ATP-dependent ligases in trypanothione biosynthesis - Kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

FEBS Journal

Volumn 275, Issue 21, 2008, Pages 5408-5421

  Oza, Sandra L ^a   Chen, Shoujun ^b   Wyllie, Susan ^a   Coward, James K ^b   Fairlamb, Alan H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Drug discovery; Enzyme mechanism; Glutathionylspermidine synthetase; Slow binding inhibition; Trypanothione synthetase

Indexed keywords

ADENOSINE TRIPHOSPHATE; ENZYME INHIBITOR; GLUTATHIONE; GLUTATHIONYLSPERMIDINE; LIGASE; PHOSPHINIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PSEUDOPEPTIDE; SPERMIDINE; SPERMIDINE DERIVATIVE; SPERMIDINE SYNTHASE; TRYPANOTHIONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CATALYSIS; CRITHIDIA FASCICULATA; DISSOCIATION CONSTANT; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ESCHERICHIA COLI; LEISHMANIA MAJOR; LEISHMANIASIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ADENOSINE TRIPHOSPHATE; AMIDE SYNTHASES; ANIMALS; CATALYSIS; CRITHIDIA FASCICULATA; ENZYME INHIBITORS; GLUTATHIONE; KINETICS; LIGASES; MOLECULAR MIMICRY; PEPTIDES; PHOSPHINIC ACIDS; PROTOZOA; SPERMIDINE;

CRITHIDIA FASCICULATA; ESCHERICHIA COLI; KINETOPLASTIDA; LEISHMANIA MAJOR; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 53849103947     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06670.x     Document Type: Article

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