-
1
-
-
0029148660
-
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
-
Bose R., Verheij M., Haimovitz-Friedman A., Scotto K., Fuks Z., Kolesnick R. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 82:1995;405-414.
-
(1995)
Cell
, vol.82
, pp. 405-414
-
-
Bose, R.1
Verheij, M.2
Haimovitz-Friedman, A.3
Scotto, K.4
Fuks, Z.5
Kolesnick, R.6
-
2
-
-
0028095477
-
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
-
Cifone M.G., De Maria R., Roncaioli P., Rippo M.R., Azuma M., Lanier L.L., Santoni A., Testi R. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J. Exp. Med. 177:1994;1547-1552.
-
(1994)
J. Exp. Med.
, vol.177
, pp. 1547-1552
-
-
Cifone, M.G.1
De Maria, R.2
Roncaioli, P.3
Rippo, M.R.4
Azuma, M.5
Lanier, L.L.6
Santoni, A.7
Testi, R.8
-
3
-
-
0032571251
-
CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase
-
Cock J.G., Tepper A.D., de Vries E., van Blitterswijk W.J., Borst J. CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase. J. Biol. Chem. 273:1998;7560-7565.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7560-7565
-
-
Cock, J.G.1
Tepper, A.D.2
De Vries, E.3
Van Blitterswijk, W.J.4
Borst, J.5
-
4
-
-
0028934811
-
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
-
Dbaibo G.S., Pushkareva M.Y., Jayadev S., Schwarz J.K., Horowitz J.M., Obeid L.M., Hannun Y.A. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc. Natl. Acad. Sci. USA. 92:1995;1347-1351.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 1347-1351
-
-
Dbaibo, G.S.1
Pushkareva, M.Y.2
Jayadev, S.3
Schwarz, J.K.4
Horowitz, J.M.5
Obeid, L.M.6
Hannun, Y.A.7
-
5
-
-
0031041448
-
Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway
-
Dbaibo G.S., Perry D.K., Gamard C.J., Platt R., Poirier G.G., Obeid L.M., Hannun Y.A. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J. Exp. Med. 185:1997;481-490.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 481-490
-
-
Dbaibo, G.S.1
Perry, D.K.2
Gamard, C.J.3
Platt, R.4
Poirier, G.G.5
Obeid, L.M.6
Hannun, Y.A.7
-
6
-
-
0032528176
-
P53-dependent ceramide response to genotoxic stress
-
Dbaibo G.S., Pushkareva M.Y., Rachid R.A., Alter N., Smyth M.J., Obeid L.M., Hannun Y.A. p53-dependent ceramide response to genotoxic stress. J. Clin. Invest. 102:1998;329-339.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 329-339
-
-
Dbaibo, G.S.1
Pushkareva, M.Y.2
Rachid, R.A.3
Alter, N.4
Smyth, M.J.5
Obeid, L.M.6
Hannun, Y.A.7
-
7
-
-
0032536876
-
Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells
-
De Maria R., Rippo M.R., Schuchman E.H., Testi R. Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells. J. Exp. Med. 187:1998;897-902.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 897-902
-
-
De Maria, R.1
Rippo, M.R.2
Schuchman, E.H.3
Testi, R.4
-
8
-
-
0026723048
-
Ceramide stimulates a cytosolic protein phosphatase
-
Dobrowsky R.T., Hannun Y.A. Ceramide stimulates a cytosolic protein phosphatase. J. Biol. Chem. 267:1992;5048-5051.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 5048-5051
-
-
Dobrowsky, R.T.1
Hannun, Y.A.2
-
10
-
-
0030828425
-
Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity
-
Duan R.D., Nilsson A. Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity. Hepatology. 26:1997;823-830.
-
(1997)
Hepatology
, vol.26
, pp. 823-830
-
-
Duan, R.D.1
Nilsson, A.2
-
11
-
-
0028862061
-
Alkaline sphingomyelinase activity in rat gastrointestinal tract: Distribution and characteristics
-
Duan R.D., Nyberg L., Nilsson A. Alkaline sphingomyelinase activity in rat gastrointestinal tract: distribution and characteristics. Biochim. Biophys. Acta. 1259:1995;49-55.
-
(1995)
Biochim. Biophys. Acta
, vol.1259
, pp. 49-55
-
-
Duan, R.D.1
Nyberg, L.2
Nilsson, A.3
-
12
-
-
0032508379
-
Purification and characterization of ceramide-activated protein phosphatases
-
Galadari S., Kishikawa K., Kamibayashi C., Mumby M.C., Hannun Y.A. Purification and characterization of ceramide-activated protein phosphatases. Biochemistry. 37:1998;11232-11238.
