메뉴 건너뛰기




Volumn 5, Issue , 2006, Pages

Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 2; CELL CYCLE PROTEIN 25; CYCLIN A; CYCLIN B; DNA; UNCLASSIFIED DRUG;

EID: 33846653627     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-5-76     Document Type: Article
Times cited : (164)

References (37)
  • 2
    • 33644826904 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of flavopiridol in children with refractory solid tumors: A Children's Oncology Group Study
    • 10.1200/JCO.2004.01.0660
    • Whitlock JA Krailo M Reid JM Ruben SL Ames MM Owen W Reaman G Phase I clinical and pharmacokinetic study of flavopiridol in children with refractory solid tumors: A Children's Oncology Group Study J Clin Oncol 2005, 23:9179-9186 10.1200/JCO.2004.01.0660 16361620
    • (2005) J Clin Oncol , vol.23 , pp. 9179-9186
    • Whitlock, J.A.1    Krailo, M.2    Reid, J.M.3    Ruben, S.L.4    Ames, M.M.5    Owen, W.6    Reaman, G.7
  • 3
    • 1242274347 scopus 로고    scopus 로고
    • Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer
    • 10.1016/j.urology.2003.09.061 14972467
    • deVere White RW Hackman RM Soares SE Beckett LA Li Y Sun B Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer Urology 2004, 63:259-263. 10.1016/j.urology.2003.09.061 14972467
    • (2004) Urology , vol.63 , pp. 259-263
    • deVere White, R.W.1    Hackman, R.M.2    Soares, S.E.3    Beckett, L.A.4    Li, Y.5    Sun, B.6
  • 4
    • 0033646291 scopus 로고    scopus 로고
    • Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: Current status
    • 10.1517/13543784.9.12.2903 11093360
    • Kelland LR Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: Current status Expert Opin Investig Drugs 2000, 9:2903-2911. 10.1517/13543784.9.12.2903 11093360
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2903-2911
    • Kelland, L.R.1
  • 6
    • 23044498269 scopus 로고    scopus 로고
    • Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    • 10.1158/0008-5472.CAN-04-4604 16061678
    • Li Y Ahmed F Ali S Philip PA Kucuk O Sarkar FH Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells Cancer Res 2005, 65:6934-6942. 10.1158/0008-5472.CAN-04-4604 16061678
    • (2005) Cancer Res , vol.65 , pp. 6934-6942
    • Li, Y.1    Ahmed, F.2    Ali, S.3    Philip, P.A.4    Kucuk, O.5    Sarkar, F.H.6
  • 7
    • 0037161915 scopus 로고    scopus 로고
    • Involvement of nuclear factor-kappa B, bax and bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells
    • 10.1038/sj.onc.1205474 12032841
    • Gupta S Afaq F Mukhtar H Involvement of nuclear factor-kappa B, bax and bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells Oncogene 2002, 21:3727-3738. 10.1038/ sj.onc.1205474 12032841
    • (2002) Oncogene , vol.21 , pp. 3727-3738
    • Gupta, S.1    Afaq, F.2    Mukhtar, H.3
  • 8
    • 0029826521 scopus 로고    scopus 로고
    • The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes
    • 8968050
    • Lepley DM Li B Birt DF Pelling JC The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes Carcinogenesis 1996, 17:2367-2375. 8968050
    • (1996) Carcinogenesis , vol.17 , pp. 2367-2375
    • Lepley, D.M.1    Li, B.2    Birt, D.F.3    Pelling, J.C.4
  • 10
    • 0037039712 scopus 로고    scopus 로고
    • Effect of flavonoids on cell cycle progression in prostate cancer cells
    • 10.1016/S0304-3835(01)00738-8 11790449
    • Kobayashi T Nakata T Kuzumaki T Effect of flavonoids on cell cycle progression in prostate cancer cells Cancer Lett 2002, 176:17-23. 10.1016/S0304-3835(01)00738-8 11790449
    • (2002) Cancer Lett , vol.176 , pp. 17-23
    • Kobayashi, T.1    Nakata, T.2    Kuzumaki, T.3
  • 11
    • 0033855919 scopus 로고    scopus 로고
    • The therapeutic potential of flavonoids
    • 10.1517/13543784.9.9.2103 11060796
    • Wang H The therapeutic potential of flavonoids Expert Opin Investig Drugs 2000, 9:2103-2119. 10.1517/13543784.9.9.2103 11060796
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2103-2119
    • Wang, H.1
  • 12
    • 0034807826 scopus 로고    scopus 로고
    • Dietary agents in cancer prevention: Flavonoids and isoflavonoids
    • 10.1016/S0163-7258(01)00137-1 11578656
    • Birt D Hendrich S Wang W Dietary agents in cancer prevention: Flavonoids and isoflavonoids Pharmacol Ther 2001, 90:157-177. 10.1016/ S0163-7258(01)00137-1 11578656
    • (2001) Pharmacol Ther , vol.90 , pp. 157-177
    • Birt, D.1    Hendrich, S.2    Wang, W.3
