메뉴 건너뛰기




Volumn 4, Issue 5, 2008, Pages 855-864

Brain ischemia and ischemic blood-brain barier as etiological factors in sporadic Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid plaques; Brain ischemia; Dementia; Ischemic blood brain barrier; Leukocytes; Neuronal death; Platelets

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; BETA SECRETASE; CLUSTERIN; ESTROGEN; GAMMA SECRETASE;

EID: 56849119259     PISSN: 11766328     EISSN: None     Source Type: Journal    
DOI: 10.2147/ndt.s3739     Document Type: Review
Times cited : (33)

References (109)
  • 1
    • 0038452658 scopus 로고    scopus 로고
    • Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity
    • Abramov AY, Canevari L, Duchen MR. 2003. Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J Neurosci, 23:5088-95.
    • (2003) J Neurosci , vol.23 , pp. 5088-5095
    • Abramov, A.Y.1    Canevari, L.2    Duchen, M.R.3
  • 3
    • 7444267473 scopus 로고    scopus 로고
    • Amyloid beta (1-42) and its beta (25-35) fragment induce activation and membrane translocation of cytosolic phospholipase A (2) in bovine retina capillary pericytes
    • Anfuso CD, Assero G, Lupo G, et al. 2004. Amyloid beta (1-42) and its beta (25-35) fragment induce activation and membrane translocation of cytosolic phospholipase A (2) in bovine retina capillary pericytes. Biochem Biophys Acta, 1686:125-38.
    • (2004) Biochem Biophys Acta , vol.1686 , pp. 125-138
    • Anfuso, C.D.1    Assero, G.2    Lupo, G.3
  • 4
    • 33750468310 scopus 로고    scopus 로고
    • Alzheimer's disease, brain immune privilege and memory: A hypothesis
    • Arshavsky YL. 2006. Alzheimer's disease, brain immune privilege and memory: A hypothesis. J Neural Transm, 113:1697-707.
    • (2006) J Neural Transm , vol.113 , pp. 1697-1707
    • Arshavsky, Y.L.1
  • 5
    • 0742306942 scopus 로고    scopus 로고
    • Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology - a pilot study
    • Attems J, Jellinger KA. 2004. Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology - a pilot study. Acta Neuropathol, 107:83-90.
    • (2004) Acta Neuropathol , vol.107 , pp. 83-90
    • Attems, J.1    Jellinger, K.A.2
  • 6
    • 0141853765 scopus 로고    scopus 로고
    • Amyloid-beta: A chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β
    • Atwood CS, Obrenovich ME, Liu T, et al. 2003a. Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β. Brain Res Brain Res Rev, 43:1-16.
    • (2003) Brain Res Brain Res Rev , vol.43 , pp. 1-16
    • Atwood, C.S.1    Obrenovich, M.E.2    Liu, T.3
  • 7
    • 0141518676 scopus 로고    scopus 로고
    • Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply
    • Atwood CS, Bowen RL, Smith MA, et al. 2003b. Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply. Brain Res Brain Res Rev, 43:164-78.
    • (2003) Brain Res Brain Res Rev , vol.43 , pp. 164-178
    • Atwood, C.S.1    Bowen, R.L.2    Smith, M.A.3
  • 8
    • 2342537053 scopus 로고    scopus 로고
    • Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats
    • Badan I, Dinca I, Buchhold B, et al. 2004. Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats. Eur J Neurosci, 19:2270-80.
    • (2004) Eur J Neurosci , vol.19 , pp. 2270-2280
    • Badan, I.1    Dinca, I.2    Buchhold, B.3
  • 9
    • 3042836549 scopus 로고    scopus 로고
    • The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
    • Bailey TL, Rivara CB, Rocher AB, et al. 2004. The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease. Neurol Res, 26:573-8.
    • (2004) Neurol Res , vol.26 , pp. 573-578
    • Bailey, T.L.1    Rivara, C.B.2    Rocher, A.B.3
  • 10
    • 0028980771 scopus 로고
    • Glial expression of the β-amyloid precursor protein (APP) in global ischemia
    • Banati RB, Gehrmann J, Wießner C, et al. 1995. Glial expression of the β-amyloid precursor protein (APP) in global ischemia. J Cereb Blood Flow Metab, 15:647-54.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 647-654
    • Banati, R.B.1    Gehrmann, J.2    Wießner, C.3
  • 11
    • 0032032446 scopus 로고    scopus 로고
    • Selective neuronal vulnerability and specific glial reactions in hippocampal and neocortical organotypic cultures submitted to ischemia
    • Bernaudin M, Nouvelot A, MacKensie ET, et al. 1998. Selective neuronal vulnerability and specific glial reactions in hippocampal and neocortical organotypic cultures submitted to ischemia. Exp Neurol, 150:30-9.
    • (1998) Exp Neurol , vol.150 , pp. 30-39
    • Bernaudin, M.1    Nouvelot, A.2    MacKensie, E.T.3
  • 12
    • 0037040519 scopus 로고    scopus 로고
    • Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion
    • Butler TL, Kassed CA, Sanberg PR, et al. 2002. Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion. Brain Res, 929:252-60.
    • (2002) Brain Res , vol.929 , pp. 252-260
    • Butler, T.L.1    Kassed, C.A.2    Sanberg, P.R.3
  • 13
    • 0028842459 scopus 로고
    • Early endothelial damage and leukocyte accumulation in piglet brains following cardiac arrest
    • Caceres MJ, Schleien CL, Kuluz JW, et al. 1995. Early endothelial damage and leukocyte accumulation in piglet brains following cardiac arrest. Acta Neuropathol, 90:582-91.
