Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 11, 2000, Pages 3420-3428

  Swiderski, R E ^a   Ross, J L ^a   Fingert, J H ^a   Clark, A F ^a   Alward, W L M ^a   Stone, E M ^a   Sheffield, V C ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; COMPLEMENTARY RNA; EYE PROTEIN; MESSENGER RNA; MYOCILIN; SULFUR 35; UNCLASSIFIED DRUG;

ADULT; AGED; AQUEOUS HUMOR OUTFLOW; ARACHNOID; ARTICLE; CILIARY MUSCLE; CORNEA STROMA; DURA MATER; ENDOTHELIUM; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; INTRAOCULAR PRESSURE; IRIS; OPEN ANGLE GLAUCOMA; OPTIC NERVE; PIA MATER; PRIORITY JOURNAL; RETINA; SCHLEMM CANAL; SCLERA; TRABECULAR MESHWORK;

AGED; AGED, 80 AND OVER; BLOTTING, NORTHERN; CILIARY BODY; ENDOTHELIUM; EYE PROTEINS; GENE EXPRESSION; GLYCOPROTEINS; HUMAN; IN SITU HYBRIDIZATION; MIDDLE AGE; MUSCLE, SMOOTH; OPTIC NERVE; RNA, MESSENGER; SCLERA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRABECULAR MESHWORK;

EID: 0033779717     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Therapy for glaucoma: Costs and consequences
2. Genetic linkage of familial open angle glaucoma to chromosome 1q21-q31
3. Fine mapping of the autosomal dominant juvenile open angle glaucoma (GLC1A) region and evaluation of candidate genes
4. Identification of a gene that causes primary open angle glaucoma
5. Molecular evolution of olfactomedin
6. Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)
7. Analysis of myocilin mutations in 1703 glaucoma patients from five different populations
8. Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells
9. Homozygotes carrying an autosomal dominant TIGR mutation do not manifest glaucoma
10. GLC1A mutations point to regions of potential functional importance on the the TIGR/myoc protein
11. A cellular assay distinguishes normal and mutant TIGR/myocilin protein
12. A trabecular meshwork glucocorticoid response (TIGR) gene mutation affects translocational processing
13. Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product
14. Localization of the stress proteins αβ-crystallin and trabecular meshwork inducible glucocorticoid response protein in normal and glaucomatous trabecular meshwork
15. Expression of GLC1A (Myocilin, TIGR) in the trabecular meshwork
16. Isolation, culture, and characterization of endothelial cells from Schlemm's canal
17. Identification of the region in the N-terminal domain responsible for the cytoplasmic localization of Myoc/Tigr and its association with microtubules
18. Immunofluorescence method for quantifying the trabecular meshwork glucocorticoid response (TIGR) protein in trabecular meshwork and Schlemm's canal cells
19. Localization of myocilin/trabecular meshwork-inducible glucocorticoid response protein in the human eye
20. A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: Molecular cloning, tissue expression, and chromosomal mapping
21. Recurrent mutations in a single exon encoding the evolutionary conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma
22. Characterization of the murine TIGR/myocilin gene
23. Characterization and comparison of the human and mouse GLC1A glaucoma genes
24. Characterization of the mouse Myoc/Tigr gene
25. Expression pattern and in situ localization of the mouse homologue of the human MYOC (GLC1A) gene in adult brain
26. Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin
27. Modulation of myocilin/TIGR expression in human trabecular mesh-work
28. Mouse myocilin (myoc) gene expression in ocular tissues
29. The myocilin (MYOC) gene expression in the human trabecular meshwork
30. Mechanisms of optic nerve damage in primary open angle glaucoma
31. The optic nerve in glaucoma
32. Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma
33. The optic nerve head in glaucomatous optic neuropathy
34. Pressures in the juxtacanalicular tissue and Schlemm's canal in monkeys
35. Extracellular matrix of the trabecular meshwork and optic nerve head
36. A GLC1A gene Gln368Stop mutation in a patient with normal-tension open-angle glaucoma
37. Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate
38. Expression of the glaucoma gene myocilin in cells of the human optic nerve head
39. Expression of myocilin/TIGR in human optic nerve head (ONH) and astrocytes