Chapter 12 Molecular Approaches to Glaucoma. Intriguing Clues for Pathology

Current Topics in Membranes

Volumn 62, Issue , 2008, Pages 379-425

  Tamm, Ernst R ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 53049097158     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1063-5823(08)00412-2     Document Type: Review

References (243)

1. Abderrahim H., Jaramillo-Babb V.L., Zhou Z., and Vollrath D. Characterization of the murine TIGR/myocilin gene. Mamm. Genome 9 (1998) 673-675
2. Adam M.F., Belmouden A., Binisti P., Brézin A.P., Valtot F., Béchetoille A., Dascotte J.-C., Copin B., Gomez L., Chaventre A., Bach J.-F., and Garchon H.-J. Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma. Hum. Mol. Gen. 12 (1997) 2091-2097
3. Adams J.C. Thrombospondins: Multifunctional regulators of cell interactions. Annu. Rev. Cell Dev. Biol. 17 (2001) 25-51
4. Ahmed F., Torrado M., Johnson E., Morrison J., and Tomarev S.I. Changes in mRNA levels of the Myoc/Tigr gene in the rat eye after experimental elevation of intraocular pressure or optic nerve transection. Invest. Ophthalmol. Vis. Sci. 42 (2001) 3165-3172
5. Alge C.S., Priglinger S.G., Neubauer A.S., Kampik A., Zillig M., Bloemendal H., and Welge-Lussen U. Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3575-3582
6. Allen J.B., Davidson M.G., Nasisse M.P., Fleisher L.N., and McGahan M.C. The lens influences aqueous humor levels of transforming growth factor-beta 2. Graefes Arch. Clin. Exp. Ophthalmol. 236 (1998) 305-311
7. Alvarado J.A., and Murphy C.G. Outflow obstruction in pigmentary and primary open angle glaucoma. Arch. Ophthalmol. 110 (1992) 1769-1778
8. Alward W.L., Fingert J.H., Coote M.A., Johnson A.T., Lerner S.F., Junqua D., Durcan F.J., McCartney P.J., Mackey D.A., Sheffield V.C., and Stone E.M. Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene. N. Engl. J. Med. 338 (1998) 1022-1027
9. Alward W.L., Kwon Y.H., Kawase K., Craig J.E., Hayreh S.S., Johnson A.T., Khanna C.L., Yamamoto T., Mackey D.A., Roos B.R., Affatigato L.M., Sheffield V.C., et al. Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma. Am. J. Ophthalmol. 136 (2003) 904-910
10. Annes J.P., Munger J.S., and Rifkin D.B. Making sense of latent TGFβ activation. J. Cell Sci. 116 (2003) 217-224
11. Aroca-Aguilar J.D., Sanchez-Sanchez F., Ghosh S., Coca-Prados M., and Escribano J. Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227. J. Biol. Chem. 280 (2005) 21043-21051
12. Aung T., Ebenezer N.D., Brice G., Child A.H., Prescott Q., Lehmann O.J., Hitchings R.A., and Bhattacharya S.S. Prevalence of optineurin sequence variants in adult primary open angle glaucoma: Implications for diagnostic testing. J. Med. Genet. 40 (2003) e101
13. Aung T., Rezaie T., Okada K., Viswanathan A.C., Child A.H., Brice G., Bhattacharya S.S., Lehmann O.J., Sarfarazi M., and Hitchings R.A. Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene. Invest. Ophthalmol. Vis. Sci. 46 (2005) 2816-2822
14. Ayala-Lugo R.M., Pawar H., Reed D.M., Lichter P.R., Moroi S.E., Page M., Eadie J., Azocar V., Maul E., Ntim-Amponsah C., Bromley W., Obeng-Nyarkoh E., et al. Variation in optineurin (OPTN) allele frequencies between and within populations. Mol. Vis. 13 (2007) 151-163
15. Bachmann B., Birke M., Kook D., Eichhorn M., and Lütjen-Drecoll E. Ultrastructural and biochemical evaluation of the porcine anterior chamber perfusion model. Invest. Ophthalmol. Vis. Sci. 47 (2006) 2011-2020
16. Baird P.N., Richardson A.J., Craig J.E., Mackey D.A., Rochtchina E., and Mitchell P. Analysis of optineurin (OPTN) gene mutations in subjects with and without glaucoma: The Blue Mountains Eye Study. Clin. Experiment. Ophthalmol. 32 (2004) 518-522
17. Bataller R., and Brenner D.A. Liver fibrosis. J. Clin. Invest. 115 (2005) 209-218
18. Bernstein K.A., Gallagher J.E., Mitchell B.M., Granneman S., and Baserga S.J. The small-subunit processome is a ribosome assembly intermediate. Eukaryot. Cell 3 (2004) 1619-1626
19. Beuret N., Rutishauser J., Bider M.D., and Spiess M. Mechanism of endoplasmic reticulum retention of mutant vasopressin precursor caused by a signal peptide truncation associated with diabetes insipidus. J. Biol. Chem. 274 (1999) 18965-18972
20. Borisuth N.S., Tripathi B.J., and Tripathi R.C. Identification and partial characterization of TGF-beta 1 receptors on trabecular cells. Invest. Ophthalmol. Vis. Sci. 33 (1992) 596-603
21. Bornstein P. Thrombospondins as matricellular modulators of cell function. J. Clin. Invest. 107 (2001) 929-934
22. Caballero M., and Borrás T. Inefficient processing of an olfactomedin-deficient myocilin mutant: Potential physiological relevance to glaucoma. Biochem. Biophys. Res. Commun. 282 (2001) 662-670
23. Caballero M., Rowlette L.L., and Borrás T. Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain. Biochim. Biophys. Acta 1502 (2000) 447-460
24. Chalasani M.L., Radha V., Gupta V., Agarwal N., Balasubramanian D., and Swarup G. A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants. Invest. Ophthalmol. Vis. Sci. 48 (2007) 1607-1614
25. Chatziantoniou C., and Dussaule J.C. Insights into the mechanisms of renal fibrosis: Is it possible to achieve regression?. Am. J. Physiol. Renal. Physiol. 289 (2005) F227-F234
26. Chen D., Zhao M., and Mundy G.R. Bone morphogenetic proteins. Growth Factors 22 (2004) 233-241
27. Chen J., Li H., SundarRaj N., and Wang J.H. Alpha-smooth muscle actin expression enhances cell traction force. Cell. Motil. Cytoskeleton 64 (2007) 248-257
28. Chudgar S.M., Deng P., Maddala R., Epstein D.L., and Rao P.V. Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway. Mol. Vis. 12 (2006) 1117-1126
