Catalysis of the 4-hydroxylation of retinoic acids by CYP3A7 in human fetal hepatic tissues

Drug Metabolism and Disposition

Volumn 28, Issue 9, 2000, Pages 1051-1057

  Chen, Hao ^a,b   Fantel, Alan G ^a   Juchau, Mont R ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; CYTOCHROME P450; DRUG METABOLITE; ISOTRETINOIN; OXYGENASE; RETINOIC ACID;

ARTICLE; CATALYSIS; DRUG HYDROXYLATION; EMBRYOTOXICITY; ENZYME ACTIVITY; FETUS; GESTATIONAL AGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME; MICROSOME; PRIORITY JOURNAL;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CATALYSIS; CELL LINE, TRANSFORMED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; FETUS; GESTATIONAL AGE; HUMANS; HYDROXYLATION; ISOENZYMES; KINETICS; MICROSOMES, LIVER; TRETINOIN; TROLEANDOMYCIN;

EID: 0033835442     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Novel retinoic acid receptor ligands in Xenopus embryos
2. Catalytic activity and quantitation of cytochrome P-450 2E1 in prenatal human brain
3. Expression, induction and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver
4. Ethanol-mediated transplacental induction of CYP2E1 in fetal rat liver
5. Induction in vitro and complete coding region sequence of cytochrome P4501Al cDNA from cultured whole rat conceptuses during early organogenesis
6. Microinjections of cultured rat conceptuses: Studies with 4-oxo-all-trans-retinoic acid, 4-oxo-13-cis-retinoic acid and all-trans-retinoyl-β-glucuronide
7. Cytochrome P450 3A: Ontogeny and drug disposition
8. Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: Role in intrauterine toxicity
9. Cytochrome-P450-dependent biotransformation of xenobiotics in human and rodent embryonic tissues
10. Cytochrome P450 in human fetal liver: Significance and fetal-specific expression
11. Four forms of cytochrome P450 in human liver: Purification and their capacity to activate promutagens
12. Retinoic acid embryopathy
13. Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8
14. Receptors as tools for understanding the toxicity of retinoids
15. Participation of P450 3A enzymes in rat hepatic microsomal retinoic acid 4-hydroxylation
16. Heterologous expression and kinetic characterization of human cytochromes P-450: Validation of a pharmaceutical tool for drug metabolism research
17. The roles of retinoids in vertebrate development
18. Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes
19. Differential catalytic properties in metabolism of endogenous and exogenous substrate among CYP3A enzymes expressed in COS-7 cells
20. Induction and developmental expression of cytochrome P450lA1 messenger RNA in rat and human tissues: Detection by the polymerase chain reaction
21. All-trans-retinol is a ligand for the retinoic acid receptors
22. Metabolism of all-trans-retinoic acid in hamster liver microsomes: Oxidation of 4-hydroxy- to 4-keto-retinoic acid
23. Role of isoenzymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal
24. Selective expression of cytochrome P4503A mRNAs in embryonic and adult human liver
25. Retinoids as teratogens
26. Expression of cytochrome P450RAl(CYP26) in human fetal hepatic and cephalic tissues
27. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase
28. Functional CYP3A isoforms in human embryonic tissues: Expression during organogenesis