Positive and negative regulatory mechanisms in high-affinity IgE receptor-mediated mast cell activation

Archivum Immunologiae et Therapiae Experimentalis

Volumn 56, Issue 6, 2008, Pages 385-399

  Roth, Kristy ^a   Chen, Wei Min ^b   Lin, Tong Jun ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b FUJIAN PROVINCIAL HOSPITAL   (China)

Author keywords

Allergy; Fc RI; IgE; Mast cells; Signal transduction

Indexed keywords

IMMUNOGLOBULIN E RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; SERINE; THREONINE;

CALCIUM MOBILIZATION; CELL ACTIVATION; ENZYME ACTIVATION; HUMAN; MAST CELL; NONHUMAN; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANAPHYLAXIS; ANIMALS; CALCIUM; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; HYPERSENSITIVITY; INFLAMMATION; MAP KINASE SIGNALING SYSTEM; MAST CELLS; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; RECEPTORS, IGE; SIGNAL TRANSDUCTION;

EID: 58549100242     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-008-0041-2     Document Type: Review

References (116)

1. Abramson J. and Pecht I. (2002): Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62dok and SHIP and affects RBL-2H3 cell cycle. Immunol. Lett., 82, 23-28.
2. Asai K., Kitaura J., Kawakami Y., Yamagata N., Tsai M., Carbone D. P., Liu F. T., Galli S. J., and Kawakami T. (2001): Regulation of mast cell survival by IgE. Immunity, 14, 791-800.
3. Atkinson T. P., Lee C. W., Rhee S. G. and Hohman R. J. (1993): Orthovanadate induces translocation of phospholipase C-gamma 1 and -gamma 2 in permeabilized mast cells. J. Immunol., 151, 1448-1455.
4. Azzolina A., Bongiovanni A. and Lampiasi N. (2003): Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells. Biochim. Biophys. Acta, 1643, 75-83.
5. Baba Y., Nishida K., Fujii Y., Hirano T., Hikida M. and Kurosaki T. (2008): Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat. Immunol., 9, 81-88.
6. Beach D., Gonen R., Bogin Y., Reischl I. G. and Yablonski D. (2007): Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1. J. Biol. Chem., 282, 2937-2946.
7. Blank U. and Rivera J. (2004): The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol., 25, 266-273.
8. Boudreau R. T., Hoskins D. W. and Lin T. J. (2004): Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcεRI-mediated activation: involvement of p38 MAPK. J. Leukoc. Biol., 76, 1075-1081.
9. Boyce J. A. (2003): The role of mast cells in asthma. Prostaglandins Leukot. Essent. Fatty Acids, 69, 195-205.
10. Chang L. and Karin M. (2001): Mammalian MAP kinase signalling cascades. Nature, 410, 37-40.
11. Cho S. H., Woo C. H., Yoon S. B. and Kim J. H. (2004): Protein kinase Cdelta functions downstream of Ca2+ mobilization in FcepsilonRI signaling to degranulation in mast cells. J. Allergy Clin. Immunol., 114, 1085-1092.
12. Choi O. H., Adelstein R. S. and Beaven M. A. (1994): Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C. J. Biol. Chem., 269, 536-541.
13. Choi W. S., Kim Y. M., Combs C., Frohman M. A. and Beaven M. A. (2002): Phospholipases D1 and D2 regulate different phases of exocytosis in mast cells. J. Immunol., 168, 5682-5689.
14. Costello P. S., Turner M., Walters A. E., Cunningham C. N., Bauer P. H., Downward J. and Tybulewicz V. L. (1996): Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene, 13, 2595-2605.
15. Duffy S. M., Lawley W. J., Conley E. C. and Bradding P. (2001): Resting and activation-dependent ion channels in human mast cells. J. Immunol., 167, 4261-4270.
16. Dvorak A. M. (1997): New aspects of mast cell biology. Int. Arch. Allergy Immunol., 114, 1-9.
17. Ebinu J. O., Stang S. L., Teixeira C., Bottorff D. A., Hooton J., Blumberg P. M., Barry M., Bleakley R. C., Ostergaard H. L. and Stone J. C. (2000): RasGRP links T-cell receptor signaling to Ras. Blood, 95, 3199-3203.
