A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

Biochemical and Biophysical Research Communications

Volumn 340, Issue 4, 2006, Pages 1224-1228

  Ujiki, Michael B ^a   Milam, Ben ^a   Ding, Xian Zhong ^a   Roginsky, Alexandra B ^a   Salabat, M Reza ^a   Talamonti, Mark S ^a   Bell, Richard H ^a   Gu, Wenxin ^b   Silverman, Richard B ^a,b   Adrian, Thomas E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Annexin V; Apoptosis; Cell cycle arrest; Pancreatic cancer; Sansalvamide A

Indexed keywords

CYCLODEPSIPEPTIDE; LIPOCORTIN 5; SANSALVAMIDE A; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSTASIS; DNA SYNTHESIS INHIBITION; DRUG INHIBITION; DRUG STRUCTURE; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN BINDING;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PANCREATIC NEOPLASMS;

FUNGI;

EID: 30544431590     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.131     Document Type: Article

References (10)

1. S.F. Sener, A. Fremgen, H.R. Menck, and D.P. Winchester Pancreatic cancer: report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the national cancer database J. Am. Coll. Surg. 189 1999 1 7
2. G.N. Belofsky, P.R. Jensen, and W. Fenical Sansalvamide: a new cytotoxic cyclic depsipeptide produced by a marine fungus of the genus Fusarium Tetrahedron Lett. 40 1999 2913 2916
3. S. Liu, W. Gu, D. Lo, X.Z. Ding, M. Ujiki, T.E. Adrian, G.A. Soff, and R.B. Silverman N-methylsansalvamide A peptide analogues. Potent new antitumor agents J. Med. Chem. 48 2005 3630 3638
4. G.L. Amidon, and H.J. Lee Absorption of peptide and peptidomimetic drugs Annu. Rev. Pharmacol. Toxicol. 34 1994 321 341
5. R.M. Wenger Synthesis of cyclosporin and analogues: structural and conformational requirements for immunosuppressive activity Prog. Allergy 38 1986 46 64
6. H. Nojima Cell cycle checkpoints, chromosome stability, and the progression of cancer Hum. Cell 10 1997 221 230
7. L.Z. Penn Apoptosis modulators as cancer therapeutics Curr. Opin. Investig. Drugs 2 2001 684 692
8. M. Nagane, H.J. Huang, and W.K. Cavenee The potential of TRAIL for cancer chemotherapy Apoptosis 6 2001 191 197
9. V.A. Fadok, D.R. Voelker, P.A. Campbell, J.J. Cohen, D.L. Bratton, and P.M. Henson Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages J. Immunol. 148 1992 2207 2216
10. G. Koopman, C.P. Reutelingsperger, G.A. Kuijten, R.M. Keehnen, S.T. Pals, and M.H. van Oers Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis Blood 84 1994 1415 1420