-
(1998)
Biochemistry
, vol.37
, pp. 11232-11238
-
-
Galadari, S.1
Kishikawa, K.2
Kamibayashi, C.3
Mumby, M.C.4
Hannun, Y.A.5
-
13
-
-
0028287960
-
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
-
Haimovitz-Friedman A., Kan C.C., Ehleiter D., Persaud R.S., McLoughlin M., Fuks Z., Kolesnick R.N. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med. 180:1994;525-535.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 525-535
-
-
Haimovitz-Friedman, A.1
Kan, C.C.2
Ehleiter, D.3
Persaud, R.S.4
McLoughlin, M.5
Fuks, Z.6
Kolesnick, R.N.7
-
14
-
-
0027994349
-
The sphingomyelin cycle and the second messenger function of ceramide
-
Hannun Y.A. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269:1994;3125-3128.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 3125-3128
-
-
Hannun, Y.A.1
-
15
-
-
0030448021
-
Functions of ceramide in coordinating cellular responses to stress
-
Hannun Y.A. Functions of ceramide in coordinating cellular responses to stress. Science. 274:1996;1855-1859.
-
(1996)
Science
, vol.274
, pp. 1855-1859
-
-
Hannun, Y.A.1
-
16
-
-
0023138332
-
Lysosphingolipids inhibit protein kinase C: Implications for the sphingolipidoses
-
Hannun Y.A., Bell R.M. Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 235:1987;670-674.
-
(1987)
Science
, vol.235
, pp. 670-674
-
-
Hannun, Y.A.1
Bell, R.M.2
-
17
-
-
0024541436
-
Functions of sphingolipids and sphingolipid breakdown products in cellular regulation
-
Hannun Y.A., Bell R.M. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science. 243:1989;500-507.
-
(1989)
Science
, vol.243
, pp. 500-507
-
-
Hannun, Y.A.1
Bell, R.M.2
-
18
-
-
0022974603
-
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
-
Hannun Y.A., Loomis C.R., Merrill A.H. Jr, Bell R.M. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem. 261:1986;12604-12609.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 12604-12609
-
-
Hannun, Y.A.1
Loomis, C.R.2
Merrill A.H., Jr.3
Bell, R.M.4
-
19
-
-
0030006040
-
Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
-
Jaffrezou J.P., Levade T., Bettaieb A., Andrieu N., Bezombes C., Maestre N., Vermeersch S., Rousse A., Laurent G. Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J. 15:1996;2417-2424.
-
(1996)
EMBO J.
, vol.15
, pp. 2417-2424
-
-
Jaffrezou, J.P.1
Levade, T.2
Bettaieb, A.3
Andrieu, N.4
Bezombes, C.5
Maestre, N.6
Vermeersch, S.7
Rousse, A.8
Laurent, G.9
-
20
-
-
0028070326
-
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor α
-
Jayadev S., Linardic C.M., Hannun Y.A. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor α J. Biol. Chem. 269:1994;5757-5763.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5757-5763
-
-
Jayadev, S.1
Linardic, C.M.2
Hannun, Y.A.3
-
21
-
-
0028930533
-
Role for ceramide in cell cycle arrest
-
Jayadev S., Liu B., Bielawska A.E., Lee J.Y., Nazaire F., Pushkareva M.Y., Obeid L.M., Hannun Y.A. Role for ceramide in cell cycle arrest. J. Biol. Chem. 270:1995;2047-2052.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 2047-2052
-
-
Jayadev, S.1
Liu, B.2
Bielawska, A.E.3
Lee, J.Y.4
Nazaire, F.5
Pushkareva, M.Y.6
Obeid, L.M.7
Hannun, Y.A.8
-
22
-
-
0030611270
-
Phospholipase A2 is necessary for tumor necrosis factor α induced ceramide generation in L929 cells
-
Jayadev S., Hayter H.L., Andrieu N., Gamard C.J., Liu B., Balu R., Hayakawa M., Ito F., Hannu Y.A. Phospholipase A2 is necessary for tumor necrosis factor α induced ceramide generation in L929 cells. J. Biol. Chem. 272:1997;17196-17203.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17196-17203
-
-
Jayadev, S.1
Hayter, H.L.2
Andrieu, N.3
Gamard, C.J.4
Liu, B.5
Balu, R.6
Hayakawa, M.7
Ito, F.8
Hannu, Y.A.9
-
23
-
-
0028953260
-
Evidence that ceramide selectively inhibits protein kinase C-α translocation and modulates bradykinin activation of phospholipase D
-
Jones M.J., Murray A.W. Evidence that ceramide selectively inhibits protein kinase C-α translocation and modulates bradykinin activation of phospholipase D. J. Biol. Chem. 270:1995;5007-5013.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 5007-5013
-
-
Jones, M.J.1
Murray, A.W.2
-
24
-
-
0026534541
-
Elevated ceramide levels in GH4C1 cells treated with retinoic acid
-
Kalen A., Borchardt R.A., Bell R.M. Elevated ceramide levels in GH4C1 cells treated with retinoic acid. Biochim. Biophys. Acta. 1125:1992;90-96.
