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Volumn 66, Issue 18, 2006, Pages 9211-9220

Inhibition of Hsp90 compromises the DNA damage response to radiation

Author keywords

[No Author keywords available]

Indexed keywords

17 (DIMETHYLAMINOETHYLAMINO) 17 DEMETHOXYGELDANAMYCIN; ATM PROTEIN; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; UNCLASSIFIED DRUG;

EID: 33749469341     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2181     Document Type: Article
Times cited : (141)

References (50)
  • 1
    • 0036219609 scopus 로고    scopus 로고
    • Hsp90 inhibitors as novel cancer chemotherapeutic agents
    • Neckers L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 2002;8:S55-61.
    • (2002) Trends Mol Med , vol.8
    • Neckers, L.1
  • 2
    • 0141596941 scopus 로고    scopus 로고
    • Overview: Translating Hsp90 biology into Hsp90 drugs
    • Workman P. Overview: translating Hsp90 biology into Hsp90 drugs. Curr Cancer Drug Targets 2003;3:297-300.
    • (2003) Curr Cancer Drug Targets , vol.3 , pp. 297-300
    • Workman, P.1
  • 3
    • 0141568014 scopus 로고    scopus 로고
    • Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin: A multitarget approach to radiosensitization
    • Russell JS, Burgan WE, Oswald KA, Camphausen K, Tofilon PJ. Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin: a multitarget approach to radiosensitization. Clin Cancer Res 2003;9:3749-55.
    • (2003) Clin Cancer Res , vol.9 , pp. 3749-3755
    • Russell, J.S.1    Burgan, W.E.2    Oswald, K.A.3    Camphausen, K.4    Tofilon, P.J.5
  • 4
    • 9744236616 scopus 로고    scopus 로고
    • 2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17- demethoxygeldanamycin
    • 2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin. Clin Cancer Res 2004;10:8077-84.
    • (2004) Clin Cancer Res , vol.10 , pp. 8077-8084
    • Bull, E.E.1    Dote, H.2    Brady, K.J.3
  • 5
    • 9144261127 scopus 로고    scopus 로고
    • Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity
    • Bisht KS, Bradbury CM, Mattson D, et al. Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res 2003;63:8984-95.
    • (2003) Cancer Res , vol.63 , pp. 8984-8995
    • Bisht, K.S.1    Bradbury, C.M.2    Mattson, D.3
  • 6
    • 0346995281 scopus 로고    scopus 로고
    • Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids
    • Enmon R, Yang WH, Ballangrud AM, et al. Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids. Cancer Res 2003;63:8393-9.
    • (2003) Cancer Res , vol.63 , pp. 8393-8399
    • Enmon, R.1    Yang, W.H.2    Ballangrud, A.M.3
  • 7
    • 18744390800 scopus 로고    scopus 로고
    • Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor
    • Harashima K, Akimoto T, Nonaka T, Tsuzuki K, Mitsuhashi N, Nakano T. Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor. Int J Radiat Biol 2005;81:63-76.
    • (2005) Int J Radiat Biol , vol.81 , pp. 63-76
    • Harashima, K.1    Akimoto, T.2    Nonaka, T.3    Tsuzuki, K.4    Mitsuhashi, N.5    Nakano, T.6
  • 8
    • 0742304429 scopus 로고    scopus 로고
    • Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation
    • Machida H, Matsumoto Y, Shirai M, Kubota N. Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation. Int J Radiat Biol 2003;79:973-80.
    • (2003) Int J Radiat Biol , vol.79 , pp. 973-980
    • Machida, H.1    Matsumoto, Y.2    Shirai, M.3    Kubota, N.4
  • 9
    • 23044480581 scopus 로고    scopus 로고
    • ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition
    • Dote H, Cerna D, Burgan WE, Camphausen K, Tofilon PJ. ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition. Cancer Res 2005;65:6967-75.
    • (2005) Cancer Res , vol.65 , pp. 6967-6975
    • Dote, H.1    Cerna, D.2    Burgan, W.E.3    Camphausen, K.4    Tofilon, P.J.5
  • 10
    • 20444478652 scopus 로고    scopus 로고
    • Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine
    • Dote H, Cerna D, Burgan WE, et al. Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine. Clin Cancer Res 2005;11:4571-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 4571-4579
    • Dote, H.1    Cerna, D.2    Burgan, W.E.3
  • 11
    • 0037427860 scopus 로고    scopus 로고
    • A cross-platform public domain PC image-analysis program for the comet assay
    • Konca K, Lankoff A, Banasik A, et al. A cross-platform public domain PC image-analysis program for the comet assay. Mutat Res 2003;534:15-20.
    • (2003) Mutat Res , vol.534 , pp. 15-20
    • Konca, K.1    Lankoff, A.2    Banasik, A.3
  • 12
    • 0036146085 scopus 로고    scopus 로고
    • Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation
    • Xu B, Kim ST, Lim DS, Kastan MB. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 2002;22:1049-59.
    • (2002) Mol Cell Biol , vol.22 , pp. 1049-1059
    • Xu, B.1    Kim, S.T.2    Lim, D.S.3    Kastan, M.B.4
  • 13
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998;273:5858-68.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 14
