A stereoselective synthesis of phosphinic acid phosphapeptides corresponding to glutamyl-γ-glutamate and incorporation into potent inhibitors of folylpoly-γ-glutamyl synthetase

Journal of Organic Chemistry

Volumn 70, Issue 17, 2005, Pages 6757-6774

  Hartley, David M ^a   Coward, James K ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; CARBOXYLIC ACIDS; CHROMATOGRAPHIC ANALYSIS; PURIFICATION; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

ELECTROPHILES; PHOSPHINIC ACID; PSEUDOPEPTIDE; RADICAL ADDITION;

PROTEINS;

FOLYLPOLY GAMMA GLUTAMYL SYNTHETASE; GAMMA GLUTAMYLTRANSFERASE; GLUTAMIC ACID; GLUTAMYL GAMMA GLUTAMATE; GLYCINE; PEPTIDE; PHOSPHAPEPTIDE; PHOSPHINIC ACID DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG;

ARBUZOV REACTION; ARTICLE; CARBON METABOLISM; CHIRALITY; DERIVATIZATION; METHODOLOGY; PEPTIDE ANALYSIS; STEREOCHEMISTRY; SYNTHESIS;

ENZYME INHIBITORS; GLUTAMATES; MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHASES; PHOSPHINIC ACIDS; PHOSPHOPEPTIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 23644459646     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0507439     Document Type: Article

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