Lower serum L-tryptophan availability in depression as a marker of a more generalized disorder in protein metabolism

Neuropsychopharmacology

Volumn 15, Issue 3, 1996, Pages 243-251

  Maes, Michael ^a,c   Wauters, Annick ^b   Verkerk, Robert ^a   Demedts, Paul ^b   Neels, Hugo ^b   Van Gastel, Ann ^d   Cosyns, Paul ^d   Scharpé, Simon ^a   Desnyder, Roger ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b Lab of Clin Chem and Toxicology   (Belgium)

^c Clinical Research Center for Mental Health of Antwerp   (Belgium)

^d AZ Stuivenberg ^*

Author keywords

Acute phase proteins; Albumin; Electrophoresis; L tryptophan; Serotonin

Indexed keywords

ALBUMIN; PROTEIN; TRYPTOPHAN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; HUMAN; MELANCHOLIA; PRIORITY JOURNAL;

EID: 0030250007     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0893-133X(95)00181-C     Document Type: Article

References (62)

1. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders. Washington, DC, American Psychiatric Association
2. Arnold FJ, Meyerson LR (1990): Olfactory bulbectomy alters alpha-1 acid glycoprotein levels in rat plasma. Br Res Bull 25:259-262
3. Ashley DVM, Barclay DV, Chauffard FE et al. (1982): Plasma amino acid responses in humans to evening meals of differing nutritional composition. Am J Clin Nutr 36: 143-153
4. Ashley DVM, Liardon R, Leathwood PD (1985): Breakfast meal composition influences plasma tryptophan to large neutral amino acid ratios of healthy lean young men. J Neural Transm 63:271-283
5. Blackburn GL, Moldawer LL, Usui S, Bothe AJr, O'Keefe SJD, Bistrian BR (1979): Branched chain amino acid administration and metabolism during starvation, injury, and infection. Surgery 86:307-314
6. Brown RR, Lee CM, Kohler PC, Hank JA, Storer BE, Sondel PM (1989): Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin-2. Cancer Res 49:4941-4944
7. Castell JV, Gomez-Lechon MJ, David M, Andus T, Geiger T, Trullenque R, Fabra R, Heinrich PC (1989): Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 242:237-239
8. Cowen PJ, Parry-Billings M, Newsholme EA (1989): Decreased plasma tryptophan levels in major depression. J Affect Disord 16:27-31
9. Curzon G (1990): Availability of amino acids to the brain and implication for transmitter amine function. In Richardson MA (ed), Amino Acids in Psychiatric Disease. Washington DC, American Psychiatric Press, pp 33-48
10. Curzon G, Knott PJ (1975): Rapid effects of environmental disturbance on rat plasma unesterified fatty acid and tryptophan concentrations and their prevention by anti-lipolytic drugs. Br J Pharmacol 54:389-396
11. Curzon G, Sarna GS (1984): Tryptophan transport to the brain: Newer findings and older ones reconsidered. In Schlossberger HG, Kochen W, Linzen B, Steinhart H (eds), Progress in Tryptophan and Serotonin Research. Berlin-New York, Walter De Cruyter, pp 145-157
12. Delgado PL, Charney DS, Price LH, Landis H, Heninger GR (1990): Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjects. Life Sci 45: 2323-2332
13. DeMyer MK, Shea PA, Hendric HC, Yoshimura NN (1981): Plasma tryptophan and five other amino acids in depressed and normal subjects. Arch Gen Psychiatry 38: 642-646
14. Fernstrom JD (1984): Tryptophan availability and serotonin synthesis in rat brain: Effects of experimental diabetes. In Schlossberger HG, Kochen W, Linzen B, Steinhart H (eds), Progress in Tryptophan and Serotonin Research. Berlin-New York, Walter de Gruyter, pp 161-172
15. Fernstrom JD, Fernstrom MH, Grubb PE (1987): Twenty-four hour variations in rat blood and brain levels of the aromatic and branched-chain amino acids: Chronic effects of dietary protein content. Metabol 36:643-650
16. Fleck A (1989): Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc Nutr Soc 48:347-354
17. Fuchs D, Moller AA, Reibnegger C, Stockle E, Werner ER, Wachter H (1990): Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms. J AIDS 3:873-876
18. Fuchs D, Moller AA, Reibnegger G, Werner ER, Werner-Felmayer G, Dierich MP, Wachter H (1991): Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection. Immunol Lett 28:207-211
