Alzheimer's disease, brain immune privilege and memory: A hypothesis

Journal of Neural Transmission

Volumn 113, Issue 11, 2006, Pages 1697-1707

  Arshavsky, Y I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Autoimmunity; Blood brain barrier; Declarative memory; Immune privilege

Indexed keywords

ANTIGEN;

ALZHEIMER DISEASE; AMNESIA; AUTOIMMUNITY; BLOOD BRAIN BARRIER; BRAIN; CEREBROVASCULAR DISEASE; COMMUNICATION SKILL; DNA RECOMBINATION; GENETIC ANALYSIS; HUMAN; HYPOTHESIS; IMMUNE SYSTEM; LANGUAGE ABILITY; MATHEMATICAL COMPUTING; MEMORY; MEMORY CONSOLIDATION; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

ALZHEIMER DISEASE; AUTOIMMUNITY; BLOOD-BRAIN BARRIER; BRAIN; HUMANS; MEMORY; NERVE DEGENERATION;

EID: 33750468310     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-006-0524-4     Document Type: Review

References (124)

1. AK Abbas AH Lichtman 2003 Cellular and molecular immunology 6 Saunders Philadelphia
2. PS Aisen 2002 The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease Lancet Neurol 1 279 284
3. H Akiyama S Barger S Barnum B Bradt J Bauer 2000 Inflammation and Alzheimer's disease Neurobiol Aging 21 383 421
4. G Aliev D Seyidova BT Lamb ME Obrenovich SL Siedlak HV Vinters RP Friedland JC LaManna MA Smith G Perry 2003 Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice Neurol Res 25 665 674
5. H Arai N Sagi I Noguchi S Haga T Ishii Y Makino K Kosaka 1989 An immunohistochemical study of beta-protein in Alzheimer-type dementia brains J Neurol 236 214 217
6. YI Arshavsky 2003a Cellular and network properties in the functioning of the nervous system: from central pattern generators to cognition Brain Res Rev 41 229 267
7. YI Arshavsky 2003b Long-term memory: does it have a structural or chemical basis? Trends Neurosci 26 465 466
8. KH Ashe 2001 Learning and memory in transgenic mice modeling Alzheimer's disease Learn Mem 8 301 308
9. HP Bahrick 1984 Semantic memory content in permastore: fifty years of memory for Spanish learned in school J Exp Psychol Gen 113 1 29
10. HP Bahrick PO Bahrick RP Wittlinger 1975 Fifty years of memories for names and faces J Exp Psychol Gen 104 54 75
11. CH Bailey ER Kandel K Si 2004 The persistence of long-term memory; a molecular approach to self-sustaining changes in learning-induced synaptic growth Neuron 44 49 57
12. CF Barker RE Billingham 1977 Immunologically privileged sites Adv Immunol 25 1 54
13. C Bouras BM Riederer E Kovari PR Hof P Giannakopoulos 2005 Humoral immunity in brain aging and Alzheimer's disease Brain Res Rev 48 477 487
14. JC Breitner KA Welsh MJ Helms PC Gaskell BA Gau AD Roses MA Pericak-Vance AM Saunders 1995 Delayed onset of Alzheimer's disease with nonsteroidal antiinflammatory and histamine H2 blocking drugs Neurobiol Aging 16 523 530
15. K Chalmers GK Wilcock S Love 2003 APOE epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Aβ protein Neuropathol Appl Neurobiol 29 231 238
16. L Claudio 1996 Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients Acta Neuropathol (Berl) 91 6 14
17. M Colón-Cesario J Wang X Ramos HG García JJ Dávila J Laguna G Rosado S Peña de Ortiz 2006 An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning J Neurosci 26 5524 5533
18. F Crick 1984 Memory and molecular turnover Nature 312 101
19. MR D'Andrea 2003 Evidence linking neuronal cell death to autoimmunity in Alzheimer's disease Brain Res 982 19 30
20. MR D'Andrea 2005 Evidence that immunoglobulin-positive neurons in Alzheimer's disease are dying via the classical antibody-dependent complement pathway Am J Alzheimers Dis Other Demen 20 144 150
21. HP Davis LR Squire 1984 Protein synthesis and memory: a review Psychol Bull 96 518 559
