Intracellular signaling pathways in IgE-dependent mast cell activation

Archivum Immunologiae et Therapiae Experimentalis

Volumn 54, Issue 6, 2006, Pages 393-401

  Kopeć, Agnieszka ^a   Panaszek, Bernard ^a   Fal, Andrzej M ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Fc RI; Fyn kinase; Intracellular signaling; Lyn kinase; MAPK; Mast cell activation; Phospholipase C

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CURCUMIN; FC RECEPTOR; GENISTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PICEATANNOL; PROTEIN KINASE C; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE INHIBITOR; R 112; SERINE PROTEINASE; TRYPSIN; TYRPHOSTIN; UO 126; VASCULOTROPIN;

ALLERGIC ASTHMA; ALLERGIC RHINITIS; ATHEROSCLEROSIS; ATOPIC DERMATITIS; AUTOIMMUNE DISEASE; CELL ACTIVATION; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; LEUKEMIA CELL LINE; MAST CELL; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UNSPECIFIED SIDE EFFECT;

ANIMALS; CELL DEGRANULATION; CELL MEMBRANE; CELL NUCLEUS; HUMANS; IMMUNOGLOBULIN E; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAST CELLS; MASTOCYTOSIS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTORS, IGE; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 33845696410     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-006-0049-4     Document Type: Review

References (98)

1. Akimoto S., Ishikawa O., Igarashi Y., Kurosawa M. and Miyachi Y. (1998): Dermal mast cells in scleroderma: their skin density, tryptase/chymase phenotypes and degranulation. Br. J. Dermatol., 138, 399-406.
2. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., Shibuya M. and Fukami Y. (1987): Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem., 262, 5592-5595.
3. Almeida A., Mustin D., Forman M. F., Brower G. L., Janicki J. S. and Carver W. (2002): Effects of mast cells on the behavior of isolated heart fibroblasts: modulation of collagen remodeling and gene expression. J. Cell Physiol., 191, 51-59.
4. Armstrong S. C. (2005): Analysis of mitogen-activated protein kinase activation. Methods Mol. Biol., 315, 151-164.
5. Baek O. S., Kang O. H., Choi Y. A., Choi S. C., Kim T. H. and Lee Y. M. (2003): Curcumin inhibits protease-activated receptor-2 and -4-mediated mast cell activation. Clin. Chim. Acta, 338, 135-141.
6. Barile S., Medda E., Nistico L., Bordignon V., Cordiali-Fei P., Carducci M., Rainaldi A., Marinelli R. and Bonifati C. (2006): Vascular endothelial growth factor gene polymorphisms increase the risk to develop psoriasis. Exp., Dermatol., 15, 368-376.
7. Beaven M. A. and Baumgartner R. A. (1996): Downstream signals initiated in mast cells by Fcepsilon RI and other receptors. Curr. Opin. Immunol., 8, 766-772.
8. Benhamou M., Stephan V., Robbins K. C. and Siraganian R. P. (1992): High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations. J. Biol. Chem., 267, 7310-7314.
9. Benoist C. and Mathis D. (2002): Mast cells in autoimmune disease. Nature, 420, 875-878.
10. Cairns J. A. and Walls A. F. (1997): Mast cell tryptase stimulate the synthesis of type I collagen in human lung fibroblasts. J. Clin. Invest., 99, 1313-1321.
11. Cao J., Cetrulo C. L. and Theoharides T. C. (2006): Corticotropin- releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway. Mol. Pharmacol., 69, 998-1006.
12. Cao J., Papadopoulou N., Kempuraj D., Boucher W. S., Sugimoto K., Cetrulo C. L. and Theoharides T. C. (2005): Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J. Immunol., 174, 7665-7675.
13. Choi I. W., Kim D. K., Ko H. M. and Lee H. K. (2004): Administration of antisense phosphorotioate oligonucleotide to the p65 subunit of NF-κB inhibits established asthmatic asthmatic reaction in mice. Int. Immunopharmacol., 4, 1817-1828.
14. Chrousos G. P. (1995): The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med., 332, 1351-1362.
15. Church M. K., El-Lati S. and Caulfield J. P. (1991): Neuropeptide-induced secretion from human skin mast cells. Int. Arch. Allergy Appl. Immunol., 94, 310-318.