18. Enslen H., Brancho D. M. and Davis R. J. (2000): Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. EMBO J., 19, 1301-1311.
19. Evans J. H., Spencer D. M., Zweifach A. and Leslie C. C. (2001): Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes. J. Biol. Chem., 276, 30150-30160.
20. Furumoto Y., Brooks S., Olivera A., Takagi Y., Miyagishi M., Taira K., Casellas R., Beaven M. A., Gilfillan A. M. and Rivera J. (2006): Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J. Immunol., 176, 5167-5171.
21. Gu H., Saito K., Klaman L. D., Shen J., Fleming T., Wang Y., Pratt J. C., Lin G., Lim B., Kinet J. P. and Neel B. G. (2001): Essential role for Gab2 in the allergic response. Nature, 412, 186-190.
22. Gustin S. E., Thien C. B. and Langdon W. Y. (2006): Cblb is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells. J. Immunol., 177, 5980-5989.
23. Hakimi J., Seals C., Kondas J. A., Pettine L., Danho W. and Kochan J. (1990): The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding. J. Biol. Chem., 265, 22079-22081.
24. Hammarberg T. and Radmark O. (1999): 5-lipoxygenase binds calcium. Biochemistry, 38, 4441-4447.
25. Hata D., Kawakami Y., Inagaki N., Lantz C. S., Kitamura T., Khan W. N., Maeda-Yamamoto M., Miura T., Han W., Hartman S. E., Yao L., Nagai H., Goldfeld A. E., Alt F. W., Galli S. J., Witte O. N. and Kawakami T. (1998): Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. J. Exp. Med., 187, 1235-1247.
26. Hernandez-Hansen V., Smith A. J., Surviladze Z., Chigaev A., Mazel T., Kalesnikoff J., Lowell C. A., Krystal G., Sklar L. A., Wilson B. S. and Oliver J. M. (2004): Dysregulated Fc epsilon RI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J. Immunol., 173, 100-112.
27. Hibbs M. L., Tarlinton D. M., Armes J., Grail D., Hodgson G., Maglitto R., Stacker S. A. and Dunn A. R. (1995): Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell, 83, 301-311.
28. Hiragun T., Peng Z. and Beaven M. A. (2006): Cutting edge: dexamethasone negatively regulates Syk in mast cells by up-regulating SRC-like adaptor protein. J. Immunol., 177, 2047-2050.
29. Hiragun T., Peng Z. and Beaven M. A. (2005): Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. Mol. Pharmacol., 67, 598-603.
30. Hirasawa N., Santini F. and Beaven M. A. (1995): Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules. J. Immunol., 154, 5391-5402.
31. Hirasawa N., Scharenberg A., Yamamura H., Beaven M. A. and Kinet J. P. (1995): A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor. J. Biol. Chem., 270, 10960-10967.
32. Holst J., Sim A. T. and Ludowyke R. I. (2002): Protein phosphatases 1 and 2A transiently associate with myosin during the peak rate of secretion from mast cells. Mol. Cell Biol., 13, 1083-1098.
33. Hoth M. and Penner R. (1992): Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature, 355, 353-356.
34. Hundley T. R., Gilfillan A. M., Tkaczyk C., Andrade M. V., Metcalfe D. D. and Beaven M. A. (2004): Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells. Blood, 104, 2410-2417.
35. Ishiai M., Kurosaki M., Inabe K., Chan A. C., Sugamura K., and Kurosaki T. (2000): Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane. J. Exp. Med., 192, 847-856.
36. Ishizuka T., Oshiba A., Sakata N., Terada N., Johnson G. L. and Gelfand E. W. (1996): Aggregation of the FcepsilonRI on mast cells stimulates c-Jun amino-terminal kinase activity. A response inhibited by wortmannin. J. Biol. Chem., 271, 12762-12766.
37. Jabril-Cuenod B., Zhang C., Scharenberg A. M., Paolini R., Numerof R., Beaven M. A. and Kinet J. P. (1996): Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2. J. Biol. Chem., 271, 16268-16272.
