-
1
-
-
14744298238
-
Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS
-
Toulany M, Dittmann K, Baumann M, Rodemann HP. Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS. Radiother Oncol 2005;74:117-29.
-
(2005)
Radiother Oncol
, vol.74
, pp. 117-129
-
-
Toulany, M.1
Dittmann, K.2
Baumann, M.3
Rodemann, H.P.4
-
2
-
-
0942268145
-
Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- And HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance
-
Zhou H, Kim YS, Peletier A, et al. Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. Int J Radiat Oncol Biol Phys 2004;58:344-52.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 344-352
-
-
Zhou, H.1
Kim, Y.S.2
Peletier, A.3
-
3
-
-
0035829685
-
Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells
-
Koniaras K, Cuddihy AR, Christopoulos H, Hogg A, O'Connell MJ. Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene 2001;20:7453-63.
-
(2001)
Oncogene
, vol.20
, pp. 7453-7463
-
-
Koniaras, K.1
Cuddihy, A.R.2
Christopoulos, H.3
Hogg, A.4
O'Connell, M.J.5
-
4
-
-
0030810968
-
Enhanced radiosensitivity by inhibition of nuclear factor κ B activation in human malignant glioma cells
-
Yamagishi N, Miyakoshi J, Takebe H. Enhanced radiosensitivity by inhibition of nuclear factor κ B activation in human malignant glioma cells. Int J Radiat Biol 1997;72:157-62.
-
(1997)
Int J Radiat Biol
, vol.72
, pp. 157-162
-
-
Yamagishi, N.1
Miyakoshi, J.2
Takebe, H.3
-
5
-
-
24944528429
-
NF-{kappa}B inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation
-
Epub 2005 March 31
-
Kim BY, Kim KA, Kwon O, et al. NF-{kappa}B inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation. Carcinogenesis. Epub 2005 March 31.
-
Carcinogenesis
-
-
Kim, B.Y.1
Kim, K.A.2
Kwon, O.3
-
6
-
-
0037089516
-
Inhibition of radiation-induced nuclear factor-κB activation by an anti-Ras single-chain antibody fragment: Lack of involvement in radiosensitization
-
Russell JS, Raju U, Gumin GJ, et al. Inhibition of radiation-induced nuclear factor-κB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization. Cancer Res 2002;62: 2318-26.
-
(2002)
Cancer Res
, vol.62
, pp. 2318-2326
-
-
Russell, J.S.1
Raju, U.2
Gumin, G.J.3
-
7
-
-
0033531272
-
2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells
-
2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells. Oncogene 1999;18:249-56.
-
(1999)
Oncogene
, vol.18
, pp. 249-256
-
-
Chen, P.1
Gatei, M.2
O'Connell, M.J.3
-
8
-
-
9744236616
-
2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17- demethoxygeldanamycin
-
2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin. Clin Cancer Res 2004;10: 8077-84.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8077-8084
-
-
Bull, E.E.1
Dote, H.2
Brady, K.J.3
-
9
-
-
0141568014
-
Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin: A multitarget approach to radiosensitization
-
Russell JS, Burgan W, Oswald KA, Camphausen K, Tofilon PJ. Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin: a multitarget approach to radiosensitization. Clin Cancer Res 2003;9:3749-55.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3749-3755
-
-
Russell, J.S.1
Burgan, W.2
Oswald, K.A.3
Camphausen, K.4
Tofilon, P.J.5
-
10
-
-
9144261127
-
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity
-
Bisht KS, Bradbury CM, Mattson D, et al. Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res 2003;63:8984-95.
-
(2003)
Cancer Res
, vol.63
, pp. 8984-8995
-
-
Bisht, K.S.1
Bradbury, C.M.2
Mattson, D.3
-
11
-
-
18744390800
-
Heat shock protein 90 (Hsp90) chaperone complex inhibitor, Radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor
-
Harashima K, Akimoto T, Nonaka T, et al. Heat shock protein 90 (Hsp90) chaperone complex inhibitor, Radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor. Int J Radiat Biol 2005;81:63-76.
-
(2005)
Int J Radiat Biol
, vol.81
, pp. 63-76
-
-
Harashima, K.1
Akimoto, T.2
Nonaka, T.3
-
12
-
-
0346995281
-
Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids
-
Enmon R, Yang WH, Ballangrud AM, et al. Combination treatment with 17-N-allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-additive growth suppression in human prostate carcinoma spheroids. Cancer Res 2003;63:8393-9.
-
(2003)
Cancer Res
, vol.63
, pp. 8393-8399
-
-
Enmon, R.1
Yang, W.H.2
Ballangrud, A.M.3
-
13
-
-
0036219609
-
Hsp90 inhibitors as novel cancer chemotherapeutic agents
-
Neckers L. Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 2002;8:555-61.
