메뉴 건너뛰기




Volumn 98, Issue 3, 2006, Pages 838-850

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

Author keywords

Cholesterol; Neural apoptosis regulated convertase 1 proprotein convertase subtilisin kexin like 9; Neurogenesis; P19 cells; Proprotein convertase; Zebrafish

Indexed keywords

FURIN; MESSENGER RNA; NEURAL APOPTOSIS REGULATED CONVERTASE 1; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE SUBTILISIN KEXIN LIKE 9; PROTEINASE; RETINOIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 33745875635     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03928.x     Document Type: Article
Times cited : (90)

References (60)
  • 1
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel M., Varret M., Rabes J. P. et al. (2003) Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat. Genet. 34, 154-156.
    • (2003) Nat. Genet. , vol.34 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabes, J.P.3
  • 2
    • 29944443017 scopus 로고    scopus 로고
    • Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia
    • Allard D., Amsellem S., Abifadel M. et al. (2005) Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia. Hum. Mutat. 26, 497.
    • (2005) Hum. Mutat. , vol.26 , pp. 497
    • Allard, D.1    Amsellem, S.2    Abifadel, M.3
  • 3
    • 26944489690 scopus 로고    scopus 로고
    • Dual regulation of the LDL receptor - Some clarity and new questions
    • Attie A. D. and Seidah N. G. (2005) Dual regulation of the LDL receptor - some clarity and new questions. Cell Metab. 1, 290-292.
    • (2005) Cell Metab. , vol.1 , pp. 290-292
    • Attie, A.D.1    Seidah, N.G.2
  • 4
    • 0025762119 scopus 로고
    • PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues
    • Benjannet S., Rondeau N., Day R., Chretien M. and Seidah N. G. (1991) PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc. Natl Acad. Sci. USA 88, 3564-3568.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3564-3568
    • Benjannet, S.1    Rondeau, N.2    Day, R.3    Chretien, M.4    Seidah, N.G.5
  • 5
    • 0027368472 scopus 로고
    • Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: Glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2
    • Benjannet S., Rondeau N., Paquet L., Boudreault A., Lazure C., Chretien M. and Seidah N. G. (1993) Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2. Biochem. J. 294, 735-743.
    • (1993) Biochem. J. , vol.294 , pp. 735-743
    • Benjannet, S.1    Rondeau, N.2    Paquet, L.3    Boudreault, A.4    Lazure, C.5    Chretien, M.6    Seidah, N.G.7
  • 6
    • 0035815635 scopus 로고    scopus 로고
    • Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production
    • Benjannet S., Elagoz A., Wickham L. et al. (2001) Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J. Biol. Chem. 276, 10 879-10 887.
    • (2001) J. Biol. Chem. , vol.276 , pp. 10879-10887
    • Benjannet, S.1    Elagoz, A.2    Wickham, L.3
  • 7
    • 10344253854 scopus 로고    scopus 로고
    • NARC-1/PCSK9 and its natural mutants: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
    • Benjannet S., Rhainds D., Essalmani R. et al. (2004) NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J. Biol. Chem. 279, 48 865-48 875.
    • (2004) J. Biol. Chem. , vol.279 , pp. 48865-48875
    • Benjannet, S.1    Rhainds, D.2    Essalmani, R.3
  • 9
    • 0027765503 scopus 로고
    • Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin
    • Breslin M. B., Lindberg I., Benjannet S., Mathis J. P., Lazure C. and Seidah N. G. (1993) Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin. J. Biol. Chem. 268, 27 084-27 093.
    • (1993) J. Biol. Chem. , vol.268 , pp. 27084-27093
    • Breslin, M.B.1    Lindberg, I.2    Benjannet, S.3    Mathis, J.P.4    Lazure, C.5    Seidah, N.G.6
  • 10
    • 0033613147 scopus 로고    scopus 로고
    • A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
    • Brown M. S. and Goldstein J. L. (1999) A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl Acad. Sci. USA 96, 11 041-11 048.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11041-11048
    • Brown, M.S.1    Goldstein, J.L.2
  • 11
    • 0034681260 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
    • Brown M. S., Ye J., Rawson R. B. and Goldstein J. L. (2000) Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100, 391-398.
