-
1
-
-
0033083293
-
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias
-
Barrett M.P., Mottram J.C., Coombs G.H. Recent advances in identifying and validating drug targets in trypanosomes and leishmanias. Trends Microbiol. 7:1999;82-88.
-
(1999)
Trends Microbiol.
, vol.7
, pp. 82-88
-
-
Barrett, M.P.1
Mottram, J.C.2
Coombs, G.H.3
-
7
-
-
0000537243
-
Metabolism and functions of glutathione
-
Dolphin D, Poulson R, Avramovic O, editors. New York: Wiley
-
Meister A. Metabolism and functions of glutathione. In: Dolphin D, Poulson R, Avramovic O, editors. Glutathione: chemical, biochemical, and medical aspects. Part A, vol. 11. New York: Wiley; 1989. p. 367-474.
-
(1989)
Glutathione: chemical, biochemical, and medical aspects
, vol.11
, Issue.PART A
, pp. 367-474
-
-
Meister, A.1
-
8
-
-
0033767925
-
Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and Saccharomyces cerevisiae responses to oxidative stress
-
Carmel-Harel O., Storz G. Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and Saccharomyces cerevisiae responses to oxidative stress. Annu. Rev. Microbiol. 54:2000;439-461.
-
(2000)
Annu. Rev. Microbiol.
, vol.54
, pp. 439-461
-
-
Carmel-Harel, O.1
Storz, G.2
-
9
-
-
0021933665
-
Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids
-
Fairlamb A.H., Cerami A. Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids. Mol. Biochem. Parasitol. 14:1985;187-198.
-
(1985)
Mol. Biochem. Parasitol.
, vol.14
, pp. 187-198
-
-
Fairlamb, A.H.1
Cerami, A.2
-
10
-
-
0022002912
-
Trypanothione: A novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids
-
Fairlamb A.H., Blackburn P., Ulrich P., Chait B.T., Cerami A. Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. Science. 227:1985;1485-1487.
-
(1985)
Science
, vol.227
, pp. 1485-1487
-
-
Fairlamb, A.H.1
Blackburn, P.2
Ulrich, P.3
Chait, B.T.4
Cerami, A.5
-
11
-
-
0023051830
-
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulphide-containing flavoprotein reductases
-
Shames S.L., Fairlamb A.H., Cerami A., Walsh C.T. Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulphide-containing flavoprotein reductases. Biochemistry. 25:1986;3519-3526.
-
(1986)
Biochemistry
, vol.25
, pp. 3519-3526
-
-
Shames, S.L.1
Fairlamb, A.H.2
Cerami, A.3
Walsh, C.T.4
-
12
-
-
0023263401
-
Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei
-
Henderson G.B., Fairlamb A.H., Cerami A. Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei. Mol. Biochem. Parasitol. 24:1987;39-45.
-
(1987)
Mol. Biochem. Parasitol.
, vol.24
, pp. 39-45
-
-
Henderson, G.B.1
Fairlamb, A.H.2
Cerami, A.3
-
13
-
-
0030861413
-
A unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata
-
Nogoceke E., Gommel D.U., Kiess M., Kalisz H.M., Flohé L. A unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata. Biol. Chem. 378:1997;827-836.
-
(1997)
Biol. Chem.
, vol.378
, pp. 827-836
-
-
Nogoceke, E.1
Gommel, D.U.2
Kiess, M.3
Kalisz, H.M.4
Flohé, L.5
-
14
-
-
0026793462
-
Metabolism and functions of trypanothione in the Kinetoplastida
-
Fairlamb A.H., Cerami A. Metabolism and functions of trypanothione in the Kinetoplastida. Annu. Rev. Microbiol. 46:1992;695-729.
-
(1992)
Annu. Rev. Microbiol.
, vol.46
, pp. 695-729
-
-
Fairlamb, A.H.1
Cerami, A.2
-
15
-
-
0033230579
-
Glutathione and trypanothione in parasitic hydroperoxide metabolism
-
Flohé L., Hecht H.J., Steinert P. Glutathione and trypanothione in parasitic hydroperoxide metabolism. Free Radic. Biol. Med. 27:1999;966-984.
-
(1999)
Free Radic. Biol. Med.
, vol.27
, pp. 966-984
-
-
Flohé, L.1
Hecht, H.J.2
Steinert, P.3
-
16
-
-
0027494350
-
Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which overexpress trypanothione reductase: Sensitivity towards agents that are thought to induce oxidative stress
-
Kelly J.M., Taylor M.C., Smith K., Hunter K.J., Fairlamb A.H. Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which overexpress trypanothione reductase: sensitivity towards agents that are thought to induce oxidative stress. Eur. J. Biochem. 218:1993;29-37.
-
(1993)
Eur. J. Biochem.
, vol.218
, pp. 29-37
-
-
Kelly, J.M.1
Taylor, M.C.2
Smith, K.3
Hunter, K.J.4
Fairlamb, A.H.5
-
17
-
-
0035815655
-
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase
-
Dormeyer M., Reckenfelderbaumer N., Ludemann H., Krauth-Siegel R.L. Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase. J. Biol. Chem. 276:2001;10602-10606.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10602-10606
-
-
Dormeyer, M.1
Reckenfelderbaumer, N.2
Ludemann, H.3
Krauth-Siegel, R.L.4
-
18
-
-
0029841913
-
Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania
-
Mukhopadhyay R., Dey S., Xu N., Gage D., Lightbody J., Ouellette M.et al. Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania. Proc. Natl. Acad. Sci. USA. 93:1996;10383-10387.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10383-10387
-
-
Mukhopadhyay, R.1
Dey, S.2
Xu, N.3
Gage, D.4
Lightbody, J.5
Ouellette, M.6
-
19
-
-
0030926411
-
Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages
-
Dumas C., Ouellette M., Tovar J.et al. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. EMBO J. 16:1997;2590-2598.
-
(1997)
EMBO J.
, vol.16
, pp. 2590-2598
-
-
Dumas, C.1
Ouellette, M.2
Tovar, J.3
-
20
-
-
0032574808
-
Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: Effect on parasite intracellular survival
-
Tovar J., Cunningham M.L., Smith A.C., Croft S.L., Fairlamb A.H. Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival. Proc. Natl. Acad. Sci. USA. 95:1998;5311-5316.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 5311-5316
-
-
Tovar, J.1
Cunningham, M.L.2
Smith, A.C.3
Croft, S.L.4
Fairlamb, A.H.5
-
21
-
-
0031854156
-
Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus
-
Tovar J., Wilkinson S., Mottram J.C., Fairlamb A.H. Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus. Mol. Microbiol. 29:1998;653-660.
-
(1998)
Mol. Microbiol.
, vol.29
, pp. 653-660
-
-
Tovar, J.1
Wilkinson, S.2
Mottram, J.C.3
Fairlamb, A.H.4
-
22
-
-
0033977079
-
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress
-
Krieger S., Schwarz W., Ariyanayagam M.R., Fairlamb A.H., Krauth-Siegel R.L., Clayton C. Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress. Mol. Microbiol. 35:2000;542-552.
-
(2000)
Mol. Microbiol.
, vol.35
, pp. 542-552
-
-
Krieger, S.1
Schwarz, W.2
Ariyanayagam, M.R.3
Fairlamb, A.H.4
Krauth-Siegel, R.L.5
Clayton, C.6
-
23
-
-
0027092987
-
Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata
-
Smith K., Nadeau K., Walsh C., Fairlamb A.H. Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata. Protein Sci. 1:1992;874-883.
-
(1992)
Protein Sci.
, vol.1
, pp. 874-883
-
-
Smith, K.1
Nadeau, K.2
Walsh, C.3
Fairlamb, A.H.4
-
24
-
-
0032584748
-
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata
-
Tetaud E., Manai F., Barrett M.P., Nadeau K., Walsh C.T., Fairlamb A.H. Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata. J. Biol. Chem. 273:1998;19383-19390.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 19383-19390
-
-
Tetaud, E.1
Manai, F.2
Barrett, M.P.3
Nadeau, K.4
Walsh, C.T.5
Fairlamb, A.H.6
-
25
-
-
0029036040
-
Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase
-
Bollinger J.M. Jr., Kwon D.S., Huisman G.W., Kolter R., Walsh C.T. Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase. J. Biol. Chem. 270:1995;14031-14041.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14031-14041
-
-
Bollinger J.M., Jr.1
Kwon, D.S.2
Huisman, G.W.3
Kolter, R.4
Walsh, C.T.5
-
28
-
-
0035400398
-
Ovothiol and trypanothione as antioxidants in trypanosomatids
-
Ariyanayagam M.R., Fairlamb A.H. Ovothiol and trypanothione as antioxidants in trypanosomatids. Mol. Biochem. Parasitol. 115:2001;189-198.
