Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227

Journal of Biological Chemistry

Volumn 280, Issue 22, 2005, Pages 21043-21051

  Aroca Aguilar, J Daniel ^a   Sánchez Sánchez, Francisco ^a   Ghosh, Sikha ^b   Coca Prados, Miguel ^b   Escribano, Julio ^a  

^a Universidad de Castilla La Mancha   (Spain)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; DISEASES; IMMUNOLOGY; PATHOLOGY; PROTEINS; TISSUE;

GLAUCOMA; MYOCILIN; NONOCULAR TISSUES; PATHOGENESIS;

MUTAGENESIS;

AMINO ACID; ARGININE; GLYCOPROTEIN; ISOLEUCINE; LEUCINE ZIPPER PROTEIN; MYOCILIN;

ADULT; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; BLINDNESS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; EYE; GENE MUTATION; GENETIC TRANSFECTION; GLAUCOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MALE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; WESTERN BLOTTING; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BLOTTING, WESTERN; BREFELDIN A; CATTLE; CELL LINE; COMPUTATIONAL BIOLOGY; COS CELLS; CULTURE MEDIA; CYTOSKELETAL PROTEINS; EXTRACELLULAR MATRIX PROTEINS; EYE PROTEINS; GLAUCOMA; GLYCOPROTEINS; GREEN FLUORESCENT PROTEINS; HUMANS; ISOLEUCINE; LEUCINE; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

EID: 20444371356     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501340200     Document Type: Article

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