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Volumn 1138, Issue , 2008, Pages 181-198

Review of the apoptosis pathways in pancreatic cancer and the anti-apoptotic effects of the novel sea cucumber compound, frondoside A

Author keywords

Apoptosis pathways; Frondoside A; Pancreatic cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 9; FRONDOSIDE A; LIPOCORTIN 5; NATURAL PRODUCT; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN P21; THYMIDINE; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 53149130259     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1414.025     Document Type: Conference Paper
Times cited : (77)

References (87)
  • 2
    • 33745649188 scopus 로고    scopus 로고
    • Locally advanced pancreatic cancer: Current therapeutic approach
    • Cardenes, H.R., E.G. Chiorean, J.J. DeWitt, et al. 2006. Locally advanced pancreatic cancer: current therapeutic approach. Ocologist 11 : 612 623.
    • (2006) Ocologist , vol.11 , pp. 612-623
    • Cardenes, H.R.1    Chiorean, E.G.2    Dewitt, J.J.3
  • 3
    • 0027195774 scopus 로고
    • One hundred and forty-five consecutive pancreatico-duodenectomies without mortality
    • &
    • Cameron, J.L., H.A. Pitt & C.J. Yeo. 1993. One hundred and forty-five consecutive pancreatico-duodenectomies without mortality. Ann. Surg. 217 : 430 438.
    • (1993) Ann. Surg. , vol.217 , pp. 430-438
    • Cameron, J.L.1    Pitt, H.A.2    Yeo, C.J.3
  • 4
    • 14544270277 scopus 로고    scopus 로고
    • Does anyone survive pancreatic ductal adenocarcinoma? a nationwide study re-evaluating the data of the Finnish Cancer Registry
    • Carpelan-Holmström, M., S. Nordling, E. Pukkala, et al. 2005. Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Pancreas 54 : 385 387.
    • (2005) Pancreas , vol.54 , pp. 385-387
    • Carpelan-Holmström, M.1    Nordling, S.2    Pukkala, E.3
  • 5
    • 0033804934 scopus 로고    scopus 로고
    • New direction in systemic therapy of pancreatic cancer
    • &
    • Serafini, F.M. & A.S. Rosemurgy. 2000. New direction in systemic therapy of pancreatic cancer. Cancer Control 7 : 437 444.
    • (2000) Cancer Control , vol.7 , pp. 437-444
    • Serafini, F.M.1    Rosemurgy, A.S.2
  • 6
    • 33746042207 scopus 로고    scopus 로고
    • Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer
    • Giovannetti, E., V. Mey, S. Nannizzi, et al. 2006. Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. Mol. Cancer Ther. 6 : 1387 1395.
    • (2006) Mol. Cancer Ther. , vol.6 , pp. 1387-1395
    • Giovannetti, E.1    Mey, V.2    Nannizzi, S.3
  • 7
    • 33846816556 scopus 로고    scopus 로고
    • Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
    • Nakano, Y., S. Tanno, K. Koizumi, et al. 2007. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br. J. Cancer 96 : 457 463.
    • (2007) Br. J. Cancer , vol.96 , pp. 457-463
    • Nakano, Y.1    Tanno, S.2    Koizumi, K.3
  • 8
    • 33748540080 scopus 로고    scopus 로고
    • Molecular pathogenesis of pancreatic adenocarcinoma: Potential clinical implications
    • &
    • Talar-Wojnarowska, R. & E. Malecka-Panas. 2006. Molecular pathogenesis of pancreatic adenocarcinoma: potential clinical implications. Med. Sci. Monit. 2 : 186 193.
    • (2006) Med. Sci. Monit. , vol.2 , pp. 186-193
    • Talar-Wojnarowska, R.1    Malecka-Panas, E.2
  • 9
    • 1642312315 scopus 로고    scopus 로고
    • Genetic alterations in pancreatic carcinoma
    • &
    • Schneider, G. & R.M. Schmid. 2003. Genetic alterations in pancreatic carcinoma. Mol. Cancer 2 : 15.
    • (2003) Mol. Cancer , vol.2 , pp. 15
    • Schneider, G.1    Schmid, R.M.2
  • 10
    • 3543092021 scopus 로고    scopus 로고
    • Pathways of apoptotic and non-apoptotic death in tumor cells
    • &
    • Okada, H. & T.W. Mak. 2004. Pathways of apoptotic and non-apoptotic death in tumor cells. Nature Rev. Cancer 4 : 592 603.