16. Constantinides P. (1995): Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction. Circulation, 92, 1083-1088.
17. Dery O., Corvera C. U., Steinhoff M. and Bunnett N. W. (1998): Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol., 274, 142-152.
18. Duan W., Aguinaldo Datiles A. M., Leung B. P., Vlahos C. J. and Wong W. S. (2005): An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model. Int. Immunopharmacol., 5, 495-502.
19. Duan W., Chan J. H., Wong C. H., Leung B. P. and Wong W. S. (2004): Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J. Immunol., 172, 7053-7059.
20. Dugina T. N., Kiseleva E. V., Glusa E. and Strukova S. M. (2003): Activation of mast cells induced by agonists of proteinase-activated receptors under normal conditions and during acute inflammation in rats. Eur. J. Pharmacol., 471, 141-147.
21. FurumotoY., Gonzales-Espinosa C., Gomez E., Kovarowa M., Odom S., Parravicini V., Ryana J. J. and Rivera J. (2004): Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor. Immunol. Res., 30, 241-253.
22. Gomez G., Gonzalez-Espinosa C., Odom S., Baez G., Cid M. E., Ryan J. J. and Rivera J. (2005): Impaired FcεRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells. J. Immunol., 175, 7602-7610.
23. Gu H., Saito K., Klaman L.D., Shen J., Fleming T., Wang Y., Pratt J.C., Lin G., Lim B., Kinet J.P. and Neel B. G. (2001): Essential role for Gab2 in the allergic response. Nature, 412, 186-190.
24. Hamawy M. M., Mergenhagen S. E. and Siraganian R. P. (1995): Protein tyrosine phosphorylation as a mechanism of signaling in mast cells and basophils. Cell. Signal., 7, 535-544.
25. Hara M., Ono K., Hwang M. W., Iwasaki A., Okada M., Nakatani K., Sasayama S. and Matsumori A. (2002): Evidence for a role of mast cells in the evolution to congestive heart failure. J. Exp. Med., 195, 375-378.
26. Hawkins R. A., Claman H. N., Clark R. A. and Steigerwald J. C. (1985): Increased dermal mast cell population in progressive systemic sclerosis: A link in chronic fibrosis? Ann. Intern. Med., 102, 182-187.
27. He S. H., He Y. S. and Xie H. (2004): Activation of human colon mast cells through proteinase activated receptor-2. World J. Gastroenterol., 10, 327-331.
28. Herrmann M., Scholmerich J. and Straub R. H. (2000): Stress and rheumatic diseases. Rheum. Dis. Clin. North Am., 26, 737-763.
29. Holgate S. T. and Kay A. B. (1985): Mast cells, mediators and asthma. Clin. Allergy, 15, 221-234.
30. Jabril-Cuenod B., Zhang C., Unsworth E., Paolini R., Numerof R., Beaven M. A. and Kinet J. P. (1996): Syk-dependent phosphorylation of Shc: A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2. J. Biol. Chem., 271, 16268-16272.
31. Kandere-Grzybowska K., Letourneau R., Kempuraj D., Donelan J., Poplawski S., Boucher W., Athanassiou A. and Theoharides T. C. (2003): IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells. J. Immunol., 171, 4830-4836.
32. Karalis K., Sano H., Redwine J., Listwak S., Wilder R. L. and Chrousos G. P. (1991): Autocrine or paracrine inflammatory actions of corticotropin- releasing hormone in vivo. Science, 254, 421-423.
33. Karimi K., Kool M., Nijkamp F. P. and Redegeld F. A. (2004): Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. Eur. J. Pharmacol., 489, 49-54.
34. Karimi K., Redegeld F. A., Heijdra B. and Nijkamp F. P. (1999): Stem cell factor and interleukin-4 induce murine bone marrow cells to develop into mast cells with connective tissue type characteristics in vitro. Exp. Hematol., 27, 654-662.
35. Kawabuchi M., Satomi Y., Takao T., Shimonisi Y., Nada S., Nagai K., Tarakhovsky A. and Okada M. (2000): Transmembrane phosphoprotein Cbp regulates the activities of Src family tyrosine kinases. Nature, 404, 999-1003.
36. Kawakami T., Inagaki N., Takei M., Fukamachi H., Coggeshall K. M., Ishizaka K. and Ishizaka T. (1992): Tyrosine phosphorylation is required for mast cell activation by Fc epsilon RI cross-linking. J. Immunol., 148, 3513-3519.