29. Cicha I., Yilmaz A., Klein M., Raithel D., Brigstock D.R., Daniel W.G., Goppelt-Struebe M., and Garlichs C.D. Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 1008-1013
30. Clark A.F., Kawase K., English-Wright S., Lane D., Steely H.T., Yamamoto T., Kitazawa Y., Kwon Y.H., Fingert J.H., Swiderski R.E., Mullins R.F., Hageman G.S., et al. Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head. FASEB J. 15 (2001) 1251-1253
31. Collaborative Normal-Tension Glaucoma Study Group. Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Am. J. Ophthalmol. 126 (1998) 487-497
32. Collaborative Normal-Tension Glaucoma Study Group. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Collaborative Normal-Tension Glaucoma Study Group. Am. J. Ophthalmol. 126 (1998) 498-505
33. Cousins S.W., McCabe M.M., Danielpour D., and Streilein J.W. Identification of transforming growth factor-beta as an immunosuppresive factor in aqueous humor. Invest. Ophthalmol. Vis. Sci. 32 (1991) 2201-2211
34. Crawford S.E., Stellmach V., Murphy-Ullrich J.E., Ribeiro S.M., Lawler J., Hynes R.O., Boivin G.P., and Bouck N. Thrombospondin-1 is a major activator of TGF-β1 in vivo. Cell 93 (1998) 1159-1170
35. Danielson P.E., Forss-Petter S., Battenberg E.L., deLecea L., Bloom F.E., and Sutcliffe J.G. Four structurally distinct neuron-specific olfactomedin-related glycoproteins produced by differential promoter utilization and alternative mRNA splicing from a single gene. J. Neurosci. Res. 38 (1994) 468-478
36. de Kater A.W., Shahsafaei A., and Epstein D.L. Localization of smooth muscle and nonmuscle actin isoforms in the human aqueous outflow pathway. Invest. Ophthalmol. Vis. Sci. 33 (1992) 424-429
37. De Marco N., Buono M., Troise F., and Diez-Roux G. Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus. J. Biol. Chem. 281 (2006) 16147-16156
38. di Mola F.F., Di Sebastiano P., Gardini A., Innocenti P., Zimmermann A., Buchler M.W., and Friess H. Differential expression of connective tissue growth factor in inflammatory bowel disease. Digestion 69 (2004) 245-253
39. Dudley A.T., Lyons K.M., and Robertson E.J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9 (1995) 2795-2807
40. Eichhorn M., and Lütjen-Drecoll E. Distribution of endothelin-like immunoreactivity in the human ciliary epithelium. Curr.Eye Res. 12 (1993) 753-757
41. Ellgaard L., and Helenius A. Quality control in the endoplasmic reticulum. Nat. Rev. Mol. Cell Biol. 4 (2003) 181-191
42. Engelender S., Sharp A.H., Colomer V., Tokito M.K., Lanahan A., Worley P., Holzbaur E.L., and Ross C.A. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum. Mol. Genet. 6 (1997) 2205-2212
43. Ethier C.R. The inner wall of Schlemm's canal. Exp. Eye Res. 74 (2002) 161-172
44. Faber P.W., Barnes G.T., Srinidhi J., Chen J., Gusella J.F., and MacDonald M.E. Huntingtin interacts with a family of WW domain proteins. Hum. Mol. Genet. 7 (1998) 1463-1474
45. Fautsch M.P., and Johnson D.H. Characterization of myocilin-myocilin interactions. Invest. Ophthalmol. Vis. Sci. 42 (2001) 2324-2331
46. Fautsch M.P., Bahler C.K., Jewison D.J., and Johnson D.H. Recombinant TIGR/MYOC increases outflow resistance in the human anterior segment. Invest. Ophthalmol. Vis. Sci. 41 (2000) 4163-4168
47. Fautsch M.P., Vrabel A.M., Peterson S.L., and Johnson D.H. In vitro and in vivo characterization of disulfide bond use in myocilin complex formation. Mol. Vis. 10 (2004) 417-425
48. Fautsch M.P., Bahler C.K., Vrabel A.M., Howell K.G., Loewen N., Teo W.L., Poeschla E.M., and Johnson D.H. Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor. Invest. Ophthalmol. Vis. Sci. 47 (2006) 213-221
49. Filla M.S., Liu X., Nguyen T.D., Polansky J.R., Brandt C.R., Kaufman P.L., and Peters D.M. In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin. Invest. Ophthalmol. Vis. Sci. 43 (2002) 151-161
50. Fine B.S., Yanoff M., and Stone R.A. A clinicopathologic study of four cases of primary open-angle glaucoma compared to normal eyes. Am. J. Ophthalmol. 91 (1981) 88-105
51. Fingert J.H., Ying L., Swiderski R., Nystuen A.M., Arbour N.C., Alward W.L.M., Sheffiled V.C., and Stone E.M. Characterization and comparison of the human and mouse GLC1A glaucoma genes. Genome Res. 8 (1998) 377-384
52. Fingert J.H., Heon E., Liebmann J.M., Yamamoto T., Craig J.E., Rait J., Kawase K., Hoh S.T., Buys Y.M., Dickinson J., Hockey R.R., Williams-Lyn D., et al. Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Hum. Mol. Genet. 8 (1999) 899-905
53. Fingert J.H., Stone E.M., Sheffield V.C., and Alward W.L. Myocilin glaucoma. Surv. Ophthalmol. 47 (2002) 547-561
54. Fingert J.H., Alward W.L., Kwon Y.H., Shankar S.P., Andorf J.L., Mackey D.A., Sheffield V.C., and Stone E.M. No association between variations in the WDR36 gene and primary open-angle glaucoma. Arch. Ophthalmol. 125 (2007) 434-436
55. Fleenor D.L., Shepard A.R., Hellberg P.E., Jacobson N., Pang I.H., and Clark A.F. TGFbeta2-induced changes in human trabecular meshwork: Implications for intraocular pressure. Invest. Ophthalmol. Vis. Sci. 47 (2006) 226-234
56. Flügel C., Tamm E., Lütjen-Drecoll E., and Stefani F.H. Age-related loss of α-smooth muscle actin in normal and glaucomatous human trabecular meshwork of different age groups. J. Glaucoma 1 (1992) 165-173
57. Flügel-Koch C., Ohlmann A., Piatigorsky J., and Tamm E.R. Overexpression of TGF-β1 alters early development of cornea and lens in transgenic mice. Dev. Dyn. 225 (2002) 111-125
58. Flügel-Koch C., Ohlmann A., Fuchshofer R., Welge-Lüssen U., and Tamm E.R. Thrombospondin-1 in the trabecular meshwork: Localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro. Exp. Eye Res. 79 (2004) 649-663
59. Fuchshofer R., Welge-Lüssen U., and Lütjen-Drecoll E. The effect of TGF-beta2 on human trabecular meshwork extracellular proteolytic system. Exp. Eye Res. 77 (2003) 757-765
