Further LDL cholesterol lowering through targeting PCSK9 for coronary artery disease

Endocrine, Metabolic and Immune Disorders - Drug Targets

Volumn 8, Issue 4, 2008, Pages 238-243

  Cao, Guoqing ^a   Qian, Yue Wei ^a   Kowala, Mark C ^a   Konrad, Robert J ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Endocytosis; LDL cholesterol; LDL receptor; PCSK9; Proprotein convertase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; APOLIPOPROTEIN B; ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCLONAL ANTIBODY; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; HYPOCHOLESTEROLEMIC AGENT; PCSK9 PROTEIN, HUMAN; SMALL INTERFERING RNA;

CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG RESPONSE; DRUG TARGETING; GENE LOCUS; GENE MUTATION; HOMEOSTASIS; HUMAN; HYPERCHOLESTEROLEMIA; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW; RISK REDUCTION; RNA INTERFERENCE; ANIMAL; BLOOD; DRUG EFFECT; GENE THERAPY; GENETICS; PHYSIOLOGY;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL, LDL; CORONARY ARTERY DISEASE; GENE THERAPY; HOMEOSTASIS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; OLIGONUCLEOTIDES, ANTISENSE; RECEPTORS, LDL; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES;

EID: 58249083266     PISSN: 18715303     EISSN: None     Source Type: Journal    
DOI: 10.2174/187153008786848286     Document Type: Review

References (51)