-
(1992)
Biochim. Biophys. Acta
, vol.1125
, pp. 90-96
-
-
Kalen, A.1
Borchardt, R.A.2
Bell, R.M.3
-
25
-
-
0026007737
-
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon. Specific role in cell differentiation
-
Kim M.-Y., Linardic C., Obeid L., Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon. Specific role in cell differentiation. J. Biol. Chem. 266:1991;484-489.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 484-489
-
-
Kim, M.-Y.1
Linardic, C.2
Obeid, L.3
Hannun, Y.4
-
26
-
-
0028093490
-
Acid sphingomyelinase is not essential for the IL-1 and tumor necrosis factor receptor signaling pathway leading to NF-κB activation
-
Kuno K., Sukegawa K., Ishikawa Y., Orii T., Matsushima K. Acid sphingomyelinase is not essential for the IL-1 and tumor necrosis factor receptor signaling pathway leading to NF-κB activation. Int. Immunol. 6:1994;1269-1272.
-
(1994)
Int. Immunol.
, vol.6
, pp. 1269-1272
-
-
Kuno, K.1
Sukegawa, K.2
Ishikawa, Y.3
Orii, T.4
Matsushima, K.5
-
27
-
-
15844387528
-
Ceramide inactivates cellular protein kinase Cα
-
Lee J.Y., Hannun Y.A., Obeid L.M. Ceramide inactivates cellular protein kinase Cα J. Biol. Chem. 271:1996;13169-13174.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13169-13174
-
-
Lee, J.Y.1
Hannun, Y.A.2
Obeid, L.M.3
-
28
-
-
0032168201
-
Cell-cycledependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M
-
Lee J.Y., Leonhardt L.G., Obeid L.M. Cell-cycledependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. Biochem. J. 334:1998;457-461.
-
(1998)
Biochem. J.
, vol.334
, pp. 457-461
-
-
Lee, J.Y.1
Leonhardt, L.G.2
Obeid, L.M.3
-
29
-
-
0027978352
-
Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle
-
Linardic C.M., Hannun Y.A. Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J. Biol. Chem. 269:1994;23530-23537.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23530-23537
-
-
Linardic, C.M.1
Hannun, Y.A.2
-
30
-
-
0030960327
-
Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione
-
Liu B., Hannun Y.A. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J. Biol. Chem. 272:1997;16281-16287.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16281-16287
-
-
Liu, B.1
Hannun, Y.A.2
-
31
-
-
0027968517
-
Renaturation and tumor necrosis factor-α stimulation of a 97-kDa ceramide-activated protein kinase
-
Liu J., Mathias S., Yang Z., Kolesnick R.N. Renaturation and tumor necrosis factor-α stimulation of a 97-kDa ceramide-activated protein kinase. J. Biol. Chem. 269:1994;3047-3052.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 3047-3052
-
-
Liu, J.1
Mathias, S.2
Yang, Z.3
Kolesnick, R.N.4
-
32
-
-
0032079524
-
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death
-
Liu B., Andrieu-Abadie N., Levade T., Zhang P., Obeid L.M., Hannun Y.A. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death. J. Biol. Chem. 273:1998;11313-11320.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11313-11320
-
-
Liu, B.1
Andrieu-Abadie, N.2
Levade, T.3
Zhang, P.4
Obeid, L.M.5
Hannun, Y.A.6
-
33
-
-
0032545461
-
Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain
-
Liu B., Hassler D.F., Smith G.K., Weaver K., Hannun Y.A. Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain. J Biol Chem. 273:1998;34472-34479.
-
(1998)
J Biol Chem.
