PKC α mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation

Leukemia

Volumn 18, Issue 3, 2004, Pages 505-512

  Jiffar, T ^a   Kurinna, S ^a   Suck, G ^a   Carlson Bremer, D ^b   Ricciardi, M R ^b   Konopleva, M ^b   Andreeff, M ^b   Ruvolo, Peter P ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Acute leukemia; Bcl2; Chemoresistance; PP2A; Protein kinase C

Indexed keywords

2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; ANTINEOPLASTIC AGENT; ETOPOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN BCL 2; PROTEIN KINASE C ALPHA; UNCLASSIFIED DRUG; BENZOPYRAN DERIVATIVE; ENZYME INHIBITOR; HA14-1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRILE; PHOSPHOPROTEIN PHOSPHATASE; PRKCA PROTEIN, HUMAN; PROTEIN KINASE C;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALPHA CHAIN; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBUNIT; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; ACUTE LYMPHOCYTIC LEUKEMIA; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZOPYRANS; CELL CYCLE; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; ETOPOSIDE; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 1542503811     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403275     Document Type: Article

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