1. Brown, M.S. and Goldstein, J.L. (1986) Science, 232(4746), 34-47.
2. Brown, M.S. and Goldstein, J.L. (1999) Proc. Natl. Acad. Sci. USA, 96(20), 11041-11048.
3. Shimano, H.; Horton, J.D.; Shimomura, I.; Hammer, R.E.; Brown, M.S. and Goldstein, J.L. (1997) J. Clin. Invest., 99(5), 846-854.
4. Pai, J.T.; Guryev, O.; Brown, M.S. and Goldstein, J.L. (1998) J. Biol. Chem., 273(40), 26138-26148.
5. Yokoyama, C.; Wang, X.; Briggs, M.R.; Admon, A.; Wu, J.; Hua, X.; Goldstein, J.L. and Brown, M.S. (1993) Cell, 75(1), 187-197.
6. Sakai, J.; Nohturfft, A.; Cheng, D.; Ho, Y.K.; Brown, M.S. and Goldstein, J.L. (1997) J. Biol. Chem., 272(32), 20213-20221.
7. Goldstein, J.L.; DeBose-Boyd, R.A. and Brown, M.S. (2006) Cell, 124(1), 35-46.
8. Radhakrishnan, A.; Ikeda, Y.; Kwon, H.J.; Brown, M.S. and Goldstein, J.L. (2007) Proc. Natl. Acad. Sci. USA, 104(16), 6511-6518.
9. Sun, L.P.; Seemann, J.; Goldstein, J.L. and Brown, M.S. (2007) Proc. Natl. Acad. Sci. USA, 104(16), 6519-6526.
10. Yang, T.; Espenshade, P.J.; Wright, M.E.; Yabe, D.; Gong, Y.; Aebersold, R.; Goldstein, J.L. and Brown, M.S. (2002) Cell, 110(4), 489-500.
11. Radhakrishnan, A.; Sun, L.P.; Kwon, H.J.; Brown, M.S. and Goldstein, J.L. (2004) Mol. Cell, 15(2), 259-268.
12. Sakai, J.; Rawson, R.B.; Espenshade, P.J.; Cheng, D.; Seegmiller, A.C.; Goldstein, J.L. and Brown, M.S. (1998) Mol. Cell, 2(4), 505-514.
13. Rawson, R.B.; Zelenski, N.G.; Nijhawan, D.; Ye, J.; Sakai, J.; Hasan, M.T.; Chang, T.Y.; Brown, M.S. and Goldstein, J.L. (1997) Mol. Cell, 1(1), 47-57.
14. Sakai, J. and Rawson, R.B. (2001) Curr. Opin. Lipidol., 12(3), 261-266.
15. Nissen, S.E. (2005) Am. J. Cardiol., 96(5A), 61F-68F.
16. Nissen, S.E.; Nicholls, S.J.; Sipahi, I.; Libby, P.; Raichlen, J.S.; Ballantyne, C.M.; Davignon, J.; Erbel, R.; Fruchart, J.C.; Tardif, J.C.; Schoenhagen, P.; Crowe, T.; Cain, V.; Wolski, K.; Goormastic, M. and Tuzcu, E.M. (2006) JAMA, 295(13), 1556-1565. Epub 2006 Mar 1513.
17. Goldstein, J.L. and Brown, M.S. (2001) Science, 292(5520), 1310-1312.
18. Abifadel, M.; Varret, M.; Rabes, J.P.; Allard, D.; Ouguerram, K.; Devillers, M.; Cruaud, C.; Benjannet, S.; Wickham, L.; Erlich, D.; Derre, A.; Villeger, L.; Farnier, M.; Beucler, I.; Bruckert, E.; Chambaz, J.; Chanu, B.; Lecerf, J.M.; Luc, G.; Moulin, P.; Weissenbach, J.; Prat, A.; Krempf, M.; Junien, C.; Seidah, N.G. and Boileau, C. (2003) Nat. Genet., 34(2), 154-156.
19. Horton, J.D.; Cohen, J.C. and Hobbs, H.H. (2007) Trends Biochem. Sci., 32(2), 71-77.
20. Cohen, J.; Pertsemlidis, A.; Kotowski, I.K.; Graham, R.; Garcia, C.K. and Hobbs, H.H. (2005) Nat. Genet., 37(2), 161-165.
21. Zhao, Z.; Tuakli-Wosornu, Y.; Lagace, T.A.; Kinch, L.; Grishin, N.V.; Horton, J.D.; Cohen, J.C. and Hobbs, H.H. (2006) Am. J. Hum. Genet., 79(3), 514-523.
22. Cohen, J.C.; Boerwinkle, E.; Mosley, T.H.Jr. and Hobbs, H.H. (2006) N. Engl. J. Med., 354(12), 1264-1272.
23. Maxwell, K.N. and Breslow, J.L. (2004) Proc. Natl. Acad. Sci. USA, 101(18), 7100-7105.
24. Park, S.W.; Moon, Y.A. and Horton, J.D. (2004) J. Biol. Chem., 279(48), 50630-50638.
25. Rashid, S.; Curtis, D.E.; Garuti, R.; Anderson, N.N.; Bashmakov, Y.; Ho, Y.K.; Hammer, R.E.; Moon, Y.A. and Horton, J.D. (2005) Proc. Natl. Acad. Sci. USA, 102(15), 5374-5379.
26. Seidah, N.G.; Benjannet, S.; Wickham, L.; Marcinkiewicz, J.; Jasmin, S.B.; Stifani, S.; Basak, A.; Prat, A. and Chretien, M. (2003) Proc. Natl. Acad. Sci. USA, 100(3), 928-933.
27. Benjannet, S.; Rhainds, D.; Essalmani, R.; Mayne, J.; Wickham, L.; Jin, W.; Asselin, M.C.; Hamelin, J.; Varret, M.; Allard, D.; Trillard, M.; Abifadel, M.; Tebon, A.; Attie, A.D.; Rader, D.J.; Boileau, C.; Brissette, L.; Chretien, M.; Prat, A. and Seidah, N.G. (2004) J. Biol. Chem., 279(47), 48865-48875.
28. Hampton, E.N.; Knuth, M.W.; Li, J.; Harris, J.L.; Lesley, S.A. and Spraggon, G. (2007) Proc. Natl. Acad. Sci. USA, 104(37), 14604-14609.
29. Piper, D.E.; Jackson, S.; Liu, Q.; Romanow, W.G.; Shetterly, S.; Thibault, S.T.; Shan, B. and Walker, N.P. (2007) Structure, 15(5), 545-552.