    • (2004) Nature Rev. Cancer , vol.4 , pp. 592-603
    • Okada, H.1    Mak, T.W.2
  • 11
  • 12
    • 0035258678 scopus 로고    scopus 로고
    • Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway
    • Elnemr, A., T. Ohta, A. Yachie, et al. 2001. Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway. Int. J. Oncol. 2 : 311 316.
    • (2001) Int. J. Oncol. , vol.2 , pp. 311-316
    • Elnemr, A.1    Ohta, T.2    Yachie, A.3
  • 13
    • 0035120415 scopus 로고    scopus 로고
    • Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells
    • Matsuzaki, H., B.M. Schmied, A. Ulrich, et al. 2001. Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells. Clin. Cancer Res. 2 : 407 414.
    • (2001) Clin. Cancer Res. , vol.2 , pp. 407-414
    • Matsuzaki, H.1    Schmied, B.M.2    Ulrich, A.3
  • 14
    • 33846222280 scopus 로고    scopus 로고
    • Regulation of TRAIL-induced apoptosis by XIAP in pancreatic cancer cells
    • Vogler, M., K. Durr, M. Jovanovic, et al. 2007. Regulation of TRAIL-induced apoptosis by XIAP in pancreatic cancer cells. Oncogene 26 : 248 257.
    • (2007) Oncogene , vol.26 , pp. 248-257
    • Vogler, M.1    Durr, K.2    Jovanovic, M.3
  • 15
    • 0034676268 scopus 로고    scopus 로고
    • L protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis
    • L protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor- mediated apoptosis. Oncogene 19 : 5477 5486.
    • (2000) Oncogene , vol.19 , pp. 5477-5486
    • Hinz, S.1    Trauzold, A.2    Boenicke, L.3
  • 16
    • 0041592591 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis in pancreatic cancer cells via changes in cell cycle, caspase activation, and GADD expression
    • &
    • Li, X., X. Ding & T.E. Adrian. 2003. Arsenic trioxide induces apoptosis in pancreatic cancer cells via changes in cell cycle, caspase activation, and GADD expression. Pancreas 27 : 174 179.
    • (2003) Pancreas , vol.27 , pp. 174-179
    • Li, X.1    Ding, X.2    Adrian, T.E.3
  • 17
    • 0036728051 scopus 로고    scopus 로고
    • Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway
    • &
    • Tong, W.G., X.Z. Ding, R.C. Witt & T.E. Adrian. 2002. Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. Mol. Cancer Ther. 1 : 929 935.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 929-935
    • Tong, W.G.1    Ding, X.Z.2    Witt, R.C.3    Adrian, T.E.4
  • 18
    • 0032515874 scopus 로고    scopus 로고
    • L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
    • L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl. Acad. Sci. U.S.A. 95 : 4386 4391.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 4386-4391
    • Hu, Y.1    Benedict, M.A.2    Wu, D.3
  • 19
    • 0035888180 scopus 로고    scopus 로고
    • L antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine
    • L antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine. Int. J. Cancer 94 : 268 274.
    • (2001) Int. J. Cancer , vol.94 , pp. 268-274
    • Xu, Z.1    Friess, H.2    Solioz, M.3
  • 20
    • 0036057585 scopus 로고    scopus 로고
    • Acquired resistance of pancreatic cancer cells towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes
    • Shi, X., S. Liu, J. Kleeff, et al. 2002. Acquired resistance of pancreatic cancer cells towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes. Oncology 62 : 354 362.
    • (2002) Oncology , vol.62 , pp. 354-362
    • Shi, X.1    Liu, S.2    Kleeff, J.3
  • 21
    • 0036092840 scopus 로고    scopus 로고
    • Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents
    • &
    • Xu, Z.W., H. Friess, M.W. Büchler & M. Solioz. 2002. Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents. Cancer Chemother. Pharmacol. 49 : 504 510.