60. Fuchshofer R., Birke M., Welge-Lüssen U., Kook D., and Lütjen-Drecoll E. Transforming growth factor-beta 2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes. Invest. Ophthalmol. Vis. Sci. 46 (2005) 568-578
61. Fuchshofer R., Yu A.H., Welge-Lüssen U., and Tamm E.R. Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 48 (2007) 715-726
62. Funayama T., Ishikawa K., Ohtake Y., Tanino T., Kurosaka D., Kimura I., Suzuki K., Ideta H., Nakamoto K., Yasuda N., Fujimaki T., Murakami A., et al. Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma. Invest. Ophthalmol. Vis. Sci. 45 (2004) 4359-4367
63. Fuse N., Takahashi K., Akiyama H., Nakazawa T., Seimiya M., Kuwahara S., and Tamai M. Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population. J. Glaucoma 13 (2004) 299-303
64. Gleizes P.E., Munger J.S., Nunes I., Harpel J.G., Mazzieri R., Noguera I., and Rifkin D.B. TGF-β latency: Biological significance and mechanisms of activation. Stem Cells 15 (1997) 190-197
65. Gobeil S., Rodrigue M.A., Moisan S., Nguyen T.D., Polansky J.R., Morissette J., and Raymond V. Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants. Invest. Ophthalmol. Vis. Sci. 45 (2004) 3560-3567
66. Gobeil S., Letartre L., and Raymond V. Functional analysis of the glaucoma-causing TIGR/myocilin protein: Integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for extracellular adhesion and secretion. Exp. Eye Res. 82 (2006) 1017-1029
67. Goldwich A., Ethier C.R., Chan D.W., and Tamm E.R. Perfusion with the olfactomedin domain of myocilin does not affect outflow facility. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1953-1961
68. Goldwich A., Baulmann D.C., Ohlmann A., Flügel-Koch C., Schocklmann H., and Tamm E.R. Myocilin is expressed in the glomerulus of the kidney and induced in mesangioproliferative glomerulonephritis. Kidney Int. 67 (2005) 140-151
69. Gonzalez P., Epstein D.L., and Borras T. Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3678-3693
70. Gordon M.O., Beiser J.A., Brandt J.D., Heuer D.K., Higginbotham E.J., Johnson C.A., Keltner J.L., Miller J.P., Parrish II R.K., Wilson M.R., and Kass M.A. The Ocular Hypertension Treatment Study: Baseline factors that predict the onset of primary open-angle glaucoma. Arch. Ophthalmol. 120 (2002) 714-720 discussion 829-30
71. Gordon-Thomson C., de Iongh R.U., Hales A.M., Chamberlain C.G., and McAvoy J.W. Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1399-1409
72. Gottanka J., Johnson D.H., Martus P., and Lütjen-Drecoll E. Severity of optic nerve damage in eyes with POAG is correlated with changes in the trabecular meshwork. J. Glaucoma 6 (1997) 123-132
73. Gottanka J., Chan D., Eichhorn M., Lütjen-Drecoll E., and Ethier C.R. Effects of TGF-β2 in perfused human eyes. Invest. Ophthalmol. Vis. Sci. 45 (2004) 153-158
74. Gould D.B., Miceli-Libby L., Savinova O.V., Torrado M., Tomarev S.I., Smith R.S., and John S.W. Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma. Mol. Cell Biol. 24 (2004) 9019-9025
75. Gould D.B., Reedy M., Wilson L.A., Smith R.S., Johnson R.L., and John S.W. Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma. Mol. Cell Biol. 26 (2006) 8427-8436
76. Granstein R.D., Staszewski R., Knisley T.L., Zeira E., Nazareno R., Latina M., and Albert D.M. Aqueous humor contains transforming growth factor-β and a small (<3500 daltons) inhibitor of thymocyte proliferation. J. Immunol. 144 (1990) 3021-3027
77. Grant W.M. Experimental aqueous perfusion in enucleated human eyes. Arch. Ophthalmol. 69 (1963) 783-801
78. Gressner A.M., and Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J. Cell. Mol. Med. 10 (2006) 76-99
79. Gupta S. A decision between life and death during TNF-alpha-induced signaling. J. Clin. Immunol. 22 (2002) 185-194
80. Hampton R.Y. ER stress response: Getting the UPR hand on misfolded proteins. Curr. Biol. 10 (2000) R518-R521
81. Hardy K.M., Hoffman E.A., Gonzalez P., McKay B.S., and Stamer W.D. Extracellular trafficking of myocilin in human trabecular meshwork cells. J. Biol. Chem. 280 (2005) 28917-28926
82. Hattula K., and Peranen J. FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Curr. Biol. 10 (2000) 1603-1606
83. Hauser M.A., Allingham R.R., Linkroum K., Wang J., LaRocque-Abramson K., Figueiredo D., Santiago-Turla C., del Bono E.A., Haines J.L., Pericak-Vance M.A., and Wiggs J.L. Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 47 (2006) 2542-2546
84. Hauser M.A., Sena D.F., Flor J., Walter J., Auguste J., Larocque-Abramson K., Graham F., Delbono E., Haines J.L., Pericak-Vance M.A., Rand Allingham R., and Wiggs J.L. Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States. J. Glaucoma 15 (2006) 358-363
85. Helbig H., Kittredge K.L., Coca-Prados M., Davis J., Palestine A.G., and Nussenblatt R.B. Mammalian ciliary-body epithelial cells in culture produce transforming growth factor-beta. Graefes Arch. Clin. Exp. Ophthalmol. 229 (1991) 84-87
86. Hewitt A.W., Dimasi D.P., Mackey D.A., and Craig J.E. A glaucoma case-control study of the WDR36 gene D658G sequence variant. Am. J. Ophthalmol. 142 (2006) 324-325
87. Higginbotham E.J., Gordon M.O., Beiser J.A., Drake M.V., Bennett G.R., Wilson M.R., and Kass M.A. The Ocular Hypertension Treatment Study: Topical medication delays or prevents primary open-angle glaucoma in African American individuals. Arch. Ophthalmol. 122 (2004) 813-820
88. Ho S.L., Dogar G.F., Wang J., Crean J., Wu Q.D., Oliver N., Weitz S., Murray A., Cleary P.E., and O'Brien C. Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome. Br. J. Ophthalmol. 89 (2005) 169-173
89. Horwitz J. Alpha-crystallin. Exp. Eye Res. 76 (2003) 145-153