  • 13
    • 0346217046 scopus 로고    scopus 로고
    • Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression
    • 10.1002/cncr.11873 14692041
    • Buchler P Reber HA Buchler MW Friess H Lavey RS Hines OJ Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression Cancer 2004, 100:201-210 10.1002/cncr.11873 14692041
    • (2004) Cancer , vol.100 , pp. 201-210
    • Buchler, P.1    Reber, H.A.2    Buchler, M.W.3    Friess, H.4    Lavey, R.S.5    Hines, O.J.6
  • 14
    • 0031962808 scopus 로고    scopus 로고
    • Effects of naturally-occurring flavonoids and bioflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs
    • 10.1016/S0952-3278(98)90125-9 9482162
    • Kim HP Mani I Iversen L Ziboh VA Effects of naturally-occurring flavonoids and bioflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs Prostaglandins Leukot Essent Fatty Acids 1998, 58:17-24. 10.1016/S0952-3278(98)90125-9 9482162
    • (1998) Prostaglandins Leukot Essent Fatty Acids , vol.58 , pp. 17-24
    • Kim, H.P.1    Mani, I.2    Iversen, L.3    Ziboh, V.A.4
  • 15
    • 0035059767 scopus 로고    scopus 로고
    • Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-cdk regulators and ERK MAP kinase activation in breast carcinoma cells
    • 11299771
    • Yin F Giuliano AE Law RE Van Herle AJ Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-cdk regulators and ERK MAP kinase activation in breast carcinoma cells Anticancer Res 2001, 21:413-420. 11299771
    • (2001) Anticancer Res , vol.21 , pp. 413-420
    • Yin, F.1    Giuliano, A.E.2    Law, R.E.3    Van Herle, A.J.4
  • 16
    • 0033933197 scopus 로고    scopus 로고
    • Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines
    • 10.1002/1098-2744(200006)28:2<102::AID-MC6>3.0.CO;2-2 10900467
    • Wang W Heideman L Chung CS Pelling JC Koehler KJ Birt DF Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines Mol Carcinog 2000, 28:102-110. 10.1002/ 1098-2744(200006)28:2<102::AID-MC6>3.0.CO;2-2 10900467
    • (2000) Mol Carcinog , vol.28 , pp. 102-110
    • Wang, W.1    Heideman, L.2    Chung, C.S.3    Pelling, J.C.4    Koehler, K.J.5    Birt, D.F.6
  • 17
    • 0033873786 scopus 로고    scopus 로고
    • Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential
    • 10.1002/1097-0215(20000815)87:4<595::AID-IJC21>3.0.CO;2-5
    • Caltagirone S Rossi C Poggi A Ranelletti FO Natali PG Brunetti M Aiello FB Piantelli M Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential Int J Cancer 2000 87 595-600 10.1002/ 1097-0215(20000815)87:4<595::AID-IJC21>3.0.CO;2-5 10918203
    • (2000) Int J Cancer , vol.87 , pp. 595-600
    • Caltagirone, S.1    Rossi, C.2    Poggi, A.3    Ranelletti, F.O.4    Natali, P.G.5    Brunetti, M.6    Aiello, F.B.7    Piantelli, M.8
  • 18
    • 0033004673 scopus 로고    scopus 로고
    • Growth inhibitory effects of flavonoids in human thyroid cancer cell lines
    • 10319943
    • Yin F Giuliano AE Van Herle AJ Growth inhibitory effects of flavonoids in human thyroid cancer cell lines Thyroid 1999, 9:369-376. 10319943
    • (1999) Thyroid , vol.9 , pp. 369-376
    • Yin, F.1    Giuliano, A.E.2    Van Herle, A.J.3
  • 19
    • 0032200397 scopus 로고    scopus 로고
    • Structure-activity relationships of flavonoids and the induction of granulocytic- or monocytic-differentiation in HL60 human myeloid leukemia cells
    • 10.1271/bbb.62.2199 9972240
    • Takahashi T Kobori M Shinmoto H Tsushida T Structure-activity relationships of flavonoids and the induction of granulocytic- or monocytic-differentiation in HL60 human myeloid leukemia cells Biosci Biotechnol Biochem 1998, 62:2199-2204. 10.1271/bbb.62.2199 9972240
    • (1998) Biosci Biotechnol Biochem , vol.62 , pp. 2199-2204
    • Takahashi, T.1    Kobori, M.2    Shinmoto, H.3    Tsushida, T.4
  • 20
    • 0029080674 scopus 로고
    • Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes
    • 10.1006/bbrc.1995.2035 7626110
    • Kuo ML Yang NC Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes Biochem Biophys Res Commun 1995, 212:767-775. 10.1006/bbrc.1995.2035 7626110
    • (1995) Biochem Biophys Res Commun , vol.212 , pp. 767-775
    • Kuo, M.L.1    Yang, N.C.2
  • 21
    • 0242610804 scopus 로고    scopus 로고
    • The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines
    • Van Dross R Xue Y Knudson A Pelling JC The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines J Nutr 2003:SUppl 133 3800-3804.