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , pp. 504-510
    • Xu, Z.W.1    Friess, H.2    Büchler, M.W.3    Solioz, M.4
  • 22
    • 0036710477 scopus 로고    scopus 로고
    • Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs
    • &
    • Baell, J.B. & D.C. Huang. 2002. Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs. Biochem. Pharmacol. 64 : 851 863.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 851-863
    • Baell, J.B.1    Huang, D.C.2
  • 23
    • 0035192884 scopus 로고    scopus 로고
    • FLICE-inhibitory proteins: Regulators of death receptor-mediated apoptosis
    • &
    • Krueger, A., S. Baumann, P.H. Krammer & S. Kirchoff. 2001. FLICE-inhibitory proteins: Regulators of death receptor-mediated apoptosis. Mol. Cell Biol. 21 : 8247 8254.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 8247-8254
    • Krueger, A.1    Baumann, S.2    Krammer, P.H.3    Kirchoff, S.4
  • 24
    • 0037151079 scopus 로고    scopus 로고
    • An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis
    • &
    • Kim, Y., N. Suh, M. Sporn & J.C. Reed. 2002. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J. Biol. Chem. 277 : 22320 22329.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22320-22329
    • Kim, Y.1    Suh, N.2    Sporn, M.3    Reed, J.C.4
  • 25
    • 18744425429 scopus 로고    scopus 로고
    • The caspase-8 inhibitor FLIP promotes activation of NFκB and Erk signaling pathways
    • Kataoka, T., R.C. Budd, N. Holler, et al. 2000. The caspase-8 inhibitor FLIP promotes activation of NFκB and Erk signaling pathways. Curr. Biol. 10 : 640 648.
    • (2000) Curr. Biol. , vol.10 , pp. 640-648
    • Kataoka, T.1    Budd, R.C.2    Holler, N.3
  • 26
    • 0036709174 scopus 로고    scopus 로고
    • Nuclear factor-κ-B and cancer: Its role in prevention and therapy
    • &
    • Bharti, A.C. & B.B. Aggarwal. 2002. Nuclear factor-κ-B and cancer: Its role in prevention and therapy. Biochem. Pharmacol. 64 : 883 888.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 883-888
    • Bharti, A.C.1    Aggarwal, B.B.2
  • 27
    • 0033082995 scopus 로고    scopus 로고
    • IAP family proteins-suppressors of apoptosis
    • &
    • Deveraux, Q.L. & J.C. Reed. 1999. IAP family proteins-suppressors of apoptosis. Genes Dev. 13 : 239 252.
    • (1999) Genes Dev. , vol.13 , pp. 239-252
    • Deveraux, Q.L.1    Reed, J.C.2
  • 28
    • 0032403126 scopus 로고    scopus 로고
    • IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
    • Tamm, I., Y. Wang, E. Sausville, et al. 1998. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 58 : 5315 5320.
    • (1998) Cancer Res. , vol.58 , pp. 5315-5320
    • Tamm, I.1    Wang, Y.2    Sausville, E.3
  • 29
    • 33745877926 scopus 로고    scopus 로고
    • Survivin expression in pancreatic intraepithelial neoplasia (PanIN): Steady increase along the developmental stages of pancreatic ductal adenocarcinoma
    • &
    • Bhanot, U., R. Heydrich, P. Moller & C. Hasel. 2006. Survivin expression in pancreatic intraepithelial neoplasia (PanIN): steady increase along the developmental stages of pancreatic ductal adenocarcinoma. Am. J. Surg. Pathol. 30 : 754 759.
    • (2006) Am. J. Surg. Pathol. , vol.30 , pp. 754-759
    • Bhanot, U.1    Heydrich, R.2    Moller, P.3    Hasel, C.4
  • 30
    • 33750690650 scopus 로고    scopus 로고
    • Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance in pancreatic cancer cells
    • Shrikhande, S.V., J. Kleeff, H. Kayed, et al. 2006. Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance in pancreatic cancer cells. Anticancer Res. 26 : 3265 3273.
    • (2006) Anticancer Res. , vol.26 , pp. 3265-3273
    • Shrikhande, S.V.1    Kleeff, J.2    Kayed, H.3
  • 31
    • 33646703545 scopus 로고    scopus 로고
    • XIAP is related to the chemoresistance and inhibited its expression by RNA interference sensitize pancreatic carcinoma cells to chemotherapeutics
    • Li, Y., Z. Jian, K. Xia, et al. 2006. XIAP is related to the chemoresistance and inhibited its expression by RNA interference sensitize pancreatic carcinoma cells to chemotherapeutics. Pancreas 32 : 288 296.
