Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli

Journal of Medicinal Chemistry

Volumn 40, Issue 23, 1997, Pages 3842-3850

  Chen, Shoujun ^a,b   Lin, Chun Hung ^a   Kwon, David S ^a   Walsh, Christopher T ^a   Coward, James K ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHONIC ACID DERIVATIVE; SPERMIDINE DERIVATIVE; SPERMIDINE SYNTHASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CATALYSIS; COMPLEX FORMATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; OXIDATION REDUCTION REACTION;

AMIDE SYNTHASES; BACTERIAL PROTEINS; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUTATHIONE; KINETICS; PHOSPHONIC ACIDS; PHOSPHOPEPTIDES; SPERMIDINE;

EID: 0030727159     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970414b     Document Type: Article

References (53)

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