The role of cytokines and growth factors in seizures and their sequelae

Progress in Neurobiology

Volumn 63, Issue 2, 2001, Pages 125-149

  Jankowsky, Joanna L ^a   Patterson, Paul H ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cytokine; Electroconvulsive shock; Epilepsy; Growth factor; IL 6; Interleukin; Kainate; Kindling; Neurotrophin; NGF; Seizure

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CYTOKINE; FIBROBLAST GROWTH FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; GROWTH FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 6; KAINIC ACID; LEUKOCYTE MIGRATION INHIBITION FACTOR; MYELOPID; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; ONCOSTATIN M; PROTEIN SYNTHESIS INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR;

ASTROCYTE; CELL ACTIVATION; ELECTRIC SHOCK; EPILEPSY; GLIOSIS; HUMAN; KINDLING; MICROGLIA; MOSSY FIBER; NERVE CELL NECROSIS; NERVE SPROUTING; NERVOUS SYSTEM DEVELOPMENT; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEIZURE;

ANIMALS; ASTROCYTES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DEATH; CYTOKINES; DISEASE MODELS, ANIMAL; GROWTH SUBSTANCES; HUMANS; MICROGLIA; MOSSY FIBERS, HIPPOCAMPAL; NERVE GROWTH FACTORS; NEURONS; REGENERATION; RNA, MESSENGER; SEIZURES; UP-REGULATION;

EID: 0035211890     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(00)00022-8     Document Type: Review

References (200)