22. V De Fonzo E Bersani F Aluffi-Pentini V Parisi 2000 A new look at the challenging world of tandem repeats Med Hypoth 54 750 760
23. JC de la Torre 2002 Alzheimer's disease: how does it start? J Alzheimer's Dis 4 497 512
24. JC de la Torre 2004 Alzheimer's disease is a vasocognopathy: a new term to describe its nature Neurol Res 26 517 524
25. I Dewachter D Moechars J van Dorpe I Tesseur C Van den Haute K Spittaels F Van Leuven 2001 Modelling Alzheimer's disease in multiple transgenic mice Biochem Soc Symp 67 203 210
26. A Dietrich W Been 2001 Memory and DNA J Theor Biol 208 145 149
27. JC Dodart H Meziane C Mathis KR Bales SM Paul A Ungerer 1999 Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein Behav Neurosci 113 982 990
28. P Eikelenboom WA van Gool 2004 Neuroinflammatory perspectives on the two faces of Alzheimer's disease J Neur Transmiss 111 281 294
29. E Farkas GI De Jong RA de Vos EN Jansen-Steur PG Luiten 2000 Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease Acta Neuropath (Berl) 100 395 402
30. IG Farkas A Czigner E Farkas E Dobo K Soos B Penke V Endresz A Mihaly 2003 Beta-amyloid peptide-induced blood-brain barrier disruption facilitates T-cell entry into the rat brain Acta Histoch 105 115 125
31. TA Ferguson DR Green TS Griffith 2002 Cell death and immune privilege Int Rev Immunol 21 153 172
32. A Filippini A Riccioli F Padula P Lauretti A D'Alessio P De Cesaris L Gandini A Lenzi E Ziparo 2001 Control and impairment of immune privilege in the testis and in semen Human Reprod Update 7 444 449
33. CJ Flickinger SS Howards ML Baran N Pessoa JC Herr 1997 Appearance of 'natural' antisperm autoantibodies after sexual maturation of normal Lewis rats J Reprod Immunol 33 127 145
34. M Frank R Kemler 2002 Protocadherins Curr Opin Cell Biol 14 557 562
35. E Gahtan JB Overmier 1999 Inflammatory pathogenesis in Alzheimer's disease: biological mechanisms and cognitive sequeli Neurosci Biobehav Rev 23 615 633
36. F Gonzalez-Scarano G Baltuch 1999 Microglia as mediators of inflammatory and degenerative diseases Annu Rev Neurosci 22 219 240
37. G Halliday SR Robinson C Shepherd J Kril 2000 Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms Clin Exp Pharmacol Physiol 27 1 8
38. J Hardy 1997 Amyloid, the preselins and Alzheimer's disease Trends Neurosci 20 154 159
39. N Hilschmann HU Barnikol S Barnikol-Watanabe H Gotz H Kratzin FP Thinnes 2001 The immunoglobulin-like genetic predetermination of the brain: the protocadherins, blueprint of the neuronal network Naturwissenschaften 88 2 12
40. K Hochedlinger R Jaenisch 2002 Monoclonal mice generated by nuclear transfer from mature B and T donor cells Nature 415 1035 1038
41. PR Hof CV Mobbs 2001 Functional neurobiology of aging Academic Press San Diego
42. R Holliday 1999 Is there an epigenetic component in long-term memory? J Theor Biol 200 339 341
43. C Iadecola 2004 Neurovascular regulation in the normal brain and in Alzheimer's disease Nat Rev Neurosci 5 347 360
44. T Ishii S Haga 1976 Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques Acta Neuropathol (Berl) 36 243 249
45. S Itagaki PL [tmp] McGeer H Akiyama 1988 Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue Neurosci Lett 91 259 264
46. S Itagaki PL [tmp] McGeer H Akiyama S Zhu D Selkoe 1989 Relationship of microglia and astrocytes to amyloid deposits of Alzheimer's disease J Neuroimmunol 24 173 182
47. G Jancso F Domoki P Santha J Varga J Fischer K Orosz B Penke A Becskei M Dux L Toth 1998 Beta-amyloid (1-42) peptide impairs blood-brain barrier function after intracarotid infusion in rats Neurosci Lett 253 139 141
48. KA Jellinger 2002 Alzheimer disease and cerebrovascular pathology: an update J Neur Transmiss 109 813 836