    • (2006) Pancreas , vol.32 , pp. 288-296
    • Li, Y.1    Jian, Z.2    Xia, K.3
  • 32
    • 33744467714 scopus 로고    scopus 로고
    • Down-regulation of survivin expression by small interfering RNA induces pancreatic cancer cell apoptosis and enhances its radiosensitivity
    • Guan, H.T., X.H. Xue, Z.J. Dai, et al. 2006. Down-regulation of survivin expression by small interfering RNA induces pancreatic cancer cell apoptosis and enhances its radiosensitivity. World J. Gastroenterol. 12 : 2901 2907.
    • (2006) World J. Gastroenterol. , vol.12 , pp. 2901-2907
    • Guan, H.T.1    Xue, X.H.2    Dai, Z.J.3
  • 33
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagan, A.M., P.G. Ekert, M. Pakusch, et al. 2000. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102 : 43 53.
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagan, A.M.1    Ekert, P.G.2    Pakusch, M.3
  • 34
    • 0347895102 scopus 로고    scopus 로고
    • Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP in situ
    • Arnt, C.R., M.V. Chiorean, M.P. Heldebrant, et al. 2002. Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP in situ. J. Biol. Chem. 277 : 44236 44243.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44236-44243
    • Arnt, C.R.1    Chiorean, M.V.2    Heldebrant, M.P.3
  • 35
    • 0033753206 scopus 로고    scopus 로고
    • The pattern of CPP32/caspase-3 expression reflects the biological behavior of the human pancreatic duct cell tumors
    • Satoh, K., K. Kaneko, M. Hirota, et al. 2000. The pattern of CPP32/caspase-3 expression reflects the biological behavior of the human pancreatic duct cell tumors. Pancreas 21 : 532 537.
    • (2000) Pancreas , vol.21 , pp. 532-537
    • Satoh, K.1    Kaneko, K.2    Hirota, M.3
  • 36
    • 14344272939 scopus 로고    scopus 로고
    • Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide
    • Roy, S., C.I. Bayly, Y. Gareau, et al. 2001. Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide. Proc. Natl. Acad. Sci. U.S.A. 98 : 6132 6137.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 6132-6137
    • Roy, S.1    Bayly, C.I.2    Gareau, Y.3
  • 37
    • 33748759801 scopus 로고    scopus 로고
    • Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
    • Putt, K.S., G.W. Chen, J.M. Pearson, et al. 2006. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nature Chem. Biol. 2 : 543 550.
    • (2006) Nature Chem. Biol. , vol.2 , pp. 543-550
    • Putt, K.S.1    Chen, G.W.2    Pearson, J.M.3
  • 40
    • 0037008761 scopus 로고    scopus 로고
    • Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
    • Gilmore, A.P., A.J. Valentjin, P. Wang, et al. 2002. Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. J. Biol. Chem. 277 : 27643 27650.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27643-27650
    • Gilmore, A.P.1    Valentjin, A.J.2    Wang, P.3
  • 41
    • 0034727895 scopus 로고    scopus 로고
    • Caspase-9: Involvement in secondary death of axotomized rat retinal ganglion cells in vivo
    • Kermer, P., R. Ankerhold, N. Klocker, et al. 2000. Caspase-9: Involvement in secondary death of axotomized rat retinal ganglion cells in vivo. Brain Res. Mol. Brain Res. 85 : 144 150.
    • (2000) Brain Res. Mol. Brain Res. , vol.85 , pp. 144-150
    • Kermer, P.1    Ankerhold, R.2    Klocker, N.3
  • 42
    • 0034307305 scopus 로고    scopus 로고
    • Inhibition of phophatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
    • &
    • Ng, S.S.W., M.S. Tsao, S. Chow & D.W. Hedley. 2000. Inhibition of phophatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res. 60 : 5451 5455.
    • (2000) Cancer Res. , vol.60 , pp. 5451-5455
    • Ng, S.S.W.1    Tsao, M.S.2    Chow, S.3    Hedley, D.W.4
  • 43
    • 0034792844 scopus 로고    scopus 로고
    • Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice
    • &
    • Ng, S.S., M.S. Tsau, T. Nicklee & D.W. Hedley. 2001. Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice. Clin. Cancer Res. 7 : 3269 3275.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3269-3275
    • Ng, S.S.1    Tsau, M.S.2    Nicklee, T.3    Hedley, D.W.4
  • 44
    • 0026462778 scopus 로고
    • Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with comcomitant increases in the level of epidermal growth factor and transforming growth factor alpha
    • Korc, M., B. Chandraseker, Y. Yamanaka, et al. 1992. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with comcomitant increases in the level of epidermal growth factor and transforming growth factor alpha. J. Clin. Invest. 90 : 1352 1360.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1352-1360
    • Korc, M.1    Chandraseker, B.2    Yamanaka, Y.3
  • 45
    • 33746784713 scopus 로고    scopus 로고
    • On the mechanisms of 12-otetradecanoylphorbol-13-acetate -induced growth arrest in pancreatic cancer cells
    • Salabat, M.R., X.Z. Ding, J.B. Flesche, et al. 2006. On the mechanisms of 12-otetradecanoylphorbol-13-acetate -induced growth arrest in pancreatic cancer cells. Pancreas 33 : 148 155.