, vol.273
, pp. 34472-34479
-
-
Liu, B.1
Hassler, D.F.2
Smith, G.K.3
Weaver, K.4
Hannun, Y.A.5
-
34
-
-
0032486257
-
Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?
-
Luberto C., Hannun Y.A. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J. Biol. Chem. 273:1998;14550-14559.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14550-14559
-
-
Luberto, C.1
Hannun, Y.A.2
-
35
-
-
0025889011
-
Characterization of a ceramide-activated protein kinase: Stimulation by tumor necrosis factor α
-
Mathias S., Dressler K.A., Kolesnick R.N. Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor α Proc. Natl. Acad. Sci. USA. 88:1991;10009-10013.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 10009-10013
-
-
Mathias, S.1
Dressler, K.A.2
Kolesnick, R.N.3
-
36
-
-
0030724987
-
KSR stimulates Raf-1 activity in a kinase-independent manner
-
Michaud N.R., Therrien M., Cacace A., Edsall L.C., Spiegel S., Rubin G.M., Morrison D.K. KSR stimulates Raf-1 activity in a kinase-independent manner. Proc. Natl. Acad. Sci. USA. 94:1997;12792-12796.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12792-12796
-
-
Michaud, N.R.1
Therrien, M.2
Cacace, A.3
Edsall, L.C.4
Spiegel, S.5
Rubin, G.M.6
Morrison, D.K.7
-
37
-
-
0030042239
-
Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells
-
Nakamura Y., Nakashima S., Ojio K., Banno Y., Miyata H., Nozawa Y. Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells. J. Immunol. 156:1996;256-262.
-
(1996)
J. Immunol.
, vol.156
, pp. 256-262
-
-
Nakamura, Y.1
Nakashima, S.2
Ojio, K.3
Banno, Y.4
Miyata, H.5
Nozawa, Y.6
-
39
-
-
0024795059
-
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation
-
Okazaki T., Bell R.M., Hannun Y.A. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem. 264:1989;19076-19080.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 19076-19080
-
-
Okazaki, T.1
Bell, R.M.2
Hannun, Y.A.3
-
42
-
-
0031013369
-
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis
-
Paumen M.B., Ishida Y., Muramatsu M., Yamamoto M., Honjo T. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J. Biol. Chem. 272:1997;3324-3329.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3324-3329
-
-
Paumen, M.B.1
Ishida, Y.2
Muramatsu, M.3
Yamamoto, M.4
Honjo, T.5
-
43
-
-
0028050242
-
Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation
-
Quintans J., Kilkus J., McShan C.L., Gottschalk A.R., Dawson G. Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem. Biophys. Res. Commun. 202:1994;710-714.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.202
, pp. 710-714
-
-
Quintans, J.1
Kilkus, J.2
McShan, C.L.3
Gottschalk, A.R.4
Dawson, G.5
-
44
-
-
0023574186
-
Acid sphingomyelinase from human urine: Purification and characterization
-
Quintern L.E., Weitz G., Nehrkorn H., Tager J.M., Schram A.W., Sandhoff K. Acid sphingomyelinase from human urine: purification and characterization. Biochim. Biophys. Acta. 922:1987;323-336.
-
(1987)
Biochim. Biophys. Acta
, vol.922
, pp. 323-336
-
-
Quintern, L.E.1
Weitz, G.2
Nehrkorn, H.3
Tager, J.M.4
Schram, A.W.5
Sandhoff, K.6
-
45
-
-
0024423426
-
Isolation of cDNA clones encoding human acid sphingomyelinase: Occurrence of alternatively processed transcripts
-
Quintern, L.E., Schuchman, E.H., Levran, O., Suchi, M., Ferlinz, K., Reinke, H., Sandhoff, K., Desnick, R.J., 1989. Isolation of cDNA clones encoding human acid sphingomyelinase: occurrence of alternatively processed transcripts. EMBO J. 2469-2473.
-
(1989)
EMBO J.
