메뉴 건너뛰기




Volumn 10, Issue 12, 2008, Pages 786-793

An update on the biology of cancer stem cells in breast cancer

Author keywords

ABC transporters; Breast cancer; Cancer; Cancer Stem Cell; Hedgehog; Notch; PEDF; Target therapies; Wnt

Indexed keywords

ANTINEOPLASTIC AGENT; TUMOR MARKER;

EID: 60549089844     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-008-0291-9     Document Type: Article
Times cited : (16)

References (77)
  • 1
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3:730-737
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 2
    • 0017785769 scopus 로고
    • Primary bioassay of human tumor stem cells
    • Hamburger AW, Salmon SE (1977) Primary bioassay of human tumor stem cells. Science 197: 461-463
    • (1977) Science , vol.197 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 3
    • 16144365969 scopus 로고    scopus 로고
    • Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
    • Larochelle A, Vormoor J, Hanenberg H et al (1996) Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med 2:1329-1337
    • (1996) Nat Med , vol.2 , pp. 1329-1337
    • Larochelle, A.1    Vormoor, J.2    Hanenberg, H.3
  • 4
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • Reynolds BA, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255: 1707-1710
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 5
    • 0027941902 scopus 로고
    • A self-renewing multipotential stem cell in embryonic rat cerebral cortex
    • Davis AA, Temple S (1994) A self-renewing multipotential stem cell in embryonic rat cerebral cortex. Nature 372:263-266
    • (1994) Nature , vol.372 , pp. 263-266
    • Davis, A.A.1    Temple, S.2
  • 6
    • 0035499887 scopus 로고    scopus 로고
    • The development of neural stem cells
    • Temple S (2001) The development of neural stem cells. Nature 414:112-117
    • (2001) Nature , vol.414 , pp. 112-117
    • Temple, S.1
  • 7
    • 0015427655 scopus 로고
    • Isolation of a continuous epithelioid cell line, HBT-3, from a human breast carcinoma
    • Bassin RH, Plata EJ, Gerwin BI et al (1972) Isolation of a continuous epithelioid cell line, HBT-3, from a human breast carcinoma. Proc Soc Exp Biol Med 141:673-680
    • (1972) Proc Soc Exp Biol Med , vol.141 , pp. 673-680
    • Bassin, R.H.1    Plata, E.J.2    Gerwin, B.I.3
  • 8
    • 0020657877 scopus 로고
    • A new human breast carcinoma cell line (PMC42) with stem cell characteristics. I. Morphologic characterization
    • Whitehead RH, Bertoncello I, Webber LM, Pedersen JS (1983) A new human breast carcinoma cell line (PMC42) with stem cell characteristics. I. Morphologic characterization. J Natl Cancer Inst 70:649-661
    • (1983) J Natl Cancer Inst , vol.70 , pp. 649-661
    • Whitehead, R.H.1    Bertoncello, I.2    Webber, L.M.3    Pedersen, J.S.4
  • 9
    • 34249332411 scopus 로고    scopus 로고
    • CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
    • Beier D, Hau P, Proescholdt M et al (2007) CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 67:4010-4015
    • (2007) Cancer Res , vol.67 , pp. 4010-4015
    • Beier, D.1    Hau, P.2    Proescholdt, M.3
  • 10
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • Dalerba P, Dylla SJ, Park IK et al (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 104:10158-10163
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10158-10163
    • Dalerba, P.1    Dylla, S.J.2    Park, I.K.3
  • 11
    • 34250315214 scopus 로고    scopus 로고
    • Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo
    • Gu G, Yuan J, Wills M, Kasper S (2007) Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer Res 67:4807-4815
    • (2007) Cancer Res , vol.67 , pp. 4807-4815
    • Gu, G.1    Yuan, J.2    Wills, M.3    Kasper, S.4
  • 12
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • Ho MM, Ng AV, Lam S, Hung JY (2007) Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 67:4827-4833
    • (2007) Cancer Res , vol.67 , pp. 4827-4833
    • Ho, M.M.1    Ng, A.V.2    Lam, S.3    Hung, J.Y.4
  • 13
    • 34248529666 scopus 로고    scopus 로고
    • Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line
    • Wang J, Guo LP, Chen LZ et al (2007) Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res 67:3716-3724
    • (2007) Cancer Res , vol.67 , pp. 3716-3724
    • Wang, J.1    Guo, L.P.2    Chen, L.Z.3
  • 14
    • 0023889974 scopus 로고
    • A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland
    • Smith GH, Medina D (1988) A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J Cell Sci 90:173-183
    • (1988) J Cell Sci , vol.90 , pp. 173-183
    • Smith, G.H.1    Medina, D.2
  • 15
    • 0033747336 scopus 로고    scopus 로고
    • A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model
    • Murphy KL, Dennis AP, Rosen JM (2000) A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model. FASEB J 14: 2291-2302
    • (2000) FASEB J , vol.14 , pp. 2291-2302
    • Murphy, K.L.1    Dennis, A.P.2    Rosen, J.M.3
  • 16
    • 0032587877 scopus 로고    scopus 로고
    • Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    • Xu X, Wagner KU, Larson D et al (1999) Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet 22:37-43
    • (1999) Nat Genet , vol.22 , pp. 37-43
    • Xu, X.1    Wagner, K.U.2    Larson, D.3
  • 18
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Herman PC, Huber SL, Herrier T et al (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1:313-323
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Herman, P.C.1    Huber, S.L.2    Herrier, T.3
  • 19
    • 25144455560 scopus 로고    scopus 로고
    • Stem cell research: Paths to cancer therapies and regenerative medicine
    • Weissman I (2005) Stem cell research: paths to cancer therapies and regenerative medicine. JAMA 294:1359-1366
    • (2005) JAMA , vol.294 , pp. 1359-1366
    • Weissman, I.1
  • 20
    • 33645643823 scopus 로고    scopus 로고
    • Concomitant versus sequential chemotherapy in the treatment of early-stage and metastatic breast cancer
    • Ocana A, Hortobagyi GN, Esteva FJ (2006) Concomitant versus sequential chemotherapy in the treatment of early-stage and metastatic breast cancer. Clin Breast Cancer 6:495-504
    • (2006) Clin Breast Cancer , vol.6 , pp. 495-504
    • Ocana, A.1    Hortobagyi, G.N.2    Esteva, F.J.3
  • 21
    • 15544389499 scopus 로고    scopus 로고
    • Chemotherapy: What progress in the last 5 years?
    • Hamilton A, Hortobagyi G (2005) Chemotherapy: what progress in the last 5 years? J Clin Oncol 23:1760-1775
    • (2005) J Clin Oncol , vol.23 , pp. 1760-1775
    • Hamilton, A.1    Hortobagyi, G.2
  • 22
    • 39749147521 scopus 로고    scopus 로고
    • Using maths to tackle cancer
    • Weinberg RA (2007) Using maths to tackle cancer. Nature 449:978-981
    • (2007) Nature , vol.449 , pp. 978-981
    • Weinberg, R.A.1
  • 23
    • 0041689748 scopus 로고    scopus 로고
    • Cancer research. Mutant stem cells may seed cancer
    • Marx J (2003) Cancer research. Mutant stem cells may seed cancer. Science 301:1308-1310
    • (2003) Science , vol.301 , pp. 1308-1310
    • Marx, J.1
  • 24
    • 85047690508 scopus 로고    scopus 로고
    • Opinion: The origin of the cancer stem cell: Current controversies and new insights
    • Bjerkvig R, Tysnes BB, Aboody KS et al (2005) Opinion: the origin of the cancer stem cell: current controversies and new insights. Nat Rev Cancer 5:899-904
    • (2005) Nat Rev Cancer , vol.5 , pp. 899-904
    • Bjerkvig, R.1    Tysnes, B.B.2    Aboody, K.S.3
  • 25
    • 0033636521 scopus 로고    scopus 로고
    • Timing of CNS cell generation: A programmed sequence of neuron and glial cell production from isolated murine cortical stem cells
    • Qian X, Shen Q, Goderie SK et al (2000) Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28: 69-80
    • (2000) Neuron , vol.28 , pp. 69-80
    • Qian, X.1    Shen, Q.2    Goderie, S.K.3
  • 26
    • 4644219809 scopus 로고    scopus 로고
    • Cancer stem cells persist in many cancer cell lines
    • Setoguchi T, Taga T, Kondo T (2004) Cancer stem cells persist in many cancer cell lines. Cell Cycle 3:414-415
    • (2004) Cell Cycle , vol.3 , pp. 414-415
    • Setoguchi, T.1    Taga, T.2    Kondo, T.3
  • 27
    • 1642474273 scopus 로고    scopus 로고
    • Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    • Kondo T, Setoguchi T, Taga T (2004) Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci U S A 101:781-786
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 781-786
    • Kondo, T.1    Setoguchi, T.2    Taga, T.3
  • 28
    • 0034687840 scopus 로고    scopus 로고
    • Direct isolation of human central nervous system stem cells
    • Uchida N, Buck DW, He D et al (2000) Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A 97:14720-14725
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 14720-14725
    • Uchida, N.1    Buck, D.W.2    He, D.3
  • 29
    • 25444452414 scopus 로고    scopus 로고
