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Apoptosis, p53, and tumor cell sensitivity to anticancer agents
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1 Brown JM, Wouters BG: Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 1998, 59:1391-1399. This review critically evaluates the role of p53 in the induction of apoptosis following DNA damage and indicates that p53 may influence the threshold and kinetics of apoptosis induction but not overall survival of a treated population.
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Cancer Res
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Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines
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2 Aldridge DR, Radford IR: Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines. Cancer Res 1998, 58:2817-2824.
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3 Weller M: Predicting the response to chemotherapy: the role of p53. Cell Tissue Res 1998, 292:435-445.
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4 Stahler F, Roemer K; Mutant p53 can provoke apoptosis in p53-deficient Hep3B cells with delayed kinetics relative to wtp53. Oncogene 1998, 17:3507-3512.
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Distinct p53-independent apoptotic cell death signalling pathways in testicular germ cell tumour cell lines
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5 Burger H, Nooter K, Boersma AW, van Wingerden KE, Looijenga LH, Jochemsen AG, Stoter G: Distinct p53-independent apoptotic cell death signalling pathways in testicular germ cell tumour cell lines. Int J Cancer 1999, 81:620-628.
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Mutant p53 gain of function: Differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
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6 Blandino G, Levine AJ, Oren M: Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene 1999, 18:477-485. This study demonstrates that only certain p53 mutants may confer a selective survival advantage for tumor cells following chemotherapy, as determined from assays of apoptosis and clonogenic survival.
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Oncogene
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Blandino, G.1
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P53 and c-erbB-2 as markers of resistance to adjuvant chemotherapy in breast cancer
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7 Tetu B, Brisson J, Plante V, Bernard P: P53 and c-erbB-2 as markers of resistance to adjuvant chemotherapy in breast cancer. Mod Pathol 1998, 11:823-830.
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Carboplatin and paclitaxel, alone and in combination: Dose escalation, measurement of renal function, and role of the p53 tumor suppressor gene
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8 Calvert AH, Ghokul S, Al-Azraqi A, Wright J, Lind M, Bailey N, et al.: Carboplatin and paclitaxel, alone and in combination: dose escalation, measurement of renal function, and role of the p53 tumor suppressor gene. Semin Oncol 1999, 26(suppl 2):90-94.
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The complexity of p53 modulation: Emerging patterns from divergent signals
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9 Giaccia AJ, Kastan MB: The complexity of p53 modulation: emerging patterns from divergent signals. Gene Dev 1998, 12:2973-2983. This provides a comprehensive review of the diversity of signals that regulate p53 function.
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Gene Dev
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Giaccia, A.J.1
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10 Palmero I, Pantoja C, Serrano M: P14ARF links the tumour suppressors RB and p53. Nature 1998, 395:124-126.
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Tumor surveillance via the ARF-p53 pathway
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11 Sherr CJ: Tumor surveillance via the ARF-p53 pathway. Gene Dev 1998, 12:2984-2991.
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Gene Dev
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The role of ATM in DNA damage responses and cancer
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12 Canman CE, Lim D-S: The role of ATM in DNA damage responses and cancer. Oncogene 1998, 17:3301-3308.
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Determination of cell fate by c-Abl activation in response4 to DNA damage
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13 Kharbanda S, Yuan Z-M, Weichselbaum R, Kufe D: Determination of cell fate by c-Abl activation in response4 to DNA damage. Oncogene 1998, 17:3309-3318.
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14 Dang CV: C-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999, 19:1-11.
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15 Fulda S, Lutz W, Schwab M, Debatin K-M: MycN sensitizes neuroblastoma cells for drug-induced apoptotis. Oncogene 18:1479-1486.
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The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis
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16 Koo HM, Gray-Goodrich M, Kohlhagen G, McWilliams MJ, Jeffers M, Vaigro-Wolff A, et al.: The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis. J Natl Cancer Inst 1999, 91:236-244.
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17
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DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1
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17 Kasibhatla S, Brunner T, Genestier L, Echeverri F, Mahboubi A, Green DR: DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1. Mol Cell 1998, 1:543-551. This study demonstrates that VP-16-and VM-26-induced, Fas-dependent apoptosis is mediated via direct transcriptional activation of FasL by both NF-κB and AP-1 in Jurkat T leukemia cells.
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18
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Regulation of Fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κB
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18 Kasibhatla S, Genestier L, Green DR: Regulation of Fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κB. J Biol Chem 1999, 274:987-992.
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Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter
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19 Faris M, Latinis KM, Kempiak SJ, Koretzky GA, Nel A: Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Mol Cell Biol 1998, 18:5414-5424.
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20 Li N, Karin M: Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms. Proc Natl Acad Sci U S A 1998, 95:13012-13017.
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A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells
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23 Tillman DM, Petak I, Houghton JA: A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells. Clin Cancer Res 1999, 5:425-430. This study demonstrates that FUra/LV-induced thymineless death is potentiated by IFN-γ in a Fas-dependent and p53-independent manner in colon carcinoma cells, indicating that Fas may be an important target for therapeutic modulation.
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24 Ruiz-Ruiz M del C, Lopez-Rivas A: P53-mediated up-regulation of CD95 is not involved in genotoxic drug-induced apoptosis of human breast tumor cells. Cell Death Diff 1999, 6:271-280.
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25 Hedlund TE, Meech SJ, Srikanth S, Kraft AS, Miller GJ, Schaak JB, Duke RC: Adenovirus-mediated expression of Fas ligand induces apoptosis of human prostate cancer cells. Cell Death Diff 1999, 6:175-182.
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Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7
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28 Yount GL, Levine KS, Kuriyama H, Haas-Kogan DA, Israel MA: Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells. Cancer Res 1999, 59:1362-1365.
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29 Wagenknecht B, Schulz JB, Gulbins E, Weller M: Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing. Cell Death Diff 1998, 5:894-900.
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Activation of the CD95 (APO-1/Fas) pathway in drug-and γ-irradiation-induced apoptosis of brain tumor cells
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30 Fulda S, Scaffidi C, Pietsch T, Krammer PH, Peter ME, Debatin K-M: Activation of the CD95 (APO-1/Fas) pathway in drug-and γ-irradiation-induced apoptosis of brain tumor cells. Cell Death Diff 1998, 5:884-893.
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31 Kontny HU, Lehrnbecher TM, Chanock SJ, Mackall CL: Simultaneous expression of Fas and nonfunctional Fas ligand in Ewing's sarcoma. Cancer Res 1998, 58:5842-5849.
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32 Gutierrez MI, Cherney B, Hussain A, Mostowski H, Tosato G, Magrath I, Bhatia K: Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis. Cancer Res 1999, 59:696-703.
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37 Tillman DM, Harwood FG, Gibson AA, Houghton JA: Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells. Cell Death Diff 1998, 5:450-457. This study identifies Fas as the most critical determinant of Fas-dependent cytotoxicity in human colon carcinoma cell lines.
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