    • (1995) Acta Neuropathol , vol.90 , pp. 582-591
    • Caceres, M.J.1    Schleien, C.L.2    Kuluz, J.W.3
  • 14
    • 0029100939 scopus 로고
    • Platelets are the primary source of amyloid-β peptide in human blood
    • Chen M, Inestrosa NC, Ross GS, et al. 1995. Platelets are the primary source of amyloid-β peptide in human blood. Biochem Biophys Res Commun, 213:96-103.
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 96-103
    • Chen, M.1    Inestrosa, N.C.2    Ross, G.S.3
  • 15
    • 0035002097 scopus 로고    scopus 로고
    • 17beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids
    • Chen J, Xu W, Jiang H. 2001. 17beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids. Anesth Analg, 92:1520-3.
    • (2001) Anesth Analg , vol.92 , pp. 1520-1523
    • Chen, J.1    Xu, W.2    Jiang, H.3
  • 16
    • 0036708602 scopus 로고    scopus 로고
    • Effects of 17beta-estradiol on blood-brain barrier disruption during focal ischemia in rats
    • Chi OZ, Liu X, Weiss HR. 2002. Effects of 17beta-estradiol on blood-brain barrier disruption during focal ischemia in rats. Horm Metab Res, 34:530-4.
    • (2002) Horm Metab Res , vol.34 , pp. 530-534
    • Chi, O.Z.1    Liu, X.2    Weiss, H.R.3
  • 17
    • 19944369069 scopus 로고    scopus 로고
    • Effects of 17beta-estradiol on blood-brain barrier disruption in focal ischemia during GABA (A) receptor inhibition
    • Chi OZ, Hunter C, Liu X, et al. 2005. Effects of 17beta-estradiol on blood-brain barrier disruption in focal ischemia during GABA (A) receptor inhibition. Horm Metab Res, 37:209-13.
    • (2005) Horm Metab Res , vol.37 , pp. 209-213
    • Chi, O.Z.1    Hunter, C.2    Liu, X.3
  • 18
    • 2542431100 scopus 로고    scopus 로고
    • The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
    • D'Andrea MR, Cole GM, Ard MD. 2004. The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging, 25:675-83.
    • (2004) Neurobiol Aging , vol.25 , pp. 675-683
    • D'Andrea, M.R.1    Cole, G.M.2    Ard, M.D.3
  • 19
    • 11144275942 scopus 로고    scopus 로고
    • Add Alzheimer's disease to the list of autoimmune diseases
    • D'Andrea MR. 2005. Add Alzheimer's disease to the list of autoimmune diseases. Med Hypotheses, 64:458-63.
    • (2005) Med Hypotheses , vol.64 , pp. 458-463
    • D'Andrea, M.R.1
  • 20
    • 0037703255 scopus 로고    scopus 로고
    • RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
    • Deane R, Du Yan S, Submamaryan RK, et al. 2003. RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat Med, 9:907-13.
    • (2003) Nat Med , vol.9 , pp. 907-913
    • Deane, R.1    Du Yan, S.2    Submamaryan, R.K.3
  • 21
    • 34848891873 scopus 로고    scopus 로고
    • Assessment of endothelial function in Alzheimer's disease: Is Alzheimer's disease a vascular disease?
    • Dede DS, Yavuz B, Yavuz BB, et al. 2007. Assessment of endothelial function in Alzheimer's disease: is Alzheimer's disease a vascular disease? J Am Geriatr Soc, 55:1613-7.
    • (2007) J Am Geriatr Soc , vol.55 , pp. 1613-1617
    • Dede, D.S.1    Yavuz, B.2    Yavuz, B.B.3
  • 22
    • 33645816954 scopus 로고    scopus 로고
    • Aβ peptide immunization restores blood-brain barrier integrity in Alzheimer disease
    • Dickstein DL, Biron KE, Ujiie M, et al. 2006. Aβ peptide immunization restores blood-brain barrier integrity in Alzheimer disease. FASEB J, 20:426-33.
    • (2006) FASEB J , vol.20 , pp. 426-433
    • Dickstein, D.L.1    Biron, K.E.2    Ujiie, M.3
  • 24
    • 24644497236 scopus 로고    scopus 로고
    • Cellular senescence in vivo: Its relevance in aging and cardiovascular disease
    • Erusalimsky JD, Kurz DJ. 2005. Cellular senescence in vivo: its relevance in aging and cardiovascular disease. Exp Gerontol, 40:634-42.
    • (2005) Exp Gerontol , vol.40 , pp. 634-642
    • Erusalimsky, J.D.1    Kurz, D.J.2
  • 25
    • 0037701180 scopus 로고    scopus 로고
    • Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brain
    • Farkas IG, Czigner A, Farkas E, et al. 2003. Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brain. Acta Histochem, 105:115-25.
    • (2003) Acta Histochem , vol.105 , pp. 115-125
    • Farkas, I.G.1    Czigner, A.2    Farkas, E.3
  • 26
    • 7344246592 scopus 로고    scopus 로고
    • Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model
    • Fiala M, Zhang L, Gan X, et al. 1998. Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model. Mol Med, 4:480-9.
    • (1998) Mol Med , vol.4 , pp. 480-489
    • Fiala, M.1    Zhang, L.2    Gan, X.3
  • 27
    • 0031257676 scopus 로고    scopus 로고
    • Influence of ischemia and reperfusion on the course of brain tissue swelling and blood-brain barrier permeability in a rodent model of transient focal cerebral ischemia
    • Gartshore G, Patterson J, Macrae IM. 1997. Influence of ischemia and reperfusion on the course of brain tissue swelling and blood-brain barrier permeability in a rodent model of transient focal cerebral ischemia. Exp Neurol, 147:353-60.
    • (1997) Exp Neurol , vol.147 , pp. 353-360
    • Gartshore, G.1    Patterson, J.2    Macrae, I.M.3
  • 28
    • 23744437416 scopus 로고    scopus 로고
    • Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia
    • Gidday JM, Gasche YG, Copin JC, et al. 2005. Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol, 289:H558-68.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Gidday, J.M.1    Gasche, Y.G.2    Copin, J.C.3
  • 29
    • 0034603509 scopus 로고    scopus 로고
    • A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease
    • Grammas P. 2000. A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease. Neurobiol Aging, 21:199-205.