    • 0036789173 scopus 로고    scopus 로고
    • Quantitative detection of (125)IdU-induced DNA double-strand breaks with γ-H2AX antibody
    • Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of (125)IdU-induced DNA double-strand breaks with γ-H2AX antibody. Radiat Res 2002;158:486-92.
    • (2002) Radiat Res , vol.158 , pp. 486-492
    • Sedelnikova, O.A.1    Rogakou, E.P.2    Panyutin, I.G.3    Bonner, W.M.4
  • 15
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    • Rothkamm K, Loblich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A 2003;100:5057-62.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Loblich, M.2
  • 16
    • 0345835371 scopus 로고    scopus 로고
    • Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks
    • Banath JP, Olive PL. Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. Cancer Res 2003;63:4347-50.
    • (2003) Cancer Res , vol.63 , pp. 4347-4350
    • Banath, J.P.1    Olive, P.L.2
  • 17
    • 0032959983 scopus 로고    scopus 로고
    • DNA damage and repair in individual cells: Applications of the comet assay in radiobiology
    • Olive PL. DNA damage and repair in individual cells: applications of the comet assay in radiobiology. Int J Radiat Biol 1999;75:395-405.
    • (1999) Int J Radiat Biol , vol.75 , pp. 395-405
    • Olive, P.L.1
  • 18
    • 24744449739 scopus 로고    scopus 로고
    • Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
    • Dittmann K, Mayer C, Fehrenbacher B, et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem 2005;280:31182-9.
    • (2005) J Biol Chem , vol.280 , pp. 31182-31189
    • Dittmann, K.1    Mayer, C.2    Fehrenbacher, B.3
  • 20
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • Chan DW, Chen BP, Prithivirajsingh S, et al. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev 2002;16:2333-8.
    • (2002) Genes Dev , vol.16 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.2    Prithivirajsingh, S.3
  • 21
    • 0141757479 scopus 로고    scopus 로고
    • DNA damage checkpoint control in cells exposed to ionizing radiation
    • Iliakis G, Wang Y, Guan J, Wang H. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 2003;22:5834-47.
    • (2003) Oncogene , vol.22 , pp. 5834-5847
    • Iliakis, G.1    Wang, Y.2    Guan, J.3    Wang, H.4
  • 22
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • Kastan MB, Lim DS. The many substrates and functions of ATM. Nat Rev Mol Cell Biol 2000;1:179-86.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 23
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003;421:499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 26
    • 1842431822 scopus 로고    scopus 로고
    • Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
    • Lee JH, Paull TT. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 2004;304:93-6.
    • (2004) Science , vol.304 , pp. 93-96
    • Lee, J.H.1    Paull, T.T.2
  • 27
    • 0034997651 scopus 로고    scopus 로고
    • Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
    • Desai-Mehta A, Cerosaletti KM, Concannon P. Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Mol Cell Biol 2001;21:2184-91.
    • (2001) Mol Cell Biol , vol.21 , pp. 2184-2191
    • Desai-Mehta, A.1    Cerosaletti, K.M.2    Concannon, P.3
  • 28
    • 18644367144 scopus 로고    scopus 로고
    • NBS1 localizes to γ-H2AX foci through interaction with the FHA/BRCT domain
    • Kobayashi J, Tauchi H, Sakamoto S, et al. NBS1 localizes to γ-H2AX foci through interaction with the FHA/BRCT domain. Curr Biol 2002;12:1846-51.
    • (2002) Curr Biol , vol.12 , pp. 1846-1851
    • Kobayashi, J.1    Tauchi, H.2    Sakamoto, S.3
  • 29
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 2000;10:886-95.
    • (2000) Curr Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 30
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • You Z, Chahwan C, Bailis J, Hunter T, Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 2005;25:5363-79.
    • (2005) Mol Cell Biol , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5
  • 31
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000;408:433-9.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 32
    • 0037178748 scopus 로고    scopus 로고
    • Interfaces between the detection, signaling, and repair of DNA damage
    • Rouse J, Jackson SP. Interfaces between the detection, signaling, and repair of DNA damage. Science 2002;297:547-51.
    • (2002) Science , vol.297 , pp. 547-551
    • Rouse, J.1    Jackson, S.P.2
  • 33
    • 4944234150 scopus 로고    scopus 로고
    • Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
    • Banath JP, Macphail SH, Olive PL. Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines. Cancer Res 2004;4:7144-9.
    • (2004) Cancer Res , vol.4 , pp. 7144-7149
    • Banath, J.P.1    Macphail, S.H.2    Olive, P.L.3
  • 34
    • 0942278942 scopus 로고    scopus 로고
    • Phosphorylation of historic H2AX as a measure of radiosensitivity