    • CD133-positive hematopoietic stem cell "stemness" genes contain many genes mutated or abnormally expressed in leukemia
    • Toren A, Bielorai B, Jacob-Hirsch J et al (2005) CD133-positive hematopoietic stem cell "stemness" genes contain many genes mutated or abnormally expressed in leukemia. Stem Cells 23:1142-1153
    • (2005) Stem Cells , vol.23 , pp. 1142-1153
    • Toren, A.1    Bielorai, B.2    Jacob-Hirsch, J.3
  • 30
    • 33745924696 scopus 로고    scopus 로고
    • Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties
    • Chiba T, Kita K, Zheng YW et al (2006) Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 44:240-251
    • (2006) Hepatology , vol.44 , pp. 240-251
    • Chiba, T.1    Kita, K.2    Zheng, Y.W.3
  • 31
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins AT, Berry PA, Hyde C et al (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 65:10946-10951
    • (2005) Cancer Res , vol.65 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3
  • 32
    • 34248140257 scopus 로고    scopus 로고
    • Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
    • Miki J, Furusato B, Li H et al (2007) Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens. Cancer Res 67:3153-3161
    • (2007) Cancer Res , vol.67 , pp. 3153-3161
    • Miki, J.1    Furusato, B.2    Li, H.3
  • 33
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M et al (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63:5821-5828
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 34
    • 11244293572 scopus 로고    scopus 로고
    • Isolation of cancer stem cells from adult glioblastoma multiforme
    • Yuan X, Curtin J, Xiong Y et al (2004) Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23:9392-9400
    • (2004) Oncogene , vol.23 , pp. 9392-9400
    • Yuan, X.1    Curtin, J.2    Xiong, Y.3
  • 35
    • 33845671339 scopus 로고    scopus 로고
    • Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    • Liu G, Yuan X, Zeng Z et al (2006) Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 5: 67
    • (2006) Mol Cancer , vol.5 , pp. 67
    • Liu, G.1    Yuan, X.2    Zeng, Z.3
  • 36
    • 12144263254 scopus 로고    scopus 로고
    • Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer
    • Florek M, Haase M, Marzesco AM et al (2005) Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer. Cell Tissue Res 319:15-26
    • (2005) Cell Tissue Res , vol.319 , pp. 15-26
    • Florek, M.1    Haase, M.2    Marzesco, A.M.3
  • 37
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien CA, Pollett A, Gallinger S, Dick JE (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445:106-110
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 38
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • Ricci-Vitiani L, Lombardi DG, Pilozzi E et al (2007) Identification and expansion of human colon-cancer-initiating cells. Nature 445:111-115
    • (2007) Nature , vol.445 , pp. 111-115
    • Ricci-Vitiani, L.1    Lombardi, D.G.2    Pilozzi, E.3
  • 39
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker N, van Es JH, Kuipers J et al (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449:1003-1007
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    Van Es, J.H.2    Kuipers, J.3
  • 41
    • 11144340909 scopus 로고    scopus 로고
    • A putative human breast stem cell population is enriched for steroid receptor-positive cells
    • Clarke RB, Spence K, Anderson E et al (2005) A putative human breast stem cell population is enriched for steroid receptor-positive cells. Dev Biol 277:443-456
    • (2005) Dev Biol , vol.277 , pp. 443-456
    • Clarke, R.B.1    Spence, K.2    Anderson, E.3
  • 42
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: Models and concepts
    • Dalerba P, Cho RW, Clarke MF (2007) Cancer stem cells: models and concepts. Annu Rev Med 58:267-284
    • (2007) Annu Rev Med , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 43
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg AP, Ohlsson R, Henikoff S (2006) The epigenetic progenitor origin of human cancer. Nat Rev Genet 7:21-33
    • (2006) Nat Rev Genet , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 44
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells - An integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S et al (2005) Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 5:744-749
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3
  • 45