    • (2000) Neurobiol Aging , vol.21 , pp. 199-205
    • Grammas, P.1
  • 30
    • 24744449326 scopus 로고    scopus 로고
    • Cerebrovascular damage as a cause for Alzheimer's disease
    • Humpel C, Marksteiner J. 2005. Cerebrovascular damage as a cause for Alzheimer's disease. Curr Neurovasc Res, 2:341-7.
    • (2005) Curr Neurovasc Res , vol.2 , pp. 341-347
    • Humpel, C.1    Marksteiner, J.2
  • 31
    • 3843134242 scopus 로고    scopus 로고
    • Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion
    • Ishikawa, M, Cooper D, Arumugam TV, et al. 2004. Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion. J Cereb Blood Flow Metab, 24:907-15.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 907-915
    • Ishikawa, M.1    Cooper, D.2    Arumugam, T.V.3
  • 32
    • 0030454479 scopus 로고    scopus 로고
    • Accumulation of apolipoprotein E and β-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death
    • Ishimaru H, Ishikawa K, Haga S, et al. 1996. Accumulation of apolipoprotein E and β-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death. NeuroReport, 7:3063-7.
    • (1996) NeuroReport , vol.7 , pp. 3063-3067
    • Ishimaru, H.1    Ishikawa, K.2    Haga, S.3
  • 33
    • 33745880715 scopus 로고    scopus 로고
    • Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats
    • Iwasaki K, Egashira N, Hatip-Al-Khatib I, et al. 2006. Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats. Brain Res, 1097:216-23.
    • (2006) Brain Res , vol.1097 , pp. 216-223
    • Iwasaki, K.1    Egashira, N.2    Hatip-Al-Khatib, I.3
  • 34
    • 0028865755 scopus 로고
    • Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain
    • Jendroska K, Poewe W, Daniel SE, et al. 1995. Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain. Acta Neuropathol, 90:461-6.
    • (1995) Acta Neuropathol , vol.90 , pp. 461-466
    • Jendroska, K.1    Poewe, W.2    Daniel, S.E.3
  • 35
    • 0033391684 scopus 로고    scopus 로고
    • The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease
    • Kalaria RN. 1999. The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann NY Acad Sci, 893:113-25.
    • (1999) Ann NY Acad Sci , vol.893 , pp. 113-125
    • Kalaria, R.N.1
  • 36
    • 0034603512 scopus 로고    scopus 로고
    • The role of cerebral ischemia in Alzheimer's disease
    • Kalaria RN. 2000. The role of cerebral ischemia in Alzheimer's disease. Neurobiol Aging, 21321-30.
    • (2000) Neurobiol Aging , pp. 21321-21330
    • Kalaria, R.N.1
  • 37
    • 0036130159 scopus 로고    scopus 로고
    • Small vessel disease and Alzheimer's dementia: Pathological considerations
    • Kalaria RN. 2002. Small vessel disease and Alzheimer's dementia: Pathological considerations. Cerebrovasc Dis, 13(Suppl 2):48-52.
    • (2002) Cerebrovasc Dis , vol.13 , Issue.SUPPL. 2 , pp. 48-52
    • Kalaria, R.N.1
  • 38
    • 33646785397 scopus 로고    scopus 로고
    • Effect of estrogen on the expression of occludin in ovariectomized mouse brain
    • Kang HS, Ahn HS, Kang HJ, et al. 2006. Effect of estrogen on the expression of occludin in ovariectomized mouse brain. Neurosci Lett, 402:30-4.
    • (2006) Neurosci Lett , vol.402 , pp. 30-34
    • Kang, H.S.1    Ahn, H.S.2    Kang, H.J.3
  • 39
    • 0025665181 scopus 로고
    • The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease
    • Kawai M, Kalaria RN, Harik SI, et al. 1990. The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Am J Pathol, 137:1435-46.
    • (1990) Am J Pathol , vol.137 , pp. 1435-1446
    • Kawai, M.1    Kalaria, R.N.2    Harik, S.I.3
  • 40
    • 0028927946 scopus 로고    scopus 로고
    • Kida E, Pluta R, Lossinsky AS, et al. 1995. Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest. II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain. Brain Res, 674:341-6.
    • Kida E, Pluta R, Lossinsky AS, et al. 1995. Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest. II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain. Brain Res, 674:341-6.
  • 41
    • 0037022288 scopus 로고    scopus 로고
    • Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
    • Koistinaho M, Kettunen MI, Goldsteins G, et al. 2002. Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation. Proc Natl Acad Sci U S A, 99:1610-5.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 1610-1615
    • Koistinaho, M.1    Kettunen, M.I.2    Goldsteins, G.3
  • 42
    • 3142781310 scopus 로고    scopus 로고
    • Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
    • Koistinaho M, Lin S, Wu X, et al. 2004. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides. Nat Med, 10:719-26.
    • (2004) Nat Med , vol.10 , pp. 719-726
    • Koistinaho, M.1    Lin, S.2    Wu, X.3
  • 43
    • 0034624286 scopus 로고    scopus 로고
    • Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells
    • Lippoldt A, Kniesel U, Liebner, S, et al. 2000. Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res, 885:251-61.
    • (2000) Brain Res , vol.885 , pp. 251-261
    • Lippoldt, A.1    Kniesel, U.2    Liebner, S.3
  • 44
    • 0035844050 scopus 로고    scopus 로고
    • Amyloid β (1-42) and its β (25-35) fragment induce in vitro phosphatidylcholine hydrolysis in bovine retina capillary pericytes
    • Lupo G, Anfuso CD, Assero G, et al. 2001. Amyloid β (1-42) and its β (25-35) fragment induce in vitro phosphatidylcholine hydrolysis in bovine retina capillary pericytes. Neurosci Lett, 303:185-8.
    • (2001) Neurosci Lett , vol.303 , pp. 185-188
    • Lupo, G.1    Anfuso, C.D.2    Assero, G.3
  • 45
    • 11844255779 scopus 로고    scopus 로고
    • Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice
    • Malm TM, Koistinaho M, Parepalo M, et al. 2005. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiol Dis, 18:134-42.
    • (2005) Neurobiol Dis , vol.18 , pp. 134-142
    • Malm, T.M.1    Koistinaho, M.2    Parepalo, M.3
  • 46
    • 0037448014 scopus 로고    scopus 로고
    • Specific uptake of Abeta 1-40 in rat brain occurs in astrocyte, but not in microglia
    • Matsunaga W, Shirokawa T, Isobe K. 2003. Specific uptake of Abeta 1-40 in rat brain occurs in astrocyte, but not in microglia. Neurosci Lett, 342:129-31.
    • (2003) Neurosci Lett , vol.342 , pp. 129-131
    • Matsunaga, W.1    Shirokawa, T.2    Isobe, K.3
  • 47
    • 0034745252 scopus 로고    scopus 로고
    • Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke
    • McCullough LD, Alkayed NJ, Traystman RJ, et al. 2001 Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke. Stroke, 32:796-802.
    • (2001) Stroke , vol.32 , pp. 796-802
    • McCullough, L.D.1    Alkayed, N.J.2    Traystman, R.J.3
  • 48
    • 0036599163 scopus 로고    scopus 로고
    • Biological markers of Alzheimer's disease
    • Mehta PD, Pirttila T. 2002. Biological markers of Alzheimer's disease. Drug Dev Res, 56:74-84.
    • (2002) Drug Dev Res , vol.56 , pp. 74-84
    • Mehta, P.D.1    Pirttila, T.2
  • 50
    • 0004776618 scopus 로고
    • Changes in cerebral microcirculation system following experimentally induced cardiac arrest: A SEM and TEM study
    • Tomita M ed, Amsterdam: Elsevier Science Publishers BV, pp
    • Mossakowski MJ, Lossinsky AS, Pluta R, et al. 1993. Changes in cerebral microcirculation system following experimentally induced cardiac arrest: a SEM and TEM study. In: Tomita M (ed). Microcirculatory stasis in the brain. Amsterdam: Elsevier Science Publishers BV, pp. 99-106.
    • (1993) Microcirculatory stasis in the brain , pp. 99-106
    • Mossakowski, M.J.1    Lossinsky, A.S.2    Pluta, R.3
  • 51
    • 0028322411 scopus 로고
    • Abnormalities of the blood-brain barrier in global cerebral ischemia in rats due to experimental cardiac arrest
    • Mossakowski MJ, Lossinsky AS, Pluta R, et al. 1994. Abnormalities of the blood-brain barrier in global cerebral ischemia in rats due to experimental cardiac arrest. Acta Neurochir Suppl (Wien), 60:274-6.
    • (1994) Acta Neurochir Suppl (Wien) , vol.60 , pp. 274-276
    • Mossakowski, M.J.1    Lossinsky, A.S.2    Pluta, R.3
  • 52
    • 1642305688 scopus 로고    scopus 로고
    • Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats
    • Nimmo AJ, Cernak I, Heath DL, et al. 2004. Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides, 38:40-7.
    • (2004) Neuropeptides , vol.38 , pp. 40-47
    • Nimmo, A.J.1    Cernak, I.2    Heath, D.L.3
  • 53
    • 1542427170 scopus 로고    scopus 로고
    • Platelets adhering to the vascular wall mediate postischemic leukocyte-endothelial cell interactions in retinal microcirculation
    • Nishijima K, Kiryu J, Tsujikawa A, et al, 2004. Platelets adhering to the vascular wall mediate postischemic leukocyte-endothelial cell interactions in retinal microcirculation. Invest Ophthalmol Vis Sci, 45:977-84.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 977-984
    • Nishijima, K.1    Kiryu, J.2    Tsujikawa, A.3
  • 54
    • 0034662501 scopus 로고    scopus 로고
    • Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
    • Niwa K, Younkin L, Ebeling C, et al. 2000. Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci U S A, 97:9735-40.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9735-9740
    • Niwa, K.1    Younkin, L.2    Ebeling, C.3
  • 55
    • 4644233023 scopus 로고    scopus 로고
    • Three-dimensional structural changes in cerebral microvessels after transient focal cerebral ischemia in rats: Scanning electron microscopic study of corrosion casts
    • Ohtake M, Morino S, Kaidoh T, et al. 2004. Three-dimensional structural changes in cerebral microvessels after transient focal cerebral ischemia in rats: Scanning electron microscopic study of corrosion casts. Neuropathology, 24:219-27.
    • (2004) Neuropathology , vol.24 , pp. 219-227
    • Ohtake, M.1    Morino, S.2    Kaidoh, T.3
  • 56
    • 0028986501 scopus 로고
    • Increased β-amyloid precursor protein expression in astrocytes in the gerbil hippocampus following ischaemia: Association with proliferation of astrocytes
    • Palacios G, Mengod G, Tortosa A, et al. 1995. Increased β-amyloid precursor protein expression in astrocytes in the gerbil hippocampus following ischaemia: Association with proliferation of astrocytes. Eur J Neurosci, 7:501-10.
    • (1995) Eur J Neurosci , vol.7 , pp. 501-510
    • Palacios, G.1    Mengod, G.2    Tortosa, A.3
  • 57
    • 3242667174 scopus 로고    scopus 로고
    • Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis
    • Paris D, Patel N, DelleDonne A, et al. 2004a. Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis. Neurosci Lett, 366:80-5.
