Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation

Journal of Experimental Medicine

Volumn 196, Issue 1, 2002, Pages 39-49

  Diehl, Sean ^a   Chow, Chi Wing ^b   Weiss, Linda ^a   Palmetshofer, Alois ^d   Twardzik, Thomas ^d   Rounds, Laura ^a   Serfling, Edgar ^d   Davis, Roger J ^b   Anguita, Juan ^c   Rincón, Mercedes ^a,e  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^e UNIVERSITY OF VERMONT   (United States)

Author keywords

CD4+ T cells; Cytokines; Gene regulation; IL 4; NFAT

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 6; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH2 CELL; TRANSCRIPTION REGULATION;

EID: 0036645028     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020026     Document Type: Article

References (49)

1. Interleukin-6-triggers the association of its receptor with a possible signal transducer, gp 130
2. Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10
3. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
4. IL-6DBP, a nuclear protein involved in inteleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP
5. The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms
6. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6
7. The role of C/EBP isoforms in the control of inflammatory and native immunity functions
8. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
9. Association and activation of JakTyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
10. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
11. Signal transduction through IL-6 receptor: Involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway
12. Interleukin 6 and its receptor: Ten years later
13. Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells
14. IL-6 rescues resting mouse T cells from apoptosis
15. Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling
16. Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus
17. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1
18. + T cells
19. Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of interleukin-4 promoter
20. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: Roles for NF-Y and NF-ATc
21. Coordinate and cooperative roles for NFAT and AP-1 in the regulation of murine IL-4 gene
22. The transcription factor NFAT4 is involved in the generation and survival of T cells
23. The transcription factor NF-ATc1 regulates lymphocytes proliferation and Th2 cytokine production
24. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc
25. Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1
26. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice
27. NF-ATp plays a prominent role in the transcriptional induction of Th2-type lymphokines
28. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
29. NFATc1 and NFATc2 together control both T and B cell activation and differentiation
30. Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells
31. + Th2 cells but not in Th1 cells
32. Inhibition of NF-kB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide
33. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes
34. Requirement for transcription factor NFAT in interleukin-2 expression
35. Rapid detection of octamer binding proteins with 'mini'-extracts prepared from a small number of cells
36. Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1
37. A common factor regulates both Th1-and Th2-specific cytokine gene expression
38. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
39. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
40. Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene
41. Isolation of cyclosporin-sensitive T cell transcription factor NFATp
42. c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1
43. Signaling and transcription in T helper development
44. + T cells
45. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
46. NF-AT components define a family of transcription factors targeted in T-cell activation
47. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
48. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
49. Cutting edge: Chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster