Estrogen attenuates over-expression of β-amyloid precursor protein messager RNA in an animal model of focal ischemia

Brain Research

Volumn 810, Issue 1-2, 1998, Pages 87-92

  Shi, Jiong ^a   Panickar, Kiran S ^a   Yang, Shao Hua ^b   Rabbani, Omid ^a   Day, Arthur L ^b   Simpkins, James W ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Amyloid precursor protein; Cerebral blood flow; Estradiol; Hypometabolism; Middle cerebral artery

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ESTROGEN; MESSENGER RNA;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; GENE OVEREXPRESSION; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; RNA ANALYSIS;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CEREBROVASCULAR CIRCULATION; DINOPROSTONE; ESTRADIOL; ESTROGENS; FEMALE; ISCHEMIC ATTACK, TRANSIENT; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032501198     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00888-9     Document Type: Article

References (29)

1. Abe K., Tanzi R.E., Kogure K. Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci. Lett. 125:1991;172-174.
2. Birge S.J. Is there a role for estrogen replacement therapy in the prevention and treatment of dementia? J. Am. Geriatr. Soc. 44(7):1996;865-870.
3. Chan P.H. Oxygen radicals in focal cerebral ischemia. Brain Pathol. 4:1994;59-65.
4. D.B. Dubal, M.L. Kashon, L.C. Pettigrew, J.M. Ren, S.P. Finklestein, S.W. Rau, P.M. Wise, Estradiol protects against ischemic injury, J. Cereb. Blood Flow Metab. (1998), in press.
5. Eber B., Schumacher M., Freidl W. Estrogen replacement therapy in older women: a neuropsychological and brain MRI study. J. Am. Geriatr. Soc. 44(11):1996;1307-1313.
6. Games D., Khan K.H., Soriano F.G., Lieberburg I., Sinha S. Evidence for altered APP processing following acute head trauma in the rodent. Soc. Neurosci. Abstr. 22:1992;1437.
7. Gibbs R.B. Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging. Ann. New York Acad. Sci. 743:1994;165-196.
8. Gorelick P.B. Status of risk factors for dementia associated with stroke. Stroke. 28(2):1997;459-463.
9. Grodstein F., Stampfer M.J., Manson J.E., Colditz G.A., Willett W.C., Rosner B., Speizer F.E., Hennekens C.H. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N. Engl. J. Med. 335(7):1996;453-461.
10. +-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron. J. Neurosci. Res. 50(4):1997;522-530.
11. Kokmen E., Whisnant J.P., O'Fallon W.M., Chu C.P., Beard C.M. Dementia after ischemic stroke: a population-based study in Rochester, Minnesota, (1960-1984). Neurology. 46(1):1996;154-159.
12. Lafferty F.W., Fiske M.E. Postmenopausal estrogen replacement: a long-term cohort study. Am. J. Med. 97(1):1994;66-77.
13. Liu C.K., Miller B.L., Cummings J.L. A quantitative MRI study of vascular dementia. Neurology. 42:1992;138-143.
14. Loeb C., Gandolfo C., Bino G. Intellectual impairment and cerebral lesions in multiple cerebral infarcts: a clinical-computed tomography study. Stroke. 19:1988;560-565.
15. Miranda R.C., Sohrabji F., Toran-Allerand D. Interactions of estrogen with the neurotrophins and their receptors during neural development. Horm. Behav. 28(4):1994;367-375.
16. Nakamura Y., Takeda M., Niigawa H., Hariguchi S., Nishimura T. Amyloid beta-protein precursor deposition in rat hippocampus lesioned by ibotenic acid injection. Neurosci Lett. 136:1992;95-98.
17. Otsuka N., Tomonaga M., Ikeda K. Rapid appearance of beta-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury. Brain Res. 568:1991;335-338.
18. Sherwin B.B. Estrogenic effects on memory in women. Ann. New York Acad. Sci. 743:1994;213-230.
19. Shi J., Simpkins J.W. 17 β-estradiol modulation of glucose transporter 1 (GLUT1) expression in blood-brain barrier. Am. J. Physiol.: Endocrinology and Metabolism. 272(6):1997;E1016-E1022.
20. Shi J., Zhang Y.Q., Simpkins J.W. Effects of 17 β-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats. Exp. Brain Res. 117:1997;200-206.
21. Shi J., Xiang Y., Simpkins J.W. Hypoglycemia enhances the expression of mRNA encoding β-amyloid precursor protein in rat primary cortical astroglial cells. Brain Res. 772:1997;247-251.
22. Simpkins J.W., Rajakumar G., Zhang Y.Q., Simpkins C.E., Greenwald D., Yu C.J., Bodor N., Day A.L. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J. Neurosurg. 87(5):1997;724-730.
23. Stephenson D.T., Rash K., Clemens J.A. Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat. Brain Res. 593:1992;128-135.
24. Tatemichi T.K., Foulkes M.A., Mohr J.P., Hewitt J.R., Hier D.B., Price T.R., Wolf P.A. Dementia in stroke survivors in the Stroke Data Bank cohort: prevalence, incidence, risk factors and computed tomographic findings. Stroke. 21:1990;858-866.
25. Tatemichi T.K., Desmond D.W., Paik M., Figueroa M., Mayetx R. Clinical determinants of dementia related to stroke. Ann. Neurol. 33:1993;568-575.
26. T.J.K. Toung, R.J. Traystman, P.D. Hurn, Estrogen-mediated neuroprotection after experimental stroke in males, Stroke (1998), in press.
27. Masliah E., Westland C.E., Rockenstein E.M., Abraham C.R., Mallory M., Veinberg I., Sheldon E., Mucke L. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 78(1):1997;135-146.
28. Smith-Swintosky V.L., Pettigrew L.C., Craddock S.D., Culwell A.R., Rydel R.E., Mattson M.P. Secreted forms of β-amyloid precusor protein protect against ischemic brain injury. J. Neurochem. 63:1994;781-784.
29. Zhang F., Eckman C., Younkin S., Hsiao K.K., Iadecola C. Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein. J. Neurosci. 17(20):1997;7655-7661.