In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: Inhibition of cytosolic phospholipase A2α overcomes the asthma-associated response

Clinical and Experimental Allergy

Volumn 38, Issue 10, 2008, Pages 1590-1605

  Whalen, K A ^a,b   Legault, H ^a   Hang, C ^a   Hill, A ^a   Kasaian, M ^a   Donaldson, D ^a,c   Bensch, G W ^f   Bensch, G ^f   Baker, J ^g   Reddy, P S ^a   Wood, N ^a   Ramarao, M K ^a   Ellis, D K ^a   Csimma, C ^a,d   McKee, C ^a,e   Clark, J D ^a   Ryan, J ^a,b   Dorner, A J ^a   O'Toole, M ^a  

^a PFIZER INC   (United States)

^b AVEO ONCOLOGY   (United States)

^c GENENTECH INC   (United States)

^d Clarus Ventures   (United States)

^e TolerRx Inc   (United States)

^f Bensch Research Associates   (United States)

^g Baker Allergy   (United States)

Author keywords

Asthmatic response to allergen; cPLA2 inhibition; Differential gene expression in asthma; Transcriptional profiling

Indexed keywords

ALLERGEN; ARACHIDONATE 5 LIPOXYGENASE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 17A; INTERLEUKIN 18; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 32; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE A2ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ALLERGIC ASTHMA; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MICROARRAY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SUBUNIT; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; ALLERGENS; ARACHIDONIC ACID; ASTHMA; BENZOIC ACIDS; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; GROUP IV PHOSPHOLIPASES A2; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; SULFONAMIDES;

EID: 53749091016     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.03059.x     Document Type: Article

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