    • (2003) J Nutr , Issue.SUPPL. 133 , pp. 3800-3804
    • Van Dross, R.1    Xue, Y.2    Knudson, A.3    Pelling, J.C.4
  • 22
    • 0025176844 scopus 로고
    • Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice
    • 2105157
    • Wei H Tye L Bresnick E Birt DF Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice Cancer Res 1990, 50:499-502. 2105157
    • (1990) Cancer Res , vol.50 , pp. 499-502
    • Wei, H.1    Tye, L.2    Bresnick, E.3    Birt, D.F.4
  • 23
    • 0030965506 scopus 로고    scopus 로고
    • Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells
    • 10.1016/S0304-3835(97)04664-8 9103293
    • Chaumontet C Droumaguet C Bex V Heberden C Gaillard-Sanchez I Martel P Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells Cancer Lett 1997, 114:207-210. 10.1016/S0304-3835(97)04664-8 9103293
    • (1997) Cancer Lett , vol.114 , pp. 207-210
    • Chaumontet, C.1    Droumaguet, C.2    Bex, V.3    Heberden, C.4    Gaillard-Sanchez, I.5    Martel, P.6
  • 24
    • 0026693966 scopus 로고
    • Animal cell cycles and their control
    • 10.1146/annurev.bi.61.070192.002301 1497317
    • Norbury C Nurse P Animal cell cycles and their control Annu Rev Biochem 1992, 61:441-470. 10.1146/annurev.bi.61.070192.002301 1497317
    • (1992) Annu Rev Biochem , vol.61 , pp. 441-470
    • Norbury, C.1    Nurse, P.2
  • 25
    • 0032924467 scopus 로고    scopus 로고
    • Cyclins and cell cycle checkpoints
    • 10.1146/annurev.pharmtox.39.1.295
    • Johnson DG Walker CL Cyclins and cell cycle checkpoints Annu Rev Parmacol Toxicol 1999, 39:295-312. 10.1146/annurev.pharmtox.39.1.295
    • (1999) Annu Rev Parmacol Toxicol , vol.39 , pp. 295-312
    • Johnson, D.G.1    Walker, C.L.2
  • 26
    • 0034754073 scopus 로고    scopus 로고
    • Design of new anticancer therapies targeting cell cycle checkpoint pathways
    • 10.1097/00001622-200111000-00011 11673689
    • Sampath D Plunkett W Design of new anticancer therapies targeting cell cycle checkpoint pathways Curr Opin Oncol 2001, 13:484-490. 10.1097/ 00001622-200111000-00011 11673689
    • (2001) Curr Opin Oncol , vol.13 , pp. 484-490
    • Sampath, D.1    Plunkett, W.2
  • 27
    • 0036847320 scopus 로고    scopus 로고
    • Regulation of G2/M events by cdc25A through phosphorylation-dependent modulation of its stability
    • 131064 12411508 10.1093/emboj/cdf567
    • Mailand N Podtelejnikov AV Groth A Mann M Bartek J Lukas J Regulation of G2/M events by cdc25A through phosphorylation-dependent modulation of its stability EMBO J 2002, 21:5911-5920. 131064 12411508 10.1093/emboj/ cdf567
    • (2002) EMBO J , vol.21 , pp. 5911-5920
    • Mailand, N.1    Podtelejnikov, A.V.2    Groth, A.3    Mann, M.4    Bartek, J.5    Lukas, J.6
  • 28
    • 0032728975 scopus 로고    scopus 로고
    • Human cyclin A is required for mitosis until mid prophase
    • 10.1083/jcb.147.2.295
    • Furuno N Den Elzen N Pines J Human cyclin A is required for mitosis until mid prophase J Cell Biol 1999, 147:95-306. 10.1083/jcb.147.2.295
    • (1999) J Cell Biol , vol.147 , pp. 95-306
    • Furuno, N.1    Den Elzen, N.2    Pines, J.3
  • 29
    • 0026583746 scopus 로고
    • Cyclin A is required at two points in the human cell cycle
    • 556537 1312467
    • Pagano M Pepperkok R Verde F Angorge W Draetta G Cyclin A is required at two points in the human cell cycle EMBO J 1992, 11:961-971. 556537 1312467
    • (1992) EMBO J , vol.11 , pp. 961-971
    • Pagano, M.1    Pepperkok, R.2    Verde, F.3    Angorge, W.4    Draetta, G.5
  • 30
    • 0030796989 scopus 로고    scopus 로고
    • Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin
    • 10.1002/(SICI)1098-2744(199707)19:2<74::AID-MC2>3.0.CO;2-L 9210954