37. Kawakami Y., Kitaura J., Satterthwaite A. B., Kato R. M., Asai K., Hartman S. E., Maeda-Yamamoto M., Lowell C. A. and Kawakami T. (2000): Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J. Immunol., 165, 1210-1219.
38. Kinet J. P. (1999): The high-affinity IgE receptor: From physiology to pathology. Annu. Rev. Immunol., 17, 931-972.
39. Kitaura J., Asai K., Maeda-Yamamoto M., Kawakami Y., Kikkawa U. and Kawakami T. (2000): Akt-dependent cytokine production in mast cells. J. Exp. Med., 192, 729-739.
40. Kohno M., Kawahito Y., Tsubouchi Y., Hashiramoto A., Yamada R., Inoue K. I., Kusaka Y., Kubo T., Elenkov I. J., Chrousos G. P., Kondo M. and Sano H. (2001): Urocortin expression in synovium of patients with rheumatoid arthritis and osteoarthritis: relation to inflammatory activity. J. Clin. Endocrinol. Metab., 86, 4344-4352.
41. Kovarova M., Tolar P., Arudchandran R., Draberova L., Rivera J. and Draber P. (2001): Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation. Mol. Cell. Biol., 21, 8318-8328.
42. Krishnaswamy G., Kelley J., Johnson D., Youngberg G., Stone W., Huang S.K., Bieber J. and Chi D. S. (2001): The human mast cell: functions in physiology and disease. Front. Biosci., 6, 1109-1127.
43. Laine P., Kaartinen M., Penttila A., Panula P., Paavonen T. and Kovanen P. T. (1999): Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery. Circulation, 99, 361-369.
44. Lawrence I. D., Warner J. L., Cohan V. L., Hubbard W. C., Kagey-Sobotka A. and Lichtenstein L. M. (1987): Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. J. Immunol., 139, 3062-3069.
45. Lee D. M., Friend D. S., Gurish M. F., Benoist C., Mathis D. and Brenner M. B. (2002): Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science, 297, 1689-1692.
46. Lin P., Fung S. J., Li S., Chen T., Repetto B., Huang K. S., Gilfillan A. M. (1994): Temporal regulation of the IgE-dependent 1,2-diacylglycerol production by tyrosine kinase activation in a rat (RBL 2H3) mast-cell line. Biochem. J., 299, 109-114.
47. Liu Y. and Rohrschneider L. R. (2002): The gift of Gab. FEBS Lett., 515, 1-7.
48. Luskova P. and Draber P. (2004): Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr. Pharm. Des., 10, 1727-1735.
49. Macfarlane S. R., Seatter M. J., Kanke T., Hunter G. D. and Plevin R. (2001): Proteinase-activated receptors. Pharmacol. Rev., 53, 245-282.
50. Malaviya R., Ikeda T. and Ross E. (1996): Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature, 381, 77-80.
51. McLachlan J. B., Hart J. P., Pizzo S. V., Shelburne C. P., Staats H. F., Gunn M. D. and Abraham S. N. (2003): Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat. Immunol., 4, 1199-1205.
52. Meltzer E. O., Berkowitz R. B. and Grossbard E. B. (2005): An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environme. J. Allergy Clin. Immunol., 115, 791-796.
53. Metcalfe D. D., Baram D. and Mekori Y. A. (1997): Mast cells. Physiol. Rev., 77, 1033-1079.
54. Metzger H. (1992): The receptor with high affinity for IgE. Immunol. Rev., 125, 37-48.
55. Metzger H. (2004): The high affinity receptor for IgE, Fcepsilon RI. Novartis Found. Symp., 257, 51-59.
56. Mori N., Suzuki R., Furuno T., McKay D. M., Wada M., Teshima R., Bienenstock J. and Nakanishi M. (2002): Nerve-mast cell (RBL) interaction: RBL membrane ruffling occurs at the contact site with an activated neurite. Am. J. Physiol., 283, 1738-1744.
57. Murakami M., Iwai S., Hiratsuka S., Yamauchi M., Nakamura K., Iwakura Y. and Shibuya M. (2006): Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocyte/macrophages. Blood, 108, 1849-1856.
58. 2+ mobilization, but not degranulation, in Lyn-deficient bone marrow-derived mast cells. J. Immunol., 158, 2350-2355.