    • (2000) Cell , vol.100 , pp. 391-398
    • Brown, M.S.1    Ye, J.2    Rawson, R.B.3    Goldstein, J.L.4
  • 12
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen J., Pertsemlidis A., Kotowski I. K., Graham R., Garcia C. K. and Hobbs H. H. (2005) Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat. Genet. 37, 161-165.
    • (2005) Nat. Genet. , vol.37 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5    Hobbs, H.H.6
  • 13
    • 0030997527 scopus 로고    scopus 로고
    • Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160
    • Decroly E., Benjannet S., Savaria D. and Seidah N. G. (1997) Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160. FEBS Lett. 405, 68-72.
    • (1997) FEBS Lett. , vol.405 , pp. 68-72
    • Decroly, E.1    Benjannet, S.2    Savaria, D.3    Seidah, N.G.4
  • 15
    • 0034708264 scopus 로고    scopus 로고
    • Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation
    • Denson L. A., Auld K. L., Schiek D. S., McClure M. H., Mangelsdorf D. J. and Karpen S. J. (2000) Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation. J. Biol. Chem. 275, 8835-8843.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8835-8843
    • Denson, L.A.1    Auld, K.L.2    Schiek, D.S.3    McClure, M.H.4    Mangelsdorf, D.J.5    Karpen, S.J.6
  • 16
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
    • Dubuc G., Chamberland A., Wassef H., Davignon J., Seidah N. G., Bernier L. and Prat A. (2004) Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 24, 1454-1459.
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3    Davignon, J.4    Seidah, N.G.5    Bernier, L.6    Prat, A.7
  • 17
    • 12644273790 scopus 로고    scopus 로고
    • Neural degeneration mutants in the zebrafish, Danio rerio
    • Furutani-Seiki M., JiangY. J., Brand M. et al. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development 123, 229-239.
    • (1996) Development , vol.123 , pp. 229-239
    • Furutani-Seiki, M.1    Jiang, Y.J.2    Brand, M.3
  • 18
    • 0029102824 scopus 로고
    • Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: Requirement for secretory cell but not the secretion granule
    • Galanopoulou A. S., Seidah N. G. and Patel Y. C. (1995) Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule. Biochem. J. 311, 111-118.
    • (1995) Biochem. J. , vol.311 , pp. 111-118
    • Galanopoulou, A.S.1    Seidah, N.G.2    Patel, Y.C.3
  • 19
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton J. D., Goldstein J. L. and Brown M. S. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 20
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton J. D., Shah N. A., Warrington J. A., Anderson N. N., Park S. W., Brown M. S. and Goldstein J. L. (2003) Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl Acad. Sci. USA 100, 12 027-12 032.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12027-12032
    • Horton, J.D.1    Shah, N.A.2    Warrington, J.A.3    Anderson, N.N.4    Park, S.W.5    Brown, M.S.6    Goldstein, J.L.7
  • 21
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi S., Brown M. S., Goldstein J. L., Gerard R. D., Hammer R. E. and Herz J. (1993) Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92, 883-893.
    • (1993) J. Clin. Invest. , vol.92 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.E.5    Herz, J.6
  • 22
    • 0030724213 scopus 로고    scopus 로고
    • Convertase PC2 and the neuroendocrine polypeptide 7B2 are co-induced and processed during neuronal differentiation of P19 embryonal carcinoma cells
    • Jeannotte R., Paquin J., Petit-Turcotte C. and Day R. (1997) Convertase PC2 and the neuroendocrine polypeptide 7B2 are co-induced and processed during neuronal differentiation of P19 embryonal carcinoma cells. DNA Cell Biol. 16, 1175-1187.
    • (1997) DNA Cell Biol. , vol.16 , pp. 1175-1187
    • Jeannotte, R.1    Paquin, J.2    Petit-Turcotte, C.3    Day, R.4
  • 23
    • 0037855769 scopus 로고    scopus 로고
    • The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1
    • Kalus I., Schnegelsberg B., Seidah N. G., Kleene R. and Schachner M. (2003) The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1. J. Biol. Chem. 278, 10 381-10 388.
    • (2003) J. Biol. Chem. , vol.278 , pp. 10381-10388
    • Kalus, I.1    Schnegelsberg, B.2    Seidah, N.G.3    Kleene, R.4    Schachner, M.5
  • 24
    • 0036083664 scopus 로고    scopus 로고
    • Proprotein convertases in tumor progression and malignancy: Novel targets in cancer therapy
    • Khatib A. M., Siegfried G., Chretien M., Metrakos P. and Seidah N. G. (2002) Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. Am. J. Pathol. 160, 1921-1935.
