메뉴 건너뛰기




Volumn 56, Issue 3, 1999, Pages 464-472

A novel domain of the inhibitory glycine receptor determining antagonist efficacies: Further evidence for partial agonism resulting from self- inhibition

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 METHYLPROPIONIC ACID; ALANINE; GLYCINE; GLYCINE RECEPTOR; ISOBUTYRIC ACID; LYSINE; MUTANT PROTEIN; NIPECOTIC ACID; PHENYLALANINE; PROTEIN SUBUNIT; STRYCHNINE; TAURINE; THREONINE;

EID: 0032868182     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.3.464     Document Type: Article
Times cited : (45)

References (31)
  • 1
    • 0024286313 scopus 로고
    • Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord
    • Akagi H and Miledi R (1988) Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord. Science (Wash DC) 242:270-273.
    • (1988) Science (Wash DC) , vol.242 , pp. 270-273
    • Akagi, H.1    Miledi, R.2
  • 2
    • 0028845059 scopus 로고
    • Nonlinear regression using spreadsheets
    • Bowen WP and Jennan JC (1995) Nonlinear regression using spreadsheets. Trends Pharmacol Sci 16:413-417.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 413-417
    • Bowen, W.P.1    Jennan, J.C.2
  • 3
    • 0031452190 scopus 로고    scopus 로고
    • Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human γ-aminobutyric acid type A receptors
    • Ebert B, Thompson SA, Saounatsou K, McKernan R, Krogsgaard-Larsen P and Wafford KA (1997) Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human γ-aminobutyric acid type A receptors. Mol Pharmacol 52:1150-1156.
    • (1997) Mol Pharmacol , vol.52 , pp. 1150-1156
    • Ebert, B.1    Thompson, S.A.2    Saounatsou, K.3    McKernan, R.4    Krogsgaard-Larsen, P.5    Wafford, K.A.6
  • 5
    • 0029046913 scopus 로고
    • Neuronal nicotinic receptors: Molecular organization and regulations
    • Galzi JL and Changeux JP (1995) Neuronal nicotinic receptors: Molecular organization and regulations. Neuropharmacology 34:563-582.
    • (1995) Neuropharmacology , vol.34 , pp. 563-582
    • Galzi, J.L.1    Changeux, J.P.2
  • 7
    • 0020570727 scopus 로고
    • Photoaffinity-labelling of the glycine receptor of rat spinal cord
    • Graham D, Pfeiffer F and Bet H (1983) Photoaffinity-labelling of the glycine receptor of rat spinal cord. Eur J Biochem 131:519-525.
    • (1983) Eur J Biochem , vol.131 , pp. 519-525
    • Graham, D.1    Pfeiffer, F.2    Bet, H.3
  • 9
    • 0002651548 scopus 로고
    • NMR studies of solution conformations of physiologically active ammo-acids
    • (Bergmann ED and Pullman B eds), Reidel Publ. Co., Dordrecht, the Netherlands.
    • Ham NS (1974) NMR studies of solution conformations of physiologically active ammo-acids, in Molecular and Quantum Pharmacology (Bergmann ED and Pullman B eds) pp 261-268, Reidel Publ. Co., Dordrecht, the Netherlands.
    • (1974) Molecular and Quantum Pharmacology , pp. 261-268
    • Ham, N.S.1
  • 10
    • 0023727310 scopus 로고
    • Taurine modulates glycine response in Xenopus oocytes injected with messenger RNA from mouse brain
    • Horikoshi T, Asanuma A, Yanagisawa K and Goto S (1988) Taurine modulates glycine response in Xenopus oocytes injected with messenger RNA from mouse brain. Mol Brain Res 4:242-246.
    • (1988) Mol Brain Res , vol.4 , pp. 242-246
    • Horikoshi, T.1    Asanuma, A.2    Yanagisawa, K.3    Goto, S.4
  • 12
    • 0029044590 scopus 로고
    • The inhibitory glycine receptor: Architecture, aynaptic localization and molecular pathology of a postsynaptic ion-channel complex
    • Kuhse J, Betz H and Kirsch J (1995) The inhibitory glycine receptor: Architecture, aynaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr Opin Neurobiol 5:318-323.
    • (1995) Curr Opin Neurobiol , vol.5 , pp. 318-323
    • Kuhse, J.1    Betz, H.2    Kirsch, J.3
  • 13
    • 0028016521 scopus 로고
    • Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia
    • Langosch D, Laube B, Rundström N, Schmieden V, Bormann J and Betz H (1994) Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia. EMBO J 13:4223-4228.
    • (1994) EMBO J , vol.13 , pp. 4223-4228
    • Langosch, D.1    Laube, B.2    Rundström, N.3    Schmieden, V.4    Bormann, J.5    Betz, H.6
  • 14
    • 0028950255 scopus 로고
    • The two-state model of receptor activation
    • Leff P (1995) The two-state model of receptor activation. Trends Pharmacol Sci 16:89-96.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 89-96
    • Leff, P.1
  • 15
    • 0026059333 scopus 로고
    • Characterization of glycinergic receptors present in cultured rat medullary neurons
    • Lewis CC, Ahmed Z and Faber DA (1991) Characterization of glycinergic receptors present in cultured rat medullary neurons. J Neurophysiol (Bethesda) 66:1291-1303.
    • (1991) J Neurophysiol (Bethesda) , vol.66 , pp. 1291-1303
    • Lewis, C.C.1    Ahmed, Z.2    Faber, D.A.3
  • 16
    • 0032520102 scopus 로고    scopus 로고
    • Properties of human glycine receptors containing the hyperekplexia mutation α1(K276E), expressed in Xenopus oocytes