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery JP (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15:740-746
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 46
    • 33750306612 scopus 로고    scopus 로고
    • Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype
    • Balic M, Lin H, Young L et al (2006) Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 12:5615-5621
    • (2006) Clin Cancer Res , vol.12 , pp. 5615-5621
    • Balic, M.1    Lin, H.2    Young, L.3
  • 47
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC et al (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-348
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3
  • 48
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R, Wang X, Chen GY et al (2007) The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 356:217-226
    • (2007) N Engl J Med , vol.356 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3
  • 49
    • 33846459466 scopus 로고    scopus 로고
    • Sorting out breast-cancer gene signatures
    • Massague J (2007) Sorting out breast-cancer gene signatures. N Engl J Med 356:294-297
    • (2007) N Engl J Med , vol.356 , pp. 294-297
    • Massague, J.1
  • 50
    • 34248550985 scopus 로고    scopus 로고
    • Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors
    • Folkins C, Man S, Xu P et al (2007) Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res 67:3560-3564
    • (2007) Cancer Res , vol.67 , pp. 3560-3564
    • Folkins, C.1    Man, S.2    Xu, P.3
  • 51
    • 68149111125 scopus 로고    scopus 로고
    • Therapeutic resistance and tumor-initiation: Molecular pathways involved in breast cancer stem cell self-renewal
    • Chang A, Li X, Wong H (2007) Therapeutic resistance and tumor-initiation: molecular pathways involved in breast cancer stem cell self-renewal. J Clin Oncol 25:528
    • (2007) J Clin Oncol , vol.25 , pp. 528
    • Chang, A.1    Li, X.2    Wong, H.3
  • 52
    • 1542503811 scopus 로고    scopus 로고
    • PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation
    • Jiffar T, Kurinna S, Suck G et al (2004) PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation. Leukemia 18:505-512
    • (2004) Leukemia , vol.18 , pp. 505-512
    • Jiffar, T.1    Kurinna, S.2    Suck, G.3
  • 53
    • 5144226566 scopus 로고    scopus 로고
    • Predicting drug sensitivity and resistance: Profiling ABC transporter genes in cancer cells
    • Szakacs G, Annereau JP, Lababidi S et al (2004) Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell 6:129-137
    • (2004) Cancer Cell , vol.6 , pp. 129-137
    • Szakacs, G.1    Annereau, J.P.2    Lababidi, S.3
  • 54
    • 4644306516 scopus 로고    scopus 로고
    • A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    • Hirschmann-Jax C, Foster AE, Wulf GG et al (2004) A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A 101:14228-14233
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14228-14233
    • Hirschmann-Jax, C.1    Foster, A.E.2    Wulf, G.G.3
  • 55
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24(-/low)/CD44+ breast cancerinitiating cells to radiation
    • Phillips TM, McBride WH, Pajonk F (2006) The response of CD24(-/low)/CD44+ breast cancerinitiating cells to radiation. J. Natl. Cancer Inst. 98:1777-85
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 56
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE, et al (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-60
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 57
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA (2005) ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5:341-54
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 60
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103:211-25
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 61
    • 0037137686 scopus 로고    scopus 로고
    • EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells
    • Doetsch F, Petreanu L, Caille I, et al (2002) EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 36:1021-34
    • (2002) Neuron , vol.36 , pp. 1021-1034
    • Doetsch, F.1    Petreanu, L.2    Caille, I.3
  • 62
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • Baselga J, Arteaga CL (2005) Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J. Clin. Oncol. 23: 2445-59
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 63
    • 33745880884 scopus 로고    scopus 로고
    • PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form gliomalike growths in response to increased PDGF signaling
    • Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, et al (2006) PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form gliomalike growths in response to increased PDGF signaling. Neuron 51:187-99
    • (2006) Neuron , vol.51 , pp. 187-199
    • Jackson, E.L.1    Garcia-Verdugo, J.M.2    Gil-Perotin, S.3
  • 64
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin M, Campbell LL, Argani P, et al (2007) Molecular definition of breast tumor heterogeneity. Cancer Cell 11:259-73
    • (2007) Cancer Cell , vol.11 , pp. 259-273
    • Shipitsin, M.1    Campbell, L.L.2    Argani, P.3
  • 65
    • 33751311939 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta signaling in human cancer: Targeting a tumor suppressor network as a therapeutic strategy
    • Biswas S, Criswell TL, Wang SE, et al (2006) Inhibition of transforming growth factor-beta signaling in human cancer: targeting a tumor suppressor network as a therapeutic strategy. Clin. Cancer Res. 12:4142-6
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4142-4146
    • Biswas, S.1    Criswell, T.L.2    Wang, S.E.3
  • 66
    • 33846821916 scopus 로고    scopus 로고
    • High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
    • Bruna A, Darken RS, Rojo F, et al (2007) High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11:147-60
    • (2007) Cancer Cell , vol.11 , pp. 147-160
    • Bruna, A.1    Darken, R.S.2    Rojo, F.3
  • 67
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284:770-6
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 68
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: A simple pathway becomes complex
    • Bray SJ. 2006. Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 7:678-89
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 69
    • 24044513994 scopus 로고    scopus 로고
    • Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling
    • Sun Y, Lowther W, Kato K, et al (2005) Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling. Oncogene 24:5365-74
    • (2005) Oncogene , vol.24 , pp. 5365-5374
    • Sun, Y.1    Lowther, W.2    Kato, K.3
  • 70
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • Fan X, Matsui W, Khaki L, Stearns D, Chun J, Li YM, Eberhart CG. 2006. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res. 66:7445-52
    • (2006) Cancer Res , vol.66 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3    Stearns, D.4    Chun, J.5    Li, Y.M.6    Eberhart, C.G.7
  • 71
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H (2005) Wnt signalling in stem cells and cancer. Nature 434:843-50
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 72
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells 28
    • Liu S, Dontu G, Mantle ID, et al (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells 28. Cancer Res. 66:6063-71
    • (2006) Cancer Res. , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3
  • 73
    • 33344455016 scopus 로고    scopus 로고
    • Pigment epitheliumderived factor is a niche signal for neural stem cell renewal
    • Ramirez-Castillejo C, Sanchez-Sanchez F, Andreu-Agullo C, et al (200)6) Pigment epitheliumderived factor is a niche signal for neural stem cell renewal. Nat. Neurosci. 9:331-9
    • (2006) Nat. Neurosci. , vol.9 , pp. 331-339
    • Ramirez-Castillejo, C.1    Sanchez-Sanchez, F.2    Andreu-Agullo, C.3
  • 74
    • 33845989501 scopus 로고    scopus 로고
    • Identification of a lipase-linked cell-membrane receptor for Pigment Epithelium-derived factor (PEDF)
    • Notari L, Baladron V, Aroca-Aguilar JD et al (2006) Identification of a lipase-linked cell-membrane receptor for Pigment Epithelium-derived factor (PEDF). J. Biol. Chem. en revision
    • (2006) J. Biol. Chem. en Revision
    • Notari, L.1    Baladron, V.2    Aroca-Aguilar, J.D.3
  • 75
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN (2007) Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat. Rev. Cancer 7:733-6
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 77
    • 0035173448 scopus 로고    scopus 로고
    • Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF
    • Ohno-Matsui K, Morita I, Tombran-Tink J, et al (2001) Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. J. Cell Physiol 189:323-33.
    • (2001) J. Cell Physiol , vol.189 , pp. 323-333
    • Ohno-Matsui, K.1    Morita, I.2    Tombran-Tink, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.