59. Odom S., Gomez G., Kovarova M., Furumoto Y., Ryan J. J., Wright H. V., Gonzalez-Espinosa C., Hibbs M. L., Harder K. W. and Rivera J. (2004): Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J. Exp. Med., 11, 1491-1502.
60. Ohtake H., Ichikawa N., Okada M. and Yamashita T. (2002): Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through Fcepsilon RI. J. Immunol., 168, 2087-2090.
61. Okayama Y., Hagaman D. D. and Metcalfe D. D. (2001): A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. J. Immunol., 166, 4705-4712.
62. Okayama Y., Kirshenbaum A. S. and Metcalfe D. D. (2000): Expression of a functional high-affinity IgG receptor, Fc gamma RI, on human mast cells: up-regulation by IFN-gamma. J. Immunol., 164, 4332-4339.
63. Okayama Y., Tkaczyk C., Metcalfe D. D. and Gilfillan A. M. (2003): Comparison of Fc epsilon RI- and Fc gamma RI-mediated degranulation and TNF-alpha synthesis in human mast cells: selective utilization of phosphatidylinositol-3-kinase for Fc gamma RI-induced degranulation. Eur. J. Immunol., 33, 1450-1459
64. On M., Billingsley J. M., Jouvin M. H. and Kinet J. P. (2004): Molecular dissection of the FcRbeta signaling amplifier. J. Biol. Chem., 279, 45782-45790.
65. 2+-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. J. Biol. Chem., 268, 1749-1756.
66. Papanicolaou D., Wilder R. L., Manolagas S. C. and Chrousos G. (1998): The pathophysiologic roles of interleukin-6 in human disease. Ann. Intern. Med., 128, 127-137.
67. Parravicini V., Gadina M., Kovarowa M., Odom S., Gonzalez-Espinosa C., Furumoto Y., Saitoh S., Samelson L. E. and Rivera J. (2002): Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat. Immunol., 3, 741-748.
68. Patella V., Marino L., Arbustini E., Lamparter-Schummert B., Verga L., Adt M. and Marone G. (1998): Stem cell factor in mast cells and increased mast cell density in idiopathic and ischaemic cardiomiopathy. Circulation, 97, 971-978.
69. Pivniouk V. I., Martin T. R., Lu-Kuo J. M., Katz H. R., Oettgen H. C. and Geha R. S. (1999): SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J. Clin. Invest., 103, 1737-1743.
70. Ravetch J. V. and Bolland S. (2001): IgG Fc receptors. Annu. Rev. Immunol., 19, 275-290.
71. Ravetch J. V. and Kinet J. P. (1991): Fc receptors. Annu. Rev. Immunol., 9, 457-492.
72. Reed C. E. and Kita H. (2004): The role of protease activation of inflammation in allergic respiratory diseases. J. Allergy Clin. Immunol., 114, 997-1008.
73. Saitoh S., Arudchandran R., Manetz T. S., Zhang W., Sommers C. L., Love P. E., Rivera J. and Samelson L. E. (2000): LAT is essential for FcepsilonRI-mediated mast cell activation. Immunity, 12, 525-535.
74. Secor V. H., Secor W. E., Gutekunst C. A. and Brown M. A. (2000): Mast cells are essential for early and onset and severe disease in a murine model of multiple sclerosis. J. Exp. Med., 191, 813-22.
75. Seow C. J., Chue S. C. and Wong W. S. (2002): Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro. Eur. J. Pharmacol., 443, 189-196.
76. Singh L. K., Pang X., Alexacos N., Letourneau R. and Theoharides T. C. (1999): Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin and substance P: a link to neurogenic skin disorders. Brain Behav. Immun., 13, 225-239.
77. Siraganian R. P., Zhang J., Suzuki K. and Sada K. (2002): Protein tyrosine kinase Syk in mast cell signaling. Mol. Immunol., 38, 1229-1233.
78. Soberman R. J. (2003): The expanding network of redox signaling: new observations, complexities, and perspectives. J. Clin. Invest., 111, 571-574.
79. Steinhoff M., Buddenkotte J., Shpacovitch V., Rattenholl A., Moormann C., Vergnolle N., Luger T. A. and Hollenberg M. D. (2005): Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr. Rev., 26, 1-43.
80. Stenton G. R., Nohara O., Dery R. E., Vliagoftis H., Gilchrist M., Johri A., Hollenberg M. D., Moqbel R. and Befus A. D. (2002): Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2. J. Pharmacol. Exp. Ther., 302, 466-474.
81. Stenton G. R., Ulanova M., Dery R., Merani S., Kim M. K., Gilchrist M., Puttagunta L., Musat-Marcu S., James D., Schreiber A. D. and Befus A. D. (2002): Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase. J. Immunol., 169, 1028-1036.
82. Stevens R. L. and Austen K. F. (1989): Recent advances in the cellular and molecular biology of mast cells. Immunol. Today, 10, 381-386.
83. Sundstrom J. B., Little D. M., Villinger F., Ellis J. E. and Ansari A. A. (2004): Signaling through Toll-like receptors triggers HIV-1 replication in latently infected mast cells. J. Immunol., 172, 4391-4401.
84. Suzuki H., Takei M., Yanagida T., Nakahata T., Kawakami H. and Fukamachi H. (1997): Early and late events in Fc epsilon RI signal transduction in human cultured mast cells. J. Immunol., 159, 5881-5888.
85. Theoharides T. C. and Cochrane D. E. (2004): Critical role of mast cells in inflammatory diseases and the effect of acute stress. J. Neuroimmunol., 146, 1-12.
86. Theoharides T. C., Donelan J. M., Papadopoulou N., Cao J., Kempuraj D. and Conti P. (2004): Mast cells as targets of corticotropin-releasing factor and related peptides. Trends Pharmacol. Sci., 25, 563-568.
87. Theoharides T. C., Singh L. K., Boucher W., Pang X., Letourneau R., Webster E. and Chrousos G. P. (1998): Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its pro-inflammatory effects. Endocrinology, 139, 403-413.
88. Tkaczyk C., Okayama Y., Woolhiser M. R., Hagaman D. D., Gilfillan A. M. and Metcalfe D. D. (2002): Activation of human mast cells through the high affinity IgG receptor. Mol. Immunol., 38, 1289-1293.
89. Tsang F. and Wong F. (2000): Inhibitors of tyrosine kinase signaling cascade attenuated antigen challenge of guinea-pig airways in vitro. Am. J. Respir. Crit. Care Med., 162, 126-133.
90. Umarova B. A., Dugina T. N., Shestakova E. V., Glusa E. and Strukova S. M. (2000): Activation of rat mast cells upon stimulation of protease-activated receptor (PAR-1). Bull. Exp. Biol. Med., 129, 314-317.
91. Upadhya B., Kontos J.L., Ardeshirpour F., Pye J., Boucher W. S., Theoharides T. C., Dehmer G. J. and Deliargyris E. N. (2004): Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure. J. Card. Fail., 10, 31-35.
92. Urban J. F., Schopf L., Morris S. C., Orekhova T., Madden K. B., Betts C. J., Gamble H. R., Byrd C., Donaldson D. and Finkelman F. D. (2000): Stat 6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism. J. Immunol., 164, 2046-2052.
93. Vliagoftis H. (2002): Thrombin induces mast cell adhesion to fibronectin: evidence for involvement of protease-activated receptor-1. J. Immunol., 169, 4551-4558.
94. Vonakis B. M., Chen H. X., Haleem-Smith H. and Metzger H. (1997): The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE. J. Biol. Chem., 272, 272-280.
95. Woolhiser M. R., Okayama Y., Gilfillan A. M. and Metcalfe D. D. (2001): IgG-dependent activation of human mast cells following up-regulation of FcgammaRI by IFN-gamma. Eur. J. Immunol., 31, 3298-3307.
96. Xie Z. H., Ambudkar I. and Siraganian R. P. (2002): The adapter molecule Gab2 regulates Fcepsilon-mediated signal transduction in mast cells. J. Immunol., 168, 4682-4691.
97. Zhang Y., Matsuo H. and Morita E. (2006): Increased production of vascular endothelial growth factor in the lesions of atopic dermatitis. Arch. Dermatol. Res., 297, 425-429.
98. Zhang W., Trible R. P., Zhu M., Liu S. K., McGlade C. J. and Samelson L. E. (2000): Association of Grb2, Gads, and phospholipase C gamma1 with phosphorylated LAT tyrosine residues. J. Biol. Chem., 275, 23355-23361.