    • (2002) Am. J. Pathol. , vol.160 , pp. 1921-1935
    • Khatib, A.M.1    Siegfried, G.2    Chretien, M.3    Metrakos, P.4    Seidah, N.G.5
  • 25
    • 0035008102 scopus 로고    scopus 로고
    • Developmental analysis of ceruloplasmin gene and liver formation in zebrafish
    • Korzh S., Emelyanov A. and Korzh V. (2001) Developmental analysis of ceruloplasmin gene and liver formation in zebrafish. Mech. Dev. 103, 137-139.
    • (2001) Mech. Dev. , vol.103 , pp. 137-139
    • Korzh, S.1    Emelyanov, A.2    Korzh, V.3
  • 27
    • 3543143089 scopus 로고    scopus 로고
    • RhoA/ROCK and Cdc42 regulate cell-cell contact and N-cadherin protein level during neurodetermination of P19 embryonal stem cells
    • Laplante I., Beliveau R. and Paquin J. (2004) RhoA/ROCK and Cdc42 regulate cell-cell contact and N-cadherin protein level during neurodetermination of P19 embryonal stem cells. J. Neurobiol. 60, 289-307.
    • (2004) J. Neurobiol. , vol.60 , pp. 289-307
    • Laplante, I.1    Beliveau, R.2    Paquin, J.3
  • 28
    • 0035940409 scopus 로고    scopus 로고
    • The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
    • Lenz O., ter Meulen J., Klenk H. D., Seidah N. G. and Garten W. (2001) The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Proc. Natl Acad. Sci. USA 98, 12 701-12 705.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12701-12705
    • Lenz, O.1    Ter Meulen, J.2    Klenk, H.D.3    Seidah, N.G.4    Garten, W.5
  • 29
    • 0038012640 scopus 로고    scopus 로고
    • In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS
    • Lossi L. and Merighi A. (2003) In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS. Prog. Neurobiol. 69, 287-312.
    • (2003) Prog. Neurobiol. , vol.69 , pp. 287-312
    • Lossi, L.1    Merighi, A.2
  • 30
    • 0033601713 scopus 로고    scopus 로고
    • Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: Their presence in Schwann cells, macrophages, and smooth muscle cells
    • Marcinkiewicz M., Marcinkiewicz J., Chen A., Leclaire F., Chretien M. and Richardson P. (1999) Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: their presence in Schwann cells, macrophages, and smooth muscle cells. J. Comp. Neurol. 403, 471-485.
    • (1999) J. Comp. Neurol. , vol.403 , pp. 471-485
    • Marcinkiewicz, M.1    Marcinkiewicz, J.2    Chen, A.3    Leclaire, F.4    Chretien, M.5    Richardson, P.6
  • 31
    • 2342451128 scopus 로고    scopus 로고
    • Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
    • Maxwell K. N. and Breslow J. L. (2004) Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc. Natl Acad. Sci. USA 101, 7100-7105.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 7100-7105
    • Maxwell, K.N.1    Breslow, J.L.2
  • 32
    • 0344236142 scopus 로고    scopus 로고
    • Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
    • Maxwell K. N., Soccio R. E., Duncan E. M., Sehayek E. and Breslow J. L. (2003) Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J. Lipid Res. 44, 2109-2119.
    • (2003) J. Lipid Res. , vol.44 , pp. 2109-2119
    • Maxwell, K.N.1    Soccio, R.E.2    Duncan, E.M.3    Sehayek, E.4    Breslow, J.L.5
  • 33
    • 12644251967 scopus 로고    scopus 로고
    • Impaired fertility in mice deficient for the testicular germ-cell protease PC4
    • Mbikay M., Tadros H., Ishida N. et al. (1997) Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proc. Natl Acad. Sci. USA 94, 6842-6846.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 6842-6846
    • Mbikay, M.1    Tadros, H.2    Ishida, N.3
  • 34
    • 0027153542 scopus 로고
    • P19 embryonal carcinoma cells
    • McBurney M. W. (1993) P19 embryonal carcinoma cells. Int. J. Dev. Biol. 37, 135-140.
