The sterol regulatory element-binding protein pathway: Control of lipid homeostasis through regulated intracellular transport

Current Opinion in Lipidology

Volumn 12, Issue 3, 2001, Pages 261-266

  Sakai, Juro ^a   Rawson, Robert B ^b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; LIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ENDOPLASMIC RETICULUM; FEEDBACK SYSTEM; GOLGI COMPLEX; HOMEOSTASIS; HUMAN; INTRACELLULAR TRANSPORT; LIPOGENESIS; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPID METABOLISM; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, TERTIARY; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

EID: 0034983188     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200106000-00004     Document Type: Review

References (25)

1. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
2. Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
3. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
4. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
5. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells
6. Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins
7. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies
8. Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein
9. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein
10. Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning
11. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
12. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes
13. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP-SREBP exit from endoplasmic reticulum
14. Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
15. Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N
16. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi
17. Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein
18. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
19. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
20. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
21. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors
22. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBP
23. Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2
24. Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease
25. Amino acid preferences for specific locations at the ends of alpha helices