    • Lepley DM Pelling JC Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin Mol Carcinog 1997, 19:74-82. 10.1002/ (SICI)1098-2744(199707)19:2<74::AID-MC2>3.0.CO;2-L 9210954
    • (1997) Mol Carcinog , vol.19 , pp. 74-82
    • Lepley, D.M.1    Pelling, J.C.2
  • 31
    • 0034819073 scopus 로고    scopus 로고
    • Apigenin acts on the tumor cell invasion process and regulates protease production
    • 10.1207/S15327914nc391_19 11588896
    • Lindenmeyer F Li H Menashi S Soria C Lu H Apigenin acts on the tumor cell invasion process and regulates protease production Nutr Cancer 2001, 39:139-147. 10.1207/S15327914nc391_19 11588896
    • (2001) Nutr Cancer , vol.39 , pp. 139-147
    • Lindenmeyer, F.1    Li, H.2    Menashi, S.3    Soria, C.4    Lu, H.5
  • 32
    • 0242576442 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells
    • 10.1016/j.bcp.2003.07.007 14609732
    • O'Prey J Brown J Fleming J Harrison PR Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells Biochem Pharmacol 2003, 66:2075-2088. 10.1016/j.bcp.2003.07.007 14609732
    • (2003) Biochem Pharmacol , vol.66 , pp. 2075-2088
    • O'Prey, J.1    Brown, J.2    Fleming, J.3    Harrison, P.R.4
  • 33
    • 0035874028 scopus 로고    scopus 로고
    • Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin-dependent kinases CDK2 and CDK1
    • 10.1016/S0006-2952(01)00583-4 11322924
    • Casagrande F Darbon JM Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin-dependent kinases CDK2 and CDK1 Biochem Pharmacol 2001, 61:1205-1215. 10.1016/S0006-2952(01)00583-4 11322924
    • (2001) Biochem Pharmacol , vol.61 , pp. 1205-1215
    • Casagrande, F.1    Darbon, J.M.2
  • 34
    • 0036144234 scopus 로고    scopus 로고
    • A p21WAF1-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34cdc2 and concomitant G2/M arrest by the chemopreventive flavonoid apigenin
    • 10.1002/mc.10016 11807956
    • McVean M Weinberg WC Pelling JC A p21WAF1-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34cdc2 and concomitant G2/M arrest by the chemopreventive flavonoid apigenin Mol Carcinog 2002, 33:36-43. 10.1002/mc.10016 11807956
    • (2002) Mol Carcinog , vol.33 , pp. 36-43
    • McVean, M.1    Weinberg, W.C.2    Pelling, J.C.3
  • 35
    • 0033960338 scopus 로고    scopus 로고
    • Apigenin inhibits endothelial-cell proliferation in G2/M phase whereas it stimulates smooth-muscle cells by inhibiting p21 and p27 expression
    • 10.1002/(SICI)1097-0215(20000301)85:5<691::AID-IJC15>3.0.CO;2-Q 10699950
    • Trochon V Blot E Cymbalista F Engelman C Tang R Thomaidis A Vasse M Soria J Lu H Soria C Apigenin inhibits endothelial-cell proliferation in G2/M phase whereas it stimulates smooth-muscle cells by inhibiting p21 and p27 expression Int J Cancer 2000, 85:691-696. 10.1002/ (SICI)1097-0215(20000301)85:5<691::AID-IJC15>3.0.CO;2-Q 10699950
    • (2000) Int J Cancer , vol.85 , pp. 691-696
    • Trochon, V.1    Blot, E.2    Cymbalista, F.3    Engelman, C.4    Tang, R.5    Thomaidis, A.6    Vasse, M.7    Soria, J.8    Lu, H.9    Soria, C.10
  • 36
    • 0035812747 scopus 로고    scopus 로고
    • Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells
    • 10.1006/bbrc.2001.5672
    • Gupta S Afaq F Mukhtar H Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells Biochem Res Commun 2001, 287:914-920. 10.1006/ bbrc.2001.5672
    • (2001) Biochem Res Commun , vol.287 , pp. 914-920
    • Gupta, S.1    Afaq, F.2    Mukhtar, H.3
  • 37
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • 10.1038/sj.onc.1204252 11313928
    • Taylor WR Stark GR Regulation of the G2/M transition by p53 Oncogene 2001, 20:1803-1815. 10.1038/sj.onc.1204252 11313928
    • (2001) Oncogene , vol.20 , pp. 1803-1815
    • Taylor, W.R.1    Stark, G.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.