicology

Volumn 20, Issue 10, 2007, Pages 1488-1497

  Driscoll, James P ^a   Kornecki, Katherine ^a   Wolkowski, Joanna P ^a   Chupak, Lou ^a   Kalgutkar, Amit S ^a   O'Donnell, John P ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B; CYTOCHROME P450 2B4; GLUTATHIONE; PHENCYCLIDINE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANESTHESIA MECHANISM; ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DECOMPOSITION; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INCUBATION TIME; LIVER MICROSOME METABOLISM; LIVER MITOCHONDRION; MACROMOLECULE; MICHAEL ADDITION; MOLECULAR WEIGHT; NONHUMAN; PROTEIN VARIANT; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2B1; GLUTATHIONE; HALLUCINOGENS; HUMANS; INDOLEQUINONES; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PHENCYCLIDINE; RATS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 35848937130     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700145k     Document Type: Article

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