Impaired Tyrosine Phosphorylation and Ca2+ Mobilization, but Not Degranulation, in Lyn-Deficient Bone Marrow-Derived Mast Cells

Journal of Immunology

Volumn 158, Issue 5, 1997, Pages 2350-2355

  Nishizumi, Hirofumi ^a   Yamamoto, Tadashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYTOKINE; IMMUNOGLOBULIN E RECEPTOR; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; BONE MARROW; CELL ADHESION; CELL DIFFERENTIATION; CELL DIVISION; DEGRANULATION; ENZYMOLOGY; IMMUNOLOGY; MAST CELL; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; BONE MARROW; CALCIUM; CELL ADHESION; CELL DEGRANULATION; CELL DIFFERENTIATION; CELL DIVISION; CYTOKINES; MAST CELLS; MICE; MICE, MUTANT STRAINS; PHOSPHORYLATION; PHOSPHOTYROSINE; RECEPTORS, IGE; SRC-FAMILY KINASES;

EID: 0031092657     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Beaven, M. A., and H. Metzger. 1993. Signal transduclion by Fc receptors: the FCεRI case. Immunol. Today 14:222.
2. Ravetch, J. V., and J.-P. Kinet. 1991. Fc receptors. Annu. Rev. Immunol. 9:457.
3. Metzger, H. 1992. The receptor with high affinity for IgE. Immunol. Rev. 125:37.
4. Samelson, L. E., and R. D. Klausner. 1992. Tyrosine kinases and tyrosine-based activation motifs: current research on activation via the T cell antigen receptor. J. Biol. Chem. 267:24913.
5. Irving, B. A., A. C. Chan, and A. Weis. 1993. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J. Exp. Med. 177:1093.
6. Wange, R. L., S. N. Malek, S. Desiderio, and L. E. Samelson. 1993. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3ε from activated Jurkat T cells. J. Biol. Chem. 268:19797.
7. Jouvin, M. H., M. Adamczewski, R. Numerof, O. Letourneur, A. Valle, and J.-P. Kinet. 1994. Differential control of the tyrosine kinases Lyn and Syk by two signaling chains of the high affinity immunoglobulin E receptor. J. Biol. Chem. 269:5918.
8. Sanchez, M., Z. Misulovin, A. L. Burkhardt, S. Mahajan, T. Costa, R. R. Franke, J. B. Bolen, and M. C. Nussenzweig. 1993. Signal transduction by immunoglobulin is mediated through Igα and Igβ. J. Exp. Med. 178:1049.
9. Chan, A. C., M. Iwashima, C. W. Turck, and A. Weiss. 1992. ZAP-70: a 70 kDa protein tyrosine kinase that associates with TCR zeta chain. Cell 71:649.
10. Yamanashi, Y., T. Kakiuchi, J. Mizuguchi, T. Yamamoto, and K. Toyoshima. 1991. Association of B cell antigen receptor with protein tyrosine kinase. Science 251:192.
11. Eisenman, E., and J. B. Bolen. 1992. Engagement of the high affinity IgE receptor activates Src protein-related tyrosine kinases. Nature 355:78.
12. Hutchcroft, J. E., G. G. Geahlen, and J. M. Oliver. 1992. FcεRI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosinc kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc. Natl. Acad. Sci. USA 89:9107.
13. Hutchcroft, J. E., M. L. Harrison, and R. L. Geahlen. 1991. B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase. J. Biol. Chem. 266:14846.
14. Hutchcroft, J. E., M. L. Harrison, and R. L. Geahlen. 1991. Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J. Biol. Chem. 267:8613.
15. Li, W., G. G. Deanin, B. Margolis, J. Schlessinger, and J. M. Oliver. 1992. FcεRI-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C-γ1 and the receptor βγ2. Mol. Cell. Biol. 12:3176.
16. Paolini, R., M. H. Jouvin, and J.-P. Kinet. 1991. Phosphorylation and dephosphorylation of the high affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement. Nature 353:855.
17. Park, D. J., H. K. Min, and S. G. Rhee. 1991. IgE-induced tyrosine phosphorylation of phospholipase C-γ1 in rat basophilic leukemia cells. J. Biol. Chem. 266:24237.
18. Margolis, B., P. Hu, S. Katazav, W. Li, J. M. Oliver, A. Ulrich, and J. Schlessinger. 1992. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356:71.
19. FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence. J. Biol. Chem. 268:6851.
20. Oliver, J. M., J. C. Seagrave, R. F. Stump, J. R. Pfeiffer, and G. G. Deanin. 1988. Signal transduction and cellular response in RBL-2H3 mast cells. Prog. Allergy 42:185.
21. Nishizumi, H., I. Taniuchi, Y. Yamanashi, D. Kitamura, D. Ilic, S. Mori, T. Watanabe, and T. Yamamoto. 1995. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3:549.
22. 4 secretion. Eur. J. Immunol. 19:2251.
23. Yamanashi, Y., Y. Fukui, B. Wongsasant, Y. Kinoshita, Y. Ichimori, K. Toyoshima, and T. Yamamoto. 1992. Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B cell antigen receptor-mediated signaling. Proc. Natl. Acad. Sci. USA 89:1118.
24. Kinashi, T., and T. A. Springer. 1994. Steel factor and c-kit regulate cell-matrix adhesion. Blood 4:1033.
25. Mushinski, J. F., F. R. Blattner, J. D. Owens, F. D. Finkelman, S. W. Kessler, L. Fitzmaurice, M. Potter, and P. W. Tucker. 1980. Mouse immunoglobulin D: construction and characterization of a cloned δ chain cDNA. Proc. Natl. Acad. Sci. USA 77:7405.
