NARC-1/PCSK9 and its natural mutants: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

Journal of Biological Chemistry

Volumn 279, Issue 47, 2004, Pages 48865-48875

  Benjannet, Suzanne ^a   Rhainds, David ^a   Essalmani, Rachid ^a   Mayne, Janice ^b   Wickham, Louise ^a   Jin, Weijun ^c   Asselin, Marie Claude ^a   Hamelin, Josée ^a   Varret, Mathilde ^d   Allard, Delphine ^d   Trillard, Mélanie ^d   Abifadel, Marianne ^d   Tebon, Angie ^e   Attie, Alan D ^e   Rader, Daniel J ^c   Boileau, Catherine ^d   Brissette, Louise ^f   Chrétien, Michel ^b   Prat, Annik ^a   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d INSERM   (France)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; METABOLISM; PATIENT TREATMENT; PROTEINS;

ENDOPLASMIC RETICULUM; LOW DENSITY LIPOPROTEINS (LDL); MISSENSE MUTATIONS;

MUTAGENESIS;

AMMONIUM CHLORIDE; APOLIPOPROTEIN B; ENZYME PRECURSOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MUTANT PROTEIN; NEURAL APOPTOSIS REGULATED CONVERTASE 1; UNCLASSIFIED DRUG;

ADENOVIRUS; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CELL SURFACE; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; LYMPHOBLAST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; WILD TYPE;

ADENOVIRIDAE; AMMONIUM CHLORIDE; ANIMALS; APOLIPOPROTEINS B; BINDING SITES; BLOTTING, WESTERN; CALCIUM; CATALYSIS; CELL LINE; CELL MEMBRANE; CELL SEPARATION; CHOLESTEROL; CHOLESTEROL, LDL; DNA, COMPLEMENTARY; ENDOPLASMIC RETICULUM; ENZYME PRECURSORS; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENE SILENCING; HETEROZYGOTE; HUMANS; HYPERCHOLESTEROLEMIA; LYMPHOCYTES; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LDL; RNA, MESSENGER; SERINE ENDOPEPTIDASES; TIME FACTORS; TRANSFECTION;

ADENOVIRIDAE;

EID: 10344253854     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409699200     Document Type: Article

References (62)

