-
2
-
-
0027322179
-
Inhibition of proliferation of human leukaemia 60 cells by methylglyoxal in vitro
-
Ayoub FM. Allen RE. Thornalley PJ. 1993 Inhibition of proliferation of human leukaemia 60 cells by methylglyoxal in vitro Leuk Res 17 397 401
-
(1993)
Leuk Res
, vol.17
, pp. 397-401
-
-
Ayoub, F.M.1
Allen, R.E.2
Thornalley, P.J.3
-
5
-
-
0030927104
-
Crystal structure of human glyoxalase I - Evidence for gene duplication and 3D domain swapping
-
Cameron AD. Olin B. Ridderstrom M. Mannervik B. Jones TA. 1997 Crystal structure of human glyoxalase I - evidence for gene duplication and 3D domain swapping EMBO J 16 3386 3395
-
(1997)
EMBO J
, vol.16
, pp. 3386-3395
-
-
Cameron, A.D.1
Olin, B.2
Ridderstrom, M.3
Mannervik, B.4
Jones, T.A.5
-
6
-
-
0033550054
-
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue
-
Cameron AD. Ridderstrom M. Olin B. Kavarana MJ. Creighton DJ. Mannervik B. 1999 Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue Biochemistry 38 13480 13490
-
(1999)
Biochemistry
, vol.38
, pp. 13480-13490
-
-
Cameron, A.D.1
Ridderstrom, M.2
Olin, B.3
Kavarana, M.J.4
Creighton, D.J.5
Mannervik, B.6
-
7
-
-
0032537553
-
Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: Evidence for optimal activation by nickel ions
-
Clugston SL. Barnard JF. Kinach R. Miedema D. Ruman R. Daub E. Honek JF. 1998 Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions Biochemistry 37 8754 8763
-
(1998)
Biochemistry
, vol.37
, pp. 8754-8763
-
-
Clugston, S.L.1
Barnard, J.F.2
Kinach, R.3
Miedema, D.4
Ruman, R.5
Daub, E.6
Honek, J.F.7
-
8
-
-
0942301191
-
Investigation of metal binding and activation of Escherichia coli glyoxalase I: Kinetic, thermodynamic and mutagenesis studies
-
Clugston SL. Yajima R. Honek JF. 2004 Investigation of metal binding and activation of Escherichia coli glyoxalase I: kinetic, thermodynamic and mutagenesis studies Biochem J 377 309 316
-
(2004)
Biochem J
, vol.377
, pp. 309-316
-
-
Clugston, S.L.1
Yajima, R.2
Honek, J.F.3
-
9
-
-
0028103275
-
The CCP4 suite: Programs for protein crystallography
-
Collaborative Computational Project Number 4
-
Collaborative Computational Project Number 4 1994 The CCP4 suite: programs for protein crystallography Acta Crystallogr D Biol Crystallogr 50 760 763
-
(1994)
Acta Crystallogr D Biol Crystallogr
, vol.50
, pp. 760-763
-
-
-
11
-
-
0034117242
-
Structure-activity study on the in vitro antiprotozoal activity of glutathione derivatives
-
D'Silva C. Daunes S. 2000 Structure-activity study on the in vitro antiprotozoal activity of glutathione derivatives J Med Chem 43 2072 2078
-
(2000)
J Med Chem
, vol.43
, pp. 2072-2078
-
-
D'Silva, C.1
Daunes, S.2
-
12
-
-
0035901550
-
An XAS investigation of product and inhibitor complexes of Ni-containing GlxI from Escherichia coli: Mechanistic implications
-
Davidson G. Clugston SL. Honek JF. Maroney MJ. 2001 An XAS investigation of product and inhibitor complexes of Ni-containing GlxI from Escherichia coli: mechanistic implications Biochemistry 40 4569 4582
-
(2001)
Biochemistry
, vol.40
, pp. 4569-4582
-
-
Davidson, G.1
Clugston, S.L.2
Honek, J.F.3
Maroney, M.J.4
-
13
-
-
0030926411
-
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages
-
Dumas C. Ouellette M. Tovar J. Cunningham ML. Fairlamb AH. Tamar S. et al. 1997 Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages EMBO J 16 2590 2598
