Allergen-specific increase in interleukin (IL)-4 and IL-5 secretion from peripheral blood mononuclear cells during birch-pollen immunotherapy

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 53, Issue 3, 1998, Pages 275-281

  Moverare R ^a   Rak, S ^b   Elfman, L ^a  

^a PFIZER INC   (United States)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Birch pollen allergens; Immunotherapy; Interleukin 5; Interleukin 4; Peripheral blood rnononuclear cells; T helper cells

Indexed keywords

ALUTARD; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; PHORBOL 12 ACETATE 13 MYRISTATE; PHYTOHEMAGGLUTININ; PLACEBO; POLLEN ANTIGEN; POLLEN EXTRACT; UNCLASSIFIED DRUG;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; BIRCH POLLEN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HELPER CELL; HUMAN; IMMUNOMODULATION; MALE; MONONUCLEAR CELL; POLLEN ALLERGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0031881643     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.1998.tb03887.x     Document Type: Article

References (26)

1. Romagnani S. Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease, Int J Clin Lab Res 1991;21:152-8.
2. 2. Proc Natl Acad Sci U S A 1988;85:6880-4.
3. Maggi E, Parronchi P, Manetti R, et al. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992;148:2142-7.
4. Demeure CE, Yang LP, Byun DG, Ishihara H, Vezzio N, Delespesse G. Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions. Eur J Immunol 1995;25:2722-5.
5. Corrigan CJ, Kay AB. T cells and eosinophils in the pathogenesis of asthma. Immunol Today 1992;13:501-7.
6. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-54.
7. Jutel M, Wyss Coray T, Carballido JM, Blaser K, Müller UR, Pichler WJ. Selective restimulation of antigen or allergen preactivated T cells using OKT3 F(ab)2 results in the secretion of TH-1 or TH-2-like cytokine patterns. Clin Exp Allergy 1995;25:1108-17.
8. Tengvall Linder M, Johansson C, Zargari A, et al. Detection of Pityrosporum orbiculare reactive T cells from skin and blood in atopic dermatitis and characterization of their cytokine profiles. Clin Exp Allergy 1996;26:1286-97.
9. Birkner T, Rumpold H, Jarolim E, et al. Evaluation of immunotherapy-induced changes in specific IgE, IgG and IgG subclasses in birch pollen allergic patients by means of immunoblotting. Correlation with clinical response. Allergy 1990;45:418-26.
10. Malling H-J, Djurup R. Diagnosis and immunotherapy of mould allergy. VII. IgG subclass response and relation to the clinical efficacy of immunotherapy with Cladosporium. Allergy 1988;43:60-70.
11. Reid MJ, Moss RB, Hsu YP, Kwasnicki JM, Commerford TM, Nelson BL. Seasonal asthma in northern California: allergic causes and efficacy of immunotherapy. J Allergy Clin Immunol 1986;78:590-600.
12. Bousquet J, Maasch H, Martinot B, Hejjaoui A, Wahl R, Michel FB. Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. II. Comparison between parameters assessing the efficacy of immunotherapy. J Allergy Clin Immunol 1988;82:439-46.
13. Lichtenstein LM, Ishizaka K, Norman PS, Sobotka AK, Hill BM. IgE antibody measurements in ragweed hay fever. Relationship to clinical severity and the results of immunotherapy. J Clin Invest 1973;52:472-82.
14. Evans R, Pence H, Kaplan H, Rocklin RE. The effect of immunotherapy on humoral and cellular responses in ragweed hay fever. J Clin Invest 1976;57:1378-85.
15. Romagnani S, Biliotti G, Passaleva A, Ricci M. In vitro lymphocyte response to pollen extract constituents in grass pollen-sensitive individuals, Int Arch Allergy Appl Immunol 1973;44:40-50.
16. Durham SR, Varney V, Gaga M, Frew AJ, Jacobson M. Kay AB. Immunotherapy and allergic inflammation. Clin Exp Allergy 1991;21 Suppl 1:206-10.
17. Ebner C, Szepfalusi Z, Ferreira F, et al. Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol 1993;150:1047-54.
18. Ebner C, Schenk S, Szepfalusi Z, et al. Multiple T cell specificities for Bet v I, the major birch pollen allergen, within single individuals. Studies using specific T cell clones and overlapping peptides. Eur J Immunol 1993;23:1523-7.
19. Ebner C, Siemann U, Najafian N, Scheiner O, Kraft D. Characterization of allergen (Bet v 1)-specific T cell lines and clones from non-allergic individuals. Int Arch Allergy Immunol 1995;107:183-5.
20. Jutel M, Pichler WJ, Skrbic D, Urwyler A, Dahinden C, Müller UR. Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. J Immunol 1995;154:4187-94.
21. McHugh SM, Deighton J, Stew AG, Lachmann PJ, Ewan PW. Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapy. Clin Exp Allergy 1995;25:828-38.
22. Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT. Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 1993;178:2123-30.
23. Varney VA, Hamid QA, Gaga M, et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993;92:644-51.
24. Moller C, Dreborg S, Einarsson R. Immunotherapy to deciduous tree pollens: specific IgE and IgG antibody patterns. Clin Allergy 1987;17:551-62.
25. Djurup R, Østerballe O. IgG subclass antibody response in grass pollen-allergic patients undergoing specific immunotherapy. Prognostic value of serum IgG subclass antibody levels early in immunotherapy. Allergy 1984; 39:433-41.
26. Ohman JL Jr. Allergen immunotherapy. Review of efficacy and current practice. Med Clin North Am 1992;76:977-91.