-
(2002)
Trends Mol Med
, vol.8
, pp. 555-561
-
-
Neckers, L.1
-
14
-
-
0034718540
-
Modulation of Akt kinase activity by binding to Hsp90
-
Sato S, Fujita N, Tsuruo T. Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci U S A 2000;97:10832-7.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10832-10837
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
15
-
-
0028786332
-
Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association
-
Schulte TW, Blagosklonny MV, Ingui C, Neckers L. Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association. J Biol Chem 1995;270:24585-8.
-
(1995)
J Biol Chem
, vol.270
, pp. 24585-24588
-
-
Schulte, T.W.1
Blagosklonny, M.V.2
Ingui, C.3
Neckers, L.4
-
16
-
-
0031550257
-
Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells
-
Pirollo KP, Hao Z, Rait A, Ho CW, Chang EH. Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells. Biochem Biophys Res Commun 1997;230: 196-201.
-
(1997)
Biochem Biophys Res Commun
, vol.230
, pp. 196-201
-
-
Pirollo, K.P.1
Hao, Z.2
Rait, A.3
Ho, C.W.4
Chang, E.H.5
-
18
-
-
0033559619
-
Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene
-
Pietras RJ, Poen JC, Gallardo D, et al. Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res 1999;59:1347-55.
-
(1999)
Cancer Res
, vol.59
, pp. 1347-1355
-
-
Pietras, R.J.1
Poen, J.C.2
Gallardo, D.3
-
19
-
-
2442689399
-
Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radio-resistance
-
Tanno S, Yanagawa N, Habiro A, et al. Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radio-resistance. Cancer Res 2004;64:3486-90.
-
(2004)
Cancer Res
, vol.64
, pp. 3486-3490
-
-
Tanno, S.1
Yanagawa, N.2
Habiro, A.3
-
20
-
-
0036139023
-
Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats
-
Egorin MJ, Lagattuta TF, Hamburger DR, et al. Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17- demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats. Cancer Chemother Pharmacol 2002;49:7-19.
-
(2002)
Cancer Chemother Pharmacol
, vol.49
, pp. 7-19
-
-
Egorin, M.J.1
Lagattuta, T.F.2
Hamburger, D.R.3
-
21
-
-
0032101569
-
Metabolism of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations
-
Egorin MJ, Rosen DM, Wolff JH, et al. Metabolism of 17-(allylamino)-17- demethoxygeldanamycin (NSC 330507) by murine and human hepatic preparations. Cancer Res 1998;58:2385-96.
-
(1998)
Cancer Res
, vol.58
, pp. 2385-2396
-
-
Egorin, M.J.1
Rosen, D.M.2
Wolff, J.H.3
-
22
-
-
0034600849
-
The ErbB signaling network: Receptor heterodimerization in development and cancer
-
Olayioye MA, Neve RM, Lane HA, Hynes NE. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 2000;19:3159-67.
-
(2000)
EMBO J
, vol.19
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
Lane, H.A.3
Hynes, N.E.4
-
23
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 1997;16:1647-55.
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
24
-
-
0037075232
-
Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2
-
Basso AD, Solit DB, Munster PN, Rosen N. Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2. Oncogene 2002;21:1159-66.
-
(2002)
Oncogene
, vol.21
, pp. 1159-1166
-
-
Basso, A.D.1
Solit, D.B.2
Munster, P.N.3
Rosen, N.4
-
25
-
-
18444404925
-
Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: Implications for cancer therapy
-
Citri A, Alroy I, Lavi S, et al. Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy. EMBO J 2002;21:2407-17.
-
(2002)
EMBO J
, vol.21
, pp. 2407-2417
-
-
Citri, A.1
Alroy, I.2
Lavi, S.3
-
27
-
-
0142240170
-
Anti-erbB receptor strategy as a gene therapeutic intervention to improve radiotherapy in malignant human tumours
-
Lammering G, Hewit TH, Valerie K, et al. Anti-erbB receptor strategy as a gene therapeutic intervention to improve radiotherapy in malignant human tumours. Int J Radiat Biol 2003;79:561-8.
-
(2003)
Int J Radiat Biol
, vol.79
, pp. 561-568
-
-
Lammering, G.1
Hewit, T.H.2
Valerie, K.3
-
28
-
-
0028838012
-
Dimerization of cell surface receptors in signal transduction
-
Heldin CH. Dimerization of cell surface receptors in signal transduction. Cell 1995;80:213-23.
-
(1995)
Cell
, vol.80
, pp. 213-223
-
-
Heldin, C.H.1
-
29
-
-
0032524350
-
Autoregulatory mechanisms in protein-tyrosine kinases
-
Hubbard SR, Mohammadi M, Schlessinger J. Autoregulatory mechanisms in protein-tyrosine kinases. J Biol Chem 1998;273:11987-90.