90. Huggins J.T., and Sahn S.A. Causes and management of pleural fibrosis. Respirology 9 (2004) 441-447
91. Ihn H. Pathogenesis of fibrosis: Role of TGF-β and CTGF. Curr. Opin. Rheumatol. 14 (2002) 681-685
92. Inatani M., Tanihara H., Katsuta H., Honjo M., Kido N., and Honda Y. Transforming growth factor-β2 levels in aqueous humor of glaucomatous eyes. Graefes Arch. Clin. Exp. Ophthalmol. 239 (2001) 109-113
93. Ito Y., Aten J., Bende R.J., Oemar B.S., Rabelink T.J., Weening J.J., and Goldschmeding R. Expression of connective tissue growth factor in human renal fibrosis. Kidney Int. 53 (1998) 853-861
94. Jacobson N., Andrews M., Shepard A.R., Nishimura D., Searby C., Fingert J.H., Hageman G., Mullins R., Davidson B.L., Kwon Y.H., Alward W.L., Stone E.M., et al. Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor. Hum. Mol. Genet. 10 (2001) 117-125
95. Jampel H.D., Roche N., Stark W.J., and Roberts A.B. Transforming growth factor-β in human aqueous humor. Curr. Eye Res. 9 (1990) 963-969
96. Jana N.R., Tanaka M., Wang G., and Nukina N. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: Their role in suppression of aggregation and cellular toxicity. Hum. Mol. Genet. 9 (2000) 2009-2018
97. Joe M.K., Sohn S., Hur W., Moon Y., Choi Y.R., and Kee C. Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells. Biochem. Biophys. Res. Commun. 312 (2003) 592-600
98. Joe M.K., Sohn S., Choi Y.R., Park H., and Kee C. Identification of flotillin-1 as a protein interacting with myocilin: Implications for the pathogenesis of primary open-angle glaucoma. Biochem. Biophys. Res. Commun. 336 (2005) 1201-1206
99. Johnson M. What controls aqueous humour outflow resistance?. Exp. Eye Res. 82 (2006) 545-557
100. Johnson M., and Erickson K. Mechanisms and routes of aqueous humor drainage. In: Albert D.M., and Jakobiec F.A. (Eds). Principles and Practice of Ophthalmology (2000), Saunders, Philadelphia 2577-2595
101. Johnston J.A., Dalton M.J., Gurney M.E., and Kopito R.R. Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 97 (2000) 12571-12576
102. Kamphuis W., and Schneemann A. Optineurin gene expression level in human trabecular meshwork does not change in response to pressure elevation. Ophthalmic Res. 35 (2003) 93-96
103. Karali A., Russell P., Stefani F.H., and Tamm E.R. Localization of myocilin/trabecular meshwork inducible glucocorticoid response protein in the human eye. Invest. Ophthalmol. Vis. Sci. 41 (2000) 729-740
104. Karavanich C., and Anholt R.R. Evolution of olfactomedin. Structural constraints and conservation of primary sequence motifs. Ann. N.Y. Acad. Sci. 855 (1998) 294-300
105. Karavanich C.A., and Anholt R.R. Molecular evolution of olfactomedin. Mol. Biol. Evol. 15 (1998) 718-726
106. Khalil N. TGF-β: From latent to active. Microbes Infect. 1 (1999) 1255-1263
107. Kim B.S., Savinova O.V., Reedy M.V., Martin J., Lun Y., Gan L., Smith R.S., Tomarev S.I., John S.W., and Johnson R.L. Targeted disruption of the myocilin gene (Myoc) suggests that human glaucoma-causing mutations are gain of function. Mol. Cell Biol. 21 (2001) 7707-7713
108. Knaupp C., Flügel-Koch C., Goldwich A., Ohlmann A., and Tamm E.R. The expression of myocilin during murine eye development. Graefes Arch. Clin. Exp. Ophthalmol. 242 (2004) 339-345
109. Kroeber M., Ohlmann A., Russell P., and Tamm E.R. Transgenic studies on the role of optineurin in the mouse eye. Exp. Eye Res. 82 (2006) 1075-1085
110. Kubota R., Noda S., Wang Y., Minoshima S., Asakawa S., Kudoh J., Mashima Y., Oguchi Y., and Shimizu N. A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: Molecular cloning, tissue expression and chromosomal mapping. Genomics 41 (1997) 360-369
111. Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., Morgan T.E., Rozovsky I., Trommer B., Viola K.L., Wals P., Zhang C., et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA 95 (1998) 6448-6453
112. Lepple-Wienhues A., Becker M., Stahl F., Berweck S., Hensen J., Noske W., Eichhorn M., and Wiederholt M. Endothelin-like immunoreactivity in the aqueous humour and in conditioned medium from cultured ciliary epithelial cells. Curr. Eye Res. 11 (1992) 1041-1046
113. Lepple-Wienhues A., Stahl F., Willner U., Schafer R., and Wiederholt M. Endothelin-evoked contractions in bovine ciliary muscle and trabecular meshwork: interaction with calcium, nifedipine and nickel. Curr.Eye Res. 10 (1991) 983-989
114. Leask A., and Abraham D.J. TGF-beta signaling and the fibrotic response. Faseb J. 18 (2004) 816-827
115. Leske M.C., Heijl A., Hussein M., Bengtsson B., Hyman L., and Komaroff E. Factors for glaucoma progression and the effect of treatment: The early manifest glaucoma trial. Arch. Ophthalmol. 121 (2003) 48-56
116. Leung Y.F., Fan B.J., Lam D.S., Lee W.S., Tam P.O., Chua J.K., Tham C.C., Lai J.S., Fan D.S., and Pang C.P. Different optineurin mutation pattern in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 44 (2003) 3880-3884
117. Li J., Tripathi B.J., Chalam K.V., and Tripathi R.C. Transforming growth factor-beta 1 and -beta 2 positively regulate TGF-beta 1 mRNA expression in trabecular cells. Invest. Ophthalmol. Vis. Sci. 37 (1996) 2778-2782
118. Li Y., Kang J., and Horwitz M.S. Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains. Mol. Cell Biol. 18 (1998) 1601-1610
119. Li J., Tripathi B.J., and Tripathi R.C. Modulation of pre-mRNA splicing and protein production of fibronectin by TGF-β2 in porcine trabecular cells. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3437-3443
120. Li Y., Aroca-Aguilar J.D., Ghosh S., Sanchez-Sanchez F., Escribano J., and Coca-Prados M. Interaction of myocilin with the C-terminal region of hevin. Biochem. Biophys. Res. Commun. 339 (2006) 797-804