19. Hamilton M (1967): Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6:278-296
20. Hasselgren PO, Pedersen P, Sax, HC, Warner BW, Fischer JE (1988): Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis. Arch Surgery 123:992-999
21. Heinrich PC, Castell JV, Andus T (1990): Interleukin-6 and the acute phase response. Biochem J 265:621-636
22. Heninger GR, Delgado PL, Charney DS, Price LH, Aghajanian GK (1992): Tryptophan-deficient diet and amino acid drink deplete plasma tryptophan and induce a relapse of depression in susceptible patients. J Chem Neuroanatomy 5:347-348
23. Hirano T (1991): Interleukin-6. In Thomson AW (ed), The Cytokine Handbook. London, Academic Press, pp 169-190
24. Joyce PR, Hawes CR, Mulder RT, Sellman JD, Wilson DA, Boswell DR (1992): Elevated levels of acute phase plasma proteins in major depression. Biol Psychiatry 32:1035-1041
25. Mackiewicz A, Ganapathi MK, Schultz D, Samols D, Reese J, Kuchner 1 (1988): Regulation of rabbit acute phase protein biosynthesis by monokines. Biochem J 258:851-857
26. McMenamy RH, Oncley JL (1958): The specific binding of L-tryptophan to serum albumin. J Biol Chem 233:1436-1440
27. Maes M, Jacobs M-P, Suy E, Minner B, Leclercq C, Christiaens F, Raus J (1990a): Suppressant effects of dexamethasone on the availability of plasma L-tryptophan and tyrosine in healthy controls and in depressed patients. Acta Psychiatr Scand 81:19-23
28. Maes M, Jacobs M-P, Suy E, Vandewoude M, Minner B, Raus J (1990b): Effects of dexamethasone on the availability of L-tryptophan and on the insulin and FFA concentrations in unipolar depressed patients. Biol Psychiatry 27:854-862
29. Maes M, Schotte C, Scharpé S, Martin M, Blockx P (1990c): The effects of glucocorticoids on the availability of L-tryptophan and tyrosine in the plasma of depressed patients. J Affect Disord 18:121-127
30. Maes M, Vandewoude M, Scharpé S, DeClerck L, Stevens W, Lepoutre L, Schotte C (1991): Anthropometric and biochemical assessment of the nutritional state in depression: Evidence for lower visceral protein plasma levels in depression. J Affect Disord 23:25-33
31. 1-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding protein plasma levels during depression: Further evidence for the existence of an inflammatory response during that illness. J Affect Disord 24:183-192
32. Maes M, Scharpé S, Bosmans E, Vandewoude M, Suy E, Uyttenbroek W, Coereman W, Vandervorst C, Raus J (1992b): Disturbances in acute phase plasma proteins during melancholia: Additional evidence for the presence of an inflammatory process during that illness. Progr Psychopharmacol Biol Psychiatry 16:501-515
33. Maes M, Meltzer HY, Scharpé S, Bosmans E, Suy E, Minner B, De Meester I, Calabrese J, Vandervorst C, Raus J, Cosyns P (1993): Relationships between lower plasma L-tryptophan levels and immune variables in depression. Psychiatr Res 49:11-27
34. Maes M, De Langhe H, Sharpé S, Meltzer HY, Cosyns P, Suy E, Bosmans E (1994a): Haptoglobin phenotypes and gene frequencies in unipolar major depression. Am J Psychiatry 151:112-116
35. Maes M, Scharpé S, Meltzer HY, Okayli G, Bosmans E, D'Hondt P, Vanden Bossche B, Cosyns P (1994b): Increased neopterin and interferon γ secretion and lower availability of L-tryptophan in major depression: Further evidence for activation of cell-mediated immunity. Psychiatry Res 54: 143-160
36. Maes M, Meltzer HYM (1995): The serotonin hypothesis of major depression. In Bloom F, Kupher D (eds), Psychopharmacology: The Fourth Generation of Progress. New York, Raven Press, pp 933-941
37. Maecs M, Scharpé S, Verkerk R, D'Hondt P, Peeters D, Cosyns P, Thompson P, De Meyer F, Wauters A, Neels H (1995): Components of biological variation, including seasonality in plasma L-tryptophan and competing amino-acids in man: Relationships to serum total protein, climatic variables, and violent suicide occurrence. Arch Gen Psychiatry 52:937-946
38. Mayer P, Geissler K, Valent P, Ceska M, Bettelheim P, Liehl E (1991): Recombinant human interleukin-6 is a potent inducer of the acute phase response and elevates the blood platelets in nonhuman primates. Exp Hematol 19:688-696