, pp. 2469-2473
-
-
Quintern, L.E.1
Schuchman, E.H.2
Levran, O.3
Suchi, M.4
Ferlinz, K.5
Reinke, H.6
Sandhoff, K.7
Desnick, R.J.8
-
46
-
-
0029834974
-
C-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells
-
Reyes J.G., Robayna I.G., Delgado P.S., Gonzalez I.H., Aguiar J.Q., Rosas F.E., Fanjul L.F., Galarreta C.M.R. c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells. J. Biol. Chem. 271:1996;21375-21380.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 21375-21380
-
-
Reyes, J.G.1
Robayna, I.G.2
Delgado, P.S.3
Gonzalez, I.H.4
Aguiar, J.Q.5
Rosas, F.E.6
Fanjul, L.F.7
Galarreta, C.M.R.8
-
47
-
-
16044364385
-
Acid sphingomyelinase deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
Santana P., Pena L.A., Haimovitz-Friedman A., Martin S., Green D., McLoughlin M., Cordon-Cardo C., Schuchman E.H., Fuks Z., Kolesnick R. Acid sphingomyelinase deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell. 86:1996;189-199.
-
(1996)
Cell
, vol.86
, pp. 189-199
-
-
Santana, P.1
Pena, L.A.2
Haimovitz-Friedman, A.3
Martin, S.4
Green, D.5
McLoughlin, M.6
Cordon-Cardo, C.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
48
-
-
0028846952
-
Requirement of AP-1 for ceramide induced apoptosis in human leukemia HL-60 cells
-
Sawai H., Okazaki T., Yamamoto H., Okano H., Takeda Y., Tashima M., Sawada H., Okuma M., Ishikura H., Umehara H., Domae N. Requirement of AP-1 for ceramide induced apoptosis in human leukemia HL-60 cells. J. Biol. Chem. 270:1995;27326-27331.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27326-27331
-
-
Sawai, H.1
Okazaki, T.2
Yamamoto, H.3
Okano, H.4
Takeda, Y.5
Tashima, M.6
Sawada, H.7
Okuma, M.8
Ishikura, H.9
Umehara, H.10
Domae, N.11
-
49
-
-
0031035381
-
Ceramide-induced translocation of protein kinase C-δ And -ε To the cytosol. Implications in apoptosis
-
Sawai H., Okazaki T., Takeda Y., Tashima M., Sawada H., Okuma M., Kishi S., Umehara H., Domae N. Ceramide-induced translocation of protein kinase C-δ and -ε to the cytosol. Implications in apoptosis. J. Biol. Chem. 272:1997;2452-2458.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2452-2458
-
-
Sawai, H.1
Okazaki, T.2
Takeda, Y.3
Tashima, M.4
Sawada, H.5
Okuma, M.6
Kishi, S.7
Umehara, H.8
Domae, N.9
-
50
-
-
0029666484
-
2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene
-
2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. J. Biol. Chem. 271:1996;18431-18436.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18431-18436
-
-
Schissel, S.L.1
Schuchman, E.H.2
Williams, K.J.3
Tabas, I.4
-
51
-
-
0025819971
-
Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs
-
Schuchman E.H., Suchi M., Takahashi T., Sandhoff K., Desnick R.J. Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. J. Biol. Chem. 266:1991;8531-8539.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 8531-8539
-
-
Schuchman, E.H.1
Suchi, M.2
Takahashi, T.3
Sandhoff, K.4
Desnick, R.J.5
-
52
-
-
0026458406
-
TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown
-
Schutze S., Potthoff K., Machleidt T., Berkovic D., Wiegmann K., Kronke M. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. Cell. 71:1992;765-776.
-
(1992)
Cell
, vol.71
, pp. 765-776
-
-
Schutze, S.1
Potthoff, K.2
Machleidt, T.3
Berkovic, D.4
Wiegmann, K.5
Kronke, M.6
-
53
-
-
0032493829
-
Cytokinemediated induction of ceramide production is redoxsensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases
-
Singh I., Pahan K., Khan M., Singh A.K. Cytokinemediated induction of ceramide production is redoxsensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases. J. Biol. Chem. 273:1998;20354-20362.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 20354-20362
-
-
Singh, I.1
Pahan, K.2
Khan, M.3
Singh, A.K.4
-
54
-
-
0029949938
-
PrICE: A downstream target for ceramide induced apoptosis and for the inhibitory action of Bcl-2
-
Smyth M.J., Perry D.K., Zhang J., Poirier G.G., Hannun Y.A., Obeid L.M. prICE: a downstream target for ceramide induced apoptosis and for the inhibitory action of Bcl-2. Biochem. J. 316:1996;25-28.
-
(1996)
Biochem. J.