    • (1993) Int. J. Dev. Biol. , vol.37 , pp. 135-140
    • McBurney, M.W.1
  • 35
    • 0029007929 scopus 로고
    • The roles of retinoids in vertebrate development
    • Means A. L. and Gudas L. J. (1995) The roles of retinoids in vertebrate development. Annu. Rev. Biochem. 64, 201-233.
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 201-233
    • Means, A.L.1    Gudas, L.J.2
  • 36
    • 4544270602 scopus 로고    scopus 로고
    • Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates
    • Muto E., Tabata Y., Taneda T., Aoki Y., Muto A., Arai K. and Watanabe S. (2004) Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. Biochimie 86, 523-531.
    • (2004) Biochimie , vol.86 , pp. 523-531
    • Muto, E.1    Tabata, Y.2    Taneda, T.3    Aoki, Y.4    Muto, A.5    Arai, K.6    Watanabe, S.7
  • 37
    • 0033780376 scopus 로고    scopus 로고
    • Effective targeted gene 'knockdown' in zebrafish
    • Nasevicius A. and Ekker S. C. (2000) Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26, 216-220.
    • (2000) Nat. Genet. , vol.26 , pp. 216-220
    • Nasevicius, A.1    Ekker, S.C.2
  • 38
    • 9644266673 scopus 로고    scopus 로고
    • Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
    • Park S. W., Moon Y. A. and Horton J. D. (2004) Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J. Biol. Chem. 279, 50 630-50 638.
    • (2004) J. Biol. Chem. , vol.279 , pp. 50630-50638
    • Park, S.W.1    Moon, Y.A.2    Horton, J.D.3
  • 39
    • 33646435074 scopus 로고    scopus 로고
    • Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia
    • Pisciotta L., Oliva C. P., Cefalu A. B. et al. (2005) Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia. Atherosclerosis 186, 443-450.
    • (2005) Atherosclerosis , vol.186 , pp. 443-450
    • Pisciotta, L.1    Oliva, C.P.2    Cefalu, A.B.3
  • 42
    • 0024470650 scopus 로고
    • Cell lines with developmental potential restricted to mesodermal lineages isolated from differentiating cultures of pluripotential P19 embryonal carcinoma cells
    • Rudnicki M. A., Reuhl K. R. and McBurney M. W. (1989) Cell lines with developmental potential restricted to mesodermal lineages isolated from differentiating cultures of pluripotential P19 embryonal carcinoma cells. Development 107, 361-372.
    • (1989) Development , vol.107 , pp. 361-372
    • Rudnicki, M.A.1    Reuhl, K.R.2    McBurney, M.W.3
  • 43
    • 0032489460 scopus 로고    scopus 로고
    • Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies
    • Sakai J., Nohturfft A., Goldstein J. L. and Brown M. S. (1998a) Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. J. Biol. Chem. 273, 5785-5793.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5785-5793
    • Sakai, J.1    Nohturfft, A.2    Goldstein, J.L.3    Brown, M.S.4
  • 44
    • 0032185770 scopus 로고    scopus 로고
    • Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells
    • Sakai J., Rawson R. B., Espenshade P. J., Cheng D., Seegmiller A. C., Goldstein J. L. and Brown M. S. (1998b) Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol. Cell 2, 505-514.
    • (1998) Mol. Cell , vol.2 , pp. 505-514
    • Sakai, J.1    Rawson, R.B.2    Espenshade, P.J.3    Cheng, D.4    Seegmiller, A.C.5    Goldstein, J.L.6    Brown, M.S.7
  • 45
    • 12644299614 scopus 로고    scopus 로고
    • Mutations affecting the development of the embryonic zebrafish brain
    • Schier A. F., Neuhauss S. C., Harvey M. et al. (1996) Mutations affecting the development of the embryonic zebrafish brain. Development 123, 165-178.
    • (1996) Development , vol.123 , pp. 165-178
    • Schier, A.F.1    Neuhauss, S.C.2    Harvey, M.3
  • 46
    • 0027077930 scopus 로고
    • The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo
    • Schulte-Merker S., Ho R. K., Herrmann B. G. and Nusslein-Volhard C. (1992) The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. Development 116, 1021-1032.
    • (1992) Development , vol.116 , pp. 1021-1032
    • Schulte-Merker, S.1    Ho, R.K.2    Herrmann, B.G.3    Nusslein-Volhard, C.4
  • 47
    • 0030065077 scopus 로고    scopus 로고
    • Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells
    • Schuppin G. T. and Rhodes C. J. (1996) Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells. Biochem. J. 313, 259-268.