    • (2004) Neurosci Lett , vol.366 , pp. 80-85
    • Paris, D.1    Patel, N.2    DelleDonne, A.3
  • 58
    • 3042704848 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by Aβ peptides
    • Paris D, Townsend K, Quadros A, et al. 2004b. Inhibition of angiogenesis by Aβ peptides. Angiogenesis, 7:75-85.
    • (2004) Angiogenesis , vol.7 , pp. 75-85
    • Paris, D.1    Townsend, K.2    Quadros, A.3
  • 59
    • 0033559257 scopus 로고    scopus 로고
    • Induction of presenilins in the rat brain after middle cerebral arterial occlusion
    • Pennypacker KR, Hernandez H, Benkovic S, et al. 1999. Induction of presenilins in the rat brain after middle cerebral arterial occlusion. Brain Res Bull, 48:539-43.
    • (1999) Brain Res Bull , vol.48 , pp. 539-543
    • Pennypacker, K.R.1    Hernandez, H.2    Benkovic, S.3
  • 60
    • 0019976860 scopus 로고
    • Edema and vascular permeability in cerebral ischemia: Comparison between ischemic neuronal damage and infarction
    • Petito CK, Pulsinelli WA, Jacobson G, et al. 1982. Edema and vascular permeability in cerebral ischemia: comparison between ischemic neuronal damage and infarction. J Neuropathol Exp Neurol, 41:423-36.
    • (1982) J Neuropathol Exp Neurol , vol.41 , pp. 423-436
    • Petito, C.K.1    Pulsinelli, W.A.2    Jacobson, G.3
  • 61
    • 0025935773 scopus 로고
    • Reassessment of new model of complete cerebral ischemia in rats. Method of induction of clinical death, pathophysiology and cerebrovascular pathology
    • Pluta R, Lossinsky AS, Mossakowski MJ, et al. 1991. Reassessment of new model of complete cerebral ischemia in rats. Method of induction of clinical death, pathophysiology and cerebrovascular pathology. Acta Neuropathol, 83:1-11.
    • (1991) Acta Neuropathol , vol.83 , pp. 1-11
    • Pluta, R.1    Lossinsky, A.S.2    Mossakowski, M.J.3
  • 62
    • 0027954307 scopus 로고
    • Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrest
    • Pluta R, Lossinsky AS, Wisniewski HM, et al. 1994a. Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrest. Brain Res, 633:41-52.
    • (1994) Brain Res , vol.633 , pp. 41-52
    • Pluta, R.1    Lossinsky, A.S.2    Wisniewski, H.M.3
  • 63
    • 0028290580 scopus 로고
    • Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's β-amyloid protein precursor in the brain
    • Pluta R, Kida E, Lossinsky AS, et al. 1994b. Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's β-amyloid protein precursor in the brain. Brain Res, 649:323-8.
    • (1994) Brain Res , vol.649 , pp. 323-328
    • Pluta, R.1    Kida, E.2    Lossinsky, A.S.3
  • 64
    • 0028081306 scopus 로고
    • Platelet occlusion phenomenon after short- and long-term survival following complete cerebral ischemia in rats produced by cardiac arrest
    • Pluta R, Lossinsky AS, Walski M, et al. 1994c. Platelet occlusion phenomenon after short- and long-term survival following complete cerebral ischemia in rats produced by cardiac arrest. J Brain Res, 35:463-71.
    • (1994) J Brain Res , vol.35 , pp. 463-471
    • Pluta, R.1    Lossinsky, A.S.2    Walski, M.3
  • 65
    • 0030056024 scopus 로고    scopus 로고
    • Evidence of blood-brain barrier permeability/leakage for circulating human Alzheimer's β-amyloid-(1-42)-peptide
    • Pluta R, Barcikowska M, Januszewski S, et al. 1996. Evidence of blood-brain barrier permeability/leakage for circulating human Alzheimer's β-amyloid-(1-42)-peptide. NeuroReport, 7:1261-5.
    • (1996) NeuroReport , vol.7 , pp. 1261-1265
    • Pluta, R.1    Barcikowska, M.2    Januszewski, S.3
  • 66
    • 0031308911 scopus 로고    scopus 로고
    • Transport of human β-amyloid peptide through the rat blood-brain barrier after global cerebral ischemia
    • Pluta R, Misicka A, Januszewski S, et al. 1997a. Transport of human β-amyloid peptide through the rat blood-brain barrier after global cerebral ischemia. Acta Neurochir Suppl, 70:247-9.
    • (1997) Acta Neurochir Suppl , vol.70 , pp. 247-249
    • Pluta, R.1    Misicka, A.2    Januszewski, S.3
  • 67
    • 0030973197 scopus 로고    scopus 로고
    • Late extracellular deposits of β-amyloid precursor protein in ischaemic rat brain show different immunoreactivity to the N- and C-terminal
    • Pluta R, Barcikowska M, Kida. E, et al. 1997b. Late extracellular deposits of β-amyloid precursor protein in ischaemic rat brain show different immunoreactivity to the N- and C-terminal. Alzheimer's Res, 3:51-7.
    • (1997) Alzheimer's Res , vol.3 , pp. 51-57
    • Pluta, R.1    Barcikowska, M.2    Kida, E.3
  • 68
    • 0033607423 scopus 로고    scopus 로고
    • Ischemic rats as a model in the study of the neurobiological role of human β-amyloid peptide. Time-dependent disappearing diffuse amyloid plaques in brain
    • Pluta R, Barcikowska M, Misicka A, et al. 1999. Ischemic rats as a model in the study of the neurobiological role of human β-amyloid peptide. Time-dependent disappearing diffuse amyloid plaques in brain. NeuroReport, 10:3615-9.