121. Liang Y., Li C., Guzman V.M., Evinger III A.J., Protzman C.E., Krauss A.H., and Woodward D.F. Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression. J. Biol. Chem. 278 (2003) 27267-27277
122. Liton P.B., Liu X., Challa P., Epstein D.L., and Gonzalez P. Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress. J. Cell. Physiol. 205 (2005) 364-371
123. Liu Y. Renal fibrosis: New insights into the pathogenesis and therapeutics. Kidney Int. 69 (2006) 213-217
124. Liu Y., and Vollrath D. Reversal of mutant myocilin non-secretion and cell killing: Implications for glaucoma. Hum. Mol. Genet. 13 (2004) 1193-1204
125. Luo G., Hofmann C., Bronckers A.L., Sohocki M., Bradley A., and Karsenty G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 9 (1995) 2808-2820
126. Luo G., Ducy P., McKee M.D., Pinero G.J., Loyer E., Behringer R.R., and Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386 (1997) 78-81
127. Lütjen-Drecoll E., and Rohen J.W. Functional morphology of the trabecular meshwork. In: Tasman W., and Jaeger E.A. (Eds). Duane's Foundations of Clinical Ophthalmology (2001), Lippincott, Philadelphia 1-30
128. Lütjen-Drecoll E., Shimizu T., Rohrbach M., and Rohen J.W. Quantitative analysis of "plaque material" in the inner and outer wall of Schlemm's canal in normal and glaucomatous eyes. Exp. Eye Res. 42 (1986) 443-455
129. Lütjen-Drecoll E., May C.A., Polansky J.R., Johnson D.H., Bloemendal H., and Nguyen T.D. Localization of the stress proteins αB-crystallin and trabecular meshwork inducible glucocorticoid response protein in normal and glaucomatous trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 39 (1998) 517-525
130. Malyukova I., Lee H.S., Fariss R.N., and Tomarev S.I. Mutated mouse and human myocilins have similar properties and do not block general secretory pathway. Invest. Ophthalmol. Vis. Sci. 47 (2006) 206-212
131. Mao M., Biery M.C., Kobayashi S.V., Ward T., Schimmack G., Burchard J., Schelter J.M., Dai H., He Y.D., and Linsley P.S. T lymphocyte activation gene identification by coregulated expression on DNA microarrays. Genomics 83 (2004) 989-999
132. Mertts M., Garfield S., Tanemoto K., and Tomarev S.I. Identification of the region in the N-terminal domain responsible for the cytoplasmic localization of Myoc/Tigr and its association with microtubules. Lab. Invest. 79 (1999) 1237-1245
133. Meyer P., Wunderlich K., Kain H.L., Prunte C., and Flammer J. Human connective tissue growth factor mRNA expression of epiretinal and subretinal fibrovascular membranes: A report of three cases. Ophthalmologica 216 (2002) 284-291
134. Monemi S., Spaeth G., DaSilva A., Popinchalk S., Ilitchev E., Liebmann J., Ritch R., Heon E., Crick R.P., Child A., and Sarfarazi M. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. Hum. Mol. Genet. 14 (2005) 725-733
135. Moreland R.J., Dresser M.E., Rodgers J.S., Roe B.A., Conaway J.W., Conaway R.C., and Hanas J.S. Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 28 (2000) 1986-1993
136. Munger J.S., Huang X., Kawakatsu H., Griffiths M.J., Dalton S.L., Wu J., Pittet J.F., Kaminski N., Garat C., Matthay M.A., Rifkin D.B., and Sheppard D. The integrin αvβ6 binds and activates latent TGFβ1: A mechanism for regulating pulmonary inflammation and fibrosis. Cell 96 (1999) 319-328
137. Murphy-Ullrich J.E., and Hook M. Thrombospondin modulates focal adhesions in endothelial cells. J. Cell Biol. 109 (1989) 1309-1319
138. Murphy-Ullrich J.E., and Poczatek M. Activation of latent TGF-β by thrombospondin-1: Mechanisms and physiology. Cytokine Growth Factor Rev. 11 (2000) 59-69
139. Nguyen T.D., Chen P., Huang W.D., Chen H., Johnson D., and Polansky J.R. Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells. J. Biol. Chem. 273 (1998) 6341-6350
140. Noda S., Mashima Y., Obazawa M., Kubota R., Oguchi Y., Kudoh J., Minoshima S., and Shimizu N. Myocilin expression in the astrocytes of the optic nerve head. Biochem. Biophys. Res. Commun. 276 (2000) 1129-1135
141. Noske W., Hensen J., and Wiederholt M. Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract. Graefes Arch. Clin. Exp. Ophthalmol. 235 (1997) 551-552
142. Obazawa M., Mashima Y., Sanuki N., Noda S., Kudoh J., Shimizu N., Oguchi Y., Tanaka Y., and Iwata T. Analysis of porcine optineurin and myocilin expression in trabecular meshwork cells and astrocytes from optic nerve head. Invest. Ophthalmol. Vis. Sci. 45 (2004) 2652-2659
143. Ochiai Y., and Ochiai H. Higher concentration of transforming growth factor-β in aqueous humor of glaucomatous eyes and diabetic eyes. Jpn. J. Ophthalmol. 46 (2002) 249-253
144. Ohlmann A., Goldwich A., Flügel-Koch C., Fuchs A.V., Schwager K., and Tamm E.R. Secreted glycoprotein myocilin is a component of the myelin sheath in peripheral nerves. Glia 43 (2003) 128-140
145. Ortego J., Escribano J., and Coca-Prados M. Cloning and characterization of subtracted cDNAs from human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett. 413 (1997) 349-353
146. Park B.C., Shen X., Samaraweera M., and Yue B.Y. Studies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types. Am. J. Pathol. 169 (2006) 1976-1989
147. Perkumas K.M., Hoffman E.A., McKay B.S., Allingham R.R., and Stamer W.D. Myocilin-associated exosomes in human ocular samples. Exp. Eye Res. 84 (2007) 209-212
148. Peters D.M., Herbert K., Biddick B., and Peterson J.A. Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions. Exp. Cell Res. 303 (2005) 218-228
149. Picht G., Welge-Luessen U., Grehn F., and Lütjen-Drecoll E. Transforming growth factor-β2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch. Clin. Exp. Ophthalmol. 239 (2001) 199-207
150. Price P.A., and Williamson M.K. Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. J. Biol. Chem. 260 (1985) 14971-14975