38. Kalesnikoff J., Huber M., Lam V., Damen J. E., Zhang J., Siraganian R. P. and Krystal G. (2001): Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity, 14, 801-811.
39. Kalesnikoff J., Baur N., Leitges M., Hughes M. R., Damen J. E., Huber M. and Krystal G. (2002): SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-κB activation. J. Immunol., 168, 4737-4746.
40. Kalesnikoff J., Lam V. and Krystal G. (2002): SHIP represses mast cell activation and reveals that IgE alone triggers signalling pathways that enhance normal mast cell survival. Mol. Immunol., 38, 1201-1206.
41. Kawakami Y., Miura T., Bissonnette R., Hata D., Khan W. N., Kitamura T., Maeda-Yamamoto M., Hartman S. E., Yao L., Alt F. W. and Kawakami T. (1997): Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proc. Natl. Acad. Sci. USA, 94, 3938-3942.
42. Kawakami Y., Hartman S. E., Holland P. M., Cooper J. A. and Kawakami T. (1998): Multiple signalling pathways for the activation of JNK in mast cells: involvement of Bruton's tyrosine kinase, protein kinase C, and JNK kinases, SEK1 and MKK7. J. Immunol., 161, 1795-1802.
43. Kettner A., Pivniouk V., Kumar L., Falet H., Lee J. S., Mulligan R. and Geha R. S. (2003): Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol. Cell Biol., 23, 2395-2406.
44. Kim S. I., Kwak J. H., Zachariah M., He Y., Wang L. and Choi M. E. (2007): TGF-beta-activated kinase 1 and TAK1-binding protein 1 cooperate to mediate TGF-beta1-induced MKK3-p38 MAPK activation and stimulation of type I collagen. Am. J. Physiol. Renal Physiol., 292, F1471-1478.
45. Kimata M., Inagaki N., Kato T., Miura T., Serizawa I. and Nagai H. (2000): Roles of mitogen-activated protein kinase pathways for mediator release from human cultured mast cells. Biochem. Pharmacol., 60, 589-594.
46. Kimata M., Shichijo M., Miura T., Serizawa I., Inagaki N. and Nagai H. (2000): Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin. Exp. Allergy, 30, 501-508.
47. Kinet J. P. (1999): The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu. Rev. Immunol., 17, 931-972.
48. Kitaura J., Asai K., Maeda-Yamamoto M., Kawakami Y., Kikkawa U. and Kawakami T. (2000): Akt-dependent cytokine production in mast cells. J. Exp. Med., 192, 729-740.
49. Klemm S., Gutermuth J., Hultner L., Sparwasser T., Behrendt H., Peschel C., Mak T. W., Jakob T. and Ruland J. (2006): The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J. Exp. Med., 203, 337-347.
50. Klemm S. and Ruland J. (2006): Inflammatory signal transduction from the Fc epsilon RI to NF-kappaB. Immunobiology, 211, 815-820.
51. Kopec A., Panaszek B. and Fal A. M. (2006): Intracellular signaling pathways in IgE-dependent mast cell activation. Arch. Immunol. Ther. Exp., 54, 393-401.
52. Kovarova M., Tolar P., Arudchandran R., Draberova L., Rivera J. and Draber P. (2001): Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation. Mol. Cell Biol., 21, 8318-8328.
53. Kubo S., Matsuoka K., Taya C., Kitamura F., Takai T., Yonekawa H. and Karasuyama H. (2001): Drastic up-regulation of Fcepsilonri on mast cells is induced by IgE binding through stabilization and accumulation of Fcepsilonri on the cell surface. J. Immunol., 167, 3427-3434.
54. Law C. L., Chandran K. A., Sidorenko S. P. and Clark E. A. (1996): Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol. Cell Biol., 16, 1305-1315.
55. Leung W. H. and Bolland S. (2007): The inositol 5′-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J. Immunol., 179, 95-102.
56. Li Q. and Verma I. M. (2002): NF-kappaB regulation in the immune system. Nat. Rev. Immunol., 2, 725-734.