    • (2006) Pancreas , vol.33 , pp. 148-155
    • Salabat, M.R.1    Ding, X.Z.2    Flesche, J.B.3
  • 46
    • 32444441115 scopus 로고    scopus 로고
    • PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
    • Bivona, T.G., S.E. Quatela, B.O. Bodemann, et al. 2006. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol. Cell 21 : 481 493.
    • (2006) Mol. Cell , vol.21 , pp. 481-493
    • Bivona, T.G.1    Quatela, S.E.2    Bodemann, B.O.3
  • 47
    • 27644460508 scopus 로고    scopus 로고
    • Erlotinib improves survival when added to gemcitabine in patients with advanced pancreatic cancer. a phase III trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG)
    • Moore, M.J., D. Goldstein, J. Hamm, et al. 2005. Erlotinib improves survival when added to gemcitabine in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG). J. Clin. Oncology 23 (Suppl. 1.
    • (2005) J. Clin. Oncology , vol.23 , pp. 1
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 49
    • 33846220461 scopus 로고    scopus 로고
    • Epidermal growth factor receptor kinase domaine mutations in esophageal and pancreatic adenocarcinomas.
    • Kwak, E.L., J. Jankowski, S.P. Thayer, et al. 2006. Epidermal growth factor receptor kinase domaine mutations in esophageal and pancreatic adenocarcinomas. Clin. Cancer Res. 12 : 4283 4287.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4283-4287
    • Kwak, E.L.1    Jankowski, J.2    Thayer, S.P.3
  • 50
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
    • Xiong, H.Q., A. Rosenberg, A. LoBuglio, et al. 2004. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II trial. J. Clin. Oncol. 22 : 2610 2616.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lobuglio, A.3
  • 51
    • 33646504884 scopus 로고    scopus 로고
    • Phase I study of the humanized anti-EGFR monoclonal antibody matuzumab (EMD
    • 72000) combined with gemcitabine in advanced pancreatic cancer.
    • Graeven, U., B. Kremer, T. Sudhoff, et al. 2006. Phase I study of the humanized anti-EGFR monoclonal antibody matuzumab (EMD 72000) combined with gemcitabine in advanced pancreatic cancer. Br. J. Cancer 94 : 1293 1299.
    • (2006) Br. J. Cancer , vol.94 , pp. 1293-1299
    • Graeven, U.1    Kremer, B.2    Sudhoff, T.3
  • 53
    • 19944429073 scopus 로고    scopus 로고
    • Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress Her-2/neu
    • Safran, H., D. Iannitti, R. Ramanathan, et al. 2004. Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress Her-2/neu. Cancer Invest. 22 : 706 712.
    • (2004) Cancer Invest. , vol.22 , pp. 706-712
    • Safran, H.1    Iannitti, D.2    Ramanathan, R.3
  • 54
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • &
    • Karin, M. & A. Lin. 2002. NF-κB at the crossroads of life and death. Nature Immunol. 3 : 221 222.
    • (2002) Nature Immunol. , vol.3 , pp. 221-222
    • Karin, M.1    Lin, A.2
  • 55
    • 0035864344 scopus 로고    scopus 로고
    • Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin
    • Arlt, A., J. Vorndamm, M. Breitenbroich, et al. 2001. Inhibition of NF-κB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene 20 : 859 868.
    • (2001) Oncogene , vol.20 , pp. 859-868
    • Arlt, A.1    Vorndamm, J.2    Breitenbroich, M.3
  • 56
    • 23044498269 scopus 로고    scopus 로고
    • Inactivation of nuclear factor κb by soy isoflavone genestein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    • Li, Y., F. Ahmed, S. Ali, et al. 2005. Inactivation of nuclear factor κB by soy isoflavone genestein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res. 65 : 6934 6942.