-
(2001)
Mol. Biochem. Parasitol.
, vol.115
, pp. 189-198
-
-
Ariyanayagam, M.R.1
Fairlamb, A.H.2
-
29
-
-
0037183969
-
A single enzyme catalyses formation of trypanothione from glutathione and spermidine in Trypanosoma cruzi
-
Oza S.L., Tetaud E., Ariyanayagam M.R., Warnon S.S., Fairlamb A.H. A single enzyme catalyses formation of trypanothione from glutathione and spermidine in Trypanosoma cruzi. J. Biol. Chem. 277:2002;35853-35861.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35853-35861
-
-
Oza, S.L.1
Tetaud, E.2
Ariyanayagam, M.R.3
Warnon, S.S.4
Fairlamb, A.H.5
-
30
-
-
0037508926
-
Biosynthesis of trypanothione in Trypanosoma brucei brucei
-
Comini M., Menge U., Flohé L. Biosynthesis of trypanothione in Trypanosoma brucei brucei. Biol. Chem. 384:2003;653-656.
-
(2003)
Biol. Chem.
, vol.384
, pp. 653-656
-
-
Comini, M.1
Menge, U.2
Flohé, L.3
-
31
-
-
0037097023
-
Characterization of recombinant glutathionylspermidine synthetase/ amidase from Crithidia fasciculata
-
Oza S.L., Ariyanayagam M.R., Fairlamb A.H. Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata. Biochem. J. 364:2002;679-686.
-
(2002)
Biochem. J.
, vol.364
, pp. 679-686
-
-
Oza, S.L.1
Ariyanayagam, M.R.2
Fairlamb, A.H.3
-
32
-
-
0023832140
-
Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata
-
Shim H., Fairlamb A.H. Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata. J. Gen. Microbiol. 134:1988;807-817.
-
(1988)
J. Gen. Microbiol.
, vol.134
, pp. 807-817
-
-
Shim, H.1
Fairlamb, A.H.2
-
33
-
-
0031606457
-
A dansyl chloride-HPLC method for the determination of polyamines
-
Morgan D, editor. Totowa, NJ: Humana Press
-
Hunter KJ. A dansyl chloride-HPLC method for the determination of polyamines. In: Morgan D, editor. Polyamine protocols, vol. 79. Totowa, NJ: Humana Press; 1998. p. 119-23.
-
(1998)
Polyamine protocols
, vol.79
, pp. 119-123
-
-
Hunter, K.J.1
-
34
-
-
0022490910
-
Solid-phase extraction and determination of dansyl derivatives of unconjugated and conjugated polyamines by reversed-phase liquid chromatography: Improved separation systems for polyamines in cerebrospinal fluid, urine and tissue
-
Kabra P.M., Lee H.K., Lubich W.P., Marton L.J. Solid-phase extraction and determination of dansyl derivatives of unconjugated and conjugated polyamines by reversed-phase liquid chromatography: improved separation systems for polyamines in cerebrospinal fluid, urine and tissue. J. Chromatogr. 380:1986;19-32.
-
(1986)
J. Chromatogr.
, vol.380
, pp. 19-32
-
-
Kabra, P.M.1
Lee, H.K.2
Lubich, W.P.3
Marton, L.J.4
-
35
-
-
0030833927
-
Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli
-
Lin C.-H., Kwon D.S., Bollinger J.M. Jr., Walsh C.T. Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli. Biochemistry. 36:1997;14930-14938.