26. Uehara, S., Y. Hitoshi, F. Numata, M. Makino, M. Howard, T. Mizuochi, and K. Takatsu. 1994. An IFN-γ-dependent pathway plays a critical role in the pathogenesis of murine immunodeficiency syndrome induced by LPBM5 murine leukemia virus. Int. Immunol. 6:1937.
27. Torigoe, T., R. O'Connor, D. Santoli, and J. C. Reed. 1992. Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines. Blood 80:617.
28. Fukamachi, H., N. Yamada, T. Miura, T. Kato, M. Ishikawa, E. Gulbins, A. Altman, Y. Kawakami, and T. Kawakami. 1994. Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by FcεRI cross-linking. J. Immunol. 152:642.
29. rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or FcεRI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells. Eur. J. Immunol. 23: 3286.
30. Matthews, G., E. Neher, and R. Penner. 1989. Second messenger-activated calcium influx in rat peritoneal mast cells. J. Physiol. 418:105.
31. McCloskey, M. A. 1988. Cholera toxin potentiates IgE-coupled inositol phospholipid hydrolysis and mediator secretion by RBL-2H3 cells. Proc. Natl. Acad. Sci. USA 85:7260.
32. Saito, H., K. Ishizaka, and T. Ishizaka. 1989. Effect of nonhydrolyzable guanosine phosphate on IgE-mediated activation of phospholipase C and histamine release from rodent mast cells. J. Immunol. 143:250.
33. Kawakami, T., N. Inagaki, T. Masao, H. Fukamachi, K. M. Coggeshall, K. Ishizaka, and T. Ishizaka. 1992. Tyrosine phosphorylation is required for mast cell activation by FcεRI cross-linking. J. Immunol. 148:3513.
34. Shakarijian, M. P., E. Eisenman, R. C. Penhallow, and J. B. Bolen. 1993. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibition in a rat mast cell line. J. Biol. Chem. 268:15252.
35. Wilson, B. S., N. Kapp, R. J. Lee, J. R. Pfeiffer, M. Martinez, Y. Platt, F. Letourneur, and J. M. Oliver. 1995. Distinct functions of the FcεRI γ and β subunits in the control of FcεRI-mediated tyrosine kinase activation and signaling responses in RBL-2H3 mast cells. J. Biol. Chem. 270:4013.
36. Benhamou, M., and R. P. Siraganian. 1992. Protein-tyrosine phosphorylation: an essential component of FcεRI signaling. Immunol. Today 13:195.
37. Hibbs, M. L., D. M. Tarlinton, J. Armes, D. Grail, G. Hodgson, R. Maglitto, S. A. Stacker, and A. R. Dunn. 1995. Multiple defects in the immnune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83:301.
38. Ilic, D., Y. Furuta, S. Kanazawa, N. Takeda, K. Sobue, N. Nakatsuji, S. Nomura, J. Fujimoto, M. Okada, T. Yamamoto, and S. Aizawa. 1995. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377:539.
39. Plaut, M., J. H. Pierce, C. J. Watson, J. Hanley-Hyde, R. P. Nordan, and W. E. Paul. 1989. Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores. Nature 339:64.
40. Millard, P. J., T. A. Ryan, W. W. Webb, and C. Fewtrell. 1989. Immunoglobulin E receptor cross-linking induces oscillations in intracellular free ionized calcium in individual tumor mast cells. J. Biol. Chem. 264:19730.
41. Jones, S. V., O. H. Choi, and M. A. Beaven. 1991. Carbachol induces secretion in a mast cell line (RBL-2H3) transfected with the ml muscarinic receptor gene. FEBS Lett. 289:47.
42. Marcilla, A., O. M. Rivero-Lezcano, A. Agarwal, and K. C. Robbins. 1995. Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fcγ receptors. J. Biol. Chem. 270:9115.
43. Kurosaki, T., M. Takata, Y. Yamanashi, T. Inazu, T. Taniguchi, T. Yamamoto, and H. Yamamura. 1994. Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J. Exp. Med. 179: 1725.
44. Rawlings, D. J., A. M. Scharenberg, H. Park, M. I. Wahl, S. Lin, R. M. Kata, A.-C. Fluckiger, O. N. Witte, and J.-P. Kinet. 1996. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271:822.
45. Fewtrell, C., D. Lagunoff, and H. Metzger. 1981. Secretion from rat basophilic leukaemia cells induced by calcium ionophores: effect of pH and metabolic inhibition. Biochim. Biophys. Acta 644:363.
46. Foreman, J. C., J. L. Mongar, and B. D. Gomperts. 1973. Calcium ionophores and movement of calcium ions following the physiological stimulus to a secretory process. Nature 245:249.
47. 2+ mobilization through distinct pathways. EMBO J. 13:1341.
48. Choi, O. H., J.-H. Kim, and J.-P. Kinet. 1996. Calcium mobilization via sphingosine kinase in signaling by the FcεRI antigen receptor. Nature 380:634.
49. Oliver, J. M., D. L. Burg, B. S. Wilson, J. L. McLaughlin, and R. L. Geahlen. 1994. Inhibition of mast cell FcεRI-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J. Biol. Chem. 269:29697.
50. Vallé, A., and J.-P. Kinet. 1995. N-acetyl-L-cysteine inhibits antigen-mediated Syk, but not Lyn tyrosine kinase activation in mast cells. FEBS Lett. 357:41.