1. Nerve growth factor accelerates seizure development, enhances mossy fiber sprouting, and attenuates seizure-induced decreases in neuronal density in the kindling model of epilepsy
2. Induction of β-A activin expression by synaptic activity and during neocortical development
3. Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat
4. bFGF and FGFR-3 immunoreactivity in the rat brain following systemic kainic acid administration at convulsant doses: localization of bFGF and FGFR-3 in reactive astrocytes, and FGFR-3 in microglia
5. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain
6. The FGF family of growth factors and oncogenes
7. Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy
8. Interleukin 1β inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus
9. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy
10. Hippocampal mossy fiber sprouting is not impaired in brain-derived neurotrophic factor-deficient mice
11. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures
12. Regulation of neurotrophin and trkA, trkB and trkC tyrosine kinase receptor messenger RNA expression in kindling
13. Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures
14. Cytokines: influence on glial gene expression and function
15. Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus
16. Selective inhibition of kindling development by intraventricular administration of trkB receptor body
17. Photosensitive seizures associated with interferon alfa-2a
18. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
19. aFGF, bFGF and flg mRNAs show distinct patterns of induction in the hippocampus following kainate-induced seizures
20. Interferon enhances the excitability of cultured neurones
21. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6
22. + concentration by interleukin-1β in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase
23. Neurotrophins: the biological paradox of survival factors eliciting apoptosis
24. Glia, cytokines, and neurotoxicity
25. Neurotrophin receptors: mediators of life and death
26. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4
27. Antiepileptic effects of acidic fibroblast growth factor examined in kainic acid-mediated seizures in the rat
28. Neuroprotective effect of acidic fibroblast growth factor on seizure-associated brain damage
29. Interferon inhibits synaptic potentiation in rat hippocampus
30. Intraventricular interferon-alpha stops seizures in Rasmussen's encephalitis: a case report
31. Release of TNFα in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage
32. Effects of interleukin-2 on various models of experimental epilepsy in DBA/2 mice
33. Unilateral seizures in a patient with hairy-cell leukemia treated with interferon
34. Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid
35. Molecular profile of reactive astrocytes - implications for their role in neurologic disease
36. Suppressed kindling epileptogenesis and perturbed BDNF and trkB regulation in NT-3 mutant mice
37. Dynamic changes of brain-derived neurotrophic factor protein levels in the rat forebrain after single and recurring kindling-induced seizures
38. Kainic acid induced expression of interleukin-1 receptor antagonist mRNA in the rat brain
39. Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis
40. A survey of adverse events in 11241 patients with chronic viral hepatitis treated with alpha interferon
41. Astrocytic and neuronal factors affecting axon regeneration in the damaged central nervous system
42. Effects of cholinergic denervation on seizure development and neurotrophin messenger RNA regulation in rapid hippocampal kindling
43. Regional and temporal pattern of expression of nerve growth factor and basic fibroblast growth factor mRNA in rat brain following electroconvulsive shock
44. Nerve growth factor: two receptors, multiple functions
45. Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling
46. Expression of interleukin 1α, interleukin 1β and interleukin 1 receptor antagonist mRNA in mouse brain: regulation by bacterial lipopolysaccharide (LPS) treatment
47. Interleukin-6 (IL-6) - a molecule with both beneficial and destructive potentials
48. Leukemia inhibitory factor, interleukin-6 and other cytokines using the GP130 transducing receptor: roles in inflammation and injury
49. Interleukin-1α in the brain is induced by audiogenic seizure
50. Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain
51. Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus
52. Seizure-induced changes in neurotrophin expression: implications for epilepsy
53. Seizures increase basic fibroblast growth factor mRNA in adult rat forebrain neurons and glia
54. Limbic seizures increase neuronal production of messenger RNA for nerve growth factor
55. Long-term alterations in growth factor mRNA expression following seizures
56. Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor
57. Molecular mechanisms of microglial activation. A. Implications for regeneration and neurodegenerative diseases
58. Microglia: intrinsic immunoeffector cell of the brain
59. Reactive glia as rivals in regulating neuronal survival
60. The impact of microglia-derived cytokines upon gliosis in the CNS
61. Neurochemical and morphological changes associated with human epilepsy
62. Possible coordinated gene expressions for FGF receptor, FGF-5, and FGF-2 following seizures
63. Physiological and pathological roles of interleukin-6 in the central nervous system
64. Activation of NMDA receptors increases brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampal formation
65. Astroglia in CNS injury
66. Hippocampal neurotrophic factor: characterization and response to denervation
67. Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septohippocampal lesions
68. Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy
69. Morphological changes in the dentate gyrus in human temporal lobe epilepsy
70. Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system
71. Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge
72. Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation
73. Fast and widespread increase of basic fibroblast growth factor messenger RNA and protein in the forebrain after kainate-induced seizures
74. Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures
75. Increase in activin βA mRNA in rat hippocampus during long-term potentiation
76. Side effects of alpha-interferon therapy and impact on health-related quality of life in children with chronic viral hepatitis
77. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF
78. Differential regulation of cytokine expression following pilocarpine-induced seizure
79. Cytokine and growth factor involvement in long-term potentiation
80. Seizures associated with low-dose α-interferon
81. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus
82. Cytokine-induced programmed death of cultured sympathetic neurons
83. Astrocytes in kindling: relevance to epileptogenesis
84. Activation of astrocytes during epileptogenesis in the absence of neuronal degradation
85. Attenuation of kindling-induced decreases in NT-3 mRNA by thyroid hormone depletion
86. A case of chronic epileptic encephalopathy of neonatal onset - a probable concern of human cytomegalovirus
87. Suppressed epileptogenesis in BDNF mutant mice
88. Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation
89. Seizure-induced differential expression of messenger RNAs for neurotrophins and their receptors in genetically fast and slow kindling rats
90. Brain insults in rats induce increased expression of the BDNF gene through differential use of multiple promoters
91. Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor
92. Neural functions of the transforming growth factors β
93. Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brain
94. The early reactions of non-neuronal cells to brain injury
95. Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat
96. Seizure-induced increases in NGF mRNA exhibit different time courses across forebrain regions and are biphasic in the hippocampus
97. Early induction of mRNA for calbindin-D28k and BDNF but not NT-3 in rat hippocampus after kainate acid treatment
98. Acute exposure to CNTF in vivo induces multiple components of reactive gliosis
99. Interleukin-1β directly excites hypothalamic supraoptic neurons in rats in vitro
100. Reciprocal up- and down-regulation of BDNF mRNA in tetanus toxin-induced epileptic focus and inhibitory surround in cerebral cortex
101. Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage
102. Basic fibroblast growth factor is highly neuroprotective against seizure-induced long-term behavioral deficits
103. Dentate granule cell layer collagen explant cultures: spontaneous axonal growth and induction by brain-derived neurotrophic factor or basic fibroblast growth factor
104. Prolonged increases in neurotrophic activity associated with kainate-induced hippocampal synaptic reorganization
105. The effects of seizures on the brain
106. Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression
107. Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat
108. The pathogenic and progressive features of chronic human hippocampal epilepsy
109. Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus
110. Cellular and molecular basis of epilepsy
111. Cytokines in brain development and function
112. Circuit mechanisms of seizure in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting
113. Increased production of the trkB protein tyrosine kinase receptor after brain insults
114. Cytokines in inflammatory brain lesions: helpful and harmful
115. Interleukin-1 augments γ-aminobutyric acid A receptor function in brain
116. Interferon-associated refractory status epilepticus
117. Mechanisms of hyperpolarization induced by two cytokines, hTNFα and hIL-1α in neurons of the mollusc Onchidium
118. Effects of kainic acid on messenger RNA levels of IL-1β, IL-6, TNFα and LIF in the rat brain
119. Convulsants induce interleukin-1β messenger RNA in rat brain
120. TGF-β1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration
121. Time-dependent changes in neurotrophic factor mRNA expression after kindling and long-term potentiation in rats
122. Adverse effects and drug interactions of clinical importance with antiviral drugs
123. Seizures increase trkC mRNA expression in the dentate gyrus of rat hippocampus: role of glutamate receptor activation
124. Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice cultures
125. Cytokines which signal through the LIF receptor and their actions in the nervous system
126. Interleukin-1β inhibits glutamate release in hippocampus of young, but not aged, rats
127. Altered mRNA expression for brain-derived neurotrophic factor and calcium/calmodulin-dependent protein kinase type II in hippocampi from patients with intractable temporal lobe epilepsy
128. Kainic acid as a tool for the study of temporal lobe epilepsy
129. Generation of neuronal diversity: analogies and homologies with hematopoiesis
130. BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial disagreement with mRNA levels
131. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
132. Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity
133. Glial reaction after seizure induced hippocampal lesion: immunohistochemical characterization of proliferating glial cells
134. Type 2 interleukin-1 receptor mRNA is induced by kainic acid in the rat brain
135. Behavioral and electrocortical spectrum power effects after microinfusion of lymphokines in several areas of the rat brain
136. Interferon-alpha treatment of Behcet's disease
137. Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin
138. Effects of activin-A on neurons acutely isolated from the rat supraoptic nucleus
139. Heparin-binding epidermal growth factor-like growth factor in hippocampus: modulation of expression by seizures and anti-excitotoxic action
140. Effects of in vivo BDNF infusion on amygdala kindling, sprouting, and hilar area
141. The neuroprotective effect of the recombinant interleukin-1 receptor antagonist rhIL-1RA after excitotoxic stimulation with kainic acid and its relationship to the amyloid precursor protein gene
142. Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat
143. Mossy fiber reorganization in the epileptic hippocampus
144. Whole brain irradiation inhibits dentate granule cells neurogenesis but not seizure-induced mossy fiber sprouting in adult rats
145. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
146. Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors
147. Excitotoxic brain damage in the rat induces interleukin-1β protein in microglia and astrocytes: correlation with the progression of cell death
148. Human-leukocyte gamma-interferon in the treatment of epilepsy due to cytomegalovirus infection
149. Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures
150. Interferon-alpha-n1 - a review of its pharmacological properties and therapeutic efficacy in the management of chronic viral hepatitis
151. Interleukin 1 depresses calcium currents in CA1 hippocampal neurons at pathophysiological concentrations
152. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor α
153. A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy
154. Phase II trial of recombinant interleukin-1β in patients with metastatic renal cell carcinoma
155. Protective effects of brain-derived neurotrophic factor in two models of epilepsy in the rat
156. Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats
157. Reactive astrocytes: cellular and molecular cues to biological function
158. Short- and long-term induction of basic fibroblast growth factor gene expression in rat central nervous system following kainate injection
159. Adrenalectomy reduces FGF-1 and FGF-2 gene expression in specific rat brain regions and differently affects their induction by seizures
160. Basic fibroblast growth factor mRNA increases in specific brain regions following convulsive seizures
161. Limbic seizures induce a differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the rat hippocampus
162. Cytokines - killers in the brain?
163. Interleukin-1 and neurodegeneration
164. Involvement of cytokines in acute neurodegeneration in the CNS
165. TrkB-IgG does not inhibit mossy fiber sprouting in an in vitro model
166. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure
167. Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective
168. Regional increases in brain-derived neurotrophic factor and nerve growth factor mRNAs during amygdaloid kindling, but not in acidic and basic fibroblast growth factor mRNAs
169. Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus
170. Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats
171. Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study
172. Kindling-induced neurogenesis in the dentate gyrus of the rat
173. The neurotrophic activity of fibroblast growth factors
174. Seizures during alpha interferon therapy
175. Increased neuronal β-amyloid precursor protein expression in human temporal lobe epilepsy: association with interleukin-1α immunoreactivity
176. Different patterns of induction of FGF-2, FGF-1 and BDNF mRNAs during kindling epileptogenesis in the rat
177. Activation of microglia: a dangerous interlude in immune function in the brain
178. Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice
179. The CNS lesion scar: new vistas on an old regeneration barrier
180. Modulation of voltage-activated ion currents on identified neurons of Helix pomatia L. by interleukin-1
181. Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y
182. Tumor necrosis factor alters synaptic transmission in rat hippocampal slices
183. Stem cells in the adult mammalian central nervous system
184. Strong induction of activin expression after hippocampal lesion
185. Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures
186. Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain
187. Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats
188. Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions: temporal evolution of changes as compared to neuropeptide Y
189. Antagonism of central but not peripheral cholinergic receptors retards amygdala kindling in rats
190. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors
191. Seizures in children during interferon alpha therapy
192. In situ hybridization of interleukin-1β mRNA induced by kainic acid in the rat brain
193. Interleukin-1β inhibits synaptic transmission and induces membrane hyperpolarization in amygdala neurons
194. Involvement of tumor necrosis factor alpha and interleukin-1β in enhancement of pentylenetetrazol-induced seizures caused by Shigella dysenteriae
195. Interplay between glutamate and g-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons
196. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors