The role of toll-like receptor 4 in environmental airway injury in mice

American Journal of Respiratory and Critical Care Medicine

Volumn 170, Issue 2, 2004, Pages 126-132

  Hollingsworth II, John W ^a   Cook, Donald N ^b   Brass, David M ^b   Walker, Julia K L ^b   Morgan, Daniel L ^b   Foster, W Michael ^b   Schwartz, David A ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

Endotoxin; Innate immunity; Ozone; Residual oil fly ash; Toll like receptor

Indexed keywords

LIPOPOLYSACCHARIDE; OZONE; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FLY ASH; INFLAMMATION; LOWER RESPIRATORY TRACT; LUNG LAVAGE; MALE; MOUSE; MOUSE STRAIN; NEUTROPHIL; NONHUMAN; PARTICULATE MATTER; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; WILD TYPE;

EID: 3142781951     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200311-1499oc     Document Type: Article

References (51)

1. Haglind P, Rylanders R. Occupational exposure and lung function measurements among workers in swine confinement buildings. J Occup Med 1987;29:904-907.
2. Schwartz DA. Grain dust, endotoxin, and airflow obstruction. Chest 1996; 109:575-635.
3. Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, Pauwels R, Sergysels R. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996;154:1641-1646.
4. Rizzo MC, Naspitz CK, Fernandez-Caldas E, Lockey RF, Mimica I, Sole D. Endotoxin exposure and symptoms in asthmatic children. Pediatr Allergy Immunol 1997;8:121-126.
5. Jagielo PJ, Thorne PS, Watt JL, Frees KL, Quinn TJ, Schwartz DA. Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects. Chest 1996;110:263-270.
6. O'Grady NP, Preas HL, Pugin J, Fiuza C, Tropea M, Reda D, Banks SM, Suffredini AF. Local inflammatory responses following bronchial endotoxin instillation in humans. Am J Respir Crit Care Med 2001;163: 1591-1598.
7. Schwartz D, Thorne PS, Jagielo PJ, White GE, Bleuer SA, Frees KL. Endotoxin responsiveness and grain dust-induced inflammation in the lower respiratory tract. Am J Physiol Lung Cell Mol Physiol 1994;267:L609-L617.
8. Jagielo P, Thorne PS, Kern JA, Quinn TJ, Schwartz DA. Role of endotoxin in grain dust-induced lung inflammation in mice. Am J Physiol Lung Cell Mol Physiol 1996;270:L1052-L1059.
9. Hollingsworth JW, Cook DN, Brown CK, Schwartz DA. TLR4 dependent inflammation and airway hyperreactivity to inhaled endotoxin (abstract). Am J Respir Cell Mol Biol 2002;165:A417.
10. Kline J, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA. Variable airway responsiveness to inhaled lipopolysaccharide. Am J Respir Crit Care Med 1999;160:297-303.
11. Dockery DW, Pope CA, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BB, Speizer FE. An association between air pollution and mortality in six U.S. cities. N Engl J Med 1993;329:1754-1759.
12. Samet JM, Dominici F, Curriero FC, Coursac I, Zeger SL. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med 2000;343:1742-1749.
13. Delfino RJ, Murphy-Moulton AM, Burnett RT, Brook JR, Becklake MR. Effects of air pollution on emergency room visits for respiratory illnesses in Montreal, Quebec. Am J Respir Crit Care Med 1997;155:568-576.
14. Ghio AJ, Devlin RB. Inflammatory lung injury after bronchial instillation of air pollution particles. Am J Respir Crit Care Med 2001;164:704-708.
15. Becker S, Soukup JM, Gilmour MI, Devlin RB. Stimulation of human and rat alveolar macrophages by urban air particulates: effects on oxidant radical generation and cytokine production. Toxicol Appl Pharmacol 1996;141:637-648.
16. van Eeden SF, Tan WC, Suwa T, Mukae H, Terashima T, Fujii T, Qui D, Vincent R, Hogg JC. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10)). Am J Respir Crit Care Med 2001;164:826-830.
17. Carter JD, Ghio AJ, Samet JM, Devlin RB. Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent. Toxicol Appl Pharmacol 1997;146:180-188.
18. Quay JL, Reed W, Samet J, Devlin RB. Air pollution particles induce IL-6 gene expression in human airway epithelial cells via NF-kappaB activation. Am J Respir Cell Mol Biol 1998;19:98-106.
19. Ghio AJ, Silbajoris R, Carson JL, Samet JM. Biologic effects of oil fly ash. Environ Health Perspect 2002;110:89-94.
20. Gavett SH, Madison SL, Dreher KL, Winselt DW, McGee JK, Costa DL. Metal and sulfate composition of residual oil fly ash determines airway hyperreactivity and lung injury in rats. Environ Res 1997;72:162-172.
21. Gavett SH, Madison SL, Stevens MA, Costa DL. Residual oil fly ash amplifies allergic cytokines, airway responsiveness, and inflammation in mice. Am J Respir Crit Care Med 1999;160:1897-1904.
22. Kehrl HR, Vincent LM, Kowalsky RJ, Horstman DH, O'Neil JJ, McCartney WH, Bromberg PA. Ozone exposure increases respiratory epithelial permeability in humans. Am Rev Respir Dis 1987;135:1124-1128.