, vol.316
, pp. 25-28
-
-
Smyth, M.J.1
Perry, D.K.2
Zhang, J.3
Poirier, G.G.4
Hannun, Y.A.5
Obeid, L.M.6
-
55
-
-
0028176730
-
1-β-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells
-
Strum J.C., Small G.W., Pauig S.B., Daniel L.W. 1-β-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. J. Biol. Chem. 269:1994;15493-15497.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 15493-15497
-
-
Strum, J.C.1
Small, G.W.2
Pauig, S.B.3
Daniel, L.W.4
-
56
-
-
0029127286
-
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity
-
Tepper C.G., Jayadev S., Liu B., Bielawska A., Wolff R., Yonehara S., Hannun Y.A., Seldin M.F. Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc. Natl. Acad. Sci. USA. 92:1995;8443-8447.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8443-8447
-
-
Tepper, C.G.1
Jayadev, S.2
Liu, B.3
Bielawska, A.4
Wolff, R.5
Yonehara, S.6
Hannun, Y.A.7
Seldin, M.F.8
-
57
-
-
0032584153
-
Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?
-
Tomiuk S., Hofmann K., Nix M., Zumbansen M., Stoffel W. Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Proc. Natl. Acad. Sci. USA. 95:1998;3638-3643.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3638-3643
-
-
Tomiuk, S.1
Hofmann, K.2
Nix, M.3
Zumbansen, M.4
Stoffel, W.5
-
58
-
-
0029744454
-
Ceramide inhibits phospholipase D in a cell-free system
-
Venable M.E., Bielawska A., Obeid L.M. Ceramide inhibits phospholipase D in a cell-free system. J. Biol. Chem. 271:1996;24800-24805.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24800-24805
-
-
Venable, M.E.1
Bielawska, A.2
Obeid, L.M.3
-
59
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
Verheij M., Bose R., Lin X.H., Yao B, Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitz-Friedman A., Fuks Z., Kolesnick R.N. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 380:1996;75-79.
-
(1996)
Nature
, vol.380
, pp. 75-79
-
-
Verheij, M.1
Bose, R.2
Lin, X.H.3
Yao, B.4
Jarvis, W.D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
Haimovitz-Friedman, A.11
Fuks, Z.12
Kolesnick, R.N.13
-
60
-
-
0028981358
-
Ceramide activates the stress-activated protein kinases
-
Westwick J.K., Bielawska A.E., Dbaibo G., Hannun Y.A., Brenner D.A. Ceramide activates the stress-activated protein kinases. J. Biol. Chem. 270:1995;22689-22692.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22689-22692
-
-
Westwick, J.K.1
Bielawska, A.E.2
Dbaibo, G.3
Hannun, Y.A.4
Brenner, D.A.5
-
61
-
-
9344222195
-
Bcl-2 interrupts the ceramide-mediated pathway of cell death
-
Zhang J., Alter N., Reed J.C., Borner C., Obeid L.M., Hannun Y.A. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc. Natl. Acad. Sci. USA. 93:1996;5325-5328.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 5325-5328
-
-
Zhang, J.1
Alter, N.2
Reed, J.C.3
Borner, C.4
Obeid, L.M.5
Hannun, Y.A.6
-
62
-
-
0030893370
-
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis
-
Zhang P., Liu B., Jenkins G.M., Hannun Y.A., Obeid L.M. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J. Biol. Chem. 272:1997;9609-9612.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9609-9612
-
-
Zhang, P.1
Liu, B.2
Jenkins, G.M.3
Hannun, Y.A.4
Obeid, L.M.5
-
63
-
-
0343742670
-
Kinase suppressor of Ras is ceramide-activated protein kinase
-
Zhang Y., Yao B., Delikat S., Bayoumy S., Lin X.H., Basu S., McGinley M., Chan-Hui P.Y., Lichenstein H., Kolesnick R. Kinase suppressor of Ras is ceramide-activated protein kinase. Cell. 89:1997;63-72.
-
(1997)
Cell
, vol.89
, pp. 63-72
-
-
Zhang, Y.1
Yao, B.2
Delikat, S.3
Bayoumy, S.4
Lin, X.H.5
Basu, S.6
McGinley, M.7
Chan-Hui, P.Y.8
Lichenstein, H.9
Kolesnick, R.10
-
64
-
-
0030888285
-
Tumor necrosis factor a activates NF-κB in acid sphingomyelinase-deficient mouse embryonic fibroblasts
-
Zumbansen M., Stoffel W. Tumor necrosis factor a activates NF-κB in acid sphingomyelinase-deficient mouse embryonic fibroblasts. J. Biol. Chem. 272:1997;10904-10909.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10904-10909
-
-
Zumbansen, M.1
Stoffel, W.2
|