-
(1997)
EMBO J
, vol.16
, pp. 2590-2598
-
-
Dumas, C.1
Ouellette, M.2
Tovar, J.3
Cunningham, M.L.4
Fairlamb, A.H.5
Tamar, S.6
-
14
-
-
37049228077
-
Cancerostatic action of methylglyoxal
-
Egyud LG. Szent-Gyorgyi A. 1968 Cancerostatic action of methylglyoxal Science 160 1140
-
(1968)
Science
, vol.160
, pp. 1140
-
-
Egyud, L.G.1
Szent-Gyorgyi, A.2
-
16
-
-
0022002912
-
Trypanothione: A novel bis (glutathionyl) spermidine cofactor for glutathione reductase in trypanosomatids
-
Fairlamb AH. Blackburn P. Ulrich P. Chait BT. Cerami A. 1985 Trypanothione: a novel bis (glutathionyl) spermidine cofactor for glutathione reductase in trypanosomatids Science 227 1485 1487
-
(1985)
Science
, vol.227
, pp. 1485-1487
-
-
Fairlamb, A.H.1
Blackburn, P.2
Ulrich, P.3
Chait, B.T.4
Cerami, A.5
-
17
-
-
0034254431
-
Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation
-
He MM. Clugston SL. Honek JF. Matthews BW. 2000 Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation Biochemistry 39 8719 8727
-
(2000)
Biochemistry
, vol.39
, pp. 8719-8727
-
-
He, M.M.1
Clugston, S.L.2
Honek, J.F.3
Matthews, B.W.4
-
18
-
-
37049081630
-
Synthesis of the trypanosomatid metabolites trypanothione, and N-1-mono-glutathionylspermidine and N-8-mono-glutathionylspermidine
-
Henderson GB. Ulrich P. Fairlamb AH. Cerami A. 1986 Synthesis of the trypanosomatid metabolites trypanothione, and N-1-mono-glutathionylspermidine and N-8-mono-glutathionylspermidine J Chem SocChem Commun 1986 593 594
-
(1986)
J Chem SocChem Commun
, vol.1986
, pp. 593-594
-
-
Henderson, G.B.1
Ulrich, P.2
Fairlamb, A.H.3
Cerami, A.4
-
19
-
-
84962467996
-
Catalytic mechanism of glyoxalase I: A theoretical study
-
Himo F. Siegbahn PE. 2001 Catalytic mechanism of glyoxalase I: a theoretical study J Am Chem Soc 123 10280 10289
-
(2001)
J Am Chem Soc
, vol.123
, pp. 10280-10289
-
-
Himo, F.1
Siegbahn, P.E.2
-
22
-
-
2542450775
-
Glyoxalase II of African trypanosomes is trypanothione-dependent
-
Irsch T. Krauth-Siegel RL. 2004 Glyoxalase II of African trypanosomes is trypanothione-dependent J Biol Chem 279 22209 22217
-
(2004)
J Biol Chem
, vol.279
, pp. 22209-22217
-
-
Irsch, T.1
Krauth-Siegel, R.L.2
-
24
-
-
0029895576
-
X-SITE: Use of empirically derived atomic packing preferences to identify favourable interaction regions in the binding sites of proteins
-
Laskowski RA. Thornton JM. Humblet C. Singh J. 1996 X-SITE: use of empirically derived atomic packing preferences to identify favourable interaction regions in the binding sites of proteins J Mol Biol 259 175 201
-
(1996)
J Mol Biol
, vol.259
, pp. 175-201
-
-
Laskowski, R.A.1
Thornton, J.M.2
Humblet, C.3
Singh, J.4
-
25
-
-
0028605299
-
Binding and modification of proteins by methylglyoxal under physiological conditions. a kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin
-
Lo TW. Westwood ME. McLellan AC. Selwood T. Thornalley PJ. 1994 Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin J Biol Chem 269 32299 32305
-
(1994)
J Biol Chem
, vol.269
, pp. 32299-32305
-
-
Lo, T.W.1
Westwood, M.E.2
McLellan, A.C.3
Selwood, T.4
Thornalley, P.J.5
-
28
-
-
0027396022
-
The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal
-
Phillips SA. Thornalley PJ. 1993 The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal Eur J Biochem 212 101 105
-
(1993)
