Tryptophan breakdown pathway in bipolar mania

Journal of Affective Disorders

Volumn 102, Issue 1-3, 2007, Pages 65-72

  Myint, Aye Mu ^a,b   Kim, Yong Ku ^c   Verkerk, Robert ^b   Park, Sun Hwa ^c   Scharpé, Simon ^b   Steinbusch, Harry W M ^a   Leonard, Brian E ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c Kyung Hee University Hospital   (South Korea)

Author keywords

Bipolar mania; Kynurenine; Tryptophan

Indexed keywords

3 HYDROXYANTHRANILIC ACID; AMINO ACID; KYNURENIC ACID; KYNURENINE; LITHIUM; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; RISPERIDONE; TRYPTOPHAN; VALPROIC ACID;

ADULT; ARTICLE; BIPOLAR MANIA; BLOOD LEVEL; CADAVER; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; MALE; MENTAL DISEASE; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA; SCORING SYSTEM; STATISTICAL ANALYSIS; UPREGULATION;

ADULT; ASPARTIC ACID; BIPOLAR DISORDER; BRIEF PSYCHIATRIC RATING SCALE; FEMALE; GYRUS CINGULI; HUMANS; KYNURENIC ACID; KYNURENINE; MALE; SCHIZOPHRENIA; SEVERITY OF ILLNESS INDEX; TRYPTOPHAN;

EID: 34447250001     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2006.12.008     Document Type: Article

References (41)

