Differential regulation of the human CYP3A4 promoter in transgenic mice and rats

Drug Metabolism and Disposition

Volumn 32, Issue 2, 2004, Pages 163-167

  Zhang, Weisheng ^a   Purchio, Anthony F ^a   Coffee, Richard ^b   West, David B ^a  

^a Xenogen Corporation   (United States)

^b Xenogen Biosciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; CLOTRIMAZOLE; CYTOCHROME P450 3A4; DEXAMETHASONE; GENE PRODUCT; LUCIFERASE; NIFEDIPINE; PHENOBARBITAL; PREGNENOLONE; RIFAMPICIN; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG METABOLISM; DRUG SCREENING; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; MALE; MOUSE; NONHUMAN; OUTBRED STRAIN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; SEX DIFFERENCE; SPECIES DIFFERENCE; TIME SERIES ANALYSIS; TOXICITY TESTING; TRANSGENIC ANIMAL; TRANSGENIC MOUSE; TRANSGENIC RAT; XENOBIOTIC METABOLISM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOTTING, WESTERN; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LUCIFERASES; MALE; MICE; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; XENOBIOTICS;

ANIMALIA; MUS MUSCULUS;

EID: 0842304215     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.2.163     Document Type: Article

References (19)

1. Anakk S, Ku CY, Vore M, and Strobel HW (2003) Insights into gender bias: rat cytochrome P450 3A9. J Pharmacol Exp Ther 305:703-709.
2. Barwick JL, Quattrochi LC, Mills AS, Potenza C, Tukey RH, and Guzelian PS (1996) Transspecies gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol 50:10-16.
3. Cooper KO, Reik LM, Jayyosi Z, Bandiera S, Kelley M, Ryan DE, Daniel R, McCluskey SA, Levin W, and Thomas PE (1993) Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats. Arch Biochem Biophys 301:345-354.
4. Festing MF (1986) The case for isogenic strains in toxicological screening. Arch Toxicol Suppl 9:127-137.
5. Gill TJ (1980) The use of randomly bred and genetically defined animals in biomedical research. Am J Pathol 101 (3 Suppl):S21-S32.
6. Hashimoto H, Toide K, Kitamura R, Fujita M, Tagawa S, Itoh S, and Kamataki T (1993) Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers and its transcriptional control. Eur J Biochem 218:585-595.
7. Johnson TN, Tanner MS, and Tucker GT (2000) A comparison of the ontogeny of enterocytic and hepatic cytochromes; P450 3A in the rat. Biochem Pharmacol 60:1601-1610.
8. Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, et al. (2000) The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 14:27-39.
9. Kacew S (2001) Confounding factors in toxicity testing. Toxicology 160:87-96.
10. Kocarek TA, Schuetz EG, Strom SC, Fisher RA, and Guzelian PS (1995) Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit and human hepatocytes. Drug Metab Dispos 23:415-421.
11. Li AP, Kaminski DL, and Rasmussen A (1995) Substrates of human hepatic cytochrome P450 3A4. Toxicology 104:1-8.
12. Lin JH and Lu AY (1998) Inhibition and induction of cytochrome P450 and the clinical implications. Clin Pharmacokinet 35:361-390.
13. Maurel P (1996) The CYP3A family, in Cytochrome P450: Metabolic and Toxicological Aspects. (Ioannides C ed) pp 241-270, CRC, Boca Raton, FL.
14. Quattrochi LC and Guzelian PS (2001) Cyp3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos 29:615-622.
15. Schuetz E, Lan L, Yasuda K, Kim R, Kocarek TA, Schuetz J, and Strom S (2002) Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. Mol Pharmacol 62:439-445.
16. Wei P, Zhang J, Dowhan DH, Han Y, and Moore DD (2002) Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. Pharmacogenomics J 2:117-126.
17. Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, and Evans RM (2000) Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (Lond) 406:435-439.
18. Zhang W, Purchio A, Chen K, Burns S, Christopher CH. and Contag PR (2003a) In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors. Biochem Pharmacol 65:1889-1896.
19. Zhang W, Purchio AF, Chen K, Wu J, Lu L, Coffee R, Contag PR, and West DB (2003b) A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. Drug Metab Dispos 31:1054-1064.