151. Rao P.V., Allingham R.R., and Epstein D.L. TIGR/myocilin in human aqueous humor. Exp. Eye Res. 71 (2000) 637-641
152. Rezaie T., and Sarfarazi M. Molecular cloning, genomic structure, and protein characterization of mouse optineurin. Genomics 85 (2005) 131-138
153. Rezaie T., Child A., Hitchings R., Brice G., Miller L., Coca-Prados M., Heon E., Krupin T., Ritch R., Kreutzer D., Crick R.P., and Sarfarazi M. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science 295 (2002) 1077-1079
154. Rezaie T., Waitzman D.M., Seeman J.L., Kaufman P.L., and Sarfarazi M. Molecular cloning and expression profiling of optineurin in the rhesus monkey. Invest. Ophthalmol. Vis. Sci. 46 (2005) 2404-2410
155. Rhee D.J., Fariss R.N., Brekken R., Sage E.H., and Russell P. The matricellular protein SPARC is expressed in human trabecular meshwork. Exp. Eye Res. 77 (2003) 601-607
156. Ricard C.S., Agapova O.A., Salvador-Silva M., Kaufman P.L., and Hernandez M.R. Expression of myocilin/TIGR in normal and glaucomatous primate optic nerves. Exp. Eye Res. 73 (2001) 433-447
157. Ricard C.S., Mukherjee A., Silver F.L., and Wagenknecht P.L. Canine myocilin is associated with lipid modified by palmitic acid. Mol. Vis. 12 (2006) 1427-1436
158. Rodriguez-Vita J., Ruiz-Ortega M., Ruperez M., Esteban V., Sanchez-Lopez E., Plaza J.J., and Egido J. Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ. Res. 97 (2005) 125-134
159. Rohen J.W., and Witmer R. Electron microscopic studies on the trabecular meshwork in glaucoma simplex. Albrecht Von. Graefes Arch. Klin. Exp. Ophthalmol. 183 (1972) 251-266
160. Rohen J.W., Futa R., and Lütjen-Drecoll E. The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections. Invest. Ophthalmol. Vis. Sci. 21 (1981) 574-585
161. Rohen J.W., Lütjen-Drecoll E., Flügel C., Meyer M., and Grierson I. Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG). Exp. Eye Res. 56 (1993) 683-692
162. Russell P., Tamm E.R., Grehn F.J., Picht G., and Johnson M. The presence and properties of myocilin in the aqueous humor. Invest. Ophthalmol. Vis. Sci. 42 (2001) 983-986
163. Sage E.H., and Bornstein P. Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin. J. Biol. Chem. 266 (1991) 14831-14834
164. 2+-dependent binding to the extracellular matrix. J. Cell Biol. 109 (1989) 341-356
165. Sahlender D.A., Roberts R.C., Arden S.D., Spudich G., Taylor M.J., Luzio J.P., Kendrick-Jones J., and Buss F. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. J. Cell. Biol. 169 (2005) 285-295
166. Saika S., Ikeda K., Yamanaka O., Flanders K.C., Nakajima Y., Miyamoto T., Ohnishi Y., Kao W.W., Muragaki Y., and Ooshima A. Therapeutic effects of adenoviral gene transfer of bone morphogenic protein-7 on a corneal alkali injury model in mice. Lab. Invest. 85 (2005) 474-486
167. Sanchez-Capelo A. Dual role for TGF-beta1 in apoptosis. Cytokine Growth Factor Rev. 16 (2005) 15-34
168. Sanchez-Sanchez F., Martinez-Redondo F., Aroca-Aguilar J.D., Coca-Prados M., and Escribano J. Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin processing protease. J. Biol. Chem. 282 38 (2007) 27810-27824
169. Sato S., Nagaoka T., Hasegawa M., Tamatani T., Nakanishi T., Takigawa M., and Takehara K. Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: Association with extent of skin sclerosis and severity of pulmonary fibrosis. J. Rheumatol. 27 (2000) 149-154
170. Schnaper H.W., Hayashida T., Hubchak S.C., and Poncelet A.C. TGF-β signal transduction and mesangial cell fibrogenesis. Am. J. Physiol. Renal Physiol. 284 (2003) F243-F252
171. Schultz-Cherry S., Lawler J., and Murphy-Ullrich J.E. The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J. Biol. Chem. 269 (1994) 26783-26788
172. Senatorov V., Malyukova I., Fariss R., Wawrousek E.F., Swaminathan S., Sharan S.K., and Tomarev S. Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice. J. Neurosci. 26 (2006) 11903-11914
173. Shepard A.R., Jacobson N., Sui R., Steely H.T., Lotery A.J., Stone E.M., and Clark A.F. Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usage. BMC Genet. 4 (2003) 5
174. Shepard A.R., Jacobson N., Millar J.C., Pang I.H., Steely H.T., Searby C.C., Sheffield V.C., Stone E.M., and Clark A.F. Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure. Hum. Mol. Genet. 16 (2007) 609-617
175. Snyder D.A., Rivers A.M., Yokoe H., Menco B.P., and Anholt R.R. Olfactomedin: Purification, characterization, and localization of a novel olfactory glycoprotein. Biochemistry 30 (1991) 9143-9153
176. Sohn S., Hur W., Joe M.K., Kim J.H., Lee Z.W., Ha K.S., and Kee C. Expression of wild-type and truncated myocilins in trabecular meshwork cells: Their subcellular localizations and cytotoxicities. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3680-3685
177. Stamer W.D., Perkumas K.M., Hoffman E.A., Roberts B.C., Epstein D.L., and McKay B.S. Coiled-coil targeting of myocilin to intracellular membranes. Exp. Eye Res. 83 (2006) 1386-1395
178. Stone E.M., Fingert J.H., Alward W.L.M., Nguyen T.D., Polansky J.R., Sunden S.L.F., Nishimura D., Clark A.F., Nystuen A., Nichols B.E., Mackey D.A., Ritch R., et al. Identification of a gene that causes primary open angle glaucoma. Science 275 (1997) 668-670
179. Stroissnigg H., Repitz M., Miloloza A., Linhartova I., Beug H., Wiche G., and Propst F. FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation. Exp. Cell Res. 278 (2002) 133-145
180. Swiderski R.E., Ying L., Cassell M.D., Alward W.L., Stone E.M., and Sheffield V.C. Expression pattern and in situ localization of the mouse homologue of the human MYOC (GLC1A) gene in adult brain. Brain Res. Mol. Brain Res. 68 (1999) 64-72
181. Swiderski R.E., Ross J.L., Fingert J.H., Clark A.F., Alward W.L., Stone E.M., and Sheffield V.C. Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3420-3428