-
(1998)
J Biol Chem
, vol.273
, pp. 11987-11990
-
-
Hubbard, S.R.1
Mohammadi, M.2
Schlessinger, J.3
-
30
-
-
0030772168
-
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
-
Schmidt-Ullrich RK, Mikkelsen RB, Dent P, et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 1997;15:1191-7.
-
(1997)
Oncogene
, vol.15
, pp. 1191-1197
-
-
Schmidt-Ullrich, R.K.1
Mikkelsen, R.B.2
Dent, P.3
-
31
-
-
0141534450
-
EBBB receptor tyrosine kinases and cellular radiation responses
-
Schmidt-Ullrich RK, Contessa JN, Lammering G, Amorino G, Lin PS. EBBB receptor tyrosine kinases and cellular radiation responses. Oncogene 2003;22: 5855-65.
-
(2003)
Oncogene
, vol.22
, pp. 5855-5865
-
-
Schmidt-Ullrich, R.K.1
Contessa, J.N.2
Lammering, G.3
Amorino, G.4
Lin, P.S.5
-
32
-
-
0035868359
-
The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells
-
Bowers G, Reardon D, Hewitt T, et al. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. Oncogene 2001;20:1388-97.
-
(2001)
Oncogene
, vol.20
, pp. 1388-1397
-
-
Bowers, G.1
Reardon, D.2
Hewitt, T.3
-
33
-
-
2142843806
-
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
-
Pinkas-Kramarski R, Soussan L, Waterman H, et al. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 1996;15: 2452-67.
-
(1996)
EMBO J
, vol.15
, pp. 2452-2467
-
-
Pinkas-Kramarski, R.1
Soussan, L.2
Waterman, H.3
-
34
-
-
0029118223
-
The cellular response to neuregulins is governed by complex interactions of the erbB receptor family
-
Riese DJ II, van Raaij TM, Plowman GD, Andrews GC, Stern DF. The cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol Cell Biol 1995;15: 5770-6.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5770-5776
-
-
Riese II, D.J.1
Van Raaij, T.M.2
Plowman, G.D.3
Andrews, G.C.4
Stern, D.F.5
-
35
-
-
0024395587
-
Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts
-
Kokai Y, Myers JN, Wada T, et al. Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell 1989;58: 287-92.
-
(1989)
Cell
, vol.58
, pp. 287-292
-
-
Kokai, Y.1
Myers, J.N.2
Wada, T.3
-
36
-
-
0347993069
-
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress
-
Arlander SJ, Eapen AK, Vroman BT, et al. Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress. J Biol Chem 2003;278:52572-7.
-
(2003)
J Biol Chem
, vol.278
, pp. 52572-52577
-
-
Arlander, S.J.1
Eapen, A.K.2
Vroman, B.T.3
-
38
-
-
0033637762
-
Survivin as a radioresistance factor in pancreatic cancer
-
Asanuma K, Moriai R, Yajima T, et al. Survivin as a radioresistance factor in pancreatic cancer. Jpn J Cancer Res 2000;91:1204-9.
-
(2000)
Jpn J Cancer Res
, vol.91
, pp. 1204-1209
-
-
Asanuma, K.1
Moriai, R.2
Yajima, T.3
-
39
-
-
0037376549
-
Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: Survivin as a radioresistance factor
-
Rodel C, Haas J, Groth A, et al. Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor. Int J Radiat Oncol Biol Phys 2003;55:1341-7.
-
(2003)
Int J Radiat Oncol Biol Phys
, vol.55
, pp. 1341-1347
-
-
Rodel, C.1
Haas, J.2
Groth, A.3
-
40
-
-
4844227693
-
Survivin as a therapeutic target for radiation sensitization in lung cancer
-
Lu B, Mu Y, Cao C, et al. Survivin as a therapeutic target for radiation sensitization in lung cancer. Cancer Res 2004;64:2840-5.
-
(2004)
Cancer Res
, vol.64
, pp. 2840-2845
-
-
Lu, B.1
Mu, Y.2
Cao, C.3
-
41
-
-
6344261577
-
Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms
-
Chakravarti A, Zhai GG, Zhang M, et al. Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms. Oncogene 2004;23:7494-506.
-
(2004)
Oncogene
, vol.23
, pp. 7494-7506
-
-
Chakravarti, A.1
Zhai, G.G.2
Zhang, M.3
-
42
-
-
20044382800
-
Navigating the chaperone network: An integrative map of physical and genetic interactions mediated by the hsp90 chaperone
-
Zhao R, Davey M, Hsu YC, et al. Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 2005;120:715-27.
-
(2005)
Cell
, vol.120
, pp. 715-727
-
-
Zhao, R.1
Davey, M.2
Hsu, Y.C.3
|