57. Lin L. L., Wartmann M., Lin A. Y., Knopf J. L., Seth A. and Davis R. J. (1993): cPLA2 is phosphorylated and activated by MAP kinase. Cell, 72, 269-278.
58. Lin P. and Gilfillan A. M. (1992): The role of calcium and protein kinase C in the IgE-dependent activation of phosphatidylcholine-specific phospholipase D in a rat mast (RBL 2H3) cell line. Eur. J. Biochem., 207, 163-168.
59. Liou J., Kim M. L., Heo W. D., Jones J. T., Myers J. W., Ferrell J. E. Jr. and Meyer T. (2005): STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr. Biol., 15, 1235-1241.
60. Liu Y., Furuta K., Teshima R., Shirata N., Sugimoto Y., Ichikawa A. and Tanaka S. (2005): Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE. J. Biol. Chem., 280, 38976-38981.
61. Liu Y., Zhu M., Nishida K., Hirano T. and Zhang W. (2007): An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J. Exp. Med., 204, 93-103.
62. Ludowyke R. I., Holst J., Mudge L. M. and Sim A. T. (2000): Transient translocation and activation of protein phosphotase 2A during mast cell secretion. J. Biol. Chem., 275, 6144-6152.
63. Ludowyke R. I., Warton K. and Scurr L. L. (1998): Inhibition of antigen and calcium ionophore induced secretion from RBL-2H3 cells by phosphatase inhibitors. Cell Biol. Int., 22, 855-865.
64. Maier J. V., Brema S., Tuckermann J., Herzer U., Klein M., Stassen M., Moorthy A. and Cato A. C. (2007): Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids. Mol. Endocrinol., 21, 2663-2671.
65. Mark Duffy S., Berger P., Cruse G., Yang W., Bolton S. J. and Bradding P. (2004): The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells. J. Allergy Clin. Immunol., 114, 66-72.
66. Matsumoto R., Wang D., Blonska M., Li H., Kobayashi M., Pappu B., Chen Y. and Lin X. (2005): Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity, 23, 575-585.
67. Melendez A. J. and Khaw A. K. (2002): Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem., 277, 17255-17262.
68. Nechushtan H., Leitges M., Cohen C., Kay G. and Razin E. (2000): Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta. Blood, 95, 1752-1757.
69. Newton A. C. (2003): Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem. J., 370, 361-371.
70. Nilsson G., Blom T., Kusche-Gullberg M., Kjellen L., Butterfield J.H., Sundstrom C., Nilsson K. and Hellman L. (1994): Phenotypic characterization of the human mast-cell line HMC-1. Scand. J. Immunol., 39, 489-498.
71. Nishida K., Yamasaki S., Ito Y., Kabu K., Hattori K., Tezuka T., Nishizumi H., Kitamura D., Goitsuka R., Geha R. S., Yamamoto T., Yagi T. and Hirano T. (2005): Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J. Cell Biol., 170, 115-126.
72. Nishizuka Y. (1995): Protein kinase C and lipid signaling for sustained cellular responses. FASEB J., 9, 484-496.
73. Nishizumi H. and Yamamoto T. (1997): Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J. Immunol., 158, 2350-2355.
74. Nunomura S., Gon Y., Yoshimaru T., Suzuki Y., Nishimoto H., Kawakami T. and Ra C. (2005): Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. Int. Immunol., 17, 685-694.
75. Odom S., Gomez G., Kovarova M., Furumoto Y., Ryan J. J., Wright H. V., Gonzalez-Espinosa C., Hibbs M. L., Harder K. W. and Rivera J. (2004): Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J. Exp. Med., 199, 1491-1502.
76. Olivera A., Mizugishi K., Tikhonova A., Ciaccia L., Odom S., Proia R. L. and Rivera J. (2007): The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity, 26, 287-297.
77. Ott V. L., Tamir I., Niki M., Pandolfi P. P. and Cambier J. C. (2002): Downstream of kinase, p62dok, is a mediator of Fc gamma RIIB inhibtion of Fc epsilon RI signalling. J. Immunol., 168, 4430-4439.