182. Taguchi M., Kanno H., Kubota R., Miwa S., Shishiba Y., and Ozawa Y. Molecular cloning and expression profile of rat myocilin. Mol. Genet. Metab. 70 (2000) 75-80
183. Takahashi H., Noda S., Imamura Y., Nagasawa A., Kubota R., Mashima Y., Kudoh J., Oguchi Y., and Shimizu N. Mouse myocilin (Myoc) gene expression in ocular tissues. Biochem. Biophys. Res. Commun. 248 (1998) 104-109
184. Tamm E., Flügel C., Stefani F.H., and Rohen J.W. Contractile cells in the human scleral spur. Exp. Eye Res. 54 (1992) 531-543
185. Tamm E., Russell P., Epstein D.L., Johnson D.H., and Piatigorsky J. Modulation of Myocilin/TIGR expression in human trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2577-2582
186. Tamm E.R. Myocilin and glaucoma: Facts and ideas. Prog. Retin. Eye Res. 21 (2002) 395-428
187. Tamm E.R., Russell P., Johnson D.H., and Piatigorsky J. Human and monkey trabecular meshwork accumulate alpha B-crystallin in response to heat shock and oxidative stress. Invest. Ophthalmol. Vis. Sci. 37 (1996) 2402-2413
188. Tamm E.R., Siegner A., Baur A., and Lütjen-Drecoll E. Transforming growth factor-β1 induces α-smooth muscle-actin expression in cultured human and monkey trabecular meshwork. Exp. Eye Res. 62 (1996) 389-397
189. Tamm E.R., Toris C.B., Crowston J.G., Sit A., Lim S., Lambrou G., and Alm A. Basic science of intraocular pressure. In: Weinreb R.N., Brandt J.D., Garway-Heath D., and Medeiros F. (Eds). Intraocular Pressure. Reports and Consensus Statements of the 4th Global AIGS Consensus Meeting on Intraocular Pressure (2007), Kugler Publications, Amsterdam 1-14
190. Tezel G., and Wax M.B. Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J. Neurosci. 20 (2000) 8693-8700
191. Tezel G., Li L.Y., Patil R.V., and Wax M.B. TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1787-1794
192. The AGIS Investigators. The advanced glaucoma intervention study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am. J. Ophthalmol. 130 (2000) 429-440
193. Tian B., Geiger B., Epstein D.L., and Kaufman P.L. Cytoskeletal involvement in the regulation of aqueous humor outflow. Invest. Ophthalmol. Vis. Sci. 41 (2000) 619-623
194. Tomarev S.I., Tamm E.R., and Chang B. Characterization of the mouse myoc/tigr gene. Biochem. Biophys. Res. Commun. 245 (1998) 887-893
195. Tomarev S.I., Wistow G., Raymond V., Dubois S., and Malyukova I. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Invest. Ophthalmol. Vis. Sci. 44 (2003) 2588-2596
196. Torrado M., Trivedi R., Zinovieva R., Karavanova I., and Tomarev S.I. Optimedin: A novel olfactomedin-related protein that interacts with myocilin. Hum. Mol. Genet. 11 (2002) 1291-1301
197. Tripathi R.C. Aqueous outflow pathway in normal and glaucomatous eyes. Br. J. Ophthalmol. 56 (1972) 157-174
198. Tripathi R.C., Borisuth N.S., Kolli S.P., and Tripathi B.J. Trabecular cells express receptors that bind TGF-β1 and TGF- β2: A qualitative and quantitative characterization. Invest. Ophthalmol. Vis. Sci. 34 (1993) 260-263
199. Tripathi R.C., Li J.P., Borisuth N.S.C., and Tripathi B.J. Trabecular cells of the eye express messenger RNA for transforming growth factor-β1 and secrete this cytokine. Invest. Ophthalmol. Vis. Sci. 34 (1993) 2562-2569
200. Tripathi R.C., Chan W.F.A., Li J., and Tripathi B.J. Trabecular cells express the TGF-β2 gene and secrete this cytokine. Exp. Eye Res. 58 (1994) 523-528
201. Tripathi R.C., Li J., Chan W.F.A., and Tripathi B.J. Aqueous humor in glaucomatous eyes contains an increased level of TGF-β2. Exp. Eye Res. 58 (1994) 723-727
202. Ueda J., Wentz-Hunter K.K., Cheng E.L., Fukuchi T., Abe H., and Yue B.Y. Ultrastructural localization of myocilin in human trabecular meshwork cells and tissues. J. Histochem. Cytochem. 48 (2000) 1321-1330
203. van Setten G.B., Blalock T.D., Grotendorst G., and Schultz G.S. Detection of connective tissue growth factor in human aqueous humor. Ophthalmic Res. 34 (2002) 306-308
204. van Setten G., Aspiotis M., Blalock T.D., Grotendorst G., and Schultz G. Connective tissue growth factor in pterygium: Simultaneous presence with vascular endothelial growth factor - Possible contributing factor to conjunctival scarring. Graefes Arch. Clin. Exp. Ophthalmol. 241 (2003) 135-139
205. van Setten G.B., Blalock T.D., Grotendorst G., and Schultz G.S. Detection of connective tissue growth factor (CTGF) in human tear fluid: Preliminary results. Acta Ophthalmol. Scand. 81 (2003) 51-53
206. Vittitow J., and Borras T. Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure. Biochem. Biophys. Res. Commun. 298 (2002) 67-74
207. Vittitow J., and Borras T. Genes expressed in the human trabecular meshwork during pressure-induced homeostatic response. J. Cell. Physiol. 201 (2004) 126-137
208. Vollrath D., and Liu Y. Temperature sensitive secretion of mutant myocilins. Exp. Eye Res. 82 (2006) 1030-1036
209. Wang S., and Hirschberg R. BMP7 antagonizes TGF-beta-dependent fibrogenesis in mesangial cells. Am. J. Physiol. Renal. Physiol. 284 (2003) F1006-F1013
210. Wang S., and Hirschberg R. Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells. J. Biol. Chem. 279 (2004) 23200-23206
211. Wang J., Zohar R., and McCulloch C.A. Multiple roles of alpha-smooth muscle actin in mechanotransduction. Exp. Cell Res. 312 (2006) 205-214
212. Wang J.T., Kunzevitzky N.J., Dugas J.C., Cameron M., Barres B.A., and Goldberg J.L. Disease gene candidates revealed by expression profiling of retinal ganglion cell development. J. Neurosci. 27 (2007) 8593-8603
213. Weisschuh N., Neumann D., Wolf C., Wissinger B., and Gramer E. Prevalence of myocilin and optineurin sequence variants in German normal tension glaucoma patients. Mol. Vis. 11 (2005) 284-287