23. Koren HS, Devlin RB, Graham DE, Mann R, McGee MP, Horstman DH, Kozumbo WJ, Becker S, House DE, McDonnell WF, et al. Ozone-induced inflammation in the lower airways of human subjects. Am Rev Respir Dis 1989;139:407-415.
24. Foster WM, Brown RH, Macri K, Mitchell CS. Bronchial reactivity of healthy subjects: 18-20 h postexposure to ozone. J Appl Physiol 2000; 89:1804-1810.
25. Foster WM, Stetkiewicz PT. Regional clearance of solute from the respiratory epithelia: 18-20 h postexposure to ozone. J Appl Physiol 1996; 81:1143-1149.
26. 1 and FVC do not correlate with measures of inflammation. Am J Respir Crit Care Med 1996;153:904-909.
27. Weinmann GG, Bowes SM, Gerbase MW, Kimball AW, Frank R. Response to acute ozone exposure in healthy men: results of a screening procedure. Am J Respir Crit Care Med 1995;15133-40.
28. Kleeberger SR, Levitt RC, Zhang LY, Longphre M, Harkema J, Jedlicka A, Eleff SM, DiSilvestre D, Holroyd KJ. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice. Nat Genet 1997;17:475-478.
29. Kleeberger SR, Reddy S, Zhang LY, Jedlicka AE. Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4. Am J Respir Cell Mol Biol 2000;22:620-627.
30. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C. Defective LPS signaling in C3H/Hej and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998;282:2085-2088.
31. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S. Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999;162:3749-3752.
32. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000;25:187-191.
33. Soukup JM, Becker S. Human alveolar macrophage responses to air pollution particulates are associated with insoluble components of coarse material, including particulate endotoxin. Toxicol Appl Pharmacol 2001;171:20-26.
34. Dong W, Lewtas J, Luster MI. Role of endotoxin in tumor necrosis factor alpha expression from alveolar macrophages treated with urban air particles. Exp Lung Res 1996;22:577-592.
35. Becker S, Fenton MJ, Soukup JM. Involvement of microbial components and toll-like receptors 2 and 4 in cytokine responses to air pollution particles. Am J Respir Cell Mol Biol 2002;27:611-618.
36. Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF 3rd. The extra domain A of fibronectin activates toll-like receptor 4. J Biol Chem 2001;276:10229-10233.
37. Devlin RB, McKinnon KP, Noah T, Becker S, Koren HS. Ozone-induced release of cytokines and fibronectin by alveolar macrophages and airway epithelial cells. Am J Physiol 1994;266:L612-L619.
38. Kleeberger SR, Reddy SP, Zhang LY, Cho HY, Jedlicka AE. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 2001;280:L326-L333.
39. Visscher PM. Speed congenics: accelerated genome recovery using genetic markers. Genet Res 1999;74:81-85.
40. Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA. Subchronic endotoxin inhalation causes persistent airway disease. Am J Physiol Lung Cell Mol Physiol 2003;285:L755-L761.
41. Hamelmann E, Schwarze J, Takeda K, Oshiba A, Larsen GL, Irvin CG, Gelfand EW. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997;156:766-775.
42. Drazen JM, Finn PW, De Sanctis GT. Mouse models of airway responsiveness: physiological basis of observed outcomes and analysis of selected examples using these outcome indicators. Annu Rev Physiol 1999;61:593-625.
43. Schwarze J, Hamelmann E, Larsen G, Gelfand EW. Whole body plethysmography (WBP) in mice detects airway sensitization through changes in lower airways function. J Allergy Clin Immunol 1996;97:293.
44. Whitehead GS, Walker JK, Berman KG, Foster WM, Schwartz DA. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol 2003;285:L32-L42.
45. Motusky H. Intuitive biostatistics. New York: Oxford University Press; 1995.
46. Dreher KL, Jaskot RH, Lehmann JR, Richards JH, McGee JK, Ghio AJ, Costa DL. Soluble transition metals mediate residual oil fly ash induced acute lung injury. J Toxicol Environ Health 1997;50:285-305.
47. Kodavanti UP, Jaskot RH, Su WY, Costa DL, Ghio AJ, Dreher KL. Genetic variability in combustion particle-induced chronic lung injury. Am J Physiol 1997;272:L521-L532.
48. Hirschfeld M, Ma Y, Weis JH, Vogel SN, Weis JJ. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J Immunol 2000;165:618-622.
49. Yazawa N, Fujimoto M, Sato S, Miyake K, Asano N, Nagai Y, Takeuchi O, Takeda K, Okochi H, Akira S, et al. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood 2003;102:1374-1380.
50. Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S, et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003;424:743-748.
51. Cook DN, Wang S, Wang Y, Howles GP, Whitehead GS, Berman KG, Church TD, Frank BC, Gaspard RM, Yu Y, et al. Genetic regulation of endotoxin-induced airway disease. Genomics (In press).