1. Seidah, N. G., and Chretien, M. (1999) Brain Res. 848, 45-62
2. Zhou, A., Webb, G., Zhu, X., and Steiner, D. F. (1999) J. Biol. Chem. 274, 20745-20748
3. Seidah, N. G., Mowla, S. J., Hamelin, J., Mamarbachi, A. M., Benjannet, S., Toure, B. B., Basak, A., Munzer, J. S., Marcinkiewicz, J., Zhong, M., Barale, J. C., Lazure, C., Murphy, R. A., Chretien, M., and Marcinkiewicz, M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1321-1326
4. Sakai, J., Rawson, R. B., Espenshade, P. J., Cheng, D., Seegmiller, A. C., Goldstein, J. L., and Brown, M. S. (1998) Mol. Cell 2, 505-514
5. Seidah, N. G., Benjannet, S., Wickham, L., Marcinkiewicz, J., Jasmin, S. B., Stifani, S., Basak, A., Prat, A., and Chretien, M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 928-933
6. Seidah, N. G., and Prat, A. (2002) Essays Biochem. 38, 79-94
7. Thomas, G. (2002) Nat. Rev. Mol. Cell. Biol. 3, 753-766
8. Taylor, N. A., Van de Ven, W. J., and Creemers, J. W. (2003) FASEB J. 17, 1215-1227
9. Roebroek, A. J., Umans, L., Pauli, I. G., Robertson, E. J., van Leuven, F., Van de Ven, W. J., and Constam, D. B. (1998) Development (Camb.) 125, 4863-4876
10. Yang, J., Goldstein, J. L., Hammer, R. E., Moon, Y. A., Brown, M. S., and Horton, J. D. (2001) Proc. Natl. Acad. Sci. U. S. A. 88, 13607-13612
11. Naureckiene, S., Ma, L., Sreekumar, K., Purandare, U., Lo, C. F., Huang, Y., Chiang, L. W., Grenier, J. M., Ozenberger, B. A., Jacobsen, J. S., Kennedy, J. D., DiStefano, P. S., Wood, A., and Bingham, B. (2003) Arch. Biochem. Biophys. 420, 55-67
12. Jackson, R. S., Creemers, J. W., Ohagi, S., Raffin-Sanson, M. L., Sanders, L., Montague, C. T., Hutton, J. C., and O'Rahilly, S. (1997) Nat. Genet. 16, 303-306
13. Jackson, R. S., Creemers, J. W., Farooqi, I. S., Raffin-Sanson, M. L., Varro, A., Dockray, G. J., Holst, J. J., Brubaker, P. L., Corvol, P., Polonsky, K. S., Ostrega, D., Becker, K. L., Bertagna, X., Hutton, J. C., White, A., Dattani, M. T., Hussain, K., Middleton, S. J., Nicole, T. M., Milla, P. J., Lindley, K. J., and O'Rahilly, S. (2003) J. Clin. Investig. 112, 1550-1560
14. Abifadel, M., Varret, M., Rabes, J. P., Allard, D., Ouguerram, K., Devillers, M., Cruaud, C., Benjannet, S., Wickham, L., Erlich, D., Derre, A., Villeger, L., Farnier, M., Beucler, I., Bruckert, E., Chambaz, J., Chanu, B., Lecerf, J. M., Luc, G., Moulin, P., Weissenbach, J., Prat, A., Krempf, M., Junien, C., Seidah, N. G., and Boileau, C. (2003) Nat. Genet. 34, 154-156
15. Rader, D. J., Cohen, J., and Hobbs, H. H. (2003) J. Clin. Investig. 111, 1795-1803
16. Timms, K. M., Wagner, S., Samuels, M. E., Forbey, K., Goldfine, H., Jammulapati, S., Skolnick, M. H., Hopkins, P. N., Hunt, S. C., and Shattuck, D. M. (2004) Hum. Genet. 114, 349-353
17. Leren, T. P. (2004) Clin. Genet. 65, 419-422
18. Shioji, K., Mannami, T., Kokubo, Y., Inamoto, N., Takagi, S., Goto, Y., Nonogi, H., and Iwai, N. (2004) J. Hum. Genet. 49, 109-114
19. Horton, J. D., Shah, N. A., Warrington, J. A., Anderson, N. N., Park, S. W., Brown, M. S., and Goldstein, J. L. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 12027-12032
20. Maxwell, K. N., Soccio, R. E., Duncan, E. M., Sehayek, E., and Breslow, J. L. (2003) J. Lipid Res. 44, 2109-2119
21. Dubuc, G., Chamberland, A., Wassef, H., Davignon, J., Seidah, N. G., Bernier, L., and Prat, A. (2004) Arterioscler. Thromb. Vasc. Biol. 24, 1454-1459
22. Sakai, J., Nohturfft, A., Goldstein, J. L., and Brown, M. S. (1998) J. Biol. Chem. 273, 5785-5793
23. Brown, M. S., and Goldstein, J. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11041-11048
24. Bergeron, E., Basak, A., Decroly, E., and Seidah, N. G. (2003) Biochem. J. 373, 475-484
25. Conesa, M., Prat, A., Mort, J. S., Marvaldi, J., Lissitzky, J. C., and Seidah, N. G. (2003) Biochem. J. 370, 703-711
26. Benjannet, S., Elagoz, A., Wickham, L., Mamarbachi, M., Munzer, J. S., Basak, A., Lazure, C., Cromlish, J. A., Sisodia, S., Checler, F., Chretien, M., and Seidah, N. G. (2001) J. Biol. Chem. 276, 10879-10887
