TGF-β latency: Biological significance and mechanisms of activation

Stem Cells

Volumn 15, Issue 3, 1997, Pages 190-197

  Gleizes, Pierre Emmanuel ^a,b   Munger, John S ^a   Nunes, Irene ^a   Harpel, John G ^a   Mazzieri, Roberta ^a   Noguera, Irene ^a   Rifkin, Daniel B ^a  

^a Kaplan Cancer Center   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bioavailability; Extracellular matrix; Growth factor; Latent TGF binding protein (LTBP); Proteases; Transforming growth factor

Indexed keywords

CARRIER PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

COMPLEX FORMATION; EXTRACELLULAR MATRIX; HUMAN; METABOLIC ACTIVATION; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN BINDING; PROTEIN PROCESSING; REVIEW;

EID: 0030946194     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.150190     Document Type: Review

References (70)

1. Massague J. The transforming growth factor-beta family. Annu Rev Cell Biol 1990;6:597-641.
2. Lawrence DA. Identification and activation of latent transforming growth factor beta. Methods Enzymol 1991;198:327-336.
3. Theodorescu D, Bergsma D, Man MS et al. Cloning and overexpression of TGF-β1 cDNA in a mammary adenocarcinoma: in vitro and in vivo effects. Growth Factors 1991;5:305-316.
4. Pierce D Jr, Johnson MD, Matsui Y et al. Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. Genes Dev 1993;7:2308-2317.
5. Boulanger J, Reyes-Moreno C, Koutsilieris M. Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor-β1 in MG-63 human osteosarcoma cells. Int J Cancer 1995;61:692-697.
6. Arrick BA, Lopez AR, Elfman F et al. Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor β1. J Cell Biol 1992;118:715-726.
7. Kulkarni AB, Huh CG, Becker D et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993;90:770-774.
8. Diebold RJ, Eis MJ, Yin M et al. Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. Proc Natl Acad Sci USA 1995;92:12215-12219.
9. Dickson MC, Martin JS, Cousins FM et al. Defective hematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice. Development 1995;121:1845-1854.
10. Borkowski TA, Letterio JJ, Fair AG et al. A role for endogenous transforming growth factor β1 in Langherans cell biology: the skin of transforming growth factor β1 null mice is devoid of epidermal Langherans cells. J Exp Med 1996;184:2417-2422.
11. Proetzel G, Pawlowski SA, Wiles MV et al. Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet 1995;11:409-414.
12. Roberts AB, Sporn MB. The transforming growth factor-βs. In: Roberts AB, Sporn MB, eds. Peptide Growth Factors and Their Receptors. I. New York: Springer-Verlag, 1990:419-472.
13. Glick AB, Lee MM, Darwiche N et al. Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma. Genes Dev 1994;8:2429-2440.
14. Sachs L. The control of hematopoiesis and leukemia: from basic biology to the clinic. Proc Natl Acad Sci USA 1996;93:4742-4749.
15. Zhou L, Dey CR, Wert SE et al. Arrested lung morphogenesis in transgenic mice bearing an SP-C-TGF-beta I chimeric gene. Dev Biol 1996;175:227-238.
16. Sellheyer K, Bickenbach JR, Rothnagel JA et al. Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice. Proc Natl Acad Sci USA 1993;90:5237-5241,
17. Sanderson N, Factor V, Nagy P et al. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA 1995;92:2572-2576.
18. Galbreath E, Kim SJ, Park K et al. Overexpression of TCP-beta 1 in the central nervous system of transgenic mice results in hydrocephalus. J Neuropath Exp Neurol 1995;54:339-349.
19. Gentry LE, Nash BW. The pro-domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor. Biochemistry 1990;29:6851-6857.
20. Dubois CM, Laprise MH, Blanchette F et al. Processing of transforming growth factor beta 1 precursor by human furin convertase. J Biol Chem 1995;270:10618-10624.
21. Purchio AF, Cooper JA, Brunner AM et al. Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor. J Biol Chem 1988;263:14211-14215.
22. Daopin S, Piez KA, Ogawa Y et al. Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. Science 1992;257:369-373.
23. Schlunegger MP, Grutter MG. An unusual feature revealed by the crystal structure at 2.2. Å resolution of human transforming growth factor-beta 2. Nature 1992;358:430-434.
24. McMahon GA, Dignam JD, Gentry LE. Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide. Biochem J 1996;313:343-351.
25. Brown PD, Wakefield LM, Levinson AD et al. Physicochemical activation of recombinant latent transforming growth factor-betas 1, 2, and 3. Growth Factors 1990;3:35-43.
26. Lawrence DA, Pircher R, Jullien P. Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions. Biochem Biophys Res Commun 1985;133:1026-1034.
27. Oreffo R, Mundy G, Seyedin S et al. Activation of the bone-derived latent TGF-beta complex by isolated osteoclasts. Biochem Biophys Res Commun 1989;158:817-822.
28. Bonewald LF, Mundy GR. Role of transforming growth factor beta in bone remodeling: a review. Connect Tissue Res 1989;23:201-208.
29. Barcellos-Hoff MH, Dix TA. Redox-mediated activation of latent transforming growth factor-β1. Mol Endocrinol 1996; 10:1079-1083.
30. Barcellos-Hoff MH, Derynck R, Tsang ML et al. Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest 1994;93:892-899.
31. Miyazono K, Heldin CH. Role for carbohydrate structures in TGF-beta 1 latency. Nature 1989;338:158-160.
32. Schultz-Cherry S, Hinshaw VS. Influenza virus neuraminidase activates latent transforming growth factor β. J Virol 1996;70:8624-8629.
33. Lyons RM, Gentry LE, Purchio AF et al. Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J Cell Biol 1990;110:1361-1367.
34. Lyons RM, Keski-Oja J, Moses HL. Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. J Cell Biol 1988;106:1659-1665.
35. Schultz-Cherry S, Lawler J, Murphy-Ullrich JE. The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-β. J Biol Chem 1994;269:26783-26788.
36. Schultz-Cherry S, Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol 1993;122:923-932.
37. Souchelnitskiy S, Chambaz EM, Feige JJ. Thrombospondins selectively activate one of the two latent forms of transforming growth factor-β present in adrenocortical cell-conditioned medium. Endocrinology 1995;136:5118-5126.
38. Miyazono K, Hellman U, Wemstedt C et al. Latent high molecular weight complex of transforming growth factor β1. J Biol Chem 1988;263:6407-6415.
39. Kanzaki T, Olofsson A, Moren A et al. TGF-β1 binding protein: a component of the large latent complex of TGF-β1 with multiple repeat sequences. Cell 1990;61:1051-1061.
40. Tsuji T, Okada F, Yamagushi K et al. Molecular cloning of the large subunit of transforming growth factor type βmasking protein and expression of the mRNA in various rat tissues. Proc Natl Acad Sci USA 1990;87:8835-8839.
41. Gibson MA, Hatzinikolas G, Davis EC et al. Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils. Mol Cell Biol 1995;15:6932-6942.
42. Moren A, Olofsson A, Stenman G et al. Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein. J Biol Chem 1994;269:32469-32478.
43. Yin W, Smiley E, Germiller J et al. Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). J Biol Chem 1995;270:10147-10160.
44. Miyazono K, Olofsson A, Colosetti P et al. A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO J 1991;10:1091-1101.
45. Dallas SL, Park-Snyder S, Miyazono K et al. Characterization and autoregulation of latent transforming growth factor β (TGFβ) complexes in osteoblast-like cell lines: production of a latent complex lacking the latent TGFβ-binding protein. J Biol Chem 1994;269:6815-6822.
46. Gleizes P-E, Beavis RC, Mazzieri R et al. Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-β binding protein-1 (LTBP-I) that mediates bonding to the latent transforming growth factor-β1. J Biol Chem 1996;271:29891-29896.