    • (2005) Cancer Res. , vol.65 , pp. 6934-6942
    • Li, Y.1    Ahmed, F.2    Ali, S.3
  • 57
    • 0035114253 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of p53 and p16 (INK4a) results in pancreatic cancer regression in vitro and in vivo
    • Ghaneh, P., W. Greenhalf, M. Humphreys, et al. 2001. Adenovirus-mediated transfer of p53 and p16 (INK4a) results in pancreatic cancer regression in vitro and in vivo. Gene Ther. 8 : 199 208.
    • (2001) Gene Ther. , vol.8 , pp. 199-208
    • Ghaneh, P.1    Greenhalf, W.2    Humphreys, M.3
  • 58
    • 0033590192 scopus 로고    scopus 로고
    • Lipoxygenase inhibitors induce apoptosis, morphological changes and carbonic anhydrase expression in pancreatic cancer cells
    • &
    • Ding, X.Z., C.A. Kuszynski, T.H. El-Metwally & T.E. Adrian. 1999. Lipoxygenase inhibitors induce apoptosis, morphological changes and carbonic anhydrase expression in pancreatic cancer cells. Biochem. Biophys. Res. Comm. 266 : 392 399.
    • (1999) Biochem. Biophys. Res. Comm. , vol.266 , pp. 392-399
    • Ding, X.Z.1    Kuszynski, C.A.2    El-Metwally, T.H.3    Adrian, T.E.4
  • 59
    • 0033859744 scopus 로고    scopus 로고
    • Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells
    • &
    • Ding, X.Z., W.G. Tong & T.E. Adrian. 2000. Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Anticancer Res. 20 : 2625 2631.
    • (2000) Anticancer Res. , vol.20 , pp. 2625-2631
    • Ding, X.Z.1    Tong, W.G.2    Adrian, T.E.3
  • 60
    • 0036971423 scopus 로고    scopus 로고
    • 5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue
    • Hennig, R., X.Z. Ding, W.G. Tong, et al. 2002. 5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue. Am. J. Pathol. 161 : 421 428.
    • (2002) Am. J. Pathol. , vol.161 , pp. 421-428
    • Hennig, R.1    Ding, X.Z.2    Tong, W.G.3
  • 61
    • 22244445832 scopus 로고    scopus 로고
    • 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions
    • Hennig, R., P. Grippo, X.Z. Ding, et al. 2005. 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. Cancer Res. 65 : 6011 6016.
    • (2005) Cancer Res. , vol.65 , pp. 6011-6016
    • Hennig, R.1    Grippo, P.2    Ding, X.Z.3
  • 62
    • 0035545994 scopus 로고    scopus 로고
    • 12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation
    • &
    • Ding, X.Z., W.G. Tong & T.E. Adrian. 2001. 12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation. Int. J. Cancer 94 : 630 636.
    • (2001) Int. J. Cancer , vol.94 , pp. 630-636
    • Ding, X.Z.1    Tong, W.G.2    Adrian, T.E.3
  • 63
    • 0042175375 scopus 로고    scopus 로고
    • Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer
    • &
    • Ding, X.Z., W.G. Tong & T.E. Adrian. 2003. Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer. Oncology 65 : 285 294.
    • (2003) Oncology , vol.65 , pp. 285-294
    • Ding, X.Z.1    Tong, W.G.2    Adrian, T.E.3
  • 64
    • 0036795009 scopus 로고    scopus 로고
    • Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells
    • &
    • Tong, W.G., X.Z. Ding & T.E. Adrian. 2002. Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Clin. Cancer Res. 8 : 3232 3242.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3232-3242
    • Tong, W.G.1    Ding, X.Z.2    Adrian, T.E.3
  • 65
    • 20844460134 scopus 로고    scopus 로고
    • LY293111 improves efficacy of gemcitabine therapy on pancreatic cancer in a fluorescent orthotopic model in athymic mice
    • Hennig, R., J. Ventura, R. Segersvard, et al. 2005. LY293111 improves efficacy of gemcitabine therapy on pancreatic cancer in a fluorescent orthotopic model in athymic mice. Neoplasia 7 : 417 425.
    • (2005) Neoplasia , vol.7 , pp. 417-425
    • Hennig, R.1    Ventura, J.2    Segersvard, R.3
  • 66
    • 0036832620 scopus 로고    scopus 로고
    • Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells
    • &
    • Ding, X.Z. & T.E. Adrian. 2002. Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Pancreas 25 : e71 e76.
