Cutting edge: Guinea pigs with a natural C3a-receptor defect exhibit decreased bronchoconstriction in allergic airway disease: Evidence for an involvement of the C3a anaphylatoxin in the pathogenesis of asthma

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5401-5405

  Bautsch, W ^a   Hoymann, H G ^a   Zhang, Q ^a   Meier Wiedenbach, I ^a   Raschke, U ^a   Ames, R S ^a   Sohns, B ^a   Flemme, N ^a   Zu Vilsendorf, A M ^a   Grove, M ^a   Klos, A ^a   Kohl, J ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT COMPONENT C3A;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; FEMALE; GENE FUNCTION; GUINEA PIG; IMMUNOPATHOGENESIS; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STOP CODON;

EID: 0034669961     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5401     Document Type: Article

References (33)

1. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema
2. Induction and regulation of the IgE response
3. Treatment of allergic asthma with monoclonal anti-IgE antibody: rhuMAb-E25 study group
4. A genomewide search for asthma susceptibility loci in ethnically diverse populations
5. Tumour necrosis factor haplotypes and asthma
6. Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes
7. Anaphylatoxins and biological responses
8. Immunopharmacology of anaphylatoxin-induced bronchoconstrictor responses
9. Synergism between inflammatory mediators in vivo: Induction of airway hyperresponsiveness to C3a in the guinea pig
10. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1
11. C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway
12. C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation
13. A comparison of C3a and C5a-mediated- stable adhesion of rolling eosinophils in postcapillary venules and transendothelial migration in vitro and in vivo
14. Molecular cloning and characterization of the human anaphylatoxin C3a receptor
15. Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells
16. The mouse anaphylatoxin C3a receptor: Molecular cloning, genomic organization, and functional expression
17. Cloning and characterization of rat C3a receptor: Differential expression of rat C3a and C5a receptors by LPS stimulation
18. Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor
19. Molecular cloning of two isoforms of the guinea pig C3a anaphylatoxin receptor: Alternative splicing in the large extracellular loop
20. ELISA of complement C3a in bronchoalveolar lavage fluid
21. Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase
22. Guinea pigs deficient in C2, C4, C3 or the C3a receptor
23. Minor role of the C3a receptor in systemic anaphylaxis in the guinea pig
24. Chimeric receptors of the human C3a receptor and C5a receptor (CD88)
25. The human C3a receptor is expressed on neutrophils and monocytes but not on B or T lymphocytes
26. Measurement of lung function in rodents in vivo
27. A noninvasive technique for measurement of changes in specific airways resistance
28. A new aerosol generating device for use in animal physiology
29. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: Analysis in a guinea pig model in vivo
30. Regulation of B cell functions by C3a and C3a(desArg): Suppression of TNF-α, IL-6, and the polyclonal immune response
31. Human T lymphocytes express the C3a receptor
32. Temporal relationships between leukocytes, IL-5 and IL-8 in guinea pig lungs, plasma cortisol and airway function after antigen challenge
33. A role for the C3a anaphylatoxin in the effector phase of asthma