78. Ozawa K., Yamada K., Kazanietz M. G., Blumberg P. M. and Beaven M. A. (1993): Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells. J. Biol. Chem., 268, 2280-2283.
79. Ozawa T., Nakata K., Mizuno K. and Yakura H. (2007): Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells. Internat. Immunol., 19, 1049-1061.
80. Pandey V., Mihara S., Fensome-Green A., Bolsover S. and Cockcroft S. (2004): Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca2+, degranulation, and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line. J. Immunol., 172, 4048-4058.
81. Paolini R., Molfetta R., Beitz L.O., Zhang J., Scharenberg A. M., Piccoli M., Frati L., Siraganian R. and Santoni A. (2002): Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fc?RI and Syk in RBL cells. J. Biol. Chem., 277, 36940-36947.
82. Parekh A. B. and Penner R. (1997): Store depletion and calcium influx. Physiol. Rev., 77, 901-930.
83. Parekh A. B. and Putney J. W. Jr. (2005): Store-operated calcium channels. Physiol. Rev., 85, 757-810.
84. Parravicini V., Gadina M., Kovarova M., Odom S., Gonzalez-Espinosa C., Furumoto Y., Saitoh S., Samelson L. E., O'Shea J. J. and Rivera J. (2002): Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat. Immunol., 3, 741-748.
85. Peirce M. J., Cox S. E., Munday M. R. and Peachell P. T. (1997): Preliminary characterization of the role of protein serine/threonine phosphatases in the regulation of human lung mast cell function. Br. J. Pharmacol., 120, 239-246.
86. Peng Y., Power M.R., Li B. and Lin T. J. (2005): Inhibition of IKK down-regulates antigen + IgE-induced TNF production by mast cells: a role for the IKK-IkappaB-NF-kappaB pathway in IgE-dependent mast cell activation. J. Leukoc. Biol., 77, 975-983.
87. Peng Z. and Beaven M. A. (2005): An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cells. J. Immunol., 174, 5201-5208.
88. Petrie R. J., Schnetkamp P. P., Patel K. D., Awasthi-Kalia M. and Deans J. P. (2000): Transient translocation of the B cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: evidence toward a role in calcium regulation. J. Immunol., 165, 1220-1227.
89. Ra C., Jouvin M. H. and Kinet J. P. (1989): Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells. J. Biol. Chem., 264, 15323-15327.
90. Roos J., DiGregorio P. J., Yeromin A. V., Ohlsen K., Lioudyno M., Zhang S., Safrina O., Kozak J. A., Wagner S. L., Cahalan M. D., Velicelebi G. and Stauderman K. A. (2005): STIM1, an essential and conserved component of store-operated Ca2+ channel function. J. Cell Biol., 169, 435-445.
91. Saitoh S., Odom S., Gomez G., Sommers C. L., Young H. A., Rivera J. and Samelson L. E. (2003): The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. J. Exp. Med., 198, 831-843.
92. Sim A.T. R., Ludowyke R. I. and Verrills N. M. (2006): Mast cell function: regulation of degranulation by serine/threonine phosphatases. Pharmacol. Ther., 112, 425-439.
93. Siraganian R. P. (2003): Mast cell signal transduction from the high-affinity IgE receptor. Curr. Opin. Immunol., 15, 639-646.
94. Sommer K., Guo B., Pomerantz J. L., Bandaranayake A. D., Moreno-Garcia M. E., Ovechkina Y. L. and Rawlings D. J. (2005): Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity, 23, 561-574.
95. Song J. M., Hagen G. M., Roess D. A., Pecht I. and Barisas B. G. (2002): The mast cell function-associated antigen and its interactions with the type 1 Fc epsilon receptor. Biochemistry, 41, 881-889.
96. Stassen M., Klein M., Becker M., Bopp T., Neudorfl C., Richter C., Heib V., Klein-Hessling S., Serfling E., Schild H. and Schmitt E. (2007): p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1. Mol. Immunol., 44, 926-933.