    • (1999) NeuroReport , vol.10 , pp. 3615-3619
    • Pluta, R.1    Barcikowska, M.2    Misicka, A.3
  • 69
    • 0034021843 scopus 로고    scopus 로고
    • The role of apolipoprotein E in the deposition of β-amyloid peptide during ischemia-reperfusion brain injury. A model of early Alzheimer's disease
    • Pluta R. 2000. The role of apolipoprotein E in the deposition of β-amyloid peptide during ischemia-reperfusion brain injury. A model of early Alzheimer's disease. Ann NY Acad Sci, 903:324-34.
    • (2000) Ann NY Acad Sci , vol.903 , pp. 324-334
    • Pluta, R.1
  • 70
    • 0034575227 scopus 로고    scopus 로고
    • Possible reverse transport of β-amyloid peptide across the blood-brain barrier
    • Pluta R, Misicka A, Barcikowska M, et al. 2000. Possible reverse transport of β-amyloid peptide across the blood-brain barrier. Acta Neurochir Suppl, 76:73-7.
    • (2000) Acta Neurochir Suppl , vol.76 , pp. 73-77
    • Pluta, R.1    Misicka, A.2    Barcikowska, M.3
  • 71
    • 7244245889 scopus 로고    scopus 로고
    • Proteins associated with Alzheimer's disease in conditions predisposing to Alzheimer's-type neurodegeneration
    • Pluta R. 2001. Proteins associated with Alzheimer's disease in conditions predisposing to Alzheimer's-type neurodegeneration. J Cereb Blood Flow Metab, 21(Suppl 1):S424.
    • (2001) J Cereb Blood Flow Metab , vol.21 , Issue.SUPPL. 1
    • Pluta, R.1
  • 72
    • 0037111362 scopus 로고    scopus 로고
    • Glial expression of the beta-amyloid peptide in cardiac arrest
    • Pluta R. 2002a. Glial expression of the beta-amyloid peptide in cardiac arrest. J Neurol Sci, 203-204:277-80.
    • (2002) J Neurol Sci , vol.203-204 , pp. 277-280
    • Pluta, R.1
  • 73
    • 0036451992 scopus 로고    scopus 로고
    • Astroglial expression of the beta-amyloid in ischemia-reperfusion brain injury
    • Pluta R. 2002b. Astroglial expression of the beta-amyloid in ischemia-reperfusion brain injury. Ann NY Acad Sci, 977:102-8.
    • (2002) Ann NY Acad Sci , vol.977 , pp. 102-108
    • Pluta, R.1
  • 74
    • 1442328306 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction and amyloid precursor protein accumulation in microvascular compartment following ischemia-reperfusion brain injury with 1-year survival
    • Pluta R. 2003. Blood-brain barrier dysfunction and amyloid precursor protein accumulation in microvascular compartment following ischemia-reperfusion brain injury with 1-year survival. Acta Neurochir Suppl, 86:117-22.
    • (2003) Acta Neurochir Suppl , vol.86 , pp. 117-122
    • Pluta, R.1
  • 75
    • 7244248761 scopus 로고    scopus 로고
    • Alzheimer lesions after ischemia-reperfusion brain injury
    • Pluta R. 2004a. Alzheimer lesions after ischemia-reperfusion brain injury. Folia Neuropathol, 42:181-6.
    • (2004) Folia Neuropathol , vol.42 , pp. 181-186
    • Pluta, R.1
  • 76
    • 27744583160 scopus 로고    scopus 로고
    • From brain ischemia-reperfusion injury to possible sporadic Alzheimer's disease
    • Pluta R. 2004b. From brain ischemia-reperfusion injury to possible sporadic Alzheimer's disease. Curr Neurovasc Res, 1:441-53.
    • (2004) Curr Neurovasc Res , vol.1 , pp. 441-453
    • Pluta, R.1
  • 77
    • 26044455494 scopus 로고    scopus 로고
    • Pathological opening of the blood-brain barrier to horseradish peroxidase and amyloid precursor protein following ischemia-reperfusion brain injury
    • Pluta R. 2005. Pathological opening of the blood-brain barrier to horseradish peroxidase and amyloid precursor protein following ischemia-reperfusion brain injury. Chemotherapy, 51:223-6.
    • (2005) Chemotherapy , vol.51 , pp. 223-226
    • Pluta, R.1
  • 78
    • 34248195715 scopus 로고    scopus 로고
    • Ischemia-reperfusion factors in sporadic Alzheimer's disease
    • Welsh EM ed, New York: Nova Science Publishers, pp
    • Pluta R. 2006a. Ischemia-reperfusion factors in sporadic Alzheimer's disease. In: Welsh EM (ed). New research on Alzheimer's disease. New York: Nova Science Publishers, pp. 183-234.
    • (2006) New research on Alzheimer's disease , pp. 183-234
    • Pluta, R.1
  • 79
    • 33748931285 scopus 로고    scopus 로고
    • Is the ischemic blood-brain barrier insufficiency responsible for full-blown Alzheimer's disease?
    • Pluta R. 2006b. Is the ischemic blood-brain barrier insufficiency responsible for full-blown Alzheimer's disease? Neurol Res, 28:266-71.
    • (2006) Neurol Res , vol.28 , pp. 266-271
    • Pluta, R.1
  • 80
    • 33744999632 scopus 로고    scopus 로고
    • Micro-blood-brain barrier openings and cytotoxic fragments of amyloid precursor protein accumulation in white matter after ischemic brain injury in long-lived rats
    • Pluta R, Ułamek M, Januszewski S. 2006. Micro-blood-brain barrier openings and cytotoxic fragments of amyloid precursor protein accumulation in white matter after ischemic brain injury in long-lived rats. Acta Neurochir Suppl, 96:267-71.