49. KA Jellinger J Attems 2005 Prevalence and pathogenic role of cerebrovascular lesions in Alzheimer disease J Neurol Sci 229-230 37 41
50. CL Joachim JH Morris DJ Selkoe 1988 Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases Ann Neurol 24 50 56
51. RN Kalaria 1999 The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease Ann N Y Acad Sci 893 113 125
52. RN Kalaria 2003 Vascular factors in Alzheimer's disease Int Psychogeriatr 15 [Suppl] 1 47 52
53. ER Kandel 2001 The molecular biology of memory storage: a dialog between genes and synapses Biosci Rep 21 565 611
54. RJ Kelleher A Govindarajan S Tonegawa 2004 Translational regulatory mechanisms in persistent forms of synaptic plasticity Neuron 44 59 73
55. SU Kim J de Vellis 2005 Microglia in health and disease J Neurosci Res 81 302 313
56. S Kumar-Singh D Pirici E [tmp] McGowan S Serneels C Ceuterick J Hardy K Duff D Dickson C Van Broeckhoven 2005 Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls Am J Pathol 167 527 543
57. R Lamprecht J LeDoux 2004 Structural plasticity and memory Nat Rev Neurosci 5 45 54
58. S Leibowitz RAC Hughes 1983 Immunology of the nervous system Edward Arnold London
59. JM Levenson JD Sweatt 2005 Epigenetic mechanisms in memory formation Nat Rev Neurosci 6 108 118
60. A Licandro S Ferla B Tavolato 1983 Alzheimer's disease and senile brains: an immunofluorescence study Rivis Patol Nerv Ment 104 75 87
61. AS Lossinsky HM Wisniewski 1998 Immunoultrastructural expression of ICAM-1 and PECAM-1 occurs prior to structural maturity of the murine blood-brain barrier Develop Neurosci 20 518 524
62. AR Luria 1976 The Neuropsychology of memory Winston New York
63. DM Mann JS Davies J Hawkes PO Yates 1982 Immunohistochemical staining of senile plaques Neuropathol Appl Neurobiol 8 55 61
64. LA Mattiace P Davies DW Dickson 1990 Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors Am J Pathol 136 101 114
65. MP Mattson 1997 Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives Physiol Rev 77 1081 1132
66. MK Matyszak 1998 Inflammation in the CNS: balance between immunological privilege and immune responses Progr Neurobiol 56 19 35
67. PL [tmp] McGeer H Akiyama S Itagaki EG [tmp] McGeer 1989 Immune system response in Alzheimer's disease Canad J Neurol Sci [Suppl] 16 516 527
68. PL [tmp] McGeer EG [tmp] McGeer 2001 Inflammation, autotoxicity and Alzheimer disease Neurobiol Aging 22 799 809
69. PL [tmp] McGeer J Rogers 1992 Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease Neurology 42 447 449
70. E [tmp] McGowan F Pickford J Kim L Onstead MP Murphy J Beard P Das K Jansen M DeLucia WL Lin G Dolios R Wang CB Eckman DW Dickson M Hutton J Hardy T Golde 2005 Aβ42 is essential for parenchymal and vascular amyloid deposition in mice Neuron 47 191 199
71. McGowan PO, Hope T, Kelsoe GH, Meck WH, Williams CL (2004) Recombination activating gene 1 (RAG1) may have a novel function in brain. Soc Neurosci, 34th Annual Meeting, 32221
72. N Methia P Andre A Hafezi-Moghadam M Economopoulos KL Thomas DD Wagner 2001 ApoE deficiency compromises the blood brain barrier especially after injury Molec Med 7 810 815
73. T Miyakawa T Kimura S Hirata N Fujise T Ono K Ishizuka J Nakabayashi 2000 Role of blood vessels in producing pathological changes in the brain with Alzheimer's disease Ann N Y Acad Sci 903 46 54
74. D Moechars I Dewachter K Lorent D Reverse V Baekelandt A Naidu I Tesseur K Spittaels CV Haute F Checler E Godaux B Cordell F Van Leuven 1999 Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain J Biol Chem 274 6483 6492
75. H Neumann 2001 Control of glial immune function by neurons Glia 36 191 199
