Selective neuronal vulnerability and specific glial reactions in hippocampal and neocortical organotypic cultures submitted to ischemia

Experimental Neurology

Volumn 150, Issue 1, 1998, Pages 30-39

  Bernaudin, Myriam ^a   Nouvelot, André ^a   MacKenzie, Eric T ^a   Petit, Edwige ^a  

^a UNIVERSITÉ DE CAEN   (France)

Author keywords

Hippocampal and neocortical organotypic cultures; Histotoxic ischemia; Microglial and astroglial reactions; Selective neuronal vulnerability

Indexed keywords

SODIUM CYANATE; THIONINE;

ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN ISCHEMIA; CELL INTERACTION; CONTROLLED STUDY; GLIOSIS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MACROGLIA; MICROGLIA; MOUSE; NEOCORTEX; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0032032446     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6728     Document Type: Article

References (46)

1. Akira T., Henry D., Baldwin R. A., Wasterlain C. G. Nitric oxide participates in excitotoxic mechanisms induced by histochemical hypoxia. Brain Res. 645:1994;285-290.
2. Bruce A. J., Sakhi S., Schreiber S. S., Baudry M. Development of kainic acid andND. Exp. Neurol. 132:1995;209-219.
3. Buchs P.-A., Stoppini L., Muller D. Structural modifications associated with synaptic development in area CA1 of rat hippocampal organotypic cultures. Dev. Brain Res. 71:1993;81-91.
4. Coltman B. W., Ide C. F. Temporal characterization of microglia, IL-1β-like immunoreactivity and astrocytes in the dentate gyrus of hippocampal organotypic slice cultures. Int. J. Dev. Neurosci. 14:1996;707-719.
5. Colton C. A., Abel C., Patchett J., Keri J., Yao J. Lectin staining of cultured CNS microglia. J. Histochem. Cytochem. 40:1992;505-512.
6. Elkabes S., DiCicco-Bloom E. M., Black I. B. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J. Neurosci. 16:1996;2508-2521.
7. Gähwiler B. H. Organotypic cultures of neural tissue. Trends Neurosci. 11:1988;484-489.
8. Gähwiler B. H. Organotypic monolayer cultures of nervous tissue. J. Neurosci. Methods. 4:1981;329-342.
9. Gehrmann J., Banati R. B., Wiessner C., Hossmann K.-A., Kreutzberg G. W. Reactive microglia in cerebral ischaemia: an early mediator of tissue damage. Neuropathol. Appl. Neurobiol. 21:1995;277-289.
10. Gehrmann J., Bonnekoh P., Miyazawa T., Hossmann K.-A., Kreutzberg G. W. Immunocytochemical study of an early microglial activation in ischemia. J. Cereb. Blood Flow Metab. 12:1992;257-269.
11. Gerdes J., Li L., Schlueter C., Duchrow M., Wohlenberg C., Gerlach C., Stahmer I., Kloth S., Brand E., Flad H.-D. Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am. J. Pathol. 138:1991;867-873.
12. Gerdes J., Lemke H., Baisch H., Wacker H.-H., Schwab U., Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133:1984;1710-1715.
13. Giulian D., Vaca K. Inflammatory glia mediate delayed neuronal damage after ischemia in the central nervous system. Stroke. 24:1993;I-84-I-90.
14. Giulian D., Woodward J., Young D. G., Krebs J. F., Lachman L. B. Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J. Neurosci. 8:1988;2485-2490.
15. Giulian D. Ameboid microglia as effectors of inflammation in the central nervous system. J. Neurosci. Res. 18:1987;155-171.
16. Giulian D., Baker T. J. Peptides released by ameboid microglia regulate astroglial proliferation. J. Cell. Biol. 101:1985;2411-2415.
17. Gunasekar P. G., Sun P. W., Kanthasamy A. G., Borowitz J. L., Isom G. E. Cyanide-induced neurotoxicity involves nitric oxide and reactive oxygen species generation afterND. J. Pharmacol. Exp. Ther. 277:1996;150-155.
18. Hailer N. P., Järhult J. D., Nitsch R. Resting microglial cells in vitro: Analysis of morphology and adhesion molecule expression in organotypic hippocampal slice cultures. Glia. 18:1996;319-331.
19. Jørgensen M. B., Finsen B. R., Jensen M. B., Castellano B., Diemer N. H., Zimmer J. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus. Exp. Neurol. 102:1993;70-88.
20. Kreutzberg G. W. Microglia: A sensor for pathological events in the CNS. Trends Neurosci. 19:1996;312-318.
21. Kunkler P. E., Kraig R. P. Reactive astrocytosis from excitotoxic injury in hippocampal organ culture parallels that seen in vivo. J. Cereb. Blood Flow Metab. 17:1997;26-43.
22. Kusumoto M., Dux E., Paschen W., Hossmann K.-A. Susceptibility of hippocampal and cortical neurons to argon-mediated in vitro ischemia. J. Neurochem. 67:1996;1613-1621.
23. Marty S., Dusart I., Peschanski M. Glial changes following an excitotoxic lesion in the CNS-I. microglia/macrophages. Neuroscience. 45:1991;529-539.
24. Matesic D. F., Lin R. C. S. Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forbrain. J. Neurochem. 63:1994;1012-1020.
25. McCormick D., Yu C., Hobbs C., Hall P.-A. The relevance of antibody concentration to the immunohistological quantification of cell proliferation-associated antigens. Histopathology. 22:1993;543-547.
26. Morioka T., Kalehua A. N., Streit W. J. The microglial reaction in the rat dorsal hippocampus following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 11:1991;966-973.
27. Myers K. M., Fiskum G., Liu Y., Simmens S. J., Bredesen D. E., Murphy A. N. Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J. Neurochem. 65:1995;2432-2440.
28. Newell D. W., Papermaster B. V., Malouf A. T. Glutamate and non-glutamate receptor mediated toxicity caused by oxygen and glucose deprivation in organotypic hippocampal cultures. J. Neurosci. 15:1995;7702-7711.
29. Newell D. W., Malouf A. T., Franck J. E. Glutamate-mediated selective vulnerability to ischemia is present in organotypic cultures of hippocampus. Neurosci. Lett. 116:1990;325-330.
30. Ohno M., Aotani H., Shimada M. Glial responses to hypoxic/ischemic encephalopathy in neonatal rat cerebrum. Dev. Brain Res. 84:1995;294-298.
31. Patel M. N., Yim G. K. W., Isom G. E. N-methyl-D-aspartate receptors mediate cyanide-induced cytotoxicity in hippocampal cultures. Neurotoxicology. 14:1993;35-40.
32. 2+. Neurosci. Lett. 131:1991;42-44.
33. Petito C. K., Morgello S., Felix J. C., Lesser M. L. The two patterns of reactive astrocytosis in postischemic rat brain. J. Cerebr. Blood Flow Metab. 10:1990;850-859.
34. Pulsinelli W. A., Brierley J. B., Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11:1982;491-498.
35. Schmidt-Kastner R., Freund T. F. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience. 40:1991;599-636.
36. Stoppini L., Buchs P.-A., Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods. 37:1991;173-182.
37. Strasser U., Fischer G. Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation. J. Neurosci. Methods. 57:1995;177-186.
38. Streit W. J. An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4). J. Histochem. Cytochem. 38:1990;1683-1686.
39. Tønder N., Zimmer J. Hypoxic and excitotoxic lesions in organotypic hippocampal slice cultures. Soc. Neurosci. Abstr. 17:1991;789A.
40. Torp R., Haug F. M., Tønder N., Zimmer J., Ottersen O. P. Neuroactive amino acids in organotypic slice cultures of the rat hippocampus: An immunocytochemical study of the distribution of GABA, glutamate, glutamine and taurine. Neuroscience. 46:1992;807-823.
41. Vanicky I., Balchen T., Diemer N. H. Alterations in MAP2 immunostainability after prolonged complete brain ischaemia in the rat. Neuroreport. 7:1995;161-164.
42. Vornov J. J. Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia. J. Neurochem. 65:1995;1681-1691.
43. Vornov J. J., Tasker R. C., Coyle J. T. Delayed protection by MK-801 and tetrodotoxin in a rat organotypic hippocampal culture model of ischemia. Stroke. 25:1994;457-465.
44. Vornov J. J., Tasker R. C., Coyle J. T. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Exp. Neurol. 114:1991;11-22.
45. Wilde G. J. C., Pringle A. K., Wright P., Iannotti F. Differential vulnerability of the CA1 and CA3 subfields of the hippocampus to superoxide and hydroxyl radicals in vitro. J. Neurochem. 69:1997;883-886.
46. Zimmer J., Gähwiler B. H. Cellular and connective organization of slice cultures of the rat hippocampus and fascia dentata. J. Comp. Neurol. 228:1984;432-446.