Heme-regulated eIF2α kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and β-thalassemia

Journal of Clinical Investigation

Volumn 115, Issue 6, 2005, Pages 1562-1570

  Han, An Ping ^a   Fleming, Mark D ^b   Chen, Jane Jane ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; INITIATION FACTOR 2ALPHA; PROTEIN HEME REGULATED EUKARYOTIC INITIATION FACTOR 2ALPHA KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG; GLOBIN; HEME; INITIATION FACTOR 2; PROTEIN KINASE R;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA THALASSEMIA; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; ERYTHROPOIETIC PROTOPORPHYRIA; FEMALE; GENOTYPE PHENOTYPE CORRELATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TRANSLATION REGULATION; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; ERYTHROCYTE; GENETICS; HEAT INJURY; HUMAN; METABOLISM; MOUSE MUTANT; OXIDATIVE STRESS; PATHOLOGY; PHENOTYPE; PROTEIN SYNTHESIS;

ANIMALS; BETA-THALASSEMIA; DISEASE MODELS, ANIMAL; EIF-2 KINASE; ERYTHROCYTES; EUKARYOTIC INITIATION FACTOR-2; GLOBINS; HEAT STRESS DISORDERS; HEME; HUMANS; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PHENOTYPE; PROTEIN BIOSYNTHESIS; PROTOPORPHYRIA, ERYTHROPOIETIC;

EID: 20444464807     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI24141     Document Type: Article

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