76. JM Olichney LA Hansen JN Lee CR Hofstetter R Katzman LJ Thal 2000 Relationship between severe amyloid angiopathy, apolipoprotein E genotype, and vascular lesions in Alzheimer's disease Ann NY Acad Sci 903 138 143
77. JS Pachter HE de Vries Z Fabry 2003 The blood-brain barrier and its role in immune privilege in the central nervous system J Neuropathol Exp Neurol 62 593 604
78. S Peña de Ortiz YI Arshavsky 2001 DNA recombination as a possible mechanism in declarative memory: a hypothesis J Neurosci Res 63 72 81
79. S Peña de Ortiz M Colón YI Arshavsky 2004 Genomic theory of declarative memory V Parisi V De Fonzo F Aluffi-Pentini Dynamical genetics Signpost Kerala 345 364
80. S Peña de Ortiz M Colón Y Carrasquillo K Ren B Padilla R Silva YI Arshavsky 2003 Experience-dependent expression of the gene encoding terminal deoxynucleotidyl transferase in the mouse brain Neuroreport 14 1141 1144
81. W Penfield 1958 Some mechanisms of consciousness discovered during electrical stimulation of the brain Proc Nat Acad Sci USA 44 51 66
82. LS Perlmutter 1994 Microvascular pathology and vascular basement membrane components in Alzheimer's disease Mol Neurobiol 9 33 40
83. LS Perlmutter SA Scott E Barron HC Chui 1992 MHC class II-positive microglia in human brain: association with Alzheimer lesions J Neurosci Res 33 549 558
84. DL Price 2000 Aging of the brain and dementia of the Alzheimer type ER Kandel JH Schwartz TM Jessell Principles of neural science 4 McGraw-Hill New York 1149 1161
85. R Raghupathy C Shaha SK Gupta 1989 Autoimmunity to sperm antigens Curr Opin Immunol 2 757 760
86. RM Ransohoff P Kivisakk G Kidd 2003 Three or more routes for leukocyte migration into the central nervous system Nat Rev Immunol 3 569 581
87. K Ren S Peña de Ortiz 2002 Nonhomologous DNA end joining in the mature rat brain J Neurochem 80 949 959
88. JB Rich DX Rasmusson MF Folstein KA Carson C Kawas J Brandt 1995 Nonsteroidal anti-inflammatory drugs in Alzheimer's disease Neurology 45 51 55
89. GE Ringheim K Conant 2004 Neurodegenerative disease and the neuroimmune axis (Alzheimer's and Parkinson's disease, and viral infections) J Neuroimmunol 147 43 49
90. J Rogers J Luber-Narod SD Styren WH Civin 1988 Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease Neurobiol Aging 9 339 349
91. A Routtenberg JL Rekart 2005 Post-translational protein modification as the substrate for long-lasting memory Trends Neurosci 28 12 19
92. M Sadowski J Pankiewicz H Scholtzova YS Li D Quartermain K Duff T Wisniewski 2004 Links between the pathology of Alzheimer's disease and vascular dementia Neurochem Res 29 1257 1266
93. C Schulze JA Firth 1992 Interendothelial junctions during blood-brain barrier development in the rat: morphological changes at the level of individual tight junctional contacts Develop Brain Res 69 85 95
94. DJ Selkoe 2001 Alzheimer's disease: genes, proteins, and therapy Physiol Rev 81 741 766
95. K Si M Giustetto A Etkin R Hsu AM Janisiewicz MC Miniaci JH Kim H Zhu ER Kandel 2003a A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in Aplysia Cell 115 893 904
96. K Si S Lindquist ER Kandel 2003b A neuronal isoform of the aplysia CPEB has prion-like properties Cell 115 879 891
97. AJ Silva 2003 Molecular and cellular cognitive studies of the role of synaptic plasticity in memory J Neurobiol 54 224 237
98. AR Simard D Soulet G Gowing JP Julien S Rivest 2006 Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease Neuron 49 489 502
99. VK Singh 1997 Neuroautoimmunity: pathogenic implications for Alzheimer's disease Gerontology 43 79 94
100. DL Sparks 1997 Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? Ann N Y Acad Sci 826 128 146
101. M Stalder A Phinney A Probst B Sommer M Staufenbiel M Jucker 1999 Association of microglia with amyloid plaques in brains of APP23 transgenic mice Am J Pathol 154 1673 1684
102. PA Stewart K Hayakawa MA Akers HV Vinters 1992 A morphometric study of the blood-brain barrier in Alzheimer's disease Lab Invest 67 734 742
103. WF Stewart C Kawas M Corrada EJ Metter 1997 Risk of Alzheimer's disease and duration of NSAID use Neurology 48 626 632
104. BS Stonestreet CS Patlak KD Pettigrew CB Reilly HF Cserr 1996 Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults Am J Physiol 271 R1594 R1601
105. J Streilein 1995 Unraveling immune privilege Science 270 1158 1159
106. WJ Strittmatter AD Roses 1996 Apolipoprotein E and Alzheimer's disease Annu Rev Neurosci 19 53 77
107. J Szczygielski A Mautes WI Steudel P Falkai TA Bayer O Wirths 2005 Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies J Neural Transm 112 1547 1564
108. GM Szpak W Lechowicz E Lewandowska E Bertrand T Wierzba-Bobrowicz E Gwiazda B Schmidt-Sidor J Dymecki 2001 Neurones and microglia in central nervous system immune response to degenerative processes part 1: Alzheimer's disease and Lewy body variant of Alzheimer's disease. Quantitative study Folia Neuropathol 39 181 192
109. GM Thomas RL Huganir 2004 MAPK cascade signaling and synaptic plasticity Nat Rev Neurosci 5 173 183
110. T Togo H Akiyama E Iseki H Kondo K Ikeda M Kato T Oda K Tsuchiya K Kosaka 2002 Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases J Neuroimmunol 124 83 92
111. M Ujiie DL Dickstein DA Carlow WA Jefferies 2003 Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model Microcirculation 10 463 470
112. HV Vinters DL Secor SL Read JG Frazee U Tomiyasu TM Stanley JA Ferreiro MA Akers 1994 Microvasculature in brain biopsy specimens from patients with Alzheimer's disease: an immunohistochemical and ultrastructural study Ultrastruct Patholol 18 333 348
113. AW Vorbrodt DH Dobrogowska M Tarnawski 2001 Immunogold study of interendothelial junction-associated and glucose transporter proteins during postnatal maturation of the mouse blood-brain barrier J Neurocytol 30 705 716
114. DG Walker LF Lue 2005 Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases J Neurosci Res 81 412 425
115. DM Walsh DJ Selkoe 2004 Deciphering the molecular basis of memory failure in Alzheimer's disease Neuron 44 181 193
116. J Wang K Ren J Pérez AJ Silva S Peña de Ortiz 2003 The antimetabolite ara-CTP blocks long-term memory of conditioned taste aversion Learn Mem 10 503 510
117. H Watts PG Kennedy M Thomas 1981 The significance of anti-neuronal antibodies in Alzheimer's disease J Neuroimmunol 1 107 116
118. J Wegiel H Imaki KC Wang J Wegiel R Rubenstein 2004 Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice Brain Res 1022 19 29
119. SC Weninger BA Yankner 2001 Inflammation and Alzheimer disease: the good, the bad, and the ugly Nat Med 7 527 528
120. C Wolfson A Perrault Y Moride JM Esdaile L Abenhaim F Momoli 2002 A case-control analysis of nonsteroidal anti-inflammatory drugs and Alzheimer's disease: are they protective? Neuroepidemiology 21 81 86
121. BA Yankner 1996 Mechanisms of neuronal degeneration in Alzheimer's disease Neuron 16 921 932
122. C Zarow B Zaias SA Lyness H Chui 1999 Cerebral amyloid angiopathy in Alzheimer disease is associated with apolipoprotein E4 and cortical neuron loss Alzheimer Dis Assoc Disord 13 1 8
123. W Zhang DJ Linden 2003 The other side of the engram: experience-driven changes in neuronal intrinsic excitability Nat Rev Neurosci 4 885 900
124. BV Zlokovic 2005 Neurovascular mechanisms of Alzheimer's neurodegeneration Trends Neurosci 28 202 208