-
(1997)
Biochemistry
, vol.36
, pp. 14930-14938
-
-
Lin, C.-H.1
Kwon, D.S.2
Bollinger J.M., Jr.3
Walsh, C.T.4
-
36
-
-
0041461862
-
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi
-
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH. Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi. J Biol Chem 2003;278:27612-9.
-
(2003)
J Biol Chem
, vol.278
, pp. 27612-27619
-
-
Ariyanayagam, M.R.1
Oza, S.L.2
Mehlert, A.3
Fairlamb, A.H.4
-
37
-
-
0037387373
-
Phylogeny of Trypanosomatidae and Bodonidae (Kinetoplastida) based on 18S rRNA: Evidence for paraphyly of Trypanosoma and six other genera
-
Hughes A.L., Piontkivska H. Phylogeny of Trypanosomatidae and Bodonidae (Kinetoplastida) based on 18S rRNA: evidence for paraphyly of Trypanosoma and six other genera. Mol. Biol. Evol. 20:2003;644-652.
-
(2003)
Mol. Biol. Evol.
, vol.20
, pp. 644-652
-
-
Hughes, A.L.1
Piontkivska, H.2
-
38
-
-
0021142570
-
Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei
-
Opperdoes F.R., Baudhuin P., Coppens I., de Roe C., Edwards S.W., Weijers P.J.et al. Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei. J. Cell. Biol. 98:1984;1178-1184.
-
(1984)
J. Cell. Biol.
, vol.98
, pp. 1178-1184
-
-
Opperdoes, F.R.1
Baudhuin, P.2
Coppens, I.3
De Roe, C.4
Edwards, S.W.5
Weijers, P.J.6
-
39
-
-
0023253710
-
In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei
-
Fairlamb A.H., Henderson G.B., Bacchi C.J., Cerami A. In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei. Mol. Biochem. Parasitol. 24:1987;185-191.
-
(1987)
Mol. Biochem. Parasitol.
, vol.24
, pp. 185-191
-
-
Fairlamb, A.H.1
Henderson, G.B.2
Bacchi, C.J.3
Cerami, A.4
-
40
-
-
0023431045
-
Biochemical changes associated with α-difluoromethylornithine uptake and resistance in Trypanosoma brucei
-
Bellofatto V., Fairlamb A.H., Henderson G.B., Cross G.A.M. Biochemical changes associated with α-difluoromethylornithine uptake and resistance in Trypanosoma brucei. Mol. Biochem. Parasitol. 25:1987;227-238.
-
(1987)
Mol. Biochem. Parasitol.
, vol.25
, pp. 227-238
-
-
Bellofatto, V.1
Fairlamb, A.H.2
Henderson, G.B.3
Cross, G.A.M.4
-
41
-
-
0023006296
-
Polyamine depletion following exposure to DL-α -difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei
-
Giffin B.F., McCann P.P., Bitonti A.J., Bacchi C.J. Polyamine depletion following exposure to DL-α-difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei. J. Protozool. 33:1986;238-243.
-
(1986)
J. Protozool.
, vol.33
, pp. 238-243
-
-
Giffin, B.F.1
McCann, P.P.2
Bitonti, A.J.3
Bacchi, C.J.4
-
42
-
-
0002486260
-
Polyamine metabolism in trypanosomes
-
Hide G, Mottram JC, Coombs GH, Holmes PH, editors. Wallingford: CAB International
-
Fairlamb AH, Le Quesne SA. Polyamine metabolism in trypanosomes. In: Hide G, Mottram JC, Coombs GH, Holmes PH, editors. Trypanosomiasis and leishmaniasis: biology and control, vol. 9. Wallingford: CAB International; 1997. p. 149-61.
-
(1997)
Trypanosomiasis and leishmaniasis: biology and control
, vol.9
, pp. 149-161
-
-
Fairlamb, A.H.1
Le Quesne, S.A.2
-
43
-
-
0016788549
-
Isolation, characterization and turnover of glutathionylspermidine from Escherichia coli
-
Tabor H., Tabor C.W. Isolation, characterization and turnover of glutathionylspermidine from Escherichia coli. J. Biol. Chem. 250:1975;2648-2654.
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 2648-2654
-
-
Tabor, H.1
Tabor, C.W.2
|