27. Louie, L. G., and King, M. C. (1991) Am. J. Hum. Genet. 48, 637-638
28. Goldstein, J. L., Basu, S. K., and Brown, M. S. (1983) Methods Enzymol. 98, 241-260
29. Yoshimura, A., Yoshida, T., Seguchi, T., Waki, M., Ono, M., and Kuwano, M. (1987) J. Biol. Chem. 262, 13299-13308
30. Hatch, F. T. (1968) Adv. Lipid Res. 6, 1-68
31. Brissette, L., Charest, M. C., and Falstrault, L. (1996) Biochem. J. 318, 841-847
32. Langer, T., Strober, W., and Levy, R. I. (1972) J. Clin. Investig. 51, 1528-1536
33. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
34. Hopkins, C. R., and Trowbridge, I. S. (1983) J. Cell Biol. 97, 508-521
35. Jin, W., Millar, J. S., Broedl, U., Glick, J. M., and Rader, D. J. (2003) J. Clin. Investig. 111, 357-362
36. Gluschankof, P., and Fuller, R. S. (1994) EMBO J. 13, 2280-2288
37. Elagoz, A., Benjannet, S., Mammarbassi, A., Wickham, L., and Seidah, N. G. (2002) J. Biol. Chem. 277, 11265-11275
38. Reed, P. W., and Lardy, H. A. (1972) J. Biol. Chem. 247, 6970-6977
39. Brayden, D. J., Hanley, M. R., Thastrup, O., and Cuthbert, A. W. (1989) Br. J. Pharmacol. 98, 809-816
40. Thyberg, J., and Moskalewski, S. (1985) Exp. Cell Res. 159, 1-16
41. Hortin, G., Folz, R., Gordon, J. I., and Strauss, A. W. (1986) Biochem. Biophys. Res. Commun. 141, 326-333
42. Beisswanger, R., Corbeil, D., Vannier, C., Thiele, C., Dohrmann, U., Kellner, R., Ashman, K., Niehrs, C., and Huttner, W. B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11134-11139
43. Ouguerrram, K., Chetiveaux, M., Zair, Y., Costet, P., Abifadel, M., Varret, M., Boileau, C., Magot, T., and Krempf, M. (2004) Arterioscler. Thromb. Vasc. Biol. 8, 1448-1453
44. King-Underwood, L., Gudnason, V., Humphries, S., Seed, M., Patel, D., Knight, B., and Soutar, A. (1991) Clin. Genet. 40, 17-28
45. Gekle, M., Mildenberger, S., Freudinger, R., and Silbernagl, S. (1995) Am. J. Physiol. 268, F899-F906
46. Kopfler, W. P., Willard, M., Betz, T., Willard, J. E., Gerard, R. D., and Meidell, R. S. (1994) Circulation 90, 1319-1327
47. Krieger, M. (1983) Cell 33, 413-422
48. Seidah, N. G. (2001) in The Enzymes: Co- and Post-translational Proteolysis of Proteins (Dalbey, R. E., and Sigman, D. S., eds) pp. 237-258, Academic Press, San Diego
49. Henrich, S., Cameron, A., Bourenkov, G. P., Kiefersauer, R., Huber, R., Lindberg, I., Bode, W., and Than, M. E. (2003) Nat. Struct. Biol. 10, 520-526
50. Zhou, A., Martin, S., Lipkind, G., LaMendola, J., and Steiner, D. F. (1998) J. Biol. Chem. 273, 11107-11114
51. Benjannet, S., Rondeau, N., Paquet, L., Boudreault, A., Lazure, C., Chretien, M., and Seidah, N. G. (1993) Biochem. J. 294, 735-743
52. De Bie, I., Marcinkiewicz, M., Malide, D., Lazure, C., Nakayama, K., Bendayan, M., and Seidah, N. G. (1996) J. Cell Biol. 135, 1261-1275
53. Gregersen, N., Bross, P., Andrese, B. S., Pedersen, C. B., Corydon, T. J., and Bolund, L. (2001) J. Inherited Metab. Dis. 24, 189-212
54. Siezen, R. J., and Leunissen, J. A. (1997) Protein Sci. 6, 501-523
55. Soutar, A. K. (1992) J. Intern. Med. 231, 633-641
56. Kunst, C. B., Mezey, E., Brownstein, M. J., and Patterson, D. (1997) Nat. Genet. 15, 91-94
57. Michaely, P., Li, W. P., Anderson, R. G., Cohen, J. C., and Hobbs, H. H. (2004) J. Biol. Chem. 279, 34023-34031
58. Twisk, J., Gillian-Daniel, D. L., Tebon, A., Wang, L., Barrett, P. H., and Attie, A. D. (2000) J. Clin. Investig. 105, 521-532
59. Tremblay, A. J., Lamarche, B., Ruel, I. L., Hogue, J. C., Bergeron, J., Gagne, C., and Couture, P. (2004) J. Lipid Res. 45, 866-872
60. Wang, L., Fast, D. G., and Attie, A. D. (1997) J. Biol. Chem. 272, 27644-27651
61. Maxwell, K. N., and Breslow, J. L. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 7100-7105
62. Varret, M., Rabes, J. P., Saint-Jore, B., Cenarro, A., Marinoni, J. C., Civeira, F., Devillers, M., Krempf, M., Coulon, M., Thiart, R., Kotze, M. J., Schmidt, H., Buzzi, J. C., Kostner, G. M., Bertolini, S., Pocovi, M., Rosa, A., Farnier, M., Martinez, M., Junien, C., and Boileau, C. (1999) Am. J. Hum. Genet. 64, 1378-1387