    • (2002) Pancreas , vol.25
    • Ding, X.Z.1    Adrian, T.E.2
  • 67
    • 33846653627 scopus 로고    scopus 로고
    • Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest
    • Ujiki, M.B., X.Z. Ding, M.R. Salabat, et al. 2006. Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. Mol. Cancer 5 : 76.
    • (2006) Mol. Cancer , vol.5 , pp. 76
    • Ujiki, M.B.1    Ding, X.Z.2    Salabat, M.R.3
  • 68
    • 33750685296 scopus 로고    scopus 로고
    • [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells
    • Park, Y.J., J. Wen, S. Bang, et al. 2005. [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei Med. J. 47 : 688 697.
    • (2005) Yonsei Med. J. , vol.47 , pp. 688-697
    • Park, Y.J.1    Wen, J.2    Bang, S.3
  • 69
    • 30544431590 scopus 로고    scopus 로고
    • A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest
    • Ujiki, M.B., B. Milam, X.Z. Ding, et al. 2006. A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest. Biochem. Biophys. Res. Commun. 340 : 1224 1228.
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 1224-1228
    • Ujiki, M.B.1    Milam, B.2    Ding, X.Z.3
  • 70
    • 0014489773 scopus 로고
    • A chemical investigation of the trepeng (Stychopus japonicus Selenka): The structure of triterpenoid aglycones obtained from trepeng glycosides
    • Elyakov, G.B., T.A. Kuznetsova, et al. 1969. A chemical investigation of the trepeng (Stychopus japonicus Selenka): the structure of triterpenoid aglycones obtained from trepeng glycosides. Tetrahedron Lett. 15 : 1151 1154.
    • (1969) Tetrahedron Lett. , vol.15 , pp. 1151-1154
    • Elyakov, G.B.1    Kuznetsova, T.A.2
  • 72
    • 0014623057 scopus 로고
    • Marine biotoxins: A new source of medicinals
    • Halstead, B.W. 1969. Marine biotoxins: a new source of medicinals. Lloydia 32 : 484 488.
    • (1969) Lloydia , vol.32 , pp. 484-488
    • Halstead, B.W.1
  • 73
    • 0030706171 scopus 로고    scopus 로고
    • Antitumor agents.180. Chemical studies and cytotoxic evaluation of cumingianosides and cumindysoside A, antileukemic triterpene glucosides with a 14, 18-cycloapotirucallane skeleton
    • Kashiwada, Y., T. Fujioka, K. Mihashi, et al. 1997. Antitumor agents.180. Chemical studies and cytotoxic evaluation of cumingianosides and cumindysoside A, antileukemic triterpene glucosides with a 14, 18-cycloapotirucallane skeleton. J. Nat. Prod. 60 : 1105 1114.
    • (1997) J. Nat. Prod. , vol.60 , pp. 1105-1114
    • Kashiwada, Y.1    Fujioka, T.2    Mihashi, K.3
  • 74
    • 0345051435 scopus 로고
    • Some pharmacologic properties of holothurin a a glycosidic mixture from the sea cucumber
    • Friess, S.L., F.G. Standaert, E.R. Whitcomb, et al. 1960. Some pharmacologic properties of holothurin A a glycosidic mixture from the sea cucumber. Ann. N. Y. Acad. Sci. 17 : 893 901.
    • (1960) Ann. N. Y. Acad. Sci. , vol.17 , pp. 893-901
    • Friess, S.L.1    Standaert, F.G.2    Whitcomb, E.R.3
  • 75
    • 0017097559 scopus 로고
    • Antineoplastic agents XLV: Sea cucumber cytotoxic saponins
    • &
    • Pettit, G.R., C.L. Herald & D.L. Herald. 1976. Antineoplastic agents XLV: sea cucumber cytotoxic saponins. J. Pharm. Sci. 65 : 1558 1559.
    • (1976) J. Pharm. Sci. , vol.65 , pp. 1558-1559
    • Pettit, G.R.1    Herald, C.L.2    Herald, D.L.3
  • 76
    • 53149085480 scopus 로고
    • Some pharmacologic properties of holothurin, an active neurotoxin from the sea cucumber
    • Friess, S.L., F.G. Standaert, E.R. Whitcomb, et al. 1959. Some pharmacologic properties of holothurin, an active neurotoxin from the sea cucumber. J. Pharm. Exp. Ther. 126 : 323 329.