30. Cunningham, D.; Danley, D.E.; Geoghegan, K.F.; Griffor, M.C.; Hawkins, J.L.; Subashi, T.A.; Varghese, A.H.; Ammirati, M.J.; Culp, J.S.; Hoth, L.R.; Mansour, M.N.; McGrath, K.M.; Seddon, A.P.; Shenolikar, S.; Stutzman-Engwall, K.J.; Warren, L.C.; Xia, D. and Qiu, X. (2007) Nat. Struct. Mol. Biol., 14(5), 413-419.
31. McNutt, M.C.; Lagace, T.A. and Horton, J.D. (2007) J. Biol. Chem., 282(29), 20799-20803.
32. Li, J.; Tumanut, C.; Gavigan, J.A.; Huang, W.J.; Hampton, E.N.; Tumanut, R.; Suen, K.F.; Trauger, J.W.; Spraggon, G.; Lesley, S.A.; Liau, G.; Yowe, D. and Harris, J.L. (2007) Biochem. J., 406(2), 203-207.
33. Lagace, T.A.; Curtis, D.E.; Garuti, R.; McNutt, M.C.; Park, S.W.; Prather, H.B.; Anderson, N.N.; Ho, Y.K.; Hammer, R.E. and Horton, J.D. (2006) J. Clin. Invest., 116(11), 2995-3005.
34. Qian, Y.W.; Schmidt, R.J.; Zhang, Y.; Chu, S.; Lin, A.; Wang, H.; Wang, X.; Beyer, T.P.; Bensch, W.R.; Li, W.; Ehsani, M.E.; Lu, D.; Konrad, R.J.; Eacho, P.I.; Moller, D.E.; Karathanasis, S.K. and Cao, G. (2007) J. Lipid. Res., 48(7), 1488-1498.
35. Nassoury, N.; Blasiole, D.A.; Tebon Oler, A.; Benjannet, S.; Hamelin, J.; Poupon, V.; McPherson, P.S.; Attie, A.D.; Prat, A. and Seidah, N.G. (2007) Traffic, 8(6), 718-732.
36. Fisher, T.S.; Lo Surdo, P.; Pandit, S.; Mattu, M.; Santoro, J.C.; Wisniewski, D.; Cummings, R.T.; Calzetta, A.; Cubbon, R.M.; Fischer, P.A.; Tarachandani, A.; De Francesco, R.; Wright, S.D.; Sparrow, C.P.; Carfi, A. and Sitlani, A. (2007) J. Biol. Chem., 282(28), 20502-20512.
37. Zhang, D.W.; Lagace, T.A.; Garuti, R.; Zhao, Z.; McDonald, M.; Horton, J.D.; Cohen, J.C. and Hobbs, H.H. (2007) J. Biol. Chem., 282(25),18602-18612.
38. Kwon, H.J.; Lagace, T.A.; McNutt, M.C.; Horton, J.D. and Deisenhofer, J. (2008) Proc. Natl. Acad. Sci. USA, 105(6), 1820-1825.
39. Timms, K.M.; Wagner, S.; Samuels, M.E.; Forbey, K.; Goldfine, H.; Jammulapati, S.; Skolnick, M.H.; Hopkins, P.N.; Hunt, S.C. and Shattuck, D.M. (2004) Hum. Genet., 114(4), 349-353.
40. Alborn, W.E.; Cao, G.; Careskey, H.E.; Qian, Y.W.; Subramaniam, D.R.; Davies, J.; Conner, E.M. and Konrad, R.J. (2007) Clin. Chem., 53(10), 1814-1819.
41. Fan, D.; Yancey, P.G.; Qiu, S.; Ding, L.; Weeber, E.J.; Linton, M.F. and Fazio, S. (2008) Biochemistry, 47(6), 1631-1639.
42. Mayne, J.; Raymond, A.; Chaplin, A.; Cousins, M.; Kaefer, N.; Gyamera-Acheampong, C.; Seidah, N.G.; Mbikay, M.; Chretien, M. and Ooi, T.C. (2007) Biochem. Biophys. Res. Commun., 361(2), 451-456.
43. Dubuc, G.; Chamberland, A.; Wassef, H.; Davignon, J.; Seidah, N.G.; Bernier, L. and Prat, A. (2004) Arterioscler. Thromb. Vasc. Biol., 24(8), 1454-1459.
44. Careskey, H.E.; Davis, R.A.; Alborn, W.E.; Troutt, J.S.; Cao, G. and Konrad, R.J. (2007) J. Lipid. Res., 49(2): 394-398.
45. Grefhorst, A.; McNutt, M.C.; Lagace, T.A. and Horton, J.D. (2008) J. Lipid. Res., 49(6), 1303-1311.
46. Schmidt, R.J.; Beyer, T.P.; Bensch, W.R.; Qian, Y.W.; Lin, A.; Kowala, M.; Alborn, W.E.; Konrad, R.J. and Cao, G. (2008) Biochem. Biophys. Res. Commun., 370(4), 634-640.
47. Poirier, S.; Prat, A.; Marcinkiewicz, E.; Paquin, J.; Chitramuthu, B.P.; Baranowski, D.; Cadieux, B.; Bennett, H.P. and Seidah, N.G. (2006) J. Neurochem., 98(3), 838-850.
48. Poirier, S.; Mayer, G.; Benjannet, S.; Bergeron, E.; Marcinkiewicz, J.; Nassoury, N.; Mayer, H.; Nimpf, J.; Prat, A. and Seidah, N.G. (2008) J. Biol. Chem., 283(4), 2363-2372.
49. Trommsdorff, M.; Gotthardt, M.; Hiesberger, T.; Shelton, J.; Stockinger, W.; Nimpf, J.; Hammer, R.E.; Richardson, J.A. and Herz, J. (1999) Cell, 97(6), 689-701.
50. Homer, V.M.; Marais, A.D.; Charlton, F.; Laurie, A.D.; Hurndell, N.; Scott, R.; Mangili, F.; Sullivan, D.R.; Barter, P.J.; Rye, K.A.; George, P.M. and Lambert, G. (2007) Atherosclerosis, 196(2), 659-666
51. Graham, M.J.; Lemonidis, K.M.; Whipple, C.P.; Subramaniam, A.; Monia, B.P.; Crooke, S.T. and Crooke, R.M. (2007) J. Lipid. Res., 48(4), 763-767.