Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

Journal of Biological Chemistry

Volumn 282, Issue 28, 2007, Pages 20502-20512

  Fisher, Timothy S ^a   Surdo, Paola Lo ^b   Pandit, Shilpa ^a   Mattu, Marco ^b   Santoro, Joseph C ^a   Wisniewski, Doug ^a   Cummings, Richard T ^a   Calzetta, Alessandra ^b   Cubbon, Rose M ^a   Fischer, Paul A ^a   Tarachandani, Anil ^a   De Francesco, Raffaele ^b   Wright, Samuel D ^a   Sparrow, Carl P ^a   Carfi, Andrea ^b   Sitlani, Ayesha ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC ENDOSOMAL; LOW DENSITY LIPOPROTEIN (LDL); MISSENSE MUTANTS;

CELL CULTURE; CHOLESTEROL; DEGRADATION; ENZYME INHIBITION; PH EFFECTS; PROTEINS;

BIOCHEMICAL ENGINEERING;

LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ASSAY; CELL CULTURE; CHO CELL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; HYPOCHOLESTEROLEMIA; IN VITRO STUDY; KIDNEY; MISSENSE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PURIFICATION; WILD TYPE;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; GENES, DOMINANT; GENETIC DISEASES, INBORN; HUMANS; HYPERCHOLESTEROLEMIA; LIPOPROTEINS, LDL; LYSOSOMES; MODELS, BIOLOGICAL; MUTATION, MISSENSE; PROTEIN BINDING; RECEPTORS, LDL; SERINE ENDOPEPTIDASES;

CRICETULUS GRISEUS;

EID: 34547129121     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701634200     Document Type: Article

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