Trypanothione biosynthesis in Leishmania major

Molecular and Biochemical Parasitology

Volumn 139, Issue 1, 2005, Pages 107-116

  Oza, Sandra L ^a   Shaw, Matthew P ^a   Wyllie, Susan ^a   Fairlamb, Alan H ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Drug discovery; Enzymology; Evolution; Trypanothione metabolism

Indexed keywords

GLUTATHIONE; GLUTATHIONYLSPERMIDINE; ISOENZYME; SPERMIDINE DERIVATIVE; TRYPANOTHIONE; TRYPANOTHIONE SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME SUBSTRATE; FRAMESHIFT MUTATION; GENE IDENTIFICATION; IMMUNOFLUORESCENCE; LEISHMANIA MAJOR; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHYLOGENY; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTOZOAL GENETICS; PROTOZOON; PSEUDOGENE; SEQUENCE HOMOLOGY; STOP CODON;

AMIDE SYNTHASES; AMINO ACID SEQUENCE; ANIMALS; CRITHIDIA FASCICULATA; DNA, PROTOZOAN; EVOLUTION, MOLECULAR; GENES, PROTOZOAN; GLUTATHIONE; KINETICS; LEISHMANIA MAJOR; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PROTOZOAN PROTEINS; PSEUDOGENES; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SPERMIDINE; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

CRITHIDIA FASCICULATA; LEISHMANIA MAJOR; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 11144282719     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2004.10.004     Document Type: Article

References (29)

1. A.H. Fairlamb, P. Blackburn, P. Ulrich, B.T. Chait, and A. Cerami Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids Science 227 1985 1485 1487
2. A.H. Fairlamb, and A. Cerami Metabolism and functions of trypanothione in the Kinetoplastida Annu Rev Microbiol 46 1992 695 729
3. L. Flohé, H.J. Hecht, and P. Steinert Glutathione and trypanothione in parasitic hydroperoxide metabolism Free Radic Biol Med 27 1999 966 984
4. M. Dormeyer, N. Reckenfelderbaumer, H. Ludemann, and R.L. Krauth-Siegel Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase J Biol Chem 276 2001 10602 10606
5. R.L. Krauth-Siegel, and H. Lüdemann Reduction of dehydroascorbate by trypanothione Mol Biochem Parasitol 80 1996 203 208
6. S. Wyllie, M.L. Cunningham, and A.H. Fairlamb Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani J Biol Chem 279 2004 39925 39932
7. P. Borst, and M. Ouellette New mechanisms of drug resistance in parasitic protozoa Annu Rev Microbiol 49 1995 427 460
8. R. Mukhopadhyay, S. Dey, and N. Xu Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania Proc Natl Acad Sci USA 93 1996 10383 10387
9. K. Smith, K. Nadeau, C. Walsh, and A.H. Fairlamb Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata Protein Sci 1 1992 874 883
10. E. Tetaud, F. Manai, M.P. Barrett, K. Nadeau, C.T. Walsh, and A.H. Fairlamb Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata J Biol Chem 273 1998 19383 19390
11. S.L. Oza, M.R. Ariyanayagam, and A.H. Fairlamb Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculate Biochem J 364 2002 679 686
12. S.L. Oza, E. Tetaud, M.R. Ariyanayagam, S.S. Warnon, and A.H. Fairlamb A single enzyme catalyses formation of trypanothione from glutathione and spermidine in Trypanosoma cruzi J Biol Chem 277 2002 35853 35861
13. S.L. Oza, M.R. Ariyanayagam, N. Aitcheson, and A.H. Fairlamb Properties of trypanothione synthetase from Trypanosoma brucei Mol Biochem Parasitol 131 2003 25 33
14. M. Comini, U. Menge, and L. Flohe Biosynthesis of trypanothione in Trypanosoma brucei brucei Biol Chem 384 2003 653 656
15. M.A. Comini, S.A. Guerrero, S. Haile, U. Menge, H. Lunsdorf, and L. Flohe Validation of Trypanosoma brucei trypanothione synthetase as drug target Free Radic Biol Med 36 2004 1289 1302
16. D.J. Rigden, M.J. Jedrzejas, and M.Y. Galperin Amidase domains from bacterial and phage autolysins define a family of gamma-d,l-glutamate-specific amidohydrolases Trends Biochem Sci 28 2003 230 234
17. J.M. Bollinger Jr., D.S. Kwon, G.W. Huisman, R. Kolter, and C.T. Walsh Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase J Biol Chem 270 1995 14031 14041
18. K.A. Ryan, S. Dasgupta, and S.M. Beverley Shuttle cosmid vectors for the trypanosomatid parasite Leishmania Gene 131 1993 145 150
19. M. Sarkar, C.J. Hamilton, and A.H. Fairlamb Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi J Biol Chem 278 2003 22703 22708
20. Felsenstein J. PHYLIP - Phylogeny Inference Package (Version 3.2). Cladistics 1989; 5:164-166.
21. D.S. Kwon, C.H. Lin, S.J. Chen, J.K. Coward, C.T. Walsh, and J.M. Bollinger Jr. Dissection of glutathionylspermidine synthetase/amidase from Escherichia coli into autonomously folding and functional synthetase and amidase domains J Biol Chem 272 1997 2429 2436
22. C-H. Lin, D.S. Kwon, J.M. Bollinger Jr., and C.T. Walsh Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli Biochemistry 36 1997 14930 14938
23. K. Smith, A. Borges, M.R. Ariyanayagam, and A.H. Fairlamb Glutathionylspermidine metabolism in Escherichia coli Biochem J 312 1995 465 469
24. H. Tabor, and C.W. Tabor Isolation, characterization and turnover of glutathionylspermidine from Escherichia coli J Biol Chem 250 1975 2648 2654
25. M.R. Ariyanayagam, S.L. Oza, A. Mehlert, and A.H. Fairlamb Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi J Biol Chem 278 2003 27612 27619
26. C. Dumas, M. Ouellette, and J. Tovar Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages EMBO J 16 1997 2590 2598
27. J. Tovar, M.L. Cunningham, A.C. Smith, S.L. Croft, and A.H. Fairlamb Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival Proc Natl Acad Sci USA 95 1998 5311 5316
28. J. Tovar, S. Wilkinson, J.C. Mottram, and A.H. Fairlamb Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus Mol Microbiol 29 1998 653 660
29. K. Rutherford, J. Parkhill, and J. Crook Artemis: sequence visualization and annotation Bioinformatics 16 2000 944 945