    • Olive PL, Banath JP. Phosphorylation of historic H2AX as a measure of radiosensitivity. Int J Radiat Oncol Biol Phys 2004;58:331-5.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 331-335
    • Olive, P.L.1    Banath, J.P.2
  • 36
    • 4544333242 scopus 로고    scopus 로고
    • The Mre11 complex and ATM: A two-way functional interaction in recognising and signaling DNA double strand breaks
    • Lavin MF. The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks. DNA Repair (Amst) 2004;3:1515-20.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1515-1520
    • Lavin, M.F.1
  • 37
    • 0346059615 scopus 로고    scopus 로고
    • 53BP1 and NFBD1/MDC1-1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage
    • Mochan TA, Venere M, DiTullio RA, Jr., Halazonetis TD. 53BP1 and NFBD1/MDC1-1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res 2003;63:8586-91.
    • (2003) Cancer Res , vol.63 , pp. 8586-8591
    • Mochan, T.A.1    Venere, M.2    DiTullio Jr., R.A.3    Halazonetis, T.D.4
  • 38
    • 22144462810 scopus 로고    scopus 로고
    • Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
    • Difilippantonio S, Celeste A, Fernandez-Capetillo O, et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol 2005;7:675-85.
    • (2005) Nat Cell Biol , vol.7 , pp. 675-685
    • Difilippantonio, S.1    Celeste, A.2    Fernandez-Capetillo, O.3
  • 39
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J, Coates J, Jackson SP. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005;434:605-11.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 40
    • 0023007393 scopus 로고
    • The dynamic state of heat shock proteins in chicken embryo fibroblasts
    • Collier NC, Schlesinger MJ. The dynamic state of heat shock proteins in chicken embryo fibroblasts. J Cell Biol 1986;103:1495-507.
    • (1986) J Cell Biol , vol.103 , pp. 1495-1507
    • Collier, N.C.1    Schlesinger, M.J.2
  • 41
    • 0025171925 scopus 로고
    • Nuclear localization of two steroid receptor-associated proteins, hsp90 and p59
    • Gasc JM, Renoir JM, Faber LE, Delahaye F, Baulieu EE. Nuclear localization of two steroid receptor-associated proteins, hsp90 and p59. Exp Cell Res 1990;186:362-7.
    • (1990) Exp Cell Res , vol.186 , pp. 362-367
    • Gasc, J.M.1    Renoir, J.M.2    Faber, L.E.3    Delahaye, F.4    Baulieu, E.E.5
  • 42
    • 0027503932 scopus 로고
    • HSP90 associates with specific heat shock puffs (hsr ω) in polytene chromosomes of Drosophila and Chironomus
    • Morcillo G, Diez JL, Carbajal ME, Tanguay RM. HSP90 associates with specific heat shock puffs (hsr ω) in polytene chromosomes of Drosophila and Chironomus. Chromosoma 1993;102:648-59.
    • (1993) Chromosoma , vol.102 , pp. 648-659
    • Morcillo, G.1    Diez, J.L.2    Carbajal, M.E.3    Tanguay, R.M.4
  • 43
    • 27744586073 scopus 로고    scopus 로고
    • Hsp90α recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells
    • Hung JJ, Wu CY, Liao PC, Chang WC. Hsp90α recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. J Biol Chem 2005;280:36283-92.
    • (2005) J Biol Chem , vol.280 , pp. 36283-36292
    • Hung, J.J.1    Wu, C.Y.2    Liao, P.C.3    Chang, W.C.4
  • 44
    • 12144290835 scopus 로고    scopus 로고
    • Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes
    • Stavreva DA, Muller WG, Hager GL, Smith CL, McNally JG. Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes. Mol Cell Biol 2004;24:2682-97.
    • (2004) Mol Cell Biol , vol.24 , pp. 2682-2697
    • Stavreva, D.A.1    Muller, W.G.2    Hager, G.L.3    Smith, C.L.4    McNally, J.G.5
  • 45
  • 46
    • 32944461766 scopus 로고    scopus 로고
    • Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin
    • Ohji G, Hidayat S, Nakashima A, et al. Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin. J Biochem (Tokyo) 2006;139:129-35.
    • (2006) J Biochem (Tokyo) , vol.139 , pp. 129-135
    • Ohji, G.1    Hidayat, S.2    Nakashima, A.3
  • 47
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
    • Xu B, Kim S, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 2001;21:3445-50.
    • (2001) Mol Cell Biol , vol.21 , pp. 3445-3450
    • Xu, B.1    Kim, S.2    Kastan, M.B.3
  • 48
    • 20644471358 scopus 로고    scopus 로고
    • Harmonising the response to DSBs: A new string in the ATM bow
    • Lobrich M, Jeggo, PA. Harmonising the response to DSBs: a new string in the ATM bow. DNA Repair (Amst) 2005;4:749-59.
    • (2005) DNA Repair (Amst) , vol.4 , pp. 749-759
    • Lobrich, M.1    Jeggo, P.A.2
  • 50
    • 0035890610 scopus 로고    scopus 로고
    • Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator
    • Wang Y, Li J, Booher RN, et al. Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Cancer Res 2001;61:8211-7.
    • (2001) Cancer Res , vol.61 , pp. 8211-8217
    • Wang, Y.1    Li, J.2    Booher, R.N.3


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