    • Lewis TM, Sivilotti LG, Colquhoun D, Gardiner RM, Schoepfer R and Rees M (1998) Properties of human glycine receptors containing the hyperekplexia mutation α1(K276E), expressed in Xenopus oocytes. J P7hysiol (Lond) 507:25-40.
    • (1998) J P7hysiol (Lond) , vol.507 , pp. 25-40
    • Lewis, T.M.1    Sivilotti, L.G.2    Colquhoun, D.3    Gardiner, R.M.4    Schoepfer, R.5    Rees, M.6
  • 17
    • 78651189765 scopus 로고
    • On the nature of allosteric transitions: A plausible model
    • Monod J, Wyman J and Changeux JP (1965) On the nature of allosteric transitions: A plausible model. J Mol Biol 12:88-118.
    • (1965) J Mol Biol , vol.12 , pp. 88-118
    • Monod, J.1    Wyman, J.2    Changeux, J.P.3
  • 18
    • 0028361803 scopus 로고
    • Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor
    • Rajendra S, Lynch JW, Pierce KB, French CR, Barry PH and Schofield PR (1994) Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor. J Bid Chem 269:18739-18742.
    • (1994) J Bid Chem , vol.269 , pp. 18739-18742
    • Rajendra, S.1    Lynch, J.W.2    Pierce, K.B.3    French, C.R.4    Barry, P.H.5    Schofield, P.R.6
  • 21
    • 0027977932 scopus 로고
    • Point mutation of glycine receptor al subunit in the spasmodic mouse affects agonist responses
    • Saul B, Schmieden V, Kling C, Mülhardt C, Gass P, Kuhse J and Becker C-M (1994) Point mutation of glycine receptor al subunit in the spasmodic mouse affects agonist responses. FEBS Lett 350:71-76.
    • (1994) FEBS Lett , vol.350 , pp. 71-76
    • Saul, B.1    Schmieden, V.2    Kling, C.3    Mülhardt, C.4    Gass, P.5    Kuhse, J.6    Becker, C.-M.7
  • 22
    • 0028810726 scopus 로고
    • Pharmacology of the inhibitory glycine receptor: Agonist and antagonist action of ammo acids and piperidine carboxylic acid compounds
    • Schmieden V and Betz H (1995) Pharmacology of the inhibitory glycine receptor: Agonist and antagonist action of ammo acids and piperidine carboxylic acid compounds. Mol Pharmacol 48:919-927.
    • (1995) Mol Pharmacol , vol.48 , pp. 919-927
    • Schmieden, V.1    Betz, H.2
  • 23
    • 0024438902 scopus 로고
    • Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor
    • Schmieden V, Grenningloh G, Schofield PR and Betz H (1989) Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor. EMBO J 8:695-700.
    • (1989) EMBO J , vol.8 , pp. 695-700
    • Schmieden, V.1    Grenningloh, G.2    Schofield, P.R.3    Betz, H.4
  • 24
    • 0029837997 scopus 로고    scopus 로고
    • Novel antagonists of the inhibitory glycine receptor derived from quinolinic acid compounds
    • Schmieden V, Jezequel S and Betz H (1996) Novel antagonists of the inhibitory glycine receptor derived from quinolinic acid compounds. Mol Pharmacol 50:1200-1206.
    • (1996) Mol Pharmacol , vol.50 , pp. 1200-1206
    • Schmieden, V.1    Jezequel, S.2    Betz, H.3
  • 25
    • 0026607904 scopus 로고
    • Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: Identification of amino acid residues involved in taurine activation
    • Schmieden V, Kuhse J and Betz H (1992) Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: Identification of amino acid residues involved in taurine activation. EMBO J 11:2025-2032.
    • (1992) EMBO J , vol.11 , pp. 2025-2032
    • Schmieden, V.1    Kuhse, J.2    Betz, H.3
  • 26
    • 0027424165 scopus 로고
    • Mutation of glycine receptor subunit creates β-alanine receptor responsive to GABA
    • Schmieden V, Kuhse J and Betz H (1993) Mutation of glycine receptor subunit creates β-alanine receptor responsive to GABA. Science (Wash DC) 262:256-258.
    • (1993) Science (Wash DC) , vol.262 , pp. 256-258
    • Schmieden, V.1    Kuhse, J.2    Betz, H.3
  • 29
    • 85121064073 scopus 로고
    • What confers specificity on glycine for its receptor site?
    • Tokutomi N, Kaneda M and Akaike N (1989) What confers specificity on glycine for its receptor site? Br J Pharmacol 87:363-360.
    • (1989) Br J Pharmacol , vol.87 , pp. 363-1360
    • Tokutomi, N.1    Kaneda, M.2    Akaike, N.3
  • 30
    • 0026536645 scopus 로고
    • Antagonism of ligand-gated ion channel receptors: Two domains of the glycine receptor a subunit form the strychnine-binding site
    • Vandenberg RJ, French CR, Barry PH, Shine J and Schofield R (1992a) Antagonism of ligand-gated ion channel receptors: Two domains of the glycine receptor a subunit form the strychnine-binding site. Proc Natl Acad Sci USA 89:1764-1769.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1764-1769
    • Vandenberg, R.J.1    French, C.R.2    Barry, P.H.3    Shine, J.4    Schofield, R.5
  • 31
    • 0026787189 scopus 로고
    • Distinct agonist- and antagonist-binding sites on the glycine receptor
    • Vandenberg RJ, Handford CA and Schofield R (1992b) Distinct agonist- and antagonist-binding sites on the glycine receptor. Neuron 9:491-496.
    • (1992) Neuron , vol.9 , pp. 491-496
    • Vandenberg, R.J.1    Handford, C.A.2    Schofield, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.