97. Su M. W., Yu C. L., Burakoff S. J. and Jin Y. J. (2001): Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation. J. Immunol., 166, 3975-3982.
98. Sun L., Deng L., Ea C. K., Xia Z. P. and Chen Z. J. (2004): The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell, 14, 289-301.
99. Suzuki H., Takei M., Yanagida M., Nakahata T., Kawakami T. and Fukamachi H. (1997): Early and late events in Fc epsilon RI signal transduction in human cultured mast cells. J. Immunol., 159, 5881-5888.
100. Takai T., Li M., Sylvestre D., Clynes R. and Ravetch J. V. (1994): FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell, 76, 519-529.
101. Takata M. and Kurosaki T. (1996): A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2. J. Exp. Med., 184, 31-40.
102. Turner H. and Cantrell D. A. (1997): Distinct Ras effector pathways are involved in Fc epsilon R1 regulation of the transcriptional activity of Elk-1 and NFAT in mast cells. J. Exp. Med., 185, 43-53.
103. Urtz N., Olivera A., Bofill-Cardona E., Csonga R., Billich A., Mechtcheriakova D., Bornancin F., Woisetschlager M., Rivera J. and Baumruker T. (2004): Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase. Mol. Cell Biol., 24, 8765-8777.
104. Vig M., Peinelt C., Beck A., Koomoa D.L., Rabah D., Koblan-Huberson M., Kraft S., Turner H., Fleig A., Penner R. and Kinet J. P. (2006): CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science, 312, 1220-1223.
105. Volná P., Lebduška P., Dráberová L., Šímová S., Heneberg P., Boubelík M., Bugajev V., Malissen B., Wilson B.S., Hoàejší V., Malissen M. and Dráber P. (2004): Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J. Exp. Med., 200, 1001-1013.
106. Wilde J. I. and Watson S. P. (2001): Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other? Cell. Signal., 13, 691-701.
107. Wong M. X., Roberts D., Bartley P. A. and Jackson D. E. (2002): Absence of platelet endothelial cell adhesion molecule-1 (CD31) leads to increased severity of local and systemic IgE-mediated anaphylaxis and modulation of mast cell activation. J. Immunol., 168, 6455-6462.
108. Xiao W., Nishimoto H., Hong H., Kitaura J., Nunomura S., Maeda-Yamamoto M., Kawakami Y., Lowell C. A., Ra C. and Kawakami T. (2005): Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J. Immunol., 175, 6885-6892.
109. Xie Z. H., Zhang J. and Siraganian R. P. (2000): Positive regulation of c-Jun amino-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells. J. Immunol., 164, 1521-1528.
110. Xu P., Lu J., Li Z., Yu X., Chen L. and Xu T. (2006): Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1. Biochem. Biophys. Res. Commun., 350, 969-976.
111. Yamashita Y., Charles N., Furumoto Y., Odom S., Yamashita T., Gilfillan A. M., Constant S., Bower M. A., Ryan J. J. and Rivera J. (2007): Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses. J. Immunol., 179, 740-743.
112. Young R. M., Holowka D. and Baird B. (2003): A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation. J. Biol. Chem., 278, 20746-20752.
113. Zeng R., Cannon J. L., Abraham R. T., Way M., Billadeau D. D., Bubeck-Wardenberg J. and Burkhardt J. K. (2003): SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J. Immunol., 171, 1360-1368.
114. Zhang J., Berenstein E. H., Evans R. L. and Siraganian R. P. (1996): Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. J. Exp. Med., 184, 71-79.
115. Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., Xiao W., and Dixit V. M. (2004): Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature, 427, 167-171.
116. Zhu M., Rhee I., Liu Y. and Zhang W. (2006): Negative regulation of FcεRI-mediated signalling and mast cell function by the adaptor protein LAX. J. Biol. Chem., 281, 18408-18413.