47. Saharinen J, Taipale J, Keski-Oja J. Association of the small latent transforming growth factor-β with an eight cysteine repeat of protein LTBP-I. EMBO J 1996;15:245-253.
48. Taipale J, Miyazono K, Heldin CH et al. Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein. J Cell Biol 1994;124:171-181.
49. Taipale J, Saharinen J, Hedman K et al. Latent transforming growth factor-β1 and its binding protein are components of extracellular matrix fibrils. J Histochem Cytochem 1996;44:875-889.
50. Dallas SL, Miyazono K, Skerry TM et al. Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. J Cell Biol 1995;131:539-549.
51. Nunes I, Gleizes P-E, Metz CN et al. Latent TGF-β binding protein domains involved in activation and transglutaminase-dependent crosslinking of latent TGF-β. J Cell Biol 1997; 136:1151-1163.
52. Olofsson A, Ichijo H, Moren A et al. Efficient association of an amino-terminally extended form of human latent transforming growth factor-β binding protein with the extracellular matrix. J Biol Chem 1995;270:31294-31297.
53. Taipale J, Lohi J, Saharinen J et al. Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells. J Biol Chem 1995;270:4689-4696.
54. Kojima S, Kiyomitsu N, Rifkin DB. Requirement for transglutaminase in the activation of latent transforming growth factor-β in bovine endothelial cells. J Cell Biol 1993;121:439-448.
55. Flaumenhaft R, Abe M, Mignatti P et al. Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity. J Cell Biol 1992;118:901-909.
56. Nunes I, Shapiro RL, Rifkin DB. Characterization of latent TCP-beta activation by murine peritoneal macrophages. J Immunol 1995;155:1450-1459.
57. Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-β1-like molecule by plasmin during coculture. J Cell Biol 1989;109:309-315.
58. Antonelli-Orlidge A, Saunders K, Smith S et al. An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. Proc Natl Acad Sci USA 1989;86:4544-4548.
59. Kojima S, Harpel P, Rifkin D. Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration. J Cell Biol 1991;113:1439-1445.
60. Grainger DJ, Kirschenlohr HL, Metcalfe JC et al. Proliferation of human smooth muscle cells promoted by lipoprotein(a). Science 1993;260:1655-1658.
61. Grainger DJ, Kemp PR, Liu AC et al. Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice. Nature 1994;370:460-462.
62. Lawn RM, Pearle AD, Kunz LL et al. Feedback mechanism of focal vascular lesion formation in transgenic apolipoprotein(a) mice. J Biol Chem 1996;271:31367-31371.
63. Dennis P, Rifkin, DB. Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose-6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci USA 1991;88:580-584.
64. de Bleser PJ, Jannes P, van Buul-Offers SC et al. Insulinlike growth factor-II/mannose 6-phosphate receptor is expressed on CC14-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells. Hepatology 1995;21:1429-1437.
65. Flaumenhaft R, Abe M, Sato Y et al. Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells. J Cell Biol 1993;120:995-1002.
66. Nunes I, Munger JS, Harpel JG et al. Structure and activation of the large latent transforming growth factor-β complex. Int J Obes 1996;20(suppl 3):S4-S8.
67. Nunes I, Kojima S, Rifkin DB. Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells. Cancer Res 1996;56:495-499.
68. Bizik J, Felnerova D, Grofova M et al. Active transforming growth factor-β in human melanoma cell lines: no evidence for plasmin-related activation of latent TGF-β. J Cell Biochem 1996;62:113-122.
69. Kojima S, Rifkin DB. Mechanism of retinoid-induced activation of latent transforming growth factor-β in bovine endothelial cells. J Cell Physiol 1993;155:323-332.
70. Oursler MJ, Riggs BL, Spelsberg TC. Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells. Endocrinology 1993;133:2187-2196.