    • (2006) Acta Neurochir Suppl , vol.96 , pp. 267-271
    • Pluta, R.1    Ułamek, M.2    Januszewski, S.3
  • 81
    • 34248181862 scopus 로고    scopus 로고
    • Role of ischemic blood-brain barrier on amyloid plaques development in Alzheimer's disease brain
    • Pluta R. 2007a. Role of ischemic blood-brain barrier on amyloid plaques development in Alzheimer's disease brain. Curr Neurovasc Res, 4:121-9.
    • (2007) Curr Neurovasc Res , vol.4 , pp. 121-129
    • Pluta, R.1
  • 82
    • 56849115994 scopus 로고    scopus 로고
    • Is the ischemic blood-brain barrier a Trojan horse in Alzheimer's disease brain?
    • Pluta R ed, New York: Nova Science Publishers, Inc, pp
    • Pluta R. 2007b. Is the ischemic blood-brain barrier a Trojan horse in Alzheimer's disease brain? In: Pluta R (ed). Ischemia-reperfusion pathways in Alzheimer's disease. New York: Nova Science Publishers, Inc., pp. 139-84.
    • (2007) Ischemia-reperfusion pathways in Alzheimer's disease , pp. 139-184
    • Pluta, R.1
  • 84
    • 0036675599 scopus 로고    scopus 로고
    • Angiogenesis of the blood-brain barrier in vitro and the function of cerebral pericytes
    • Ramsauer M, Krause D, Dermietzel R. 2002. Angiogenesis of the blood-brain barrier in vitro and the function of cerebral pericytes. FASEB J, 16:1274-6.
    • (2002) FASEB J , vol.16 , pp. 1274-1276
    • Ramsauer, M.1    Krause, D.2    Dermietzel, R.3
  • 85
    • 18244369771 scopus 로고    scopus 로고
    • Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion
    • Ritter LS, Stempel KM, Coull BM, et al. 2005. Leukocyte-platelet aggregates in rat peripheral blood after ischemic stroke and reperfusion. Biol Res Nurs, 6:281-8.
    • (2005) Biol Res Nurs , vol.6 , pp. 281-288
    • Ritter, L.S.1    Stempel, K.M.2    Coull, B.M.3
  • 86
    • 0032840723 scopus 로고    scopus 로고
    • Pattern of neuronal loss in the rat hippocampus following experimental cardiac arrest-induced ischemia
    • Sadowski M, Wisniewski HM, Jakubowska-Sadowska K, et al. 1999. Pattern of neuronal loss in the rat hippocampus following experimental cardiac arrest-induced ischemia. J Neurol Sci, 168:13-20.
    • (1999) J Neurol Sci , vol.168 , pp. 13-20
    • Sadowski, M.1    Wisniewski, H.M.2    Jakubowska-Sadowska, K.3
  • 87
    • 0032501198 scopus 로고    scopus 로고
    • Estrogen attenuates over-expression of beta-amyloid precursor protein messenger RNA in an animal model of focal ischemia
    • Shi J, Panickar KS, Yang SH, et al. 1998. Estrogen attenuates over-expression of beta-amyloid precursor protein messenger RNA in an animal model of focal ischemia. Brain Res, 810:87-92.
    • (1998) Brain Res , vol.810 , pp. 87-92
    • Shi, J.1    Panickar, K.S.2    Yang, S.H.3
  • 88
    • 0032408976 scopus 로고    scopus 로고
    • Blood-brain barrier damage in reperfusion following ischemia in the hippocampus of the Mongolian gerbil brain
    • Shinnou M, Ueno M, Sakamoto H, et al. 1998. Blood-brain barrier damage in reperfusion following ischemia in the hippocampus of the Mongolian gerbil brain. Acta Neurol Scand, 98:406-11.
    • (1998) Acta Neurol Scand , vol.98 , pp. 406-411
    • Shinnou, M.1    Ueno, M.2    Sakamoto, H.3
  • 89
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard AR, Soulet D, Gowing G, et al. 2006. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron, 49:489-502.
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3
  • 90
    • 0030700217 scopus 로고    scopus 로고
    • Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat
    • Simpkins JW, Rajakumar G, Zhang YQ, et al. 1997. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg, 87:724-3 0.
    • (1997) J Neurosurg , vol.87 , Issue.724 -3 , pp. 0
    • Simpkins, J.W.1    Rajakumar, G.2    Zhang, Y.Q.3
  • 91
    • 34548084591 scopus 로고    scopus 로고
    • Guarding the blood-brain barrier: A role for estrogen in the etiology of neurodegenerative disease
    • Sohrabji F. 2007. Guarding the blood-brain barrier: A role for estrogen in the etiology of neurodegenerative disease. Gene Expression, 13:311-9.
    • (2007) Gene Expression , vol.13 , pp. 311-319
    • Sohrabji, F.1
  • 92
    • 26844449402 scopus 로고    scopus 로고
    • Transgenic models of Alzheimer's disease: Learning from animals
    • Spires TL, Hyman BT. 2005. Transgenic models of Alzheimer's disease: learning from animals. NeuroRx, 2:423-37.
    • (2005) NeuroRx , vol.2 , pp. 423-437
    • Spires, T.L.1    Hyman, B.T.2
  • 93
    • 0033888999 scopus 로고    scopus 로고
    • Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease
    • Stoltzner SE, Grenfell TJ, Mori C, et al. 2000. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. Am J Pathol, 156:489-99.
    • (2000) Am J Pathol , vol.156 , pp. 489-499
    • Stoltzner, S.E.1    Grenfell, T.J.2    Mori, C.3
  • 94
    • 33845505233 scopus 로고    scopus 로고
    • Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression
    • Sun X, He G, Qing H, et al. 2006. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl Acad Sci U S A, 103:18727-32.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18727-18732
    • Sun, X.1    He, G.2    Qing, H.3
  • 95
    • 34547777983 scopus 로고    scopus 로고
    • Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging
    • Swerdlow RH. 2007. Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging. Neurobiol Aging, 28:1465-80.
