Differential expression of Bcl-2 homologs in human CD34+ hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells

Stem Cells

Volumn 18, Issue 4, 2000, Pages 261-272

  Josefsen, Dag ^a   Myklebust, June H ^a   Lømo, Jon ^a   Sioud, Mouldy ^a   Blomhoff, Heidi K ^b   Smeland, Erlend B ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Apoptosis; Bcl 2; Bcl x(L); CD34+ cells; Erythropoiesis; Hematopoiesis; Human

Indexed keywords

CD34 ANTIGEN; CELL MARKER; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; PROTEIN BCL 2; RIBOZYME; STEM CELL FACTOR;

ADULT; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL STIMULATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ERYTHROID CELL; ERYTHROPOIESIS; GRANULOCYTE; GRANULOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

EID: 0033866047     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.18-4-261     Document Type: Article

References (40)

1. Cohen JJ. Apoptosis. [Review]. Immunol Today 1993;14:126-130.
2. Chao DT, Korsmeyer SJ. BCL-2 family: regulators of cell death. Annu Rev Immunol 1998;16:395-419.
3. Reed JC. Double identity for proteins of the Bcl-2 family. Nature 1997;387:773-776.
4. Tsujimoto Y, Cossman J, Jaffe E et al. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985;228:1440-1443.
5. Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax [see comments]. Nature 1994;369:321-323.
6. Cosulich SC, Worrall V, Hedge PJ et al. Regulation of apoptosis by BH3 domains in a cell-free system. Curr Biol 1997;7:913-920.
7. Kelekar A, Thompson CB. Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol 1998;8:324-330.
8. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-1312.
9. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998;281:1322-1326.
10. L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci USA 1998;95:4386-4391.
11. L, and Apaf-1 form a ternary complex. J Biol Chem 1998;273:5841-5845.
12. L, an inhibitor of programmed cell death. Nature 1996;381:335-341.
13. L regulates apoptosis by heterodimerization-dependent and -independent mechanisms. EMBO J 1999;18:632-643.
14. Veis DJ, Sorenson CM, Shutter JR et al. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993;75:229-240.
15. Lacronique V, Varlet P, Mayeux P et al. Bcl-2 targeted over-expression into the erythroid lineage of transgenic mice delays but does not prevent the apoptosis of erythropoietin-deprived erythroid progenitors. Blood 1997;90:3050-3056.
16. Motoyama N, Wang F, Roth KA et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 1995;267:1506-1510.
17. Park JR, Bernstein ID, Hockenbery DM. Primitive human hematopoietic precursors express Bcl-x but not Bcl-2. Blood 1995;86:868-876.
18. Sanz C, Benito A, Silva M et al. The expression of Bcl-x is downregulated during differentiation of human hematopoietic progenitor cells along the granulocyte but not the monocyte/macrophage lineage. Blood 1997;89:3199-3204.
19. Ohta K, Iwai K, Kasahara Y et al. Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues. Int Immunol 1995;7:1817-1825.
20. L. Blood 1996;87:3837-3843.
21. L and Bcl-2. Blood 1996;88:1576-1582.
22. + cells. Leukemia 1992;6:845-852.
23. Gorczyca W, Bigman K, Mittelman A et al. Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia 1993;7:659-670.
24. Nicoletti I, Migliorati G, Pagliacci MC et al. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139:271-279.
25. Leirdal M, Sioud M. Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells. Br J Cancer 1999;80:1558-1564.
26. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. [Review]. Blood 1993;81:2844-2853.
27. Bender JG, Unverzagt KL, Walker DE et al. Identification and comparison of CD34-positive cells and their subpopulations from normal peripheral blood and bone marrow using multicolor flow cytometry. Blood 1991;77:2591-2596.
28. Malik P, Fisher TC, Barsky LL et al. An in vitro model of human red blood cell production from hematopoietic progenitor cells. Blood 1998;91:2664-2671.
29. Krajewski S, Bodrug S, Krajewska M et al. Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol 1995;146:1309-1319.
30. Moulding DA, Quayle JA, Hart CA et al. Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival. Blood 1998;92:2495-2502.
31. Myklebust JH, Smeland EB, Josefsen D et al. Protein kinase C-alpha isoform is involved in erythropoietin-induced erythroid differentiation of CD34(+) progenitor cells from human bone marrow. Blood 2000;95:510-518.
32. Motoyama N, Kimura T, Takahashi T et al. bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation. J Exp Med 1999;189:1691-1698.
33. L and apopain in the control of erythropoiesis by erythropoietin. Blood 1997;90:630-640.
34. Park JR, Robertson K, Hickstein DD et al. Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes. Blood 1994;84:440-445.
35. Fairbairn LJ, Cowling GJ, Reipert BM et al. Suppression of apoptosis allows differentiation and development of a multi-potent hemopoietic cell line in the absence of added growth factors. Cell 1993;74:823-832.
36. Lin EY, Orlofsky A, Wang HG et al. Al, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation. Blood 1996;87:983-992.
37. Akashi K, Kondo M, von Freeden-Jeffry U et al. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 1997;89:1033-1041.
38. Lagasse E, Weissman IL. Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 1997;89:1021-1031.
39. Maraskovsky E, O'Reilly LA, Teepe M et al. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/-mice. Cell 1997;89:1011-1019.
40. Zhou P, Qian L, Bieszczad CK et al. Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. Blood 1998;92:3226-3239.