    • (1959) J. Pharm. Exp. Ther. , vol.126 , pp. 323-329
    • Friess, S.L.1    Standaert, F.G.2    Whitcomb, E.R.3
  • 77
    • 0020364092 scopus 로고
    • A comparative study in vitro of physiological activity of triterpene glycosides of marine invertebrates of echinoderm type
    • Kuznetsova, T.A., M.M. Anisimov, A.M. Popov, et al. 1982. A comparative study in vitro of physiological activity of triterpene glycosides of marine invertebrates of echinoderm type. Comp. Biochem. Physiol. C. 73 : 41 43.
    • (1982) Comp. Biochem. Physiol. C. , vol.73 , pp. 41-43
    • Kuznetsova, T.A.1    Anisimov, M.M.2    Popov, A.M.3
  • 78
    • 0041420984 scopus 로고    scopus 로고
    • Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert
    • Zou, Z.R., Y.H. Yi, H.M. Wu, et al. 2003. Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert. J. Nat. Prod. 66 : 1055 1060.
    • (2003) J. Nat. Prod. , vol.66 , pp. 1055-1060
    • Zou, Z.R.1    Yi, Y.H.2    Wu, H.M.3
  • 79
    • 0028124522 scopus 로고
    • Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor
    • Naito, K., N. Kanbayashi, S. Nakajima, et al. 1994. Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor. Int. J. Cancer 58 : 730 735.
    • (1994) Int. J. Cancer , vol.58 , pp. 730-735
    • Naito, K.1    Kanbayashi, N.2    Nakajima, S.3
  • 80
    • 0028849274 scopus 로고
    • P21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • &
    • Waldman, T., K.W. Kinzler & B. Vogelstein. 1995. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55 : 5187 5190.
    • (1995) Cancer Res. , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 81
    • 0032748746 scopus 로고    scopus 로고
    • Apoptosis and drug response
    • Houghton, J.A. 1999. Apoptosis and drug response. Curr. Opin. Oncol. 11 : 475 481.
    • (1999) Curr. Opin. Oncol. , vol.11 , pp. 475-481
    • Houghton, J.A.1
  • 82
    • 0032575750 scopus 로고    scopus 로고
    • Caspase: Enemies within
    • &
    • Thornberry, N.A. & Y. Lazebnik. 1998. Caspase: enemies within. Science 281 : 1312 1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 83
    • 0032559799 scopus 로고    scopus 로고
    • The caspase-3 precursor has a cytosolic and mitochondrial distribution: Implications for apoptotic signaling
    • Mancini, M., D.W. Nicholson, S. Roy, et al. 1998. The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J. Cell Biol. 140 : 1485 1495.
    • (1998) J. Cell Biol. , vol.140 , pp. 1485-1495
    • Mancini, M.1    Nicholson, D.W.2    Roy, S.3
  • 84
    • 0030820875 scopus 로고    scopus 로고
    • Caspase-3 generated fragment of gelsolin: Effector of morphological change in apoptosis
    • Kothakota, S., T. Azuma, C. Reinhard, et al. 1997. Caspase-3 generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278 : 294 298.
    • (1997) Science , vol.278 , pp. 294-298
    • Kothakota, S.1    Azuma, T.2    Reinhard, C.3
  • 85
    • 0035831021 scopus 로고    scopus 로고
    • Structure basis of caspase-7 inhibition by XIAP
    • Chai, J., E. Shiozaki, S.M. Srinivasula, et al. 2001. Structure basis of caspase-7 inhibition by XIAP. Cell 104 : 769 780.
    • (2001) Cell , vol.104 , pp. 769-780
    • Chai, J.1    Shiozaki, E.2    Srinivasula, S.M.3
  • 86
    • 0034618369 scopus 로고    scopus 로고
    • MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells
    • Boucher, M.J., J. Morisset, P.H. Vachon, et al. 2000. MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J. Cell. Biochem. 79 : 355 369.
    • (2000) J. Cell. Biochem. , vol.79 , pp. 355-369
    • Boucher, M.J.1    Morisset, J.2    Vachon, P.H.3
  • 87
    • 0034525374 scopus 로고    scopus 로고
    • The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability
    • &
    • Harris, M.H. & C.B. Thompson. 2000. The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ. 7 : 1182 1191.
    • (2000) Cell Death Differ. , vol.7 , pp. 1182-1191
    • Harris, M.H.1    Thompson, C.B.2


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