Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-γ- [ψP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-γ-glutamate synthetase: Synthesis and hydrolytic stability

Journal of Medicinal Chemistry

Volumn 49, Issue 2, 2006, Pages 770-788

  Feng, Yan ^a   Coward, James K ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINE; AMINOBENZOIC ACID DERIVATIVE; BROMINE DERIVATIVE; BUFFER; CARBENE; ESTER DERIVATIVE; FOLIC ACID DERIVATIVE; GLUTAMATE SYNTHASE; GLUTARIC ACID DERIVATIVE; GLYCINE DERIVATIVE; METHOTREXATE DERIVATIVE; PHOSPHATE; PHOSPHINE DERIVATIVE; PHOSPHINIC ACID DERIVATIVE; PRODRUG; PTERIDINE DERIVATIVE; VINYL DERIVATIVE;

ALKYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; CHO CELL; CONJUGATE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HYDROLYSIS; MICHAEL ADDITION; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMINOPTERIN; ANIMALS; ANTINEOPLASTIC AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HYDROLYSIS; KINETICS; METHOTREXATE; PENTANOIC ACIDS; PEPTIDE SYNTHASES; PHOSPHINIC ACIDS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 31544482713     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050871p     Document Type: Article

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