    • (1996) Biochem. J. , vol.313 , pp. 259-268
    • Schuppin, G.T.1    Rhodes, C.J.2
  • 48
    • 0028831096 scopus 로고
    • Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: Their use as markers of neuroendocrine differentiation
    • Scopsi L., Gullo M., Rilke F., Martin S. and Steiner D. F. (1995) Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation. J. Clin. Endocrinol. Metab. 80, 294-301.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 294-301
    • Scopsi, L.1    Gullo, M.2    Rilke, F.3    Martin, S.4    Steiner, D.F.5
  • 49
    • 0033452452 scopus 로고    scopus 로고
    • Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
    • Seidah N. G. and Chretien M. (1999) Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 848, 45-62.
    • (1999) Brain Res. , vol.848 , pp. 45-62
    • Seidah, N.G.1    Chretien, M.2
  • 50
    • 0038394566 scopus 로고    scopus 로고
    • Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    • Seidah N. G. and Prat A. (2002) Precursor convertases in the secretory pathway, cytosol and extracellular milieu. Essays Biochem. 38, 79-94.
    • (2002) Essays Biochem. , vol.38 , pp. 79-94
    • Seidah, N.G.1    Prat, A.2
  • 51
    • 0025284946 scopus 로고
    • CDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: Tissue-specific mRNAs encoding candidates for pro- hormone processing proteinases
    • Seidah N. G., Gaspar L., Mion P., Marcinkiewicz M., Mbikay M. and Chretien M. (1990) cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro- hormone processing proteinases. DNA Cell Biol. 9, 789.
    • (1990) DNA Cell Biol. , vol.9 , pp. 789
    • Seidah, N.G.1    Gaspar, L.2    Mion, P.3    Marcinkiewicz, M.4    Mbikay, M.5    Chretien, M.6
  • 52
    • 13044279492 scopus 로고    scopus 로고
    • Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization
    • Seidah N. G., Mowla S. J., Hamelin J. et al. (1999) Mammalian subtilisin/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Proc. Natl Acad. Sci. USA 96, 1321-1326.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1321-1326
    • Seidah, N.G.1    Mowla, S.J.2    Hamelin, J.3
  • 54
    • 0027453569 scopus 로고
    • Structure of the zebrafish snail 1 gene and its expression in wild-type, spadetail and no tail mutant embryos
    • Thisse C., Thisse B., Schilling T. F. and Postlethwait J. H. (1993) Structure of the zebrafish snail 1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development 119, 1203-1215.
    • (1993) Development , vol.119 , pp. 1203-1215
    • Thisse, C.1    Thisse, B.2    Schilling, T.F.3    Postlethwait, J.H.4
  • 55
    • 0036791359 scopus 로고    scopus 로고
    • Furin at the cutting edge: From protein traffic to embryogenesis and disease
    • Thomas G. (2002) Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat. Rev. Mol. Cell Biol. 3, 753-766.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 753-766
    • Thomas, G.1
  • 57
    • 0037334407 scopus 로고    scopus 로고
    • Unique and conserved aspects of gut development in zebrafish
    • Wallace K. N. and Pack M. (2003) Unique and conserved aspects of gut development in zebrafish. Dev. Biol. 255, 12-29.
    • (2003) Dev. Biol. , vol.255 , pp. 12-29
    • Wallace, K.N.1    Pack, M.2
  • 58
    • 0036594237 scopus 로고    scopus 로고
    • Global gene expression patterns during neural differentiation of P19 embryonic carcinoma cells
    • Wei Y., Harris T. and Childs G. (2002) Global gene expression patterns during neural differentiation of P19 embryonic carcinoma cells. Differentiation 70, 204-219.
    • (2002) Differentiation , vol.70 , pp. 204-219
    • Wei, Y.1    Harris, T.2    Childs, G.3
  • 60
    • 0033597852 scopus 로고    scopus 로고
    • Proteolytic processing in the secretory pathway
    • Zhou A., Webb G., Zhu X. and Steiner D. F. (1999) Proteolytic processing in the secretory pathway. J. Biol. Chem. 274, 20 745-20 748.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20745-20748
    • Zhou, A.1    Webb, G.2    Zhu, X.3    Steiner, D.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.