HLA-peptide tetrameric complexes

Current Opinion in Immunology

Volumn 10, Issue 4, 1998, Pages 393-396

  Ogg, Graham S ^a   McMichael, Andrew J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; PEPTIDE; TETRAMER;

CELL FUNCTION; COMPLEX FORMATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PHENOTYPE; SHORT SURVEY; T LYMPHOCYTE SUBPOPULATION;

EID: 0032145277     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80110-6     Document Type: Article

References (18)

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8. of oustanding interest Gallimore A, Glithero A, Godkin A, Tissot A, Althage A, Pluckthun A, Elliott T, Hengartner H, Zinkernagel R. Induction and exhaustion of LCMV-specific CTL visualised using soluble tetrameric MHC class I/peptide complexes. J Exp Med. 187:1998;1383-1393 This paper describes the antigen-specific expansions of cytotoxic T lymphocytes (CTLs) observed during acute infection with lymphocytic choriomeningitis virus (LCMV). It also describes the use of chemically biotinylated β2-microglobulin to construct the tetramers.
9. of oustanding interest Ogg G, Jin X, Bonhoeffer S, Dunbar P, Nowak M, Monard S, Segal J, Cao Y, Rowland-Jones S, Cerundolo V, et al. Quantitation of HIV-specific CTLsand plasma load of viral RNA. Science. 279:1998;2103-2106 This paper describes the inverse correlation between HIV-specific cytotoxic T lymphocyte (CTL) numbers measured by HLA-peptide tetrameric complexes and plasma load of viral RNA. It also documents the correlation between cytolytic activity of uncultured cells and staining with the HLA-tetramers and the use of HLA-tetramers to sort antigen-specific CTLs using fluorescence-activated cell sorting.
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12. + T cells during the primary immune response to Epstein Barr virus in vivo. J Exp Med. 187:1998;1395-1402 This paper documents the antigen-specific cytotoxic T lymphocyte response in acute infectious mononucleosis using HLA-peptide tetrameric complexes.
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14. Braud VM, Allan DSJ, Wilson D, McMichael AJ. TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. Curr Biol. 8:1998;1-10.
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17. Colonna M, Samardis J, Cella M, Angman L, Allen R, O'Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A. Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol. 160:1998;3096-3100.
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