    • (2007) Neurobiol Aging , vol.28 , pp. 1465-1480
    • Swerdlow, R.H.1
  • 96
    • 1942520401 scopus 로고    scopus 로고
    • Astrocyte apoptosis: Implications for neuroprotection
    • Takuma K, Baba A, Matsuda T. 2004. Astrocyte apoptosis: Implications for neuroprotection. Prog Neurobiol, 72:111-27.
    • (2004) Prog Neurobiol , vol.72 , pp. 111-127
    • Takuma, K.1    Baba, A.2    Matsuda, T.3
  • 97
    • 0032031030 scopus 로고    scopus 로고
    • Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia
    • Tanimukai H, Imaizumi K, Kudo T, et al. 1998. Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia. Mol Brain Res, 54:212-8.
    • (1998) Mol Brain Res , vol.54 , pp. 212-218
    • Tanimukai, H.1    Imaizumi, K.2    Kudo, T.3
  • 98
    • 0029670094 scopus 로고    scopus 로고
    • β-amyloid-mediated vaso-activity and vascular endothelial damage
    • Thomas T, Thomas G, McLendon C, et al. 1996. β-amyloid-mediated vaso-activity and vascular endothelial damage. Nature, 380:168-71.
    • (1996) Nature , vol.380 , pp. 168-171
    • Thomas, T.1    Thomas, G.2    McLendon, C.3
  • 99
    • 0036139570 scopus 로고    scopus 로고
    • Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion
    • Ueno M, Tomimoto H, Akiguchi I, et al. 2002, Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion. J Cereb Blood Flow Metab, 22:97-104.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 97-104
    • Ueno, M.1    Tomimoto, H.2    Akiguchi, I.3
  • 100
    • 3442894794 scopus 로고    scopus 로고
    • Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    • Ujiie M, Dickstein DL, Carlow DA, et al. 2003. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation, 10:463-70.
    • (2003) Microcirculation , vol.10 , pp. 463-470
    • Ujiie, M.1    Dickstein, D.L.2    Carlow, D.A.3
  • 101
    • 22044439980 scopus 로고    scopus 로고
    • Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats
    • Van Groen T, Puurunen K, Maki HM, et al. 2005. Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats. Stroke, 36:1551-6.
    • (2005) Stroke , vol.36 , pp. 1551-1556
    • Van Groen, T.1    Puurunen, K.2    Maki, H.M.3
  • 102
    • 2142815707 scopus 로고    scopus 로고
    • Increased beta-secretase activity and expression in rats following transient cerebral ischemia
    • Wen Y, Onyewuchi O, Yang S, et al. 2004. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res, 1009:1-8.
    • (2004) Brain Res , vol.1009 , pp. 1-8
    • Wen, Y.1    Onyewuchi, O.2    Yang, S.3
  • 103
    • 0028871953 scopus 로고
    • Ultrastructural studies of cerebral vascular spasm after cardiac arrest-related global cerebral ischemia in rats
    • Wisniewski HM, Pluta R, Lossinsky AS, et al. 1995. Ultrastructural studies of cerebral vascular spasm after cardiac arrest-related global cerebral ischemia in rats. Acta Neuropathol, 90:432-40.
    • (1995) Acta Neuropathol , vol.90 , pp. 432-440
    • Wisniewski, H.M.1    Pluta, R.2    Lossinsky, A.S.3
  • 104
    • 0029687327 scopus 로고    scopus 로고
    • Beta-protein immunoreactivity in the human brain after cardiac arrest
    • Wisniewski HM, Maslinska D. 1996. Beta-protein immunoreactivity in the human brain after cardiac arrest. Folia Neuropathol, 34:65-71.
    • (1996) Folia Neuropathol , vol.34 , pp. 65-71
    • Wisniewski, H.M.1    Maslinska, D.2
  • 105
    • 0033535553 scopus 로고    scopus 로고
    • Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and ganima-secretase activity
    • Wolfe MS, Xia W, Ostaszewski BL, et al. 1999. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and ganima-secretase activity. Nature, 398:513-7.
    • (1999) Nature , vol.398 , pp. 513-517
    • Wolfe, M.S.1    Xia, W.2    Ostaszewski, B.L.3
  • 106
    • 0037394788 scopus 로고    scopus 로고
    • Adult mouse astrocytes degrade amyloid-beta in vitro and in situ
    • Wyss-Coray T, Loike JD, Brionne TC, et al. 2003. Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med, 9:453-7.
    • (2003) Nat Med , vol.9 , pp. 453-457
    • Wyss-Coray, T.1    Loike, J.D.2    Brionne, T.C.3
  • 107
    • 18044393593 scopus 로고    scopus 로고
    • Estrogens as protectants of the neurovascular unit against ischemic stroke
    • Yang SH, Liu R, Perez EJ, et al. 2005. Estrogens as protectants of the neurovascular unit against ischemic stroke. Curr Drug Targets CNS Neurol Disord, 4:169-77.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 169-177
    • Yang, S.H.1    Liu, R.2    Perez, E.J.3
  • 108
    • 34249727115 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation
    • Zhang X, Zhou K, Wang R, et al. 2007. Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation. J Biol Chem, 282:10873-80.
    • (2007) J Biol Chem , vol.282 , pp. 10873-10880
    • Zhang, X.1    Zhou, K.2    Wang, R.3
  • 109
    • 34247343262 scopus 로고    scopus 로고
    • Microvascular injury and blood-brain barrier leakage in Alzheimer's disease
    • Zipser BD, Johanson CE, Gonzalez L, et al. 2007. Microvascular injury and blood-brain barrier leakage in Alzheimer's disease. Neurobiol Aging, 27:977-86.
    • (2007) Neurobiol Aging , vol.27 , pp. 977-986
    • Zipser, B.D.1    Johanson, C.E.2    Gonzalez, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.