Eur J Biochem
, vol.212
, pp. 101-105
-
-
Phillips, S.A.1
Thornalley, P.J.2
-
29
-
-
0022973968
-
Substrate specificity of bovine liver formaldehyde dehydrogenase
-
Pourmotabbed T. Creighton DJ. 1986 Substrate specificity of bovine liver formaldehyde dehydrogenase J Biol Chem 261 14240 14244
-
(1986)
J Biol Chem
, vol.261
, pp. 14240-14244
-
-
Pourmotabbed, T.1
Creighton, D.J.2
-
30
-
-
0030027452
-
Molecular cloning, heterologous expression, and characterization of human glyoxalase II
-
Ridderstrom M. Saccucci F. Hellman U. Bergman T. Principato G. Mannervik B. 1996 Molecular cloning, heterologous expression, and characterization of human glyoxalase II J Biol Chem 271 319 323
-
(1996)
J Biol Chem
, vol.271
, pp. 319-323
-
-
Ridderstrom, M.1
Saccucci, F.2
Hellman, U.3
Bergman, T.4
Principato, G.5
Mannervik, B.6
-
31
-
-
0036833868
-
Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development
-
Schmidt A. Krauth-Siegel RL. 2002 Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development Curr Top Med Chem 2 1239 1259
-
(2002)
Curr Top Med Chem
, vol.2
, pp. 1239-1259
-
-
Schmidt, A.1
Krauth-Siegel, R.L.2
-
32
-
-
18944383472
-
Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation
-
Sousa Silva M. Ferreira AE. Tomas AM. Cordeiro C. Ponces Freire A. 2005 Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation FEBS J 272 2388 2398
-
(2005)
FEBS J
, vol.272
, pp. 2388-2398
-
-
Sousa Silva, M.1
Ferreira, A.E.2
Tomas, A.M.3
Cordeiro, C.4
Ponces Freire, A.5
-
33
-
-
9444245016
-
Distinct classes of glyoxalase I: Metal specificity of the Yersinia pestis, Pseudomonas aeruginosa and Neisseria meningitidis enzymes
-
Sukdeo N. Clugston SL. Daub E. Honek JF. 2004 Distinct classes of glyoxalase I: metal specificity of the Yersinia pestis, Pseudomonas aeruginosa and Neisseria meningitidis enzymes Biochem J 384 111 117
-
(2004)
Biochem J
, vol.384
, pp. 111-117
-
-
Sukdeo, N.1
Clugston, S.L.2
Daub, E.3
Honek, J.F.4
-
34
-
-
0030176306
-
Pharmacology of methylglyoxal: Formation, modification of proteins and nucleic acids, and enzymatic detoxification - A role in pathogenesis and antiproliferative chemotherapy
-
Thornalley PJ. 1996 Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification - a role in pathogenesis and antiproliferative chemotherapy Gen Pharmacol 27 565 573
-
(1996)
Gen Pharmacol
, vol.27
, pp. 565-573
-
-
Thornalley, P.J.1
-
35
-
-
0028038969
-
Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester
-
Thornalley PJ. Strath M. Wilson RJ. 1994 Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester Biochem Pharmacol 47 418 420
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 418-420
-
-
Thornalley, P.J.1
Strath, M.2
Wilson, R.J.3
-
37
-
-
4444278762
-
A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major
-
Vickers TJ. Greig N. Fairlamb AH. 2004 A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major Proc Natl Acad Sci USA 101 13186 13191
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13186-13191
-
-
Vickers, T.J.1
Greig, N.2
Fairlamb, A.H.3
-
38
-
-
0015055115
-
Studies on the inhibition of glyoxalase I by S-substituted glutathiones
-
Vince R. Daluge S. Wadd WB. 1971 Studies on the inhibition of glyoxalase I by S-substituted glutathiones J Med Chem 14 402 404
-
(1971)
J Med Chem
, vol.14
, pp. 402-404
-
-
Vince, R.1
Daluge, S.2
Wadd, W.B.3
|