메뉴 건너뛰기




Volumn 49, Issue 2, 2008, Pages 394-398

Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9

Author keywords

Low density lipoprotein; Low density lipoprotein cholesterol; Low density lipoprotein receptor

Indexed keywords

ATORVASTATIN; KEXIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; SUBTILISIN;

EID: 38949109659     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700437-JLR200     Document Type: Article
Times cited : (277)

References (25)
  • 1
    • 33846679386 scopus 로고    scopus 로고
    • Molecular biology of PCSK9: Its role in LDL metabolism
    • Horton, J. D., J. C. Cohen, and H. H. Hobbs. 2007. Molecular biology of PCSK9: its role in LDL metabolism. Trends Biochem. Sci. 32: 71-77.
    • (2007) Trends Biochem. Sci , vol.32 , pp. 71-77
    • Horton, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 2
    • 33746216577 scopus 로고    scopus 로고
    • The proprotein convertases and their implication in sterol and/or lipid metabolism
    • Seidah, N. G., A. M. Khatib, and A. Prat. 2006. The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol. Chem. 387: 871-877.
    • (2006) Biol. Chem , vol.387 , pp. 871-877
    • Seidah, N.G.1    Khatib, A.M.2    Prat, A.3
  • 3
    • 33646472409 scopus 로고    scopus 로고
    • PCSK9: A promising therapeutic target for dyslipidemias
    • Lambert, G., M. Krempf, and P. Costet. 2006. PCSK9: a promising therapeutic target for dyslipidemias. Trends Endocrinol. Metab. 17: 79-81.
    • (2006) Trends Endocrinol. Metab , vol.17 , pp. 79-81
    • Lambert, G.1    Krempf, M.2    Costet, P.3
  • 6
    • 13844310887 scopus 로고    scopus 로고
    • Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
    • Maxwell, K. N., E. A. Fisher, and J. L. Breslow. 2005. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc. Natl. Acad. Sci. USA. 102: 2069-2074.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2069-2074
    • Maxwell, K.N.1    Fisher, E.A.2    Breslow, J.L.3
  • 7
    • 9644266673 scopus 로고    scopus 로고
    • Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
    • Park, S. W., Y. A. Moon, and J. D. Horton. 2004. Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J. Biol. Chem. 279: 50630-50638.
    • (2004) J. Biol. Chem , vol.279 , pp. 50630-50638
    • Park, S.W.1    Moon, Y.A.2    Horton, J.D.3
  • 8
    • 10344253854 scopus 로고    scopus 로고
    • NARC-1/PCSK9 and its natural mutants: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
    • Benjannet, S., D. Rhainds, R. Essalmani, J. Mayne, L. Wickham, W. Jin, M. C. Asselin, J. Hamelin, M. Varret, D. Allard, et al. 2004. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J. Biol. Chem. 279: 48865-48875.
    • (2004) J. Biol. Chem , vol.279 , pp. 48865-48875
    • Benjannet, S.1    Rhainds, D.2    Essalmani, R.3    Mayne, J.4    Wickham, L.5    Jin, W.6    Asselin, M.C.7    Hamelin, J.8    Varret, M.9    Allard, D.10
  • 9
    • 2342451128 scopus 로고    scopus 로고
    • Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
    • Maxwell, K. N., and J. L. Breslow. 2004. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc. Natl. Acad. Sci. USA. 101: 7100-7105.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 7100-7105
    • Maxwell, K.N.1    Breslow, J.L.2
  • 12
    • 34547137377 scopus 로고    scopus 로고
    • Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells
    • McNutt, M. C., T. A. Lagace, and J. D. Horton. 2007. Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells. J. Biol. Chem. 282: 20799-20803.
    • (2007) J. Biol. Chem , vol.282 , pp. 20799-20803
    • McNutt, M.C.1    Lagace, T.A.2    Horton, J.D.3
  • 13
    • 34547108600 scopus 로고    scopus 로고
    • Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
    • Zhang, D. W., T. A. Lagace, R. Garuti, Z. Zhao, M. McDonald, J. D. Horton, J. C. Cohen, and H. H. Hobbs. 2007. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J. Biol. Chem. 282: 18602-18612.
    • (2007) J. Biol. Chem , vol.282 , pp. 18602-18612
    • Zhang, D.W.1    Lagace, T.A.2    Garuti, R.3    Zhao, Z.4    McDonald, M.5    Horton, J.D.6    Cohen, J.C.7    Hobbs, H.H.8
  • 14
    • 17144363236 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin 9: The third locus implicated in autosomal dominant hypercholesterolemia
    • Maxwell, K. N., and J. L. Breslow. 2005. Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia. Curr. Opin. Lipidol. 16: 167-172.
    • (2005) Curr. Opin. Lipidol , vol.16 , pp. 167-172
    • Maxwell, K.N.1    Breslow, J.L.2
  • 15
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
    • Dubuc, G., A. Chamberland, H. Wassef, J. Davignon, N. G. Seidah, L. Bernier, and A. Prat. 2004. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 24: 1454-1459.
    • (2004) Arterioscler. Thromb. Vasc. Biol , vol.24 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3    Davignon, J.4    Seidah, N.G.5    Bernier, L.6    Prat, A.7
  • 18
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen, J. C., E. Boerwinkle, T. H. Mosley, Jr., and H. H. Hobbs. 2006. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354: 1264-1272.
    • (2006) N. Engl. J. Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr., T.H.3    Hobbs, H.H.4
  • 22
    • 33646443979 scopus 로고    scopus 로고
    • Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
    • Berge, K. E., L. Ose, and T. P. Leren. 2006. Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy. Arterioscler. Thromb. Vasc. Biol. 26: 1094-1100.
    • (2006) Arterioscler. Thromb. Vasc. Biol , vol.26 , pp. 1094-1100
    • Berge, K.E.1    Ose, L.2    Leren, T.P.3
  • 24
    • 33947728699 scopus 로고    scopus 로고
    • Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: Two randomized controlled trials
    • Nissen, S. E., S. J. Nicholls, K. Wolski, D. C. Howey, E. McErlean, M. D. Wang, E. V. Gomez, and J. M. Russo. 2007. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. J. Am. Med. Assoc. 297: 1362-1373.
    • (2007) J. Am. Med. Assoc , vol.297 , pp. 1362-1373
    • Nissen, S.E.1    Nicholls, S.J.2    Wolski, K.3    Howey, D.C.4    McErlean, E.5    Wang, M.D.6    Gomez, E.V.7    Russo, J.M.8
  • 25
    • 34548175537 scopus 로고    scopus 로고
    • Secreted proprotein convertase subtilisin/kexin-type 9 reduces low-density lipoprotein receptor through receptor-mediated endocytosis
    • Qian, Y., R. J. Schmidt, Y. Zhang, S. Chu, A. Lin, H. Wang, X. Wang, T. P. Beyer, W. R. Bensch, W. Li, et al. 2007. Secreted proprotein convertase subtilisin/kexin-type 9 reduces low-density lipoprotein receptor through receptor-mediated endocytosis. J. Lipid Res. 48: 1488-1498.
    • (2007) J. Lipid Res , vol.48 , pp. 1488-1498
    • Qian, Y.1    Schmidt, R.J.2    Zhang, Y.3    Chu, S.4    Lin, A.5    Wang, H.6    Wang, X.7    Beyer, T.P.8    Bensch, W.R.9    Li, W.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.