1. Angst J. The course of affective disorders. Psychopathology 19 Suppl 2 (1986) 47-52
2. Anguelova M., Benkelfat C., and Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol. Psychiatry 8 (2003) 574-591
3. Anguelova M., Benkelfat C., and Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol. Psychiatry 8 (2003) 646-653
4. Diagnostic and Statistical Manual of Mental Disorders. 4th ed (1994), American Psychiatric Press, Washington, DC
5. Askland K., and Parsons M. Toward a biaxial model of "bipolar" affective disorders: Spectrum phenotypes as the products of neuroelectrical and neurochemical alterations. J. Affect. Disord. 94 (2006) 15-33
6. Bellivier F., Henry C., Szoke A., Schurhoff F., Nosten-Bertrand M., Feingold J., Launay J.M., Leboyer M., and Laplanche J.L. Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci. Lett. 255 (1998) 143-146
7. Bender D.A., and McCreanor G.M. Kynurenine hydroxylase: a potential rate-limiting enzyme in tryptophan metabolism. Biochem. Soc. Trans. 13 (1985) 441-443
8. Calabrese J.R., Shelton M.D., Rapport D.J., Youngstrom E.A., Jackson K., Bilali S., Ganocy S.J., and Findling R.L. A 20-month, double-blind, maintenance trial of lithium versus divalproex in rapid-cycling bipolar disorder. Am. J. Psychiatry 162 (2005) 2152-2161
9. Chiarugi A., Calvani M., Meli E., Traggiai E., and Moroni F. Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages. J. Neuroimmunol. 120 (2001) 190-198
10. Chuang D.M. The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials. Ann. N. Y. Acad. Sci. 1053 (2005) 195-204
11. Collier D.A., Arranz M.J., Sham P., Battersby S., Vallada H., Gill P., Aitchison K.J., Sodhi M., Li T., Roberts G.W., Smith B., Morton J., Murray R.M., Smith D., and Kirov G. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport 7 (1996) 1675-1679
12. Cooper J.D., Turnell D.C., Green B., and Verillon F. Automated sequential trace enrichment of dialysates and robotics. A technique for the preparation of biological samples prior to high-performance liquid chromatography. J. Chromatogr. 456 (1988) 53-69
13. Coryell W., Keller M., Endicott J., Andreasen N., Clayton P., and Hirschfeld R. Bipolar II illness: course and outcome over a five-year period. Psychol. Med. 19 (1989) 129-141
14. Cusin C., Serretti A., Lattuada E., Mandelli L., and Smeraldi E. Impact of clinical variables on illness time course in mood disorders. Psychiatry Res. 97 (2000) 217-227
15. Cusin C., Serretti A., Lattuada E., Lilli R., Lorenzi C., Mandelli L., Pisati E., and Smeraldi E. Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders. J. Psychiatr. Res. 35 (2001) 217-223
16. De Luca V., Likhodi O., Van Tol H.H., Kennedy J.L., and Wong A.H. Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. Psychopharmacology (Berlin) 183 (2005) 378-382
17. First M., Spitzer R.L., Gibbon M., and William J.B. Structured Clinical Interview for DSM-IV Axis I Disorder-Patient Edition (SCID-I/P, version 2.0) (1998), Biometrics Research Department, New York State Psychiatric Institute, New York
18. Gal E.M., and Sherman A.D. l-kynurenine: its synthesis and possible regulatory function in brain. Neurochem. Res. 5 (1980) 223-239
19. Gonzalez-Pinto A., Ballesteros J., Aldama A., Perez de Heredia J.L., Gutierrez M., Mosquera F., and Gonzalez-Pinto A. Principal components of mania. J. Affect Disord. 76 (2003) 95-102
20. Grant R.S., and Kapoor V. Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates. J. Neurochem. 70 (1998) 1759-1763
21. Grant R.S., Naif H., Espinosa M., and Kapoor V. IDO induction in IFN-gamma activated astroglia: a role in improving cell viability during oxidative stress. Redox Rep. 5 (2000) 101-104
22. Herve C., Beyne P., Jamault H., and Delacoux E. Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection. J. Chromatogr. B., Biomed. Sci. Appl. 675 (1996) 157-161
23. Heyes M.P., Achim C.L., Wiley C.A., Major E.O., Saito K., and Markey S.P. Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. Biochem. J. 320 Pt 2 (1996) 595-597
24. Hoekstra R., Fekkes D., Loonen A.J., Pepplinkhuizen L., Tuinier S., and Verhoeven W.M. Bipolar mania and plasma amino acids: increased levels of glycine. Eur. Neuropsychopharmacol. 16 (2006) 71-77
25. Kessing L.V. Recurrence in affective disorder. II. Effect of age and gender. Br. J. Psychiatry 172 (1998) 29-34
26. Kessing L.V., Andersen P.K., Mortensen P.B., and Bolwig T.G. Recurrence in affective disorder. I. Case register study. Br. J. Psychiatry 172 (1998) 23-28
27. Kim J.P., and Choi D.W. Quinolinate neurotoxicity in cortical cell culture. Neuroscience 23 (1987) 423-432
28. Mahmood T., and Silverstone T. Serotonin and bipolar disorder. J. Affect Disord. 66 (2001) 1-11
29. Miller C.L., Llenos I.C., Dulay J.R., and Weis S. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res. 1073-1074 (2006) 25-37
30. Murray C.J., and Lopez A.D. Evidence-based health policy-lessons from the Global Burden of Disease Study. Science 274 (1996) 740-743
31. Myint A.M., and Kim Y.K. Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Med. Hypotheses 61 (2003) 519-525
32. Myint A., Kim Y.K., Verkerk R., Scharpe S., Steinbusch H.W.M., and Leonard B.E. Kynurenine pathway in major depression: Evidence of impaired neuroprotection. J Affect Disord. 98 (2007) 143-151
33. Overall J.E., and Gorham D.R. The brief psychiatric rating scale. Psychol. Rep. 10 (1962) 799-812
34. Perkins M.N., and Stone T.W. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 247 (1982) 184-187
35. Sanacora G., Rothman D.L., Mason G., and Krystal J.H. Clinical studies implementing glutamate neurotransmission in mood disorders. Ann. N. Y. Acad. Sci. 1003 (2003) 292-308
36. Schwarcz R., Whetsell Jr. W.O., and Mangano R.M. Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219 (1983) 316-318
37. Serretti A., Lilli R., Lorenzi C., Lattuada E., Cusin C., and Smeraldi E. Serotonin transporter gene (5-HTTLPR) and major psychoses. Mol. Psychiatry 7 (2002) 95-99
38. Stone T.W., and Darlington L.G. Endogenous kynurenines as targets for drug discovery and development. Nat. Rev. Drug Discov. 1 (2002) 609-620
39. Vriend J.P., and Alexiuk N.A. Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice. Mol. Chem. Neuropathol. 27 (1996) 307-324
40. Xie X., and Hagan R.M. Cellular and molecular actions of lamotrigine: possible mechanisms of efficacy in bipolar disorder. Neuropsychobiology 38 (1998) 119-130
41. Young R.C., Biggs J.T., Ziegler V.E., and Meyer D.A. A rating scale for mania: reliability, validity and sensitivity. Br. J. Psychiatry 133 (1978) 429-435