214. Weisschuh N., Wolf C., Wissinger B., and Gramer E. Variations in the WDR36 gene in German patients with normal tension glaucoma. Mol. Vis. 13 (2007) 724-729
215. Welge-Lüssen U., May C.A., Eichhorn M., Bloemendal H., and Lütjen-Drecoll E. AlphaB-crystallin in the trabecular meshwork is inducible by transforming growth factor-beta. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2235-2241
216. Welge-Lüssen U., May C.A., and Lütjen-Drecoll E. Induction of tissue transglutaminase in the trabecular meshwork by TGF- β1 and TGF-β2. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2229-2238
217. Welihinda A.A., Tirasophon W., and Kaufman R.J. The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expr. 7 (1999) 293-300
218. Wentz-Hunter K., Ueda J., Shimizu N., and Yue B.Y. Myocilin is associated with mitochondria in human trabecular meshwork cells. J. Cell Physiol. 190 (2002) 46-53
219. Wentz-Hunter K., Ueda J., and Yue B.Y. Protein interactions with myocilin. Invest. Ophthalmol. Vis. Sci. 43 (2002) 176-182
220. Wiederholt M., Bielka S., Schweig F., Lütjen-Drecoll E., and Lepple-Wienhues A. Regulation of outflow rate and resistance in the perfused anterior segment of the bovine eye. Exp. Eye Res. 61 (1996) 223-234
221. Wiederholt M., Thieme H., and Stumpff F. The regulation of trabecular meshwork and ciliary muscle contractility. Prog. Retin. Eye Res. 19 (2000) 271-295
222. Wiggs J.L., Del Bono E.A., Schuman J.S., Hutchinson B.T., and Walton D.S. Clinical features of five pedigrees genetically linked to the juvenile glaucoma locus on chromosome 1q21-q31. Ophthalmology 102 (1995) 1782-1789
223. Willis B.C., and Borok Z. TGF-{beta}-induced EMT: Mechanisms and implications for fibrotic lung disease. Am. J. Physiol. Lung Cell. Mol. Physiol. (2007)
224. Willoughby C.E., Chan L.L., Herd S., Billingsley G., Noordeh N., Levin A.V., Buys Y., Trope G., Sarfarazi M., and Heon E. Defining the pathogenicity of optineurin in juvenile open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 45 (2004) 3122-3130
225. Wirtz M.K., Samples J.R., Xu H., Severson T., and Acott T.S. Expression profile and genome location of cDNA clones from an infant human trabecular meshwork cell library. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3698-3704
226. Wordinger R.J., Agarwal R., Talati M., Fuller J., Lambert W., and Clark A.F. Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues. Mol. Vis. 8 (2002) 241-250
227. Wordinger R.J., Fleenor D.L., Hellberg P.E., Pang I.H., Tovar T.O., Zode G.S., Fuller J.A., and Clark A.F. Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: Implications for glaucoma. Invest. Ophthalmol. Vis. Sci. 48 (2007) 1191-1200
228. Wunderlich K., Pech M., Eberle A.N., Mihatsch M., Flammer J., and Meyer P. Expression of connective tissue growth factor (CTGF) mRNA in plaques of human anterior subcapsular cataracts and membranes of posterior capsule opacification. Curr. Eye Res. 21 (2000) 627-636
229. Wunderlich K., Senn B.C., Reiser P., Pech M., Flammer J., and Meyer P. Connective tissue growth factor in retrocorneal membranes and corneal scars. Ophthalmologica 214 (2000) 341-346
230. Wunderlich K., Senn B.C., Todesco L., Flammer J., and Meyer P. Regulation of connective tissue growth factor gene expression in retinal vascular endothelial cells by angiogenic growth factors. Graefes Arch. Clin. Exp. Ophthalmol. 238 (2000) 910-915
231. Xue W., Wallin R., Olmsted-Davis E.A., and Borras T. Matrix GLA protein function in human trabecular meshwork cells: Inhibition of BMP2-induced calcification process. Invest. Ophthalmol. Vis. Sci. 47 (2006) 997-1007
232. Xue W., Comes N., and Borras T. Presence of an established calcification marker in trabecular meshwork tissue of glaucoma donors. Invest. Ophthalmol. Vis. Sci. 48 (2007) 3184-3194
233. Yam G.H., Gaplovska-Kysela K., Zuber C., and Roth J. Aggregated myocilin induces russell bodies and causes apoptosis: Implications for the pathogenesis of myocilin-caused primary open-angle glaucoma. Am. J. Pathol. 170 (2007) 100-109
234. Yamamoto T., Sawada Y., Katayama I., and Nishioka K. Nodular scleroderma: Increased expression of connective tissue growth factor. Dermatology 211 (2005) 218-223
235. Yang D.H., Kim H.S., Wilson E.M., Rosenfeld R.G., and Oh Y. Identification of glycosylated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF-beta in Hs578T human breast cancer cells. J. Clin. Endocrinol. Metab. 83 (1998) 2593-2596
236. You L., Kruse F.E., Pohl J., and Volcker H.E. Bone morphogenetic proteins and growth and differentiation factors in the human cornea. Invest. Ophthalmol. Vis. Sci. 40 (1999) 296-311
237. Yuan L., and Neufeld A.H. Tumor necrosis factor-alpha: A potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia 32 (2000) 42-50
238. Zeisberg M., Hanai J., Sugimoto H., Mammoto T., Charytan D., Strutz F., and Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat. Med. 9 (2003) 964-968
239. Zhang J., Liu W.L., Tang D.C., Chen L., Wang M., Pack S.D., Zhuang Z., and Rodgers G.P. Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. Gene 283 (2002) 83-93
240. Zhao X., and Russell P. Versican splice variants in human trabecular meshwork and ciliary muscle. Mol. Vis. 11 (2005) 603-608
241. Zhao X., Ramsey K.E., Stephan D.A., and Russell P. Gene and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta. Invest. Ophthalmol. Vis. Sci. 45 (2004) 4023-4034
242. Zhou Z., and Vollrath D. A cellular assay distinguishes normal and mutant TIGR/myocilin protein. Hum. Mol. Genet. 8 (1999) 2221-2228
243. Zillig M., Wurm A., Grehn F.J., Russell P., and Tamm E.R. Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice. Invest. Ophthalmol. Vis. Sci. 46 (2005) 223-234