39. Milson JP, Morgan MY, Sherlock S (1979): Factors affecting plasma amino acid concentrations in control subjects. Metabol 28:313-319
40. Moir ATB, Eccleston D (1968): The effect of precursor loading in the cerebral metabolism of 5-hydroxyindoles. J Neurochem 15:1093-1108
41. Moldawer LL, Georgieff M, Lundholm K (1987): Interleukin-1, tumor necrosis factor-alpha (cachectin) and the pathogertesis of cancer cachexia. Clin Physiol 7:263-274
42. Moller SE, de Beurs P, Timmerman L, Tan BK, Leynse-Ybema HJ, Cohen Stuart MH, Hopfner Petersen HE (1986): Plasma tryptophan and tyrosine ratios to competing amino acids in relation to antidepressant response to citalopram and maprotiline: A preliminary study. Psychopharmacology 88:96-100
43. Morgan CJ, Badawy AA-B (1989): Effects of a suppression test dose of dexamethasone on tryptophan metabolism and disposition in the rat. Biol Psychiatry 25:360-362
44. Moroni F, Russi P, Gallo-Mezo MA, Moneti G, Pellicciari R (1991): Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine. J Neurochem 57:1630-1635
45. Pardridge WM (1979): Tryptophan transport through the blood-brain barrier: in vivo measurement of free and albumin-bound amino acid. Life Sci 25:1519-1528
46. Prowse KR, Baumann H (1989): Interleukin-1 and interleukin-6 stimulate acute phase protein production in primary mouse hepatocytes. J Leukocyte Biol 45:55-61
47. Putnam FW (1984a): Progress in plasma proteins. In The Plasma Proteins: Structure, Function, and Genetic Control, 2nd ed. Orlando, Academic Press, pp 2-44
48. Putnam FW (1984b): Alpha, beta, gamma, omega - The structure of plasma proteins. In The Plasma Proteins: Structure, Function, and Genetic Control, 2nd ed. Orlando, Academic Press, pp 46-166
49. Rao ML (1987): Bioavailability of amino acids and amino acid precursors for neurotransmitter action: The role of hormones. In Huether G (eds), Amino Acid Availability and Brain Function in Health and Disease. Berlin, Springer Verlag, pp 29-38
50. Ritzmann SE, Daniels JC (1976): Serum protein electrophoresis and total serum proteins. In Serum Protein Abnormalities: Diagnostic and Clinical Aspects. Boston, Little, Brown and Company, pp 3-25
51. Scriver CR, Gregory DM, Sovetts D et al. (1985): Normal plasmafree amino acid values in adults: The influence of some common physiological variables. Metabol 34:868-873
52. Sluzewska A, Rybakowski JK, Laciak M, Mackiewicz A, Sobieska M, Wiktorowicz K (1995a): Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine. Ann NY Acad Sci 762:474-476
53. 1-acid glycoprotein in major depressive disorder. J Affective Disord in press
54. Smith QR, Fukui S, Robinson P, Rapaport SI (1990): Influence of cerebral blood flow on tryptophan uptake into brain. In Lubec G, Rosenthal GA (eds), Amino Acids: Chemistry, Biology, and Medicine. Leiden, Escom, pp 364-369
55. Song C, Dinan T, Leonard BE (1994): Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls. J Affective Disord 30:283-288
56. Song C, Leonard BE (1994): An acute phase protein response in the olfactory bulbectomised rat: Effect of sertraline treatment. Med Sci Res 22:313-314
57. Spitzer RL, Williams JBW, Gibbon M, First MB (1990): Structured Clinical Interview According to DSM-III-R. New York, American Press
58. Swartz CM (1990): Albumin decrement in depression and cholesterol decrement in mania. J Affective Disord 19:173-176
59. Takikawa O, Yoshida R, Yasui H, Hayaishi O (1984): The relationship between plasma kynurenine and indoleamine 2,3-dioxygenase activity in the extrahepatic tissues. In Schlossberger HG, Kochen W, Linzen B, Steinhart H (eds), Progress in Tryptophan and Serotonin Research. Berlin, Walter de Gruyter and Co, pp 517-520
60. Wolvekamp MCJ, Marquet RL (1990): Interleukin-6: Historical background, genetics, and biological significance. Immunol Lett 24:1-10
61. Young SN, Smith SE, Pihl R, Ervin FR (1985): Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 87:173-177
62. Yuwiler A, Oldendorf WH, Geller E et al. (1977): The effect of albumin binding and amino acid composition on tryptophan uptake into the brain. J Neurochem 28:1015-1023