Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP

Synapse

Volumn 38, Issue 1, 2000, Pages 102-104

  Saarelainen, Tommi ^a   Pussinen, Raimo ^a   Koponen, Eija ^a   Alhonen, Leena ^a   Wong, Garry ^a   Sirviö, Jouni ^a   Castrén, Eero ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN RECEPTOR; NEUROTROPHIC FACTOR RECEPTOR TRKB; NEUROTROPIN; RECEPTOR SUBTYPE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE OVEREXPRESSION; INHIBITION KINETICS; LONG TERM MEMORY; MALE; MAZE TEST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL PROCESSING; SPATIAL MEMORY;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; GENE EXPRESSION REGULATION; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; RECEPTOR, TRKB; SPACE PERCEPTION;

EID: 0033847296     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2396(200010)38:1<102::AID-SYN11>3.0.CO;2-K     Document Type: Article

References (20)

1. Truncated and catalytic isoforms of trkB and co-expressed in neurons of rat and mouse CNS
2. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus
3. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling
4. Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain
5. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus
6. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
7. Hippocampal long-term potentiation is impaired in mice lacking brain- derived neurotrophic factor
8. Virus-mediated gene transfer into hippocampal CA1 region restores long- term potentiation in brain-derived neurotrophic factor mutant mice
9. Subcellular localization of full-length and truncated trk receptor isoforms in polarized neurons and epithelial ceils
10. Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons
11. Learning deficit in BDNF mutant mice
12. Neurotrophins and synaptic plasticity
13. Intact spatial learning and memory in transgenic mice with reduced BDNF
14. Expression and function of TrkB variants in developing sensory neurons
15. Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs
16. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
17. Preserved induction of long-term potentiation in the stratum radiatum in the CA1 field of hippocampal slices from transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine
18. Structure and function of declarative and nondeclarative memory systems
19. A non-radioactive in situ hybridization method that does not require RNAse-free conditions
20. Functional trkB neuro-trophin receptors are intrinsic components of the adult brain postsynaptic density