Positive and negative regulation of mast cell activation by Lyn via the FcεRI

Journal of Immunology

Volumn 175, Issue 10, 2005, Pages 6885-6892

  Xiao, Wenbin ^a   Nishimoto, Hajime ^a   Hong, Hong ^a   Kitaura, Jiro ^a,e   Nunomura, Satoshi ^b   Maeda Yamamoto, Mari ^c   Kawakami, Yuko ^a   Lowell, Clifford A ^d   Ra, Chisei ^b   Kawakami, Toshiaki ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b NIHON UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF VEGETABLE AND TEA SCIENCE   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; MUTANT PROTEIN; PROTEIN KINASE B; PROTEIN KINASE LYN; PROTEIN KINASE SYK; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA CHAIN; CAPPING PHENOMENON; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INHIBITION; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SURVIVAL;

EID: 27744592100     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.10.6885     Document Type: Article

References (35)

1. Galli, S. J., M. Maurer, and C. S. Lantz. 1999. Mast cells as sentinels of innate immunity. Curr. Opin. Immunol. 11: 53-59.
2. Kinet, J. P. 1999. The high-affinity IgE receptor (FcεRI): from physiology to pathology. Annu. Rev. Immunol. 17: 931-972.
3. Kitaura, J., J. Song, M. Tsai, K. Asai, M. Maeda-Yamamoto, A. Mocsai, Y. Kawakami, F. T. Liu, C. A. Lowell, B. G. Barisas, et al. 2003. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI. Proc. Natl. Acad. Sci. USA 100: 12911-12916.
4. Turner, H., and J. P. Kinet. Signalling through the high-affinity IgE receptor FcεRI. Nature 402: B24-B30.
5. Parravicini, V., M. Gadina, M. Kovarova, S. Odom, C. Gonzalez-Espinosa, Y. Furumoto, S. Saitoh, L. E. Samelson, J. J. O'Shea, and J. Rivera. 2002. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat. Immunol. 3: 741-748.
6. Kawakami, T., and S. J. Galli. 2002. Regulation of mast-cell and basophil function and survival by IgE. Nat. Rev. Immunol. 2: 773-786.
7. Xu, Y., K. W. Harder, N. D. Huntington, M. L. Hibbs, and D. M. Tarlinton. 2005. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity 22: 9-18.
8. Hibbs, M. L., D. M. Tarlinton, J. Armes, D. Grail, G. Hodgson, R. Maglitto, S. A. Stacker, and A. R. Dunn, 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83: 301-311.
9. Odom, S., G. Gomez, M. Kovarova, Y. Furumoto, J. J. Ryan, H. V. Wright, C. Gonzalez-Espinosa, M. L. Hibbs, K. W. Harder, and J. Rivera. 2004. Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J. Exp. Med. 199: 1491-1502.
10. Kawakami, Y., J. Kitaura, A. B. Satterthwaite, R. M. Kato, K. Asai, S. E. Hartman, M. Maeda-Yamamoto, C. A. Lowell, D. J. Rawlings, O. N. Witte, et al. 2000. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J. Immunol. 165: 1210-1219.
11. 2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J. Immunol. 158: 2350-2355.
12. Hernandez-Hansen, V., A. J. Smith, Z. Surviladze, A. Chigaev, T. Mazel, J. Kalesnikoff, C. A. Lowell, G. Krystal, L. A. Sklar, B. S. Wilson, et al. 2004. Dysregulated FcεRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J. Immunol. 173: 100-112.
13. Kitaura, J., W. Xiao, M. Maeda-Yamamoto, Y. Kawakami, C. A. Lowell, and T. Kawakami. 2004. Early divergence of Fcε receptor I signals for receptor upregulation and internalization from degranulation, cytokine production, and survival. J. Immunol. 173: 4317-4323.
14. Chan, V. W., F. Meng, P. Soriano, A. L. DeFranco, and C. A. Lowell. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7: 69-81.
15. Hiraoka, S., Y. Furumoto, H. Koseki, Y. Takagaki, M. Taniguchi, K. Okumura, and C. Ra. 1999. Fc receptor β subunit is required for full activation of mast cells through Fc receptor engagement. Int. Immunol. 11: 199-207.
16. Kawakami, Y., J. Kitaura, L. Yao, R. W. McHenry, A. C. Newton, S. Kang, R. M. Kato, M. Leitges, D. J. Rawlings, and T. Kawakami. 2003. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc. Natl. Acad. Sci. USA 100: 9470-9475.
17. Furumoto, Y., S. Nunomura, T. Terada, J. Rivera, and C. Ra. 2004. The FcεRIβ immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IκB kinase phosphorylation and mast cell cytokine production. J. Biol. Chem. 279: 49177-49187.
18. Mekori, Y. A., C. K. Oh, and D. D. Metcalfe. 1993. IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3: prevention of apoptosis by c-kit ligand. J. Immunol. 151: 3775-3784.
19. Yee, N. S., I. Paek, and P. Besmer. 1994. Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice. J. Exp. Med 179: 1777-1787.
20. Thomas, S. M., and J. S. Brugge. 1997. Cellular functions regulated by Src family kinases. Annu. Rev. Cell. Dev. Biol. 13: 513-609.
21. Huber, M., C. D. Helgason, J. E. Damen, L. Liu, R. K. Humphries, and G. Krystal, 1998. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc. Natl. Acad. Sci. USA 95: 11330-11335.
22. Phee, H., A. Jacob, and K. M. Coggeshall. 2000. Enzymatic activity of the Src homology 2 domain-containing inositol phosphatase is regulated by a plasma membrane location. J. Biol. Chem. 275: 19090-19097.
23. Xie, Z. H., J. Zhang, and R. P. Siraganian. 2000. Positive regulation of c-Jun N-terminal kinase and TNF-α production but not histamine release by SHP-1 in RBL-2H3 mast cells. J. Immunol. 164: 1521-1528.
24. Kimura, T., H. Sakamoto, E. Appella, and R. P. Siraganian. 1997. The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated β subunit of the high affinity IgE receptor. J. Biol. Chem. 272: 13991-13996.
25. Kimura, T., J. Zhang, K. Sagawa, K. Sakaguchi, E. Appella, and R. P. Siraganian. 1997. Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor. J. Immunol. 159: 4426-4434.
26. Eiseman, E., and J. B. Bolen. 1992. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355: 78-80.
27. lyn protein-tyrosine kinase. Proc. Natl. Acad. Sci. USA 91: 11251-11255.
28. Kihara, H., and R. P. Siraganian. 1994. Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. J. Biol. Chem. 269: 22427-22432.
29. On, M., J. M. Billingsley, M. H. Jouvin, and J. P. Kinet. 2004. Molecular dissection of the FcεRβ signaling amplifier. J. Biol. Chem. 279: 45782-45790.
30. Holowka, D., and B. Baird. 2001. FcεRI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells. Semin. Immunol. 13: 99-105.
31. Petrie, R. J., P. P. Schnetkamp, K. D. Patel, M. Awasthi-Kalia, and J. P. Deans. 2000. Transient translocation of the B cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: evidence toward a role in calcium regulation. J. Immunol. 165: 1220-1227.
32. Su, M. W., C. L. Yu, S. J. Burakoff, and Y. J. Jin. 2001. Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation. J. Immunol. 166: 3975-3982.
33. Kosugi, A., J. Sakakura, K. Yasuda, M. Ogata, and T. Hamaoka. 2001. Involvement of SHP-1 tyrosine phosphatase in TCR-mediated signaling pathways in lipid rafts. Immunity 14: 669-680.
34. Kovarova, M., P. Tolar, R. Arudchandran, L. Draberova, J. Rivera, and P. Draber. 2001. Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcε receptor I aggregation. Mol. Cell. Biol. 21: 8318-8328.
35. Furumoto, Y., C. Gonzalez-Espinosa, G. Gomez, M. Kovarova, S. Odom, V. Parravicini, J. J. Ryana, and J